公开(公告)号：US20080146934A1

公开(公告)日：2008-06-19

申请号：US11948935

申请日：2007-11-30

申请人： Gerald Czygan ,  Michael Lippert ,  Tibor Nappholz

发明人： Gerald Czygan ,  Michael Lippert ,  Tibor Nappholz

IPC分类号： A61B8/00 ,  A61N1/00

CPC分类号： A61B8/12 ,  A61B8/06 ,  A61N1/36528 ,  A61N1/36571

摘要： A heart stimulation system comprises an electrode lead comprising at least one stimulation electrode a stimulation pulse generator adapted to generate electric stimulation pulses and being connected to said electrode lead for delivering electric stimulation pulses to at least one chamber of a heart via said stimulation electrode, and a control unit that is connected to said stimulation pulse generator. The electrode lead is a coronary sinus lead adapted to be placed inside the coronary sinus of a human heart and comprises an ultrasonic transducer that is adapted to measure a velocity of blood flow across a mitral valve of a human heart and that is placed on said coronary sinus lead such that the ultrasonic transducer is placed in the coronary sinus or the great cardiac vein when the coronary sinus lead is in its implanted state.

摘要翻译： 心脏刺激系统包括电极引线，其包括至少一个刺激电极，刺激脉冲发生器适于产生电刺激脉冲并且连接到所述电极引线，用于经由所述刺激电极将电刺激脉冲传送到心脏的至少一个腔室;以及 连接到所述刺激脉冲发生器的控制单元。 电极引线是适于放置在人心脏冠状窦内的冠状窦引线，并且包括超声换能器，其适于测量穿过人心脏二尖瓣的血液流速并且放置在所述冠状动脉 窦导线，使得当冠状窦导管处于其植入状态时，超声换能器被放置在冠状窦或大心静脉中。

公开(公告)号：US08521282B2

公开(公告)日：2013-08-27

申请号：US11948935

申请日：2007-11-30

申请人： Gerald Czygan ,  Michael Lippert ,  Tibor Nappholz

发明人： Gerald Czygan ,  Michael Lippert ,  Tibor Nappholz

IPC分类号： A61N1/365

CPC分类号： A61B8/12 ,  A61B8/06 ,  A61N1/36528 ,  A61N1/36571

摘要： A heart stimulation system comprises an electrode lead comprising at least one stimulation electrode a stimulation pulse generator adapted to generate electric stimulation pulses and being connected to said electrode lead for delivering electric stimulation pulses to at least one chamber of a heart via said stimulation electrode, and a control unit that is connected to said stimulation pulse generator. The electrode lead is a coronary sinus lead adapted to be placed inside the coronary sinus of a human heart and comprises an ultrasonic transducer that is adapted to measure a velocity of blood flow across a mitral valve of a human heart and that is placed on said coronary sinus lead such that the ultrasonic transducer is placed in the coronary sinus or the great cardiac vein when the coronary sinus lead is in its implanted state.

摘要翻译： 心脏刺激系统包括电极引线，其包括至少一个刺激电极，刺激脉冲发生器适于产生电刺激脉冲并且连接到所述电极引线，用于经由所述刺激电极将电刺激脉冲传送到心脏的至少一个腔室;以及 连接到所述刺激脉冲发生器的控制单元。 电极引线是适于放置在人心脏冠状窦内的冠状窦引线，并且包括超声换能器，其适于测量穿过人心脏二尖瓣的血液流速并且放置在所述冠状动脉 窦导线，使得当冠状窦导管处于其植入状态时，超声换能器被放置在冠状窦或大心静脉中。

公开(公告)号：US5423868A

公开(公告)日：1995-06-13

申请号：US226462

申请日：1994-04-12

申请人： Tibor Nappholz ,  Stephen R. Chinn ,  Matthew J. Gani

发明人： Tibor Nappholz ,  Stephen R. Chinn ,  Matthew J. Gani

IPC分类号： A61N1/362 ,  A61N1/368

CPC分类号： A61N1/3622 ,  A61N1/368

摘要： A dual-chamber pacemaker for confirming pacemaker mediated tachycardia (PMT) after initial detection. The minimum V-V pacing interval is extended to be slightly longer than the interval of the sensed atrial rate. If the A-V Delay intervals in successive cycles remain constant, as opposed to progressively increasing in Wenckebach fashion, then PMT is confirmed.

