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公开(公告)号：US20080103106A1
公开(公告)日：2008-05-01
申请号：US11548661
申请日：2006-10-11
申请人： James G. Karras , Susan Gregory , David Tung , Jeffrey R. Crosby
发明人： James G. Karras , Susan Gregory , David Tung , Jeffrey R. Crosby
IPC分类号： A61K31/7088 , A61P11/00
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/3525
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of IL 4R-α, airway hyperresponsiveness, and/or pulmonary inflammation.
摘要翻译： 本文公开了用于调节细胞，组织或动物中IL-4Rα的表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗与IL 4R-α表达，气道高反应性和/或肺部炎症相关的疾病和病症的药物中的用途。
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公开(公告)号：US08153603B2
公开(公告)日：2012-04-10
申请号：US11816705
申请日：2006-02-24
申请人： James G. Karras , Susan Gregory , Jeffrey R. Crosby , Mausumee Guha , David Tung , Susan M. Freier
发明人： James G. Karras , Susan Gregory , Jeffrey R. Crosby , Mausumee Guha , David Tung , Susan M. Freier
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/3525
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of IL 4R-α, airway hyperresponsiveness, and/or pulmonary inflammation.
摘要翻译： 本文公开了用于调节细胞，组织或动物中IL-4Rα的表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗与IL 4R-α的表达，气道高反应性和/或肺部炎症相关的疾病和病症的药物中的用途。
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公开(公告)号：US20090312398A1
公开(公告)日：2009-12-17
申请号：US11816705
申请日：2006-02-24
申请人： James G. Karras , Susan Gregory , Jeffrey R. Crosby , Mausumee Guha , David Tung , Susan M. Freier
发明人： James G. Karras , Susan Gregory , Jeffrey R. Crosby , Mausumee Guha , David Tung , Susan M. Freier
IPC分类号： A61K31/7125 , A61K31/712 , A61P11/00 , A61K31/7115 , A61K31/7088
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/3525
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of IL 4R-α, airway hyperresponsiveness, and/or pulmonary inflammation.
摘要翻译： 本文公开了用于调节细胞，组织或动物中IL-4Rα的表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗与IL 4R-α表达，气道高反应性和/或肺部炎症相关的疾病和病症的药物中的用途。
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4.发明授权Topical administrations of antisense compounds to VLA-4 for the treatment of respiratory conditions 失效用于治疗呼吸道疾病的VLA-4反义化合物的局部给药公开(公告)号：US08765700B2
公开(公告)日：2014-07-01
申请号：US11666001
申请日：2005-10-20
申请人： George Tachas , James G. Karras , Susan Gregory , Jeffrey R. Crosby , Kenneth W. Dobie , Frank C. Bennett
发明人： George Tachas , James G. Karras , Susan Gregory , Jeffrey R. Crosby , Kenneth W. Dobie , Frank C. Bennett
IPC分类号： C12N15/11
CPC分类号： A61K31/711 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： A method for the treatment and/or prophylaxis of an animal having a respiratory disease or condition associated with airway hyperresponsiveness, eosinophilia, neutrophilia, leukocytes or overproduction of mucus and/or with the expression of integrin α4 comprising administering to the animal a composition comprising from. 0.001 to 1000 μg per kg body weight of the animal of an antisense compound targeted to a nucleic acid molecule encoding integrin α4.
摘要翻译： 用于治疗和/或预防具有呼吸道疾病或与气道高反应性，嗜酸性粒细胞增多症，嗜中性粒细胞减少，白细胞或过度产生粘液和/或整合素α4相关的病症的动物的方法，包括向动物施用包含 。 0.001至1000μg/ kg体重的靶向编码整联蛋白α4的核酸分子的反义化合物的动物。
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公开(公告)号：US20090281169A1
公开(公告)日：2009-11-12
申请号：US12425190
申请日：2009-04-16
IPC分类号： A61K31/7088 , C07H21/04 , A61P11/00
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/3525
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of IL 4R-α, airway hyperresponsiveness, and/or pulmonary inflammation.
摘要翻译： 本文公开了用于调节细胞，组织或动物中IL-4Rα的表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗与IL 4R-α表达，气道高反应性和/或肺部炎症相关的疾病和病症的药物中的用途。
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公开(公告)号：US07507810B2
公开(公告)日：2009-03-24
申请号：US11548650
申请日：2006-10-11
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/3525
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of IL 4R-α, airway hyperresponsiveness, and/or pulmonary inflammation.
