公开(公告)号：US5720950A

公开(公告)日：1998-02-24

申请号：US260080

申请日：1994-06-15

申请人： George J. Poiani ,  David J. Riley ,  Wei-Chi Liao ,  Joachim Kahn ,  Keria Fiorella Gean

发明人： George J. Poiani ,  David J. Riley ,  Wei-Chi Liao ,  Joachim Kahn ,  Keria Fiorella Gean

IPC分类号： A61K47/48 ,  A61K49/00 ,  A61L15/26 ,  A61L27/18 ,  C08G63/664 ,  C08G63/672 ,  C08G63/685 ,  C08G81/00 ,  A61K31/765 ,  A61K9/127

CPC分类号： C08G63/672 ,  A61K47/48215 ,  A61K49/0036 ,  A61K49/0084 ,  A61L15/26 ,  A61L27/18 ,  C08G63/664 ,  C08G63/6852 ,  C08G63/6854 ,  C08G81/00 ,  Y10S514/824

摘要： The present invention concerns a method for treating fibrotic conditions by administration of an effective amount of an antifibrotic agent. The antifibrotic agent is preferably a proline analog, such as cis-4-hydroxy-L-proline (cHyp). The antifibrotic agent is operatively linked to a monomer or a polymer, with or without a linking compound, e.g., lysine. Intravenous administration is preferred. The present method facilitates the delivery and release of the antifibrotic agent to inhibit collagen accumulation and thereby to treat fibrosis where collagen metabolism is implicated. A reduced quantity of the antifibrotic agent and a corresponding reduction in the potential for toxicity resulting from prolonged administration thereof may be realized.

摘要翻译： 本发明涉及通过施用有效量的抗纤维化剂治疗纤维化病症的方法。 抗纤维化剂优选为脯氨酸类似物，例如顺式-4-羟基-L-脯氨酸（cHyp）。 抗纤维化剂与单体或聚合物可操作地连接，具有或不具有连接化合物，例如赖氨酸。 静脉内给药优选。 本方法有利于抗纤维化剂的递送和释放，以抑制胶原蛋白积聚，从而治疗涉及胶原代谢的纤维化。 可以实现减少量的抗纤维化剂和由于延长给药而引起的毒性潜在的相应降低。

公开(公告)号：US5660822A

公开(公告)日：1997-08-26

申请号：US479150

申请日：1995-06-07

申请人： George J. Poiani ,  David J. Riley ,  Wei-Chi Liao ,  Joachim Kahn ,  Keria Fiorella Gean

发明人： George J. Poiani ,  David J. Riley ,  Wei-Chi Liao ,  Joachim Kahn ,  Keria Fiorella Gean

IPC分类号： A61K47/48 ,  A61K49/00 ,  A61L27/18 ,  C08G63/685 ,  A61K31/765 ,  A61K31/785

CPC分类号： A61K49/0032 ,  A61K47/48215 ,  A61L27/18 ,  C08G63/6854 ,  Y10S514/824 ,  Y10S514/838

摘要： The present invention concerns a method for treating fibrotic conditions by administration of an effective amount of an antifibrotic agent. The antifibrotic agent is preferably a proline analog, such as cis-4-hydroxy-L-proline (cHyp). The antifibrotic agent is operatively linked to a monomer or a polymer, with or without a linking compound, e.g., lysine. Intravenous administration is preferred. The present method facilitates the delivery and release of the antifibrotic agent to inhibit collagen accumulation and thereby to treat fibrosis where collegen metabolism is implicated. A reduced quantity of the antifibrotic agent and a corresponding reduction in the potential for toxicity resulting from prolonged administration thereof may be realized.

摘要翻译： 本发明涉及通过施用有效量的抗纤维化剂治疗纤维化病症的方法。 抗纤维化剂优选为脯氨酸类似物，例如顺式-4-羟基-L-脯氨酸（cHyp）。 抗纤维化剂与单体或聚合物可操作地连接，具有或不具有连接化合物，例如赖氨酸。 静脉内给药优选。 本方法有利于抗纤维化剂的递送和释放，以抑制胶原蛋白积聚，从而治疗涉及到代谢的纤维化。 可以实现减少量的抗纤维化剂和由于延长给药而引起的毒性潜在的相应降低。

公开(公告)号：US5372807A

公开(公告)日：1994-12-13

申请号：US934818

申请日：1992-08-24

申请人： George J. Poiani ,  David J. Riley ,  Wei-Chi Liao ,  Joachim Kahn ,  Keria F. Gean

发明人： George J. Poiani ,  David J. Riley ,  Wei-Chi Liao ,  Joachim Kahn ,  Keria F. Gean

