公开(公告)号：US20180208650A1

公开(公告)日：2018-07-26

申请号：US15875125

申请日：2018-01-19

Applicant: Genzyme Corporation

Inventor： Huawei Qiu ,  Sunghae Park ,  James Stefano

IPC: C07K16/22 ,  A61P19/08 ,  A61P19/10 ,  A61P13/12 ,  A61P35/04 ,  C07K7/06

CPC classification number: C07K16/22 ,  A61K47/68 ,  A61K2039/505 ,  A61P13/12 ,  A61P19/08 ,  A61P19/10 ,  A61P35/04 ,  C07K7/06 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00

Abstract: Provided are recombinant and chemically-conjugated antibodies and fragments thereof modified with one or more poly-aspartate (poly-D) peptides (e.g., a D10 sequence) to improve localization of the antibodies or fragments to bone. Methods of making and using of these antibodies and fragments also are disclosed.

公开(公告)号：US12098194B2

公开(公告)日：2024-09-24

申请号：US17079285

申请日：2020-10-23

Applicant: Genzyme Corporation

Inventor： Huawei Qiu ,  Sunghae Park ,  James Stefano

IPC: A61K39/395 ,  A61K47/68 ,  A61P13/12 ,  A61P19/08 ,  A61P19/10 ,  A61P35/04 ,  C07K7/06 ,  C07K16/22 ,  A61K39/00

CPC classification number: C07K16/22 ,  A61K39/3955 ,  A61K47/68 ,  A61P13/12 ,  A61P19/08 ,  A61P19/10 ,  A61P35/04 ,  C07K7/06 ,  A61K2039/505 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00

Abstract: Provided are recombinant and chemically-conjugated antibodies and fragments thereof modified with one or more poly-aspartate (poly-D) peptides (e.g., a D10 sequence) to improve localization of the antibodies or fragments to bone. Methods of making and using of these antibodies and fragments also are disclosed.

公开(公告)号：US20220089763A1

公开(公告)日：2022-03-24

申请号：US17404412

申请日：2021-08-17

Applicant: Genzyme Corporation

Inventor： Clark Pan ,  Qun Zhou ,  James Stefano ,  Pradeep Dhal ,  Bo Chen ,  Diego Gianolio ,  Robert Miller ,  Huawei Qiu

IPC: C07K16/28 ,  C07K16/32 ,  C07K16/40 ,  A61K47/68 ,  A61K47/54

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

公开(公告)号：US11130816B2

公开(公告)日：2021-09-28

申请号：US16238932

申请日：2019-01-03

Applicant: Genzyme Corporation

Inventor： Clark Pan ,  Qun Zhou ,  James Stefano ,  Pradeep Dhal ,  Bo Chen ,  Diego Gianolio ,  Robert Miller ,  Huawei Qiu

IPC: C07K16/28 ,  C07K16/32 ,  C07K16/40 ,  A61K47/68 ,  A61K47/54

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

公开(公告)号：US10214589B2

公开(公告)日：2019-02-26

申请号：US15417648

申请日：2017-01-27

Applicant: Genzyme Corporation

Inventor： Clark Pan ,  Qun Zhou ,  James Stefano ,  Pradeep Dhal ,  Bo Chen ,  Diego Gianolio ,  Robert Miller ,  Huawei Qiu

IPC: C07K16/28 ,  C07K16/32 ,  C07K16/40 ,  A61K47/68 ,  A61K47/48

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

公开(公告)号：US20250066497A1

公开(公告)日：2025-02-27

申请号：US18787702

申请日：2024-07-29

Applicant: Genzyme Corporation

Inventor： Clark Pan ,  Qun Zhou ,  James Stefano ,  Pradeep Dhal ,  Bo Chen ,  Diego Gianolio ,  Robert Miller ,  Huawei Qiu

IPC: C07K16/28 ,  A61K47/54 ,  A61K47/68 ,  C07K16/32 ,  C07K16/40

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypetpide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

