公开(公告)号：US20090298938A1

公开(公告)日：2009-12-03

申请号：US12401337

申请日：2009-03-10

申请人： Ghulam Nabi Qazi ,  Subhash Chandra Taneja ,  Jaswant Singh ,  Ajit Kumar Saxena ,  Vijay Kumar Sethi ,  Bhahwal Ali Shah ,  Bal Krishan Kapahi ,  Samar Singh Andotra ,  Ajay Kumar ,  Shashi Bhushan ,  Fayaz Malik ,  Dilip Manikrao Mondhe ,  Shanmugavel Muthiah ,  Surjeet Singh ,  Monika Verma ,  Shashank Kumar Singh

发明人： Ghulam Nabi Qazi ,  Subhash Chandra Taneja ,  Jaswant Singh ,  Ajit Kumar Saxena ,  Vijay Kumar Sethi ,  Bhahwal Ali Shah ,  Bal Krishan Kapahi ,  Samar Singh Andotra ,  Ajay Kumar ,  Shashi Bhushan ,  Fayaz Malik ,  Dilip Manikrao Mondhe ,  Shanmugavel Muthiah ,  Surjeet Singh ,  Monika Verma ,  Shashank Kumar Singh

IPC分类号： A61K31/19 ,  C07C62/30

CPC分类号： A61K31/19

摘要： The present invention relates to use of compounds of general formula 1 for anticancerous activity, wherein the said compound being derived semi-synthetically from natural triterpenoic acids known as boswellic acids by the induction of apoptosis thereof cytotoxicity and anti-cancer activity displayed by semi-synthetic analogues of natural triterpenes, known as Boswellic acids. These compounds may be used for the treatment of cancer, alone or in combination with pharmaceutically acceptable or other carriers, displaying cytotoxicity and anti-cancer activity for colon, prostrate, liver, breast, central nervous system (CNS), leukemia and malignancy of other tissues, including ascites and solid tumors. The cancer cell death is mediated by induction of apoptosis and inhibition of cell proliferation at specific doses.

摘要翻译： 本发明涉及通式1的化合物用于抗癌活性的用途，其中所述化合物通过诱导其细胞凋亡的细胞毒性和半合成显示的抗癌活性而被天然三萜烯酸被称为保乳酸半合成衍生 天然三萜类似物，称为乳香酸。 这些化合物可以单独使用或与药学上可接受的或其它载体组合用于治疗癌症，显示对结肠，前列腺癌，肝癌，乳腺癌，中枢神经系统（CNS），白血病和其他恶性肿瘤的细胞毒性和抗癌活性 组织，包括腹水和实体瘤。 癌细胞死亡是通过细胞凋亡的诱导和特定剂量的细胞增殖抑制来介导的。

公开(公告)号：US08445700B2

公开(公告)日：2013-05-21

申请号：US13130702

申请日：2009-11-24

申请人： Subhash Chandra Taneja ,  Mushtaq Ahmad Aga ,  Brijesh Kumar ,  Vijay Kumar Sethi ,  Samar Singh Andotra ,  Ghulam Nabi Qazi

发明人： Subhash Chandra Taneja ,  Mushtaq Ahmad Aga ