公开(公告)号：US08765700B2

公开(公告)日：2014-07-01

申请号：US11666001

申请日：2005-10-20

申请人： George Tachas ,  James G. Karras ,  Susan Gregory ,  Jeffrey R. Crosby ,  Kenneth W. Dobie ,  Frank C. Bennett

发明人： George Tachas ,  James G. Karras ,  Susan Gregory ,  Jeffrey R. Crosby ,  Kenneth W. Dobie ,  Frank C. Bennett

IPC分类号： C12N15/11

CPC分类号： A61K31/711 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

摘要： A method for the treatment and/or prophylaxis of an animal having a respiratory disease or condition associated with airway hyperresponsiveness, eosinophilia, neutrophilia, leukocytes or overproduction of mucus and/or with the expression of integrin α4 comprising administering to the animal a composition comprising from. 0.001 to 1000 μg per kg body weight of the animal of an antisense compound targeted to a nucleic acid molecule encoding integrin α4.

摘要翻译： 用于治疗和/或预防具有呼吸道疾病或与气道高反应性，嗜酸性粒细胞增多症，嗜中性粒细胞减少，白细胞或过度产生粘液和/或整合素α4相关的病症的动物的方法，包括向动物施用包含 。 0.001至1000μg/ kg体重的靶向编码整联蛋白α4的核酸分子的反义化合物的动物。

公开(公告)号：US20090029931A1

公开(公告)日：2009-01-29

申请号：US11666001

申请日：2005-10-20

申请人： George Tachas ,  James C. Karras ,  Susan Gregory ,  Jeffrey R. Crosby ,  Kenneth W. Dobie ,  C. Frank Bennett

发明人： George Tachas ,  James C. Karras ,  Susan Gregory ,  Jeffrey R. Crosby ,  Kenneth W. Dobie ,  C. Frank Bennett

IPC分类号： A61K31/711 ,  A61P11/06 ,  A61P11/00

CPC分类号： A61K31/711 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

摘要： A method for the treatment and/or prophylaxis of an animal having a respiratory disease or condition associated with airway hyperresponsiveness, eosinophilia, neutrophilia, leukocytes or overproduction of mucus and/or with the expression of integrin α4 comprising administering to the animal a composition comprising from. 0.001 to 1000 μg per kg body weight of the animal of an antisense compound targeted to a nucleic acid molecule encoding integrin α4.

摘要翻译： 用于治疗和/或预防具有呼吸道疾病或与气道高反应性，嗜酸性粒细胞增多症，嗜中性粒细胞增多症，白细胞或过度产生粘液和/或与整联蛋白α4的表达有关的呼吸系统疾病或病症的动物的方法，包括向动物施用包含 。 0.001至1000杯/ kg体重的靶向编码整合素α4的核酸分子的反义化合物的动物。

公开(公告)号：US20080103106A1

公开(公告)日：2008-05-01

申请号：US11548661

申请日：2006-10-11

申请人： James G. Karras ,  Susan Gregory ,  David Tung ,  Jeffrey R. Crosby

发明人： James G. Karras ,  Susan Gregory ,  David Tung ,  Jeffrey R. Crosby

IPC分类号： A61K31/7088 ,  A61P11/00

CPC分类号： C12N15/1138 ,  A61K38/00 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/3525

摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of IL 4R-α, airway hyperresponsiveness, and/or pulmonary inflammation.

摘要翻译： 本文公开了用于调节细胞，组织或动物中IL-4Rα的表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗与IL 4R-α表达，气道高反应性和/或肺部炎症相关的疾病和病症的药物中的用途。

公开(公告)号：US08153603B2

公开(公告)日：2012-04-10

申请号：US11816705

申请日：2006-02-24

申请人： James G. Karras ,  Susan Gregory ,  Jeffrey R. Crosby ,  Mausumee Guha ,  David Tung ,  Susan M. Freier

发明人： James G. Karras ,  Susan Gregory ,  Jeffrey R. Crosby ,  Mausumee Guha ,  David Tung ,  Susan M. Freier

IPC分类号： A61K48/00 ,  C07H21/04

CPC分类号： C12N15/1138 ,  A61K38/00 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/3525

摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of IL 4R-α, airway hyperresponsiveness, and/or pulmonary inflammation.

摘要翻译： 本文公开了用于调节细胞，组织或动物中IL-4Rα的表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗与IL 4R-α的表达，气道高反应性和/或肺部炎症相关的疾病和病症的药物中的用途。

公开(公告)号：US20090312398A1

公开(公告)日：2009-12-17

申请号：US11816705

申请日：2006-02-24

申请人： James G. Karras ,  Susan Gregory ,  Jeffrey R. Crosby ,  Mausumee Guha ,  David Tung ,  Susan M. Freier

发明人： James G. Karras ,  Susan Gregory ,  Jeffrey R. Crosby ,  Mausumee Guha ,  David Tung ,  Susan M. Freier

IPC分类号： A61K31/7125 ,  A61K31/712 ,  A61P11/00 ,  A61K31/7115 ,  A61K31/7088

CPC分类号： C12N15/1138 ,  A61K38/00 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/3525

摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of IL 4R-α, airway hyperresponsiveness, and/or pulmonary inflammation.

摘要翻译： 本文公开了用于调节细胞，组织或动物中IL-4Rα的表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗与IL 4R-α表达，气道高反应性和/或肺部炎症相关的疾病和病症的药物中的用途。

公开(公告)号：US20130331434A1

公开(公告)日：2013-12-12

申请号：US13884067

申请日：2011-11-08

申请人： Brett P. Monia ,  Robert A. MacLeod ,  Jeffrey R. Crosby

发明人： Brett P. Monia ,  Robert A. MacLeod ,  Jeffrey R. Crosby

IPC分类号： C12N15/113

CPC分类号： C12N15/1137 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/321 ,  C12N2310/3525

摘要： Disclosed herein are methods for decreasing Factor 12 and treating or preventing thromboembolic conditions in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to Factor 12 include thrombosis, embolism, and thromboembolism, such as, deep vein thrombosis, pulmonary embolism, myocardial infarction, stroke, and mesenteric thrombosis. Methods for inhibiting Factor 12 can also be used as a prophylactic treatment to prevent individuals at risk for thrombosis and embolism.

摘要翻译： 本文公开了减少因子12并治疗或预防有此需要的个体血栓栓塞症状的方法。 通过施用靶向因子12的反义化合物可以改善的疾病状况的实例包括血栓形成，栓塞和血栓栓塞，例如深静脉血栓形成，肺栓塞，心肌梗塞，中风和肠系膜血栓形成。 抑制因子12的方法也可用作预防性治疗以预防患有血栓栓塞和栓塞危险的个体。

公开(公告)号：US09029337B2

公开(公告)日：2015-05-12

申请号：US12741959

申请日：2008-11-05

申请人： Susan M. Freier ,  Brett P. Monia ,  Hong Zhang ,  Jeffrey R. Crosby ,  Chenguang Zhao

发明人： Susan M. Freier ,  Brett P. Monia ,  Hong Zhang ,  Jeffrey R. Crosby ,  Chenguang Zhao

IPC分类号： C12N15/11 ,  C12N15/113

CPC分类号： C12N15/1137 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12Y304/21021 ,  C12N2310/3525

摘要： Disclosed herein are antisense compounds and methods for decreasing Factor 7 and treating or preventing thromboembolic complications, hyperproliferative disorders, or inflammatory conditions in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to Factor 7 include thrombosis, embolism, and thromboembolism, such as, deep vein thrombosis, pulmonary embolism, myocardial infarction, stroke, cancer, rheumatoid arthritis, and fibrosis.

摘要翻译： 本文公开了用于减少因子7并在需要其的个体中治疗或预防血栓栓塞并发症，过度增殖性疾病或炎性病症的反义化合物和方法。 通过施用靶向因子7的反义化合物可以改善的疾病状况的实例包括血栓形成，栓塞和血栓栓塞，例如深静脉血栓形成，肺栓塞，心肌梗塞，中风，癌症，类风湿性关节炎和纤维化。

公开(公告)号：US20120214862A1

公开(公告)日：2012-08-23

申请号：US13384327

申请日：2010-07-15

申请人： Susan M. Freier ,  Brett P. Monia ,  Hong Zhang ,  Jeffrey R. Crosby ,  Chenguang Zhao

