公开(公告)号：US20080146934A1

公开(公告)日：2008-06-19

申请号：US11948935

申请日：2007-11-30

申请人： Gerald Czygan ,  Michael Lippert ,  Tibor Nappholz

发明人： Gerald Czygan ,  Michael Lippert ,  Tibor Nappholz

IPC分类号： A61B8/00 ,  A61N1/00

CPC分类号： A61B8/12 ,  A61B8/06 ,  A61N1/36528 ,  A61N1/36571

摘要： A heart stimulation system comprises an electrode lead comprising at least one stimulation electrode a stimulation pulse generator adapted to generate electric stimulation pulses and being connected to said electrode lead for delivering electric stimulation pulses to at least one chamber of a heart via said stimulation electrode, and a control unit that is connected to said stimulation pulse generator. The electrode lead is a coronary sinus lead adapted to be placed inside the coronary sinus of a human heart and comprises an ultrasonic transducer that is adapted to measure a velocity of blood flow across a mitral valve of a human heart and that is placed on said coronary sinus lead such that the ultrasonic transducer is placed in the coronary sinus or the great cardiac vein when the coronary sinus lead is in its implanted state.

摘要翻译： 心脏刺激系统包括电极引线，其包括至少一个刺激电极，刺激脉冲发生器适于产生电刺激脉冲并且连接到所述电极引线，用于经由所述刺激电极将电刺激脉冲传送到心脏的至少一个腔室;以及 连接到所述刺激脉冲发生器的控制单元。 电极引线是适于放置在人心脏冠状窦内的冠状窦引线，并且包括超声换能器，其适于测量穿过人心脏二尖瓣的血液流速并且放置在所述冠状动脉 窦导线，使得当冠状窦导管处于其植入状态时，超声换能器被放置在冠状窦或大心静脉中。

公开(公告)号：US08521282B2

公开(公告)日：2013-08-27

申请号：US11948935

申请日：2007-11-30

申请人： Gerald Czygan ,  Michael Lippert ,  Tibor Nappholz

发明人： Gerald Czygan ,  Michael Lippert ,  Tibor Nappholz

IPC分类号： A61N1/365

CPC分类号： A61B8/12 ,  A61B8/06 ,  A61N1/36528 ,  A61N1/36571

摘要： A heart stimulation system comprises an electrode lead comprising at least one stimulation electrode a stimulation pulse generator adapted to generate electric stimulation pulses and being connected to said electrode lead for delivering electric stimulation pulses to at least one chamber of a heart via said stimulation electrode, and a control unit that is connected to said stimulation pulse generator. The electrode lead is a coronary sinus lead adapted to be placed inside the coronary sinus of a human heart and comprises an ultrasonic transducer that is adapted to measure a velocity of blood flow across a mitral valve of a human heart and that is placed on said coronary sinus lead such that the ultrasonic transducer is placed in the coronary sinus or the great cardiac vein when the coronary sinus lead is in its implanted state.

摘要翻译： 心脏刺激系统包括电极引线，其包括至少一个刺激电极，刺激脉冲发生器适于产生电刺激脉冲并且连接到所述电极引线，用于经由所述刺激电极将电刺激脉冲传送到心脏的至少一个腔室;以及 连接到所述刺激脉冲发生器的控制单元。 电极引线是适于放置在人心脏冠状窦内的冠状窦引线，并且包括超声换能器，其适于测量穿过人心脏二尖瓣的血液流速并且放置在所述冠状动脉 窦导线，使得当冠状窦导管处于其植入状态时，超声换能器被放置在冠状窦或大心静脉中。