摘要翻译： 初始检测后确定起搏器介入性心动过速（PMT）的双室起搏器。 最小V-V起搏间隔延长至比感测心房率的间隔稍长。 如果连续循环中的A-V延迟间隔保持不变，与Wenckebach方式逐渐增加相反，则确认PMT。

公开(公告)号：US5782881A

公开(公告)日：1998-07-21

申请号：US717305

申请日：1996-09-20

申请人： Richard Lu ,  Tibor Nappholz

发明人： Richard Lu ,  Tibor Nappholz

IPC分类号： A61N1/362 ,  A61N1/37 ,  A61N1/30

CPC分类号： A61N1/3622 ,  A61N1/3704 ,  A61N1/3712

摘要： In a cardiac pacemaker, a monitoring window is defined during the a-v delay during which signals sensed in the ventricular channel are monitored. If an abnormal signal is sensed during this window, certain features of this signal are analyzed to determine its origin, such as PVC. If the signal cannot be categorized as a known signal, a safety pacing pulse is applied.

摘要翻译： 在心脏起搏器中，在a-v延迟期间定义监测窗口，在此期间监测在心室通道中感测的信号。 如果在此窗口期间感测到异常信号，则会分析该信号的某些特征以确定其来源，如PVC。 如果信号不能被分类为已知信号，则应用安全起搏脉冲。

公开(公告)号：US06421555B1

公开(公告)日：2002-07-16

申请号：US09595022

申请日：2000-06-16

申请人： Tibor Nappholz

发明人： Tibor Nappholz

IPC分类号： A61B50428

CPC分类号： A61N1/3704 ,  A61N1/37

摘要： A method for discriminating between externally-radiated, electromagnetic interference signals and electromedical scanning signals comprises the following steps: the preamplification of the scanning signals by means of two preamplifiers; the comparison of the preamplified scanning signals by a comparator; the phase-sensitive evaluation of the comparator output signal for differentiating between scanning signals and interference signals; the feedback of the comparator output signal to the amplification control of the preamplifiers such that the comparator output signal is minimized when an interference signal is detected.

摘要翻译： 用于鉴别外部辐射，电磁干扰信号和电子扫描信号的方法包括以下步骤：通过两个前置放大器对扫描信号进行前置放大; 通过比较器比较前置放大的扫描信号; 用于区分扫描信号和干扰信号的比较器输出信号的相敏性评估; 比较器输出信号的反馈到前置放大器的放大控制，使得当检测到干扰信号时比较器输出信号被最小化。

公开(公告)号：US5755740A

公开(公告)日：1998-05-26

申请号：US956764

申请日：1997-10-22

申请人： Tibor Nappholz

发明人： Tibor Nappholz

IPC分类号： A61N1/365

CPC分类号： A61N1/36585

摘要： In a dual sensor pacer/defibrillator the output of a metabolic sensor is used to calibrate the output a second sensor over a long time period. In this manner the two sensor outputs track accurately the metabolic demand of the patient and no recalibration by a clinician is necessary.

摘要翻译： 在双传感器起搏器/去纤颤器中，代谢传感器的输出用于在长时间段内校准第二传感器的输出。 以这种方式，两个传感器输出准确地跟踪患者的代谢需求，并且不需要由临床医师重新校准。

公开(公告)号：US5609610A

公开(公告)日：1997-03-11

申请号：US530054

申请日：1995-09-19

申请人： Tibor Nappholz

发明人： Tibor Nappholz

IPC分类号： A61N1/362 ,  A61N1/368 ,  A61N1/365

CPC分类号： A61N1/3622 ,  A61N1/368 ,  A61N1/3682

摘要： In an implanted pacemaker three basic pacing intervals are established: an A-V delay, a PVARP and an alert interval. These three intervals together define an atrial-to atrial interval which is preferably a function of a metabolic indicated rate. The PVARP and alert interval are adaptively adjusted to optimize the PVARP for the patient without affecting the atrial-to-atrial interval.