公开(公告)号：US12110338B2

公开(公告)日：2024-10-08

申请号：US17404412

申请日：2021-08-17

Applicant: Genzyme Corporation

Inventor： Clark Pan ,  Qun Zhou ,  James Stefano ,  Pradeep Dhal ,  Bo Chen ,  Diego Gianolio ,  Robert Miller ,  Huawei Qiu

IPC: C07K16/28 ,  A61K47/54 ,  A61K47/68 ,  C07K16/32 ,  C07K16/40

CPC classification number: C07K16/2893 ,  A61K47/549 ,  A61K47/6803 ,  A61K47/6869 ,  A61K47/6889 ,  C07K16/28 ,  C07K16/2809 ,  C07K16/2851 ,  C07K16/32 ,  C07K16/40 ,  C07K2317/40 ,  C07K2317/41 ,  C07K2317/522 ,  C07K2317/56 ,  C07K2317/71 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypeptide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

公开(公告)号：US20210163584A1

公开(公告)日：2021-06-03

申请号：US17079285

申请日：2020-10-23

Applicant: Genzyme Corporation

Inventor： Huawei Qiu ,  Sunghae Park ,  James Stefano

IPC: C07K16/22 ,  A61P19/08 ,  A61P19/10 ,  A61P13/12 ,  C07K7/06 ,  A61P35/04 ,  A61K47/68 ,  A61K39/395

Abstract: Provided are recombinant and chemically-conjugated antibodies and fragments thereof modified with one or more poly-aspartate (poly-D) peptides (e.g., a D10 sequence) to improve localization of the antibodies or fragments to bone. Methods of making and using of these antibodies and fragments also are disclosed.

公开(公告)号：US20170267774A1

公开(公告)日：2017-09-21

申请号：US15417648

申请日：2017-01-27

Applicant: Genzyme Corporation

Inventor： Clark Pan ,  Qun Zhou ,  James Stefano ,  Pradeep Dhal ,  Bo Chen ,  Diego Gianolio ,  Robert Miller ,  Huawei Qiu

IPC: C07K16/28 ,  C07K16/32 ,  C07K16/40

CPC classification number: C07K16/2893 ,  A61K47/549 ,  A61K47/6803 ,  A61K47/6869 ,  A61K47/6889 ,  C07K16/28 ,  C07K16/2809 ,  C07K16/2851 ,  C07K16/32 ,  C07K16/40 ,  C07K2317/40 ,  C07K2317/41 ,  C07K2317/522 ,  C07K2317/56 ,  C07K2317/71 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00

Abstract: The current disclosure provides binding polypeptides (e.g., antibodies), and effector moiety conjugates thereof (e.g., antibody-drug conjugates or ADCs), comprising a site-specifically engineered drug-glycan linkage within native or engineered glycans of the binding polypetpide. The current disclosure also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen-binding polypeptides. Methods of using the antigen-binding polypeptides disclosed herein to treat disease are also provided.

公开(公告)号：US10792342B2

公开(公告)日：2020-10-06

申请号：US16048176

申请日：2018-07-27

Applicant: Genzyme Corporation

Inventor： James Stefano

IPC: A61K38/47 ,  A61K47/60 ,  A61K47/61 ,  A61K47/64 ,  C12N9/40 ,  C12N9/96 ,  A61P43/00 ,  A61P3/00

Abstract: Methods of making ligand-decorated polymer conjugates of therapeutic glycoproteins are described. Improved targeting of glycoproteins to specific tissues is achieved by masking the natural carbohydrate and other surface determinants with high molecular weight polymers, such as, e.g., PEG, polysialic acid, etc., which in turn are decorated with target-specific ligands. In some embodiments, acid-labile linkages in such conjugates or rapidly degradable masking groups allow for the intracellular release of the polymer from the glycoprotein, for example, under conditions found in lysosomes.