公开(公告)号：US20110224748A1

公开(公告)日：2011-09-15

申请号：US13041025

申请日：2011-03-04

申请人： Michael LIPPERT ,  Michael Vollkron ,  Gerald Czygan ,  Stefan Paule

发明人： Michael LIPPERT ,  Michael Vollkron ,  Gerald Czygan ,  Stefan Paule

IPC分类号： A61N1/39 ,  A61B5/02 ,  A61N1/365

CPC分类号： A61B5/0205 ,  A61B5/02028 ,  A61B5/6846 ,  A61B5/7275 ,  A61N1/365 ,  A61N1/3702 ,  G06F19/00

摘要： A monitoring device for a patient for predicting a cardiovascular anomaly and a method for operating a monitoring device is provided. Furthermore, an implantable electrotherapy device, such as an implantable cardiac pacemaker, an implantable cardioverter, or an implantable defibrillator, having a monitoring device are also provided. In an embodiment, the monitoring device acquires a value change of a hemodynamic parameter, which occurs as a result of a detected value change of a state parameter, for example, as a result of an activation or deactivation of a cardiac resynchronization therapy. By suitable evaluation of the value change of the hemodynamic parameter, the monitoring device can output an evaluation result signal which is indicative of an imminence of a cardiovascular anomaly, such as a cardiac decompensation, long beforehand and with high specificity.

摘要翻译： 提供了一种用于预测心血管异常的患者的监测装置和用于操作监测装置的方法。 此外，还提供了具有监测装置的可植入电疗设备，例如可植入心脏起搏器，植入式心律转复器或可植入除颤器。 在一个实施例中，监测装置获取血液动力学参数的值变化，其作为状态参数的检测值变化的结果，例如作为心脏再同步治疗的激活或停用的结果而发生。 通过对血液动力学参数的值变化的适当评价，监视装置可以预先长时间地以高特异性输出表示心血管异常的心血管异常现象的评价结果​​信号，例如心脏代偿失调。

公开(公告)号：US20100268294A1

公开(公告)日：2010-10-21

申请号：US12749723

申请日：2010-03-30

申请人： Michael Vollkron ,  Gerald Czygan ,  Thomas Kraemer ,  Michael Lippert ,  Olaf Skerl

发明人： Michael Vollkron ,  Gerald Czygan ,  Thomas Kraemer ,  Michael Lippert ,  Olaf Skerl

IPC分类号： A61N1/365 ,  G06N5/02 ,  G06F11/07 ,  G06F17/00 ,  A61B5/021 ,  A61B5/0452 ,  A61N1/39

CPC分类号： A61N1/3627 ,  A61B5/0215 ,  A61B5/02158 ,  A61B5/053 ,  A61B5/1076 ,  A61N1/365 ,  A61N1/36521 ,  A61N1/36528 ,  A61N1/36564 ,  A61N1/36578

摘要： Embodiments relate to a heart monitor, which is connected to or can be connected to at least one sensor for pressure and volume data or equivalent substitute variables and which comprises an evaluation unit for processing at least one input signal reflecting the temporal course of pressure and volume data or equivalent substitute variables of the heart. The evaluation unit is configured such that it segments the input signal in accordance with individual completed cardiac cycles and examines segments of the input signal obtained in this way as to whether a particular segment of the input signal represents a PV diagram, which corresponds to specified quality conditions regarding the direction of circulation, morphology and distance between a starting and end values.

摘要翻译： 实施例涉及心脏监测器，心脏监测器连接到或可以连接至至少一个用于压力和体积数据或等效替代变量的传感器，并且其包括用于处理反映压力和体积的时间过程的至少一个输入信号的评估单元 数据或等效替代变量的心脏。 评估单元被配置为使得其根据各个完成的心动周期来分段输入信号，并且检查以这种方式获得的输入信号的段是关于输入信号的特定段是否表示对应于指定质量的PV图 关于循环方向，形态以及起始和终点之间的距离的条件。

公开(公告)号：US20100010354A1

公开(公告)日：2010-01-14

申请号：US12497778

申请日：2009-07-06

申请人： Olaf Skerl ,  Michael Lippert ,  Gerald Czygan

发明人： Olaf Skerl ,  Michael Lippert ,  Gerald Czygan

IPC分类号： A61B8/14

CPC分类号： A61B5/1107 ,  A61B5/0031 ,  A61B5/029 ,  A61B5/107 ,  A61B5/6846 ,  A61B5/686 ,  A61B8/02 ,  A61B8/06 ,  A61B8/0833 ,  A61B8/12 ,  A61B8/42 ,  A61B8/4483 ,  A61B8/543 ,  A61N1/36578

