公开(公告)号：US20140379369A1

公开(公告)日：2014-12-25

申请号：US14370205

申请日：2012-01-04

申请人： Georgios Kokovidis ,  Randolph Prydekker ,  William Dowd

发明人： Georgios Kokovidis ,  Randolph Prydekker ,  William Dowd

IPC分类号： G06F19/00

CPC分类号： G06F19/3418 ,  A61B5/002 ,  A61B5/0024 ,  A61B5/7495 ,  A61B2562/08

摘要： In one aspect, disclosed is a system including a first data acquisition device configured to be coupled to the patient to acquire clinical data and a patient-assigned monitor coupled to the first data acquisition device that includes a first wireless communication module and a monitor identification code. The system also includes an ambulatory patient device having an identification code reader configured to capture the monitor identification code, a second data acquisition device configured to acquire clinical data from the patient and a second wireless communication module. Capture of the monitor identification code by the identification code reader automatically initiates wireless pairing between the patient-assigned monitor and the ambulatory patient device. Related apparatus, systems, methods and/or articles are described.

摘要翻译： 一方面，公开了一种系统，包括被配置为耦合到患者以获取临床数据的第一数据采集设备，以及耦合到第一数据采集设备的患者分配的监视器，其包括第一无线通信模块和监视器识别码 。 所述系统还包括具有识别码读取器的移动患者装置，所述识别码读取器配置成捕获所述监视器识别码;第二数据采集装置，被配置为从所述患者获取临床数据和第二无线通信模块。 通过识别码阅读器捕获监视器识别码将自动启动患者分配的监视器和流动患者设备之间的无线配对。 描述了相关装置，系统，方法和/或制品。

公开(公告)号：US4237304A

公开(公告)日：1980-12-02

申请号：US955039

申请日：1978-10-26

申请人： William Dowd ,  Richard C. Krauss ,  Edward R. Freiter

发明人： William Dowd ,  Richard C. Krauss ,  Edward R. Freiter

IPC分类号： C07D263/10 ,  C07D263/12 ,  C07D263/14

CPC分类号： C07D263/10

摘要： 1-Aryl-1-hydroxy-2-methylaminopropanes are rearranged from the erythro isomer to the threo isomer by the process of (1) forming the O,N-diacyl derivative of the arylpropanolamine; (2) reacting the product of step (1) with an anhydrous or substantially anhydrous protic acid (thereby forming a novel oxazolinium salt); and (3) reacting the oxazolinium salt from step (2) with an aqueous protic acid. The threo isomer of the arylpropanolamine is thus produced as an amine/acid salt. This salt can be further purified, if desired, by neutralizing the acid/amine salt with caustic isolating the free amine and reprotonating the free base in isopropanol with, for example, anhydrous HCl. This process is particularly applicable to manufacture of d-pseudoephedrine from 1-ephedrine.

摘要翻译： 通过（1）形成芳基丙醇胺的O，N-二酰基衍生物的方法将1-芳基-1-羟基-2-甲基氨基丙烷从红异构体重排为苏式异构体; （2）使步骤（1）的产物与无水或基本上无水的质子酸（从而形成新的恶唑啉盐）反应; 和（3）使来自步骤（2）的恶唑啉盐与水性质子酸反应。 因此，芳基丙醇胺的苏式异构体以胺/酸盐的形式制备。 如果需要，该盐可以通过用分离游离胺的苛性碱中和酸/胺盐进一步纯化，并用例如无水HCl将异丙醇中的游离碱重新分配。 该方法特别适用于从1-麻黄素制备d-伪麻黄素。

公开(公告)号：US5427766A

公开(公告)日：1995-06-27

申请号：US153113

申请日：1993-11-15

申请人： William Dowd

发明人： William Dowd

IPC分类号： A61K51/04 ,  A61K51/00 ,  A61B6/00

CPC分类号： A61K51/0493 ,  A61K2123/00

摘要： A method for detection and localization of tissues having estrogen receptors during surgery is disclosed. The method involves administering an effective amount of an estradiol derivative labeled with a radionuclide to a patient and then delaying surgery for a time interval for permitting the labeled estradiol derivative to localize in the tissue. Thereafter, an operative field of the animal is surgically accessed an the tissue within the operative filed examined with a probe to detect photon emission from the labeled estradiol derivative.

