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公开(公告)号：US07482437B2
公开(公告)日：2009-01-27
申请号：US11670467
申请日：2007-02-02
申请人： Gerald F. Sigler , Raymond A. Hui , Ina Deras , Richard Terry Root , Mitali Ghoshal , Erasmus Huber , Herbert W. Von Der Eltz , Sigrun Metz , Peter Kern
发明人： Gerald F. Sigler , Raymond A. Hui , Ina Deras , Richard Terry Root , Mitali Ghoshal , Erasmus Huber , Herbert W. Von Der Eltz , Sigrun Metz , Peter Kern
IPC分类号： C07K17/06 , C07K1/10 , C07K16/00 , C07D403/02 , C07D241/04
摘要： Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.
摘要翻译： 可用于产生HIV蛋白酶抑制剂的免疫原的活化的半抗原，可用于产生HIV蛋白酶抑制剂的抗体的免疫原，以及可用于HIV蛋白酶抑制剂沙奎那韦的免疫测定的抗体和标记的缀合物。 新型半抗原在中心非末端羟基处具有活化的功能。 还描述了与洛匹那韦，奈非那韦，安仁那韦，利托那韦和茚地那韦具有小于10％交叉反应性的沙奎那韦特异性单克隆抗体，以及产生所述抗体的鼠杂交瘤。
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公开(公告)号：US07193065B2
公开(公告)日：2007-03-20
申请号：US10669831
申请日：2003-09-24
申请人： Gerald F. Sigler , Raymond A. Hui , Ina Deras , Richard Terry Root , Mitali Ghoshal , Erasmus Huber , Herbert W. Von Der Eltz , Sigrun Metz , Peter Kern
发明人： Gerald F. Sigler , Raymond A. Hui , Ina Deras , Richard Terry Root , Mitali Ghoshal , Erasmus Huber , Herbert W. Von Der Eltz , Sigrun Metz , Peter Kern
IPC分类号： C07K16/44 , C07K17/06 , C07D239/10 , G01N33/532 , G01N33/533
摘要： Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for HIV protease inhibitors. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group common to all HIV protease inhibitors, e.g., saquinavir, nelfinavir, indinavir, amprenavir, ritonavir, lopinavir, and atazanavir.
摘要翻译： 可用于产生HIV蛋白酶抑制剂免疫原的活化半抗原，可用于产生HIV蛋白酶抑制剂抗体的免疫原，以及可用于HIV蛋白酶抑制剂免疫测定的抗体和标记的缀合物。 所述新型半抗原在所有HIV蛋白酶抑制剂（例如沙奎那韦，奈非那韦，茚地那韦，安格那韦，利托那韦，洛匹那韦和阿扎那韦）共同的中心非末端羟基上具有活化的功能。
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公开(公告)号：US07649085B2
公开(公告)日：2010-01-19
申请号：US11420502
申请日：2006-05-26
申请人： Gerald F. Sigler , Raymond A. Hui , Ina Deras , Richard Terry Root , Erasmus Huber , Herbert W. Von Der Eltz
发明人： Gerald F. Sigler , Raymond A. Hui , Ina Deras , Richard Terry Root , Erasmus Huber , Herbert W. Von Der Eltz
IPC分类号： C07K17/06 , C07K1/10 , C07K16/00 , G01N33/532 , C07D277/04
摘要： Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.
摘要翻译： 可用于产生HIV蛋白酶抑制剂免疫原的活化的半抗原，可用于产生HIV蛋白酶抑制剂的抗体的免疫原，以及可用于HIV蛋白酶抑制剂沙奎那韦免疫测定的抗体和标记的缀合物。 新型半抗原在中心非末端羟基处具有活化的功能。 还描述了与洛匹那韦，奈非那韦，安仁那韦，利托那韦和茚地那韦具有小于10％交叉反应性的沙奎那韦特异性单克隆抗体，以及产生所述抗体的鼠杂交瘤。
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公开(公告)号：US07906629B2
公开(公告)日：2011-03-15
申请号：US11669200
申请日：2007-01-31
IPC分类号： C07K1/13 , C07K1/10 , G01N33/532 , C07D213/55 , C07D401/02
摘要： Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.
摘要翻译： 可用于产生HIV蛋白酶抑制剂的免疫原的活化的半抗原，可用于产生HIV蛋白酶抑制剂的抗体的免疫原，以及可用于HIV蛋白酶抑制剂沙奎那韦的免疫测定的抗体和标记的缀合物。 新型半抗原在中心非末端羟基处具有活化的功能。 还描述了与洛匹那韦，奈非那韦，安仁那韦，利托那韦和茚地那韦具有小于10％交叉反应性的沙奎那韦特异性单克隆抗体，以及产生所述抗体的鼠杂交瘤。
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公开(公告)号：US07569678B2
公开(公告)日：2009-08-04
申请号：US11669397
申请日：2007-01-31
申请人： Gerald F. Sigler , Raymond A. Hui , Ina Deras , Erasmus Huber , Herbert W. Von Der Eltz , Sigrun Metz , Peter Kern
发明人： Gerald F. Sigler , Raymond A. Hui , Ina Deras , Erasmus Huber , Herbert W. Von Der Eltz , Sigrun Metz , Peter Kern
IPC分类号： C07K17/06 , C07K1/10 , C07K16/00 , G01N33/532 , C07D277/04
摘要： Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.