摘要： An implantable measurement arrangement for intracorporeal acoustic measurement of geometric parameters and motion parameters in and on organs and/or tissues of a patient includes an implantable device, in particular an electromedical device; an implantable sonic transducer for transmitting and receiving ultrasonic waves, the transducer being in signal connection with the implantable device; and an implantable reflector in communication with the implantable device and situated at a distance from the sonic transducer for reflecting the ultrasonic waves back in the direction of the sonic transducer. The electromedical device can analyze the ultrasonic waves picked up and reflected back by the sonic transducer.

摘要翻译： 用于体内和/或组织中几何参数和运动参数的体内声学测量的可植入测量装置包括可植入装置，特别是电动医疗装置; 用于发射和接收超声波的可植入声波换能器，所述换能器与所述可植入装置信号连接; 以及可植入反射器，其与所述可植入装置连通并且位于距离所述声音换能器一定距离处，用于将所述超声波反射回所述声音换能器的方向。 电子设备可以分析由声音传感器拾取并反射回的超声波。

公开(公告)号：US08965493B2

公开(公告)日：2015-02-24

申请号：US13040926

申请日：2011-03-04

申请人： Olaf Skerl ,  Michael Lippert ,  Gerald Czygan

发明人： Olaf Skerl ,  Michael Lippert ,  Gerald Czygan

IPC分类号： A61B5/04 ,  A61B5/053 ,  A61B5/00

CPC分类号： A61B5/0535 ,  A61B5/6846 ,  A61B5/7207 ,  A61B2562/0209 ,  A61B2562/043

摘要： An electromedical implant for monitoring a thoracic property of a living being is provided that includes a detector arrangement including an impedance measuring unit and an electrode arrangement, which are equipped to capture a measurement signal associated with the thoracic property in the form of an impedance signal; a monitoring arrangement, which is connected to the detector arrangement and equipped to generate a parameter from the measurement signal that is indicative of the thoracic property, and an evaluation unit, which is connected to the monitoring arrangement and equipped to determine an evaluation result regarding the thoracic property based on the parameter. According to the invention, the electrode arrangement comprises at least a plurality of mutually isolated electrodes, which are disposed on the housing and operatively connected by way of the impedance measuring unit and which can be separately controlled, wherein an electrode body has a strip shape.

摘要翻译： 提供了一种用于监测生命体的胸部性质的电植入物，其包括检测器装置，所述检测器装置包括阻抗测量单元和电极装置，其被配备为以阻抗信号的形式捕获与胸部特性相关联的测量信号; 监视装置，其连接到所述检测器装置，并且被配备为从所述测量信号生成指示胸部特性的参数;以及评估单元，所述评估单元连接到所述监视装置并被配备以确定关于所述检测装置的评估结果 胸部属性基于参数。 根据本发明，电极布置包括至少多个相互隔离的电极，它们设置在壳体上并且通过阻抗测量单元可操作地连接并且可以被单独控制，其中电极体具有带状。