IPC分类号： A61K47/48 ,  A61K49/00 ,  A61L15/26 ,  A61L27/18 ,  C08G63/664 ,  C08G63/672 ,  C08G63/685 ,  C08G81/00 ,  A61K31/74 ,  C07D207/00

CPC分类号： C08G63/672 ,  A61K47/48215 ,  A61K49/0036 ,  A61K49/0084 ,  A61L15/26 ,  A61L27/18 ,  C08G63/664 ,  C08G63/6852 ,  C08G63/6854 ,  C08G81/00 ,  Y10S514/824

摘要： The present invention concerns a method for treating fibrotic conditions by administration of an effective amount of an antifibrotic agent. The antifibrotic agent is preferably a proline analog, such as cis-4-hydroxy-L-proline (cHyp). The antifibrotic agent is operatively linked to a monomer or a polymer, with or without a linking compound, e.g., lysine. Intravenous administration is preferred. The present method facilitates the delivery and release of the antifibrotic agent to inhibit collagen accumulation and thereby to treat fibrosis where collegen metabolism is implicated. A reduced quantity of the antifibrotic agent and a corresponding reduction in the potential for toxicity resulting from prolonged administration thereof may be realized.

摘要翻译： 本发明涉及通过施用有效量的抗纤维化剂治疗纤维化病症的方法。 抗纤维化剂优选为脯氨酸类似物，例如顺式-4-羟基-L-脯氨酸（cHyp）。 抗纤维化剂与单体或聚合物可操作地连接，具有或不具有连接化合物，例如赖氨酸。 静脉内给药优选。 本方法有利于抗纤维化剂的递送和释放，以抑制胶原蛋白积聚，从而治疗涉及到代谢的纤维化。 可以实现减少量的抗纤维化剂和由于延长给药而引起的毒性潜在的相应降低。

公开(公告)号：US5626180A

公开(公告)日：1997-05-06

申请号：US379544

申请日：1995-03-16

申请人： Friedhelm Kahn ,  Joachim Kahn

发明人： Friedhelm Kahn ,  Joachim Kahn

IPC分类号： B22D45/00 ,  B22D23/00 ,  B22D27/00 ,  B22D27/13 ,  F02F1/24

CPC分类号： B22D27/13 ,  B22D23/006 ,  B22D27/003 ,  F02F1/24

摘要： The invention relates to a process and devices for casting components in metal alloys on the tilt casting principle in which a quantity of melt metered for casting is spread over a large gate cross section without turbulence from a melt container of the mould (30) into the mould (31) by rotating the casting device. To prevent the formation of oxide and weak structural points, the melt is taken from a metering furnace under a protective gas in a melt container connected to the mould and taken thence into the mould also under a protective gas. The melt hardens there under increased gas pressure on the feeder region of the casting, whereby its properties such as fine-grained, dense structure, high stability under load and accurately dimensioned surfaces are considerably improved.

摘要翻译： PCT No.PCT / EP94 / 01813 Sec。 371日期1995年3月16日 102（e）1995年3月16日PCT PCT 1994年6月3日PCT公布。 出版物WO94 / 29050 日期1994年12月22日本发明涉及一种用于在倾斜铸造原理中铸造金属合金中的部件的方法和装置，其中一定数量的用于铸造的熔体计量的流体在大的浇口横截面上分布而不会从模具的熔体容器中湍流 （30）通过旋转铸造装置进入模具（31）。 为了防止形成氧化物和微弱的结构点，熔融物在与模具连接的熔体容器中的保护气体下的计量炉中取出，并在保护气体下进入模具中。 在铸件的供料区域，熔体在气体压力增加的情况下，熔体会硬化，从而大大提高了其特性，如细粒度，致密结构，负载下的高稳定性和精确尺寸的表面。

公开(公告)号：US06858262B2

公开(公告)日：2005-02-22

申请号：US10019812

申请日：2001-02-21

申请人： Alexander Fischer ,  Joachim Kahn ,  Franz Josef Feikus

发明人： Alexander Fischer ,  Joachim Kahn ,  Franz Josef Feikus

IPC分类号： F02F1/00 ,  B23K26/00 ,  B23K26/08 ,  B23K26/14 ,  B23K26/34 ,  B23K101/04 ,  C23C4/16 ,  C23C24/10 ,  C23C26/00 ,  C23C26/02 ,  B05D3/06 ,  B23K26/073

CPC分类号： C23C24/10 ,  B23K26/0823 ,  B23K26/144 ,  B23K26/32 ,  B23K26/34 ,  B23K2103/08 ,  B23K2103/10 ,  B23K2103/15 ,  C23C4/16 ,  C23C26/02