摘要翻译： 公开了一种用于在手术期间具有雌激素受体的组织的检测和定位的方法。 该方法包括向患者施用有效量的用放射性核素标记的雌二醇衍生物，然后在允许标记的雌二醇衍生物定位于组织中的时间间隔内延迟手术。 此后，通过手术操作动物的手术区域，用探针检查的手术区域内的组织来检测来自标记的雌二醇衍生物的光子发射。

公开(公告)号：US4174352A

公开(公告)日：1979-11-13

申请号：US903425

申请日：1978-05-08

申请人： Thomas H. Fisher ,  William Dowd

发明人： Thomas H. Fisher ,  William Dowd

IPC分类号： C07C45/27 ,  C07C45/00

CPC分类号： C07C45/27

摘要： A process for preparing an allylic or an aromatic aldehyde, such as acrolein or benzaldehyde, the process comprising contacting in a basic, liquid, biphasic mixture and at reactive conditions an allylic halide or a halomethylated aromatic, such as allyl or benzyl chloride, with a divalent chromate ion, is improved by contacting the allylic halide or halomethylated aromatic with the divalent chromate ion in the presence of a catalytic amount of a quaternary ammonium and/or phosphonium salt, such as tetra-n-butylammonium chloride. The improved process is faster, cleaner and more complete than the process of the prior art.

摘要翻译： 一种制备烯丙基或芳族醛如丙烯醛或苯甲醛的方法，该方法包括在碱性，液体，双相混合物中和在反应条件下使烯丙基卤或卤代甲基化的芳族化合物如烯丙基或苄基氯与 二价铬酸根离子通过在催化量的季铵和/或鏻盐如四正丁基氯化铵存在下使烯丙基卤化物或卤代甲基化的芳族化合物与二价铬酸根离子接触来改善。 改进的方法比现有技术的方法更快，更清洁并且更完整。

公开(公告)号：US4186270A

公开(公告)日：1980-01-29

申请号：US973206

申请日：1978-12-26

申请人： William Dowd ,  David H. Naffziger

发明人： William Dowd ,  David H. Naffziger

IPC分类号： C07C17/32 ,  C07C51/08 ,  C07C57/30 ,  C07C57/46 ,  C07C63/33 ,  C07C63/52

CPC分类号： C07C255/00 ,  C07C17/32 ,  C07C51/08

摘要： Pure 2-(4-isobutylphenyl)propionic acid and related compounds are obtained in good yield by a multi-step process comprising chloromethylation of benzene or an alkylbenzene, conversion of the resulting benzyl chloride to the cyanide, alkylation of that product to the phenylpropionitrile or phenylbutyronitrile, reaction of unreacted benzyl cyanide with an aldehyde to inhibit its hydrolysis, and hydrolysis of the nitrile to the free acid. The products are antiinflammatory, antipyretic, and analgesic drugs.

摘要翻译： 通过包括苯或烷基苯氯甲基化的多步法，将得到的苄基氯转化成氰化物，将该产物烷基转化为苯基丙腈或将该产物烷基化，得到纯2-（4-异丁基苯基）丙酸和相关化合物， 苯基丁腈，未反应的苄基氰与醛的反应以抑制其水解，并将腈水解成游离酸。 该产品为抗炎，解热止痛药。

公开(公告)号：US4014880A

公开(公告)日：1977-03-29

申请号：US656558

申请日：1976-02-09

申请人： William Dowd ,  Peter W. Owen

发明人： William Dowd ,  Peter W. Owen

IPC分类号： C07D233/06 ,  C07D239/06 ,  C07D239/00

CPC分类号： C07D239/06 ,  C07D233/06

摘要： The reaction of 2-oxazolines with 1,2- or 1,3-alkylenediamines to form 2-imidazolines or 1,4,5,6-tetrahydropyrimidines is catalyzed by Lewis acids.

摘要翻译： 2-恶唑啉与1,2-或1,3-亚烷基二胺形成2-咪唑啉或1,4,5,6-四氢嘧啶的反应由路易斯酸催化。

公开(公告)号：US4144265A

公开(公告)日：1979-03-13

申请号：US925336

申请日：1978-07-17

申请人： William Dowd ,  Thomas H. Fisher

发明人： William Dowd ,  Thomas H. Fisher

IPC分类号： C07C255/32 ,  C07C120/04 ,  C07C121/66

CPC分类号： C07C255/32

摘要： Quaternary ammonium salts, such as methyl tributyl ammonium chloride, are novel catalysts in a nitrile-forming reaction which comprises stirring together aqueous sodium cyanide and the undistilled m-trifluoromethyl benzyl chloride product of the reaction of chloromethyl methyl ether, chlorosulfonic acid and trifluoromethyl benzene from which chloromethyl ether impurities, methanol, water and some of the unreacted trifluoromethyl benzene are removed. The process is conducted under alkaline conditions in a two-phase liquid reaction medium. m-Trifluoromethyl benzyl nitrile is prepared in excellent yields and purity.

摘要翻译： 季铵盐如甲基三丁基氯化铵是腈形成反应中的新型催化剂，其中包括将氯甲基甲基醚，氯磺酸和三氟甲基苯反应的氰化钠水溶液与未蒸馏的三氟甲基苄基氯产物一起搅拌 除去氯甲基醚杂质，甲醇，水和一些未反应的三氟甲基苯。 该方法在碱性条件下在两相液体反应介质中进行。 以三氟甲基苄腈制备出优异的产率和纯度。