公开(公告)号：US08491485B2

公开(公告)日：2013-07-23

申请号：US13038428

申请日：2011-03-02

申请人： Gerald Czygan ,  Michael Lippert ,  Olaf Skerl

发明人： Gerald Czygan ,  Michael Lippert ,  Olaf Skerl

IPC分类号： A61B5/024 ,  A61B5/026

CPC分类号： A61B5/0535 ,  A61B5/029 ,  A61B5/0295 ,  A61B5/0402 ,  A61B5/6846 ,  A61B5/721 ,  A61B5/7214 ,  A61B5/7275

摘要： An electromedical implant (100, 101, 102, 103) for monitoring a cardiac blood flow (B1) of a patient includes a detector (10, 10′, 10″) which obtains a first measurement signal (S1) associated with the cardiac blood flow (B1) and a second measurement signal (S2) associated with the epithoracic, peripheral blood flow (B2). A monitoring assembly (20) then generates a first parameter (P1) from the first measurement signal (S1) which is indicative of a time (tsys) at which blood is ejected from the heart, and a second parameter (2) from the second measurement signal (S2) which is indicative of a time (tgef) of a blood pulse in the thoracic tissue which is associated with the ejection of blood. An evaluation unit (30) then generates a pulse transit time (Δt=tgef−tsys) from the first parameter (P1) and the second parameter (P2). The detector (10, 10′, 10″) includes an impedance measuring unit (12) having an electrode assembly (11, 11′) for detection of at least the second measurement signal (S2) in the form of an impedance signal.

摘要翻译： 用于监测患者的心脏血流（B1）的电植入物（100,101,102,103）包括检测器（10,10'，10“），其获得与心脏相关联的第一测量信号（S1） 血液流（B1）和与脑外周血流（B2）相关联的第二测量信号（S2）。 监测组件（20）然后从第一测量信号（S1）产生指示从心脏喷出血液的时间（tsys）的第一参数（P1），以及来自第二测量信号的第二参数（2） 测量信号（S2），其指示与血液喷射相关联的胸部组织中的血液脉冲的时间（tgef）。 评估单元（30）然后从第一参数（P1）和第二参数（P2）产生脉冲传播时间（Deltat = tgef-tsys）。 检测器（10,10'，10“）包括具有用于以阻抗信号的形式检测至少第二测量信号（S2）的电极组件（11,11'）的阻抗测量单元（12）。

公开(公告)号：US07702389B2

公开(公告)日：2010-04-20

申请号：US11559626

申请日：2006-11-14

申请人： Gerald Czygan ,  Michael Lippert

发明人： Gerald Czygan ,  Michael Lippert

IPC分类号： A61N1/00

CPC分类号： A61N1/3627

摘要： The invention concerns implantable cardiac stimulation devices in general which have at least one stimulation pulse generator (A-STIM; RV-STIM; LV-STIM) to selectively generate a stimulation pulse for delivery to one of at least two different chambers of a heart, said chambers include right and left atria and right and left ventricles, at least one impedance measuring stage (I, U, IMP) being connected to electrodes or connectors for such electrodes to measure an intracardiac impedance when in use, a control unit (CTRL) connected to the stimulation pulse generator and to the impedance measuring unit and being adapted to process a minimum impedance value for a heart cycle to trigger stimulation pulses for two different chambers of the heart with an adjustable time delay (VVD; AVD) and to adjust said time delay depending upon the measured intracardiac impedance minimum value. According to the invention the control unit is adapted to adjust the time delay such that the minimum value of the intracardiac impedance during one heart cycle is minimized or such that the AVD delay is equal to the time interval between an atrial event and the point of time when the minimum impedance value occurs after said atrial contraction.

摘要翻译： 本发明涉及一般具有至少一个刺激脉冲发生器（A-STIM; RV-STIM; LV-STIM）的可植入心脏刺激装置，以选择性地产生用于递送至心脏的至少两个不同室中的一个的刺激脉冲， 所述腔室包括右心房和左心房以及右心室和左心室，至少一个阻抗测量平台（I，U，IMP）连接到用于这种电极的电极或连接器，用于在使用时测量心内阻抗，控制单元（CTRL） 连接到刺激脉冲发生器和阻抗测量单元，并且适于处理用于心脏周期的最小阻抗值以用可调节的时间延迟（VVD; AVD）触发心脏的两个不同腔室的刺激脉冲，并且调整所述 时间延迟取决于测量的心内阻抗最小值。 根据本发明，控制单元适于调整时间延迟，使得在一个心脏周期期间心内阻抗的最小值被最小化或使得AVD延迟等于心房事件与时间点之间的时间间隔 当在所述心房收缩之后发生最小阻抗值时。