摘要： The invention relates to a method for manufacturing a surface-alloyed cylindrical, partly cylindrical or hollow cylindrical structural member where in the zone of incidence of the energy beam there is formed a locally bounded melting bath with a heating and melting front, a solution zone and a solidification front. At the side of the energy beam the hard material powder is deposited via a conveyor device in the direction of gravity and is supplied co-ordinated with the feed movement of the workpiece in a width which corresponds to the width of the linear focus and a layer height of 0.3-3 mm is thereby produced. The hard-material powder supplied to the workpiece surface in the heating front of the melting bath is heated by an energy beam at a wavelength of 780-940 nm and in contact with the liquefied matrix alloy the powder is immediately dissolved in the melting bath. Convection is produced in the solution zone by the energy beam having a specific power of at least 104 W/cm2, so that the homogenization process in the melting zone is accelerated, where the linear focus acts on the solution zone until the hard material powder is uniformly distributed in the melting bath. In front of the energy beam the uniformly distributed powder material, which has gone into solution metallurgically in the solution zone, is subjected to directional solidification in the solidification front at a high cooling rate of 200-600 K/s at a feed rate of 500-10,000 mm/min. The invention also relates to a device for implementing the method, consisting of a workpiece clamping device, on which a workpiece is aligned and clamped above index holes and/or above working surfaces, onto whose surface a powder supply and a focusable beam from a beam head are directed.

摘要翻译： 本发明涉及一种用于制造表面合金圆柱形，部分圆柱形或中空圆柱形结构构件的方法，其中在能量束的入射区域中形成具有加热和熔融前沿的局部有界熔融浴，溶液区和 凝固前线。 在能量束的侧面，硬质材料粉末通过输送装置在重力方向沉积，并且以对应于线性焦点的宽度的宽度与工件的进给运动一致地提供一层 由此产生0.3-3mm的高度。 在熔融槽的加热前端供给到工件表面的硬质材料粉末通过波长为780-940nm的能量束加热，并与液化基质合金接触，将粉末立即溶解在熔融槽中。 通过具有至少10 4 W / cm 2的比功率的能量束在溶液区域产生对流，使得在熔融区域中的均匀化过程被加速，其中线性聚焦作用在溶液区域 直到硬质材料粉末均匀地分布在熔融浴中。 在能量束的前面，在溶液区域中冶金化成溶液的均匀分布的粉末材料在固化前沿以200-600K / s的高冷却速率以500的进料速率进行定向凝固 -10,000 mm / min。 本发明还涉及一种用于实施该方法的装置，其包括工件夹持装置，工件在其上对准并夹紧在分度孔和/或工作表面上方，在其表面上具有来自梁的粉末供应源和可聚焦梁 头指向。

公开(公告)号：US06715535B2

公开(公告)日：2004-04-06

申请号：US09835890

申请日：2001-04-16

申请人： Friedhelm Kahn ,  Joachim Kahn ,  Gerhard Eisenberger ,  Horst Paul Grüness ,  Walter Hauder ,  Johann Winkler ,  Peter Stika ,  Johann Preisinger ,  Peter Jungbauer ,  Klaus Schröter ,  Rolf Gosch

发明人： Friedhelm Kahn ,  Joachim Kahn ,  Gerhard Eisenberger ,  Horst Paul Grüness ,  Walter Hauder ,  Johann Winkler ,  Peter Stika ,  Johann Preisinger ,  Peter Jungbauer ,  Klaus Schröter ,  Rolf Gosch

IPC分类号： B22D2300

CPC分类号： B22D23/006

摘要： A method of casting has a mold assembled on a base plate. The finished mold is rotated by approximately 180° around a horizontal rotational axis. A casting container with an upwardly positioned aperture end, removed from the mold, is filled with melt for one casting operation. The casting container is sealingly coupled by the aperture end to the ingate end of the mold. The mold, together with its contacting casting container, is rotated by approximately 180° around a horizontal axis. Accordingly, the melt reaches the mold, and the casting container is removed from the coupled position away from the mold.

摘要翻译： 铸造方法具有在基板上组装的模具。 成品模具围绕水平旋转轴线旋转约180°。 具有向上定位的开口端的铸造容器，从模具中取出，填充有用于一次铸造操作的熔体。 铸造容器通过孔端密封地连接到模具的底端。 模具与其接触铸造容器一起绕水平轴线旋转大约180°。 因此，熔体到达模具，并且铸造容器从远离模具的联接位置移除。