发明人： Susan M. Freier ,  Brett P. Monia ,  Hong Zhang ,  Jeffrey R. Crosby ,  Chenguang Zhao

IPC分类号： A61K31/712

CPC分类号： C12N15/1137 ,  C07H21/00 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y304/21021 ,  C12N2310/3525

摘要： Disclosed herein are antisense compounds and methods for decreasing Factor 7 and treating or preventing thromboembolic complications in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to Factor 7 include thrombosis, embolism, and thromboembolism, such as, deep vein thrombosis, pulmonary embolism, myocardial infarction, and stroke. Antisense compounds targeting Factor 7 can also be used as a prophylactic treatment to prevent individuals at risk for thrombosis and embolism.

摘要翻译： 本文公开了用于减少因子7并在有需要的个体中治疗或预防血栓栓塞并发症的反义化合物和方法。 通过施用靶向因子7的反义化合物可以改善的疾病状况的实例包括血栓形成，栓塞和血栓栓塞，例如深静脉血栓形成，肺栓塞，心肌梗塞和中风。 靶向因子7的反义化合物也可用作预防性治疗，以预防患有血栓栓塞和栓塞风险的个体。

公开(公告)号：US20120083522A1

公开(公告)日：2012-04-05

申请号：US13262904

申请日：2010-04-15

申请人： Brett P. Monia ,  Jeffrey R. Crosby ,  Robert A. MacLeod ,  Susan M. Freier

发明人： Brett P. Monia ,  Jeffrey R. Crosby ,  Robert A. MacLeod ,  Susan M. Freier

IPC分类号： A61K31/7125 ,  A61K31/7115 ,  A61P29/00 ,  A61P19/02 ,  A61P1/00 ,  A61P19/06 ,  A61P37/00 ,  A61P37/08 ,  A61P11/06 ,  A61P35/00 ,  A61P3/00 ,  A61P37/06 ,  A61K31/712 ,  A61P3/10

CPC分类号： C12N15/113 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/7125 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y304/21027 ,  C12N2310/3521

摘要： Disclosed herein are antisense compounds and methods for modulating Factor XI and modulating an inflammatory disease, disorder or condition in an individual in need thereof. Inflammatory diseases in an individual such as arthritis and colitis can be ameliorated or prevented with the administration of antisense compounds targeted to Factor XI.

摘要翻译： 本文公开了用于调节因子XI并调节有需要的个体的炎性疾病，病症或病症的反义化合物和方法。 通过施用针对因子XI的反义化合物，可以改善或预防个体如关节炎和结肠炎中的炎性疾病。

公开(公告)号：US20100137414A1

公开(公告)日：2010-06-03

申请号：US12580241

申请日：2009-10-15

申请人： Susan M. Freier ,  Brett P. Monia ,  Hong Zhang ,  Chenguang Zhao ,  Jeffrey R. Crosby ,  Andrew M. Siwkowski

发明人： Susan M. Freier ,  Brett P. Monia ,  Hong Zhang ,  Chenguang Zhao ,  Jeffrey R. Crosby ,  Andrew M. Siwkowski

IPC分类号： A61K31/7125 ,  C07H21/00 ,  A61K31/7088 ,  A61P9/10

CPC分类号： A61K31/7125 ,  A61K31/366 ,  A61K31/4365 ,  A61K31/4545 ,  A61K31/713 ,  A61K31/727 ,  A61K31/737 ,  C07H21/00 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y304/21027

摘要： Disclosed herein are antisense compounds and methods for decreasing Factor 11 and treating or preventing thromboembolic complications in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to Factor 11 include thrombosis, embolism, and thromboembolism, such as, deep vein thrombosis, pulmonary embolism, myocardial infarction, and stroke. Antisense compounds targeting Factor 11 can also be used as a prophylactic treatment to prevent individuals at risk for thrombosis and embolism.

摘要翻译： 本文公开了用于减少因子11并在需要其的个体中治疗或预防血栓栓塞并发症的反义化合物和方法。 通过施用靶向因子11的反义化合物可以改善的疾病状况的实例包括血栓形成，栓塞和血栓栓塞，例如深静脉血栓形成，肺栓塞，心肌梗塞和中风。 靶向因子11的反义化合物也可用作预防性治疗，以预防患有血栓形成和栓塞风险的个体。