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7 条记录 (耗时 0.034 秒)

    Polymer compositions comprising antifibrotic agents, and methods of treatment, pharmaceutical compositions, and methods of preparation therefor
    4.
    发明授权
    Polymer compositions comprising antifibrotic agents, and methods of treatment, pharmaceutical compositions, and methods of preparation therefor 失效
    包含抗纤维化剂的聚合物组合物，治疗方法，药物组合物及其制备方法

    公开(公告)号：US06517824B1

    公开(公告)日：2003-02-11

    申请号：US08650324

    申请日：1996-05-20

    申请人： Joachim Kohn ,  John E. Kemnitzer, III ,  George J. Poiani ,  David J. Riley

    发明人： Joachim Kohn ,  John E. Kemnitzer, III ,  George J. Poiani ,  David J. Riley

    IPC分类号： A61K3174

    CPC分类号： A61K49/0032 ,  A61K47/60 ,  A61K49/0084 ,  A61L15/26 ,  A61L27/18 ,  C08G63/6854 ,  C08G81/00 ,  C08L79/00

    摘要： A method for treating pulmonary hypertension and other diseases involving a defect in collagen metabolism, by administration of an effective amount of a liposome encapsulated copolymer conjugate antifibrotic composition, is disclosed. The antifibrotic agent is preferably a proline analog, such as cis-4-hydroxy-L-proline (cHyp). Consistent, high loadings (>98%) of the antifibrotic agent are achieved by first forming a dipeptide with L-lysine, after which the dipeptide is copolymerized with the polymer component to form the copolymer conjugate. The polymer is preferably poly(ethylene glycol) having a weight average molecular weight of from about 500 to about 15,000. There is thus provided the efficient delivery and rateable release of the antifibrotic agent to inhibit collagen accumulation and thereby treat the diseases involved. Accordingly, there is a substantial reduction in the quantity of antifibrotic agent necessary, and thus a corresponding reduction in the potential for toxicity that would otherwise result from its prolonged administration.

    摘要翻译： 公开了通过施用有效量的脂质体包封的共聚物缀合抗纤维化组合物来治疗涉及胶原代谢缺陷的肺动脉高压和其它疾病的方法。 抗纤维化剂优选为脯氨酸类似物，例如顺式-4-羟基-L-脯氨酸（cHyp）。 通过首先用L-赖氨酸形成二肽来实现抗纤维化剂的一致，高负荷（> 98％），之后将二肽与聚合物组分共聚以形成共聚物缀合物。 聚合物优选为重均分子量为约500至约15,000的聚（乙二醇）。 因此，提供了抗纤维化剂的有效递送和有效释放以抑制胶原蛋白积累，从而治疗所涉及的疾病。 因此，所需的抗纤维化剂的量显着减少，因此由于其延长施用而导致的毒性潜力的相应降低。

    Welding electrode arrangement
    5.
    发明授权
    Welding electrode arrangement 失效
    焊接电极布置

    公开(公告)号：US4910376A

    公开(公告)日：1990-03-20

    申请号：US199254

    申请日：1988-07-01

    申请人： David J. Riley ,  John Molyneus ,  Christopher O'Neil-Bell ,  Stuart McLachlan ,  Kenneth W. Brown

    发明人： David J. Riley ,  John Molyneus ,  Christopher O'Neil-Bell ,  Stuart McLachlan ,  Kenneth W. Brown

    IPC分类号： B23K11/30 ,  B23K35/02

    CPC分类号： B23K11/30 ,  B23K35/0205

    摘要： A welding electrode arrangement comprising an inner electrode and a plurality of electrically interconnected outer electrodes defining a closed figure about the inner electrode, the outer electrodes being resilient in a direction substantially parallel to the axis of the closed figure, the outer electrodes further being in the form of a plurality of inwardly directed fingers extending from and integral with an outer connecting rim.

    摘要翻译： PCT No.PCT / GB87 / 00661 Sec。 371日期：1988年7月1日 102（e）日期1988年8月1日PCT PCT日期为1987年9月21日PCT公开号 出版物WO88 / 02296 日本时间1988年4月7日。一种焊接电极装置，包括内部电极和多个电互连的外部电极，其限定围绕内部电极的闭合图形，所述外部电极在基本上平行于闭合图形的轴线的方向上具有弹性， 外部电极还具有从外部连接边缘延伸并与外部连接边缘成一体的多个向内指向的指状物的形式。

    Methods of and apparatus for making cathode electrodes for sodium sulphur cells
    6.
    发明授权
    Methods of and apparatus for making cathode electrodes for sodium sulphur cells 失效
    制备钠硫电池阴极的方法和设备

    公开(公告)号：US4443172A

    公开(公告)日：1984-04-17

    申请号：US324922

    申请日：1981-11-25

    申请人： David J. Riley ,  Gerald McGreavy

    发明人： David J. Riley ,  Gerald McGreavy

    IPC分类号： H01M10/39 ,  H01M4/02 ,  H01M10/50 ,  H01M4/04

    CPC分类号： H01M4/02

    摘要： A cathode structure for a sodium sulphur cell is formed by putting a fibre matrix into a mould which is closed to shape the matrix to the required form with compression of the fibrous material, the mould being kept at a temperature below 12.degree. C. and preferably between 8.degree. and 10.degree. C. while liquid sulphur is injected into the compressed fibre material.

    摘要翻译： 通过将纤维基质放入模具中来形成钠硫电池的阴极结构，该模具通过压缩纤维材料而将基体形成基体以形成所需形状，模具保持在低于12℃的温度 在8℃和10℃之间，而液体硫注入到压缩纤维材料中。

    Method and apparatus for filling sodium into sodium sulphur cells
    7.
    发明授权
    Method and apparatus for filling sodium into sodium sulphur cells 失效
    将钠装入钠硫细胞的方法和装置

    公开(公告)号：US4365409A

    公开(公告)日：1982-12-28

    申请号：US193058

    申请日：1980-10-02

    申请人： David J. Riley ,  Gerald McGreavy

    发明人： David J. Riley ,  Gerald McGreavy

    IPC分类号： H01M10/39 ,  H01M2/36

    CPC分类号： H01M10/3909 ,  Y10T29/49108 ,  Y10T29/4911 ,  Y10T29/53135

    摘要： For filling sodium into the sodium reservoir of a sodium-sulphur cell, the reservoir is closed except for an open-ended metal filling tube. In a filling machine, the cell is heated to a temperature such that the sodium will remain liquid, the tube is temporarily sealed around a sodium outlet of the filling machine by an inflatable seal, the reservoir is evacuated of air, flushed with an inert gas and then evacuated for vacuum filling with a metered quantity of sodium through a sodium feed tube within said outlet and extending downwardly into the filling tube. The sodium is pressurized using an inert gas to force the sodium into the cell, the gas is evacuated and the filling tube on the cell sealed by pinching and welding.

    摘要翻译： 为了将钠填充到钠硫电池的钠储存器中，除了开放式金属填充管之外，储存器是封闭的。 在填充机中，将电池加热到使钠保持液体的温度，通过充气密封将管暂时密封在填充机的钠出口周围，将储存器抽空，用惰性气体冲洗 然后通过所述出口内的钠进料管抽真空填充计量的钠，并向下延伸到填充管中。 使用惰性气体对钠进行加压以迫使钠进入电池，将气体抽真空，并将电池上的灌装管通过夹紧和焊接密封。