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公开(公告)号：US20070149565A1
公开(公告)日：2007-06-28
申请号：US11627572
申请日：2007-01-26
申请人： Gerald Sigler , Raymond Hui , Ina Deras , Richard Root , Mitali Ghoshal , Erasmus Huber , Herbert Von Der Eltz , Sigrun Metz , Peter Kern
发明人： Gerald Sigler , Raymond Hui , Ina Deras , Richard Root , Mitali Ghoshal , Erasmus Huber , Herbert Von Der Eltz , Sigrun Metz , Peter Kern
IPC分类号： A61K31/47
摘要： Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.
摘要翻译： 可用于产生HIV蛋白酶抑制剂的免疫原的活化的半抗原，可用于产生HIV蛋白酶抑制剂的抗体的免疫原，以及可用于HIV蛋白酶抑制剂沙奎那韦的免疫测定的抗体和标记的缀合物。 新型半抗原在中心非末端羟基处具有活化的功能。 还描述了与洛匹那韦，奈非那韦，安仁那韦，利托那韦和茚地那韦具有小于10％交叉反应性的沙奎那韦特异性单克隆抗体，以及产生所述抗体的鼠杂交瘤。
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公开(公告)号：US20070148708A1
公开(公告)日：2007-06-28
申请号：US11669200
申请日：2007-01-31
申请人： Gerald Sigler , Raymond Hui , Ina Deras , Richard Root , Mitali Ghoshal , Erasmus Huber , Herbert Von Der Eltz , Sigrun Metz , Peter Kern
发明人： Gerald Sigler , Raymond Hui , Ina Deras , Richard Root , Mitali Ghoshal , Erasmus Huber , Herbert Von Der Eltz , Sigrun Metz , Peter Kern
摘要： Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavor. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.
摘要翻译： 用于产生HIV蛋白酶抑制剂的免疫原的活化的半抗原，可用于产生HIV蛋白酶抑制剂的抗体的免疫原，以及可用于HIV蛋白酶抑制剂saquinavor免疫测定的抗体和标记的缀合物。 新型半抗原在中心非末端羟基处具有活化的功能。 还描述了与洛匹那韦，奈非那韦，安仁那韦，利托那韦和茚地那韦具有小于10％交叉反应性的沙奎那韦特异性单克隆抗体，以及产生所述抗体的鼠杂交瘤。
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公开(公告)号：US20070141643A1
公开(公告)日：2007-06-21
申请号：US11670467
申请日：2007-02-02
申请人： Gerald Sigler , Raymond Hui , Ina Deras , Richard Root , Mitali Ghoshal , Erasmus Huber , Herbert Von Der Eltz , Sigrun Metz , Peter Kern
发明人： Gerald Sigler , Raymond Hui , Ina Deras , Richard Root , Mitali Ghoshal , Erasmus Huber , Herbert Von Der Eltz , Sigrun Metz , Peter Kern
IPC分类号： G01N33/53 , C07D403/02 , C12N5/06
摘要： Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.
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9.发明申请公开(公告)号：US20060264618A1
公开(公告)日：2006-11-23
申请号：US11420497
申请日：2006-05-26
申请人： Ina Deras , Gerald Sigler , Raymond Hui , Richard Root , Mitali Ghoshal , Erasmus Huber , Herbert Von Der Eltz , Sigrun Metz , Peter Kern
发明人： Ina Deras , Gerald Sigler , Raymond Hui , Richard Root , Mitali Ghoshal , Erasmus Huber , Herbert Von Der Eltz , Sigrun Metz , Peter Kern
摘要： Monoclonal antibodies specific for lopinavir having less than 10% cross-reactivity with saquinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies are described.
摘要翻译： 描述了与沙奎那韦，奈非那韦，安仁那韦，利托那韦和茚地那韦具有小于10％交叉反应性的洛匹那韦特异性单克隆抗体，以及产生所述抗体的鼠杂交瘤。
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公开(公告)号：US20060211107A1
公开(公告)日：2006-09-21
申请号：US11420502
申请日：2006-05-26
申请人： Gerald Sigler , Raymond Hui , Ina Deras , Richard Root , Erasmus Huber , Herbert Von Der Eltz
发明人： Gerald Sigler , Raymond Hui , Ina Deras , Richard Root , Erasmus Huber , Herbert Von Der Eltz
IPC分类号： C12N5/06 , C07K16/18 , C07D417/02
摘要： Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.
摘要翻译： 可用于产生HIV蛋白酶抑制剂免疫原的活化的半抗原，可用于产生HIV蛋白酶抑制剂的抗体的免疫原，以及可用于HIV蛋白酶抑制剂沙奎那韦免疫测定的抗体和标记的缀合物。 新型半抗原在中心非末端羟基处具有活化的功能。 还描述了与洛匹那韦，奈非那韦，安仁那韦，利托那韦和茚地那韦具有小于10％交叉反应性的沙奎那韦特异性单克隆抗体，以及产生所述抗体的鼠杂交瘤。
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