摘要翻译： 在植入式起搏器中，建立了三个基本起搏间隔：A-V延迟，PVARP和警报间隔。 这三个间隔一起定义心房至心房间隔，其优选地是代谢指示速率的函数。 自适应地调整PVARP和警报间隔，以优化患者的PVARP，而不影响心房间隔。

公开(公告)号：US5690690A

公开(公告)日：1997-11-25

申请号：US712238

申请日：1996-09-12

申请人： Tibor Nappholz ,  Steve Chinn

发明人： Tibor Nappholz ,  Steve Chinn

IPC分类号： A61N1/372 ,  G06F9/445 ,  A61N1/362

CPC分类号： A61N1/37252 ,  G06F8/60 ,  A61N1/37235

摘要： A system for providing cardiac stimulation to a patient includes an implantable stimulation device with a microprocessor and a separate programmer. The stimulation device includes a memory holding substantially all the information necessary to program the device, including device specific information such as various modes of operations, the operational parameters associated with each mode, as well as patient specific information. All this information is transferred to the programmer for display and for generating a program. The program is than transferred back to the device for operating its microprocessor. In this manner, any programmer can be used to generate a program for any cardiac stimulation device without the need for providing specific programming information to the programmer for each specific device.

摘要翻译： 用于向患者提供心脏刺激的系统包括具有微处理器和单独编程器的可植入刺激装置。 刺激装置包括存储器，其基本保持编程设备所需的所有信息，包括诸如各种操作模式的设备特定信息，与每个模式相关联的操作参数以及患者特定信息。 所有这些信息都传送给程序员进行显示和生成一个程序。 该程序不是转移回到用于操作其微处理器的设备。 以这种方式，可以使用任何编程器来生成用于任何心脏刺激装置的程序，而不需要为每个特定装置向编程器提供特定编程信息。

公开(公告)号：US5660183A

公开(公告)日：1997-08-26

申请号：US515996

申请日：1995-08-16

申请人： Chih-Ming J. Chiang ,  Alan D. Bernstein ,  Victor Parsonnet ,  Tibor Nappholz

发明人： Chih-Ming J. Chiang ,  Alan D. Bernstein ,  Victor Parsonnet ,  Tibor Nappholz

IPC分类号： A61N1/37 ,  A61N1/372 ,  G06F19/00 ,  A61B5/00

CPC分类号： A61N1/3702 ,  G06F19/3406 ,  G06F19/345

摘要： A diagnostic device for providing a prognosis of patient with an implanted cardiac device includes a data bank for storing statistical data relating various symptoms characterizing cardiac problems and associated complications. The device further includes an input device so that a clinician can enter patient specific data including his symptoms. A set of rules stored in a memory are used to provide a diagnosis for the patient based on the statistical data. Preferably the diagnostic device is incorporated in a programmer for a pacemaker or other implantable cardiac device.

摘要翻译： 用于向植入式心脏装置提供患者预后的诊断装置包括用于存储关于表征心脏问题和相关并发症的各种症状的统计数据的数据库。 该装置还包括输入装置，使得临床医生可以输入包括他的症状的患者特定数据。 存储在存储器中的一组规则用于基于统计数据为患者提供诊断。 优选地，诊断装置并入用于起搏器或其它可植入心脏装置的编程器中。

公开(公告)号：US5643327A

公开(公告)日：1997-07-01

申请号：US492479

申请日：1995-06-20

申请人： Albert K. Dawson ,  Tibor Nappholz

发明人： Albert K. Dawson ,  Tibor Nappholz

IPC分类号： A61N1/362 ,  A61N1/365 ,  A61N1/368

CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/3682

摘要： The cardiac output of a paced heart is optimized by measuring a parameter indicative of the volume of blood in a heart chamber as a function of a pacing parameter. The pacing parameter is adjusted so that the heart pumps the maximum volume at different rates for hearts with debilitating pathologies. This pacing parameter is then used for controlling the pacing pulses for pacing the heart. Preferably the volume parameter is the paced depolarization integral and the pacing parameter is the A-V delay.

摘要翻译： 作为起搏参数的函数，通过测量指示心室中的血液体积的参数来优化起搏心脏的心输出量。 调整起搏参数，使心脏以令人衰弱的病态泵入不同速率的最大体积。 然后，该起搏参数用于控制用于起搏心脏的起搏脉冲。 体积参数最好是起搏去极化积分，起搏参数是A-V延迟。