摘要翻译： 本文公开了用于调节细胞，组织或动物中IL-4Rα的表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗与IL 4R-α表达，气道高反应性和/或肺部炎症相关的疾病和病症的药物中的用途。
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7.发明申请Combination therapy using budesonide and antisense oligonucleotide targeted to IL4-receptor alpha 审中-公开使用针对IL4受体α的布地奈德和反义寡核苷酸的联合治疗公开(公告)号：US20100056606A1
公开(公告)日：2010-03-04
申请号：US12066633
申请日：2006-10-03
申请人： James G. Karras , Susan Gregory
发明人： James G. Karras , Susan Gregory
IPC分类号： A61K31/7088
CPC分类号： C12N15/1138 , A61K31/573 , A61K31/58 , A61K31/7088 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/31 , A61K2300/00 , C12N2310/3525
摘要： Provided herein is a method for reducing the amount of steroid required for the prevention, amelioration and/or treatment of pulmonary inflammation and/or airway hyperresponsiveness, comprising administration of the steroid and an oligonucleotide targeted to IL-4R alpha. Also described is a method for the prevention, amelioration and/or treatment of pulmonary inflammation and/or airway hyperresponsiveness comprising administration of a corticosteroid and an oligonucleotide targeted to IL-4R alpha. Further provided are compositions comprising a corticosteroid and an IL-4R alpha targeted antisense oligonucleotide.
摘要翻译： 本文提供的是减少预防，改善和/或治疗肺部炎症和/或气道高反应性所需类固醇的量的方法，包括给予类固醇和靶向IL-4Rα的寡核苷酸。 还描述了一种预防，改善和/或治疗肺部炎症和/或气道高反应性的方法，包括给予皮质类固醇和靶向IL-4Rα的寡核苷酸。 还提供了包含皮质类固醇和IL-4Rα靶向反义寡核苷酸的组合物。
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8.发明申请Topical administrations of antisense compounds to vla-4 for the treatment of respiratory conditions 失效用于治疗呼吸道疾病的vla-4反义化合物的局部给药公开(公告)号：US20090029931A1
公开(公告)日：2009-01-29
申请号：US11666001
申请日：2005-10-20
申请人： George Tachas , James C. Karras , Susan Gregory , Jeffrey R. Crosby , Kenneth W. Dobie , C. Frank Bennett
发明人： George Tachas , James C. Karras , Susan Gregory , Jeffrey R. Crosby , Kenneth W. Dobie , C. Frank Bennett
IPC分类号： A61K31/711 , A61P11/06 , A61P11/00
CPC分类号： A61K31/711 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： A method for the treatment and/or prophylaxis of an animal having a respiratory disease or condition associated with airway hyperresponsiveness, eosinophilia, neutrophilia, leukocytes or overproduction of mucus and/or with the expression of integrin α4 comprising administering to the animal a composition comprising from. 0.001 to 1000 μg per kg body weight of the animal of an antisense compound targeted to a nucleic acid molecule encoding integrin α4.
摘要翻译： 用于治疗和/或预防具有呼吸道疾病或与气道高反应性，嗜酸性粒细胞增多症，嗜中性粒细胞增多症，白细胞或过度产生粘液和/或与整联蛋白α4的表达有关的呼吸系统疾病或病症的动物的方法，包括向动物施用包含 。 0.001至1000杯/ kg体重的靶向编码整合素α4的核酸分子的反义化合物的动物。
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9.发明申请公开(公告)号：US20070270366A1
公开(公告)日：2007-11-22
申请号：US11612904
申请日：2006-12-19
申请人： James Karras , Susan Gregory , Andrew Watt , Jeffrey Crosby
发明人： James Karras , Susan Gregory , Andrew Watt , Jeffrey Crosby
CPC分类号： C12N15/1138 , C07H21/02 , C12N2310/14 , C12N2310/321 , C12N2310/3521
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
摘要翻译： 本文公开了用于调节细胞，组织或动物中IL-4Rα的表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。
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公开(公告)号：US20050261228A1
公开(公告)日：2005-11-24
申请号：US11089191
申请日：2005-03-23
申请人： C. Bennett , Brenda Baker , Susan Freier , Susan Gregory , Ronnie Hanecak , Kevin Anderson , Ming-Yi Chiang , Vickie Brown-Driver , David Ecker , Timothy Vickers , Jacqueline Wyatt , Eric Marcusson , Nicholas Dean , Sanjay Bhanot , Elizabeth Ackermann , Lex Cowsert
发明人： C. Bennett , Brenda Baker , Susan Freier , Susan Gregory , Ronnie Hanecak , Kevin Anderson , Ming-Yi Chiang , Vickie Brown-Driver , David Ecker , Timothy Vickers , Jacqueline Wyatt , Eric Marcusson , Nicholas Dean , Sanjay Bhanot , Elizabeth Ackermann , Lex Cowsert
IPC分类号： A61K38/00 , A61K48/00 , C07H21/04 , C12N15/113 , C12N15/85
CPC分类号： C12N15/1136 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of Interleukin 12 p35 subunit. The compositions comprise chemically modified antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Interleukin 12 p35 subunit. Methods of using these compounds for modulation of Interleukin 12 p35 subunit expression and for treatment of diseases associated with expression of Interleukin 12 p35 subunit are provided.
摘要翻译： 提供化合物，组合物和方法用于调节白细胞介素12p35亚基的表达。 组合物包含靶向编码白细胞介素12p35亚基的核酸的化学修饰的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节白介素12p35亚基表达和治疗与白细胞介素12p35亚基表达相关的疾病的方法。
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