公开(公告)号：US20090048524A1

公开(公告)日：2009-02-19

申请号：US12190113

申请日：2008-08-12

申请人： Hans-Jurgen WILDAU ,  Gerald Czygan ,  Michael Diebold ,  Michael Lippert ,  Claus Harder ,  Thomas Schmitz-Rode

发明人： Hans-Jurgen WILDAU ,  Gerald Czygan ,  Michael Diebold ,  Michael Lippert ,  Claus Harder ,  Thomas Schmitz-Rode

IPC分类号： A61B5/0215

CPC分类号： A61B5/0215 ,  A61B5/0031 ,  A61B5/02156 ,  A61B5/02158 ,  A61B5/6862 ,  A61B5/6876 ,  A61B5/6882 ,  A61B2560/0219 ,  A61B2560/0252 ,  A61B2560/0257

摘要： Implantable pressure measuring unit for internal pressure measurement in a blood vessel or heart of a patient, having a pressure sensor having electrical signal output, fixing means adapted to the intended measurement location for fixing the pressure sensor, a power supply unit of the pressure sensor, a signal detection unit connected by a line to the signal output of the pressure sensor, and a transmitting unit connected to a measurement data output of the signal detection unit, in particular for wireless transmission of measurement data to an analysis unit, in particular outward from the patient body.

摘要翻译： 一种用于在患者的血管或心脏中进行内部压力测量的可植入压力测量单元，具有具有电信号输出的压力传感器，适于用于固定压力传感器的预期测量位置的固定装置，压力传感器的电源单元， 信号检测单元，其通过线路连接到压力传感器的信号输出;以及发送单元，连接到信号检测单元的测量数据输出，特别是用于将测量数据无线传输到分析单元，特别是从 病人身体。

公开(公告)号：US20060135886A1

公开(公告)日：2006-06-22

申请号：US11293398

申请日：2005-12-02

申请人： Michael Lippert ,  Gerald Czygan

发明人： Michael Lippert ,  Gerald Czygan

IPC分类号： A61N1/368

CPC分类号： A61B5/0031 ,  A61B5/0537

摘要： An electromedical implant includes a measuring signal generator, an impedance measuring unit to determine the impedance of human or animal tissue, a control unit which, for controlling the measuring signal generator and the impedance measuring unit, is at least indirectly connected to the measuring signal generator and to the impedance measuring unit, as well as an electrode arrangement comprising at least two electrodes which can be directly or indirectly connected or at least temporarily connected to the measuring signal generator and to the impedance measuring unit, or to a connection for such an electrode arrangement. The measuring signal generator is designed to generate and emit a current pulse or a series of current pulses, and the control unit is designed at a specific point in time to cause the measuring signal generator (to generate and emit a current pulse, and to cause the impedance measuring unit to measure the voltage that is present between the electrodes connected to the measuring signal generator and the impedance measuring unit after the passing of at least two time periods of different length that start with commencement of the current pulse being emitted and end before the end of emitting the current pulse, and to issue a voltage value which in each case represents the measured voltage.

摘要翻译： 电动植入物包括测量信号发生器，用于确定人体或动物组织的阻抗的阻抗测量单元，用于控制测量信号发生器和阻抗测量单元的控制单元至少间接连接到测量信号发生器 和阻抗测量单元，以及包括至少两个电极的电极装置，所述至少两个电极可以直接或间接连接或至少临时连接到测量信号发生器和阻抗测量单元，或者连接到这种电极 安排。 测量信号发生器被设计成产生和发出电流脉冲或一系列电流脉冲，并且控制单元被设计在特定的时间点，以使得测量信号发生器（产生和发射电流脉冲，并引起 所述阻抗测量单元用于测量在连接到所述测量信号发生器的电极和所述阻抗测量单元之间存在的电压，所述电压在经过所述至少两个不同长度的时间段之后，所述至少两个不同长度的时间段从所述当前脉冲的开始开始并被发射 发射电流脉冲的结束，并发出在每种情况下表示测量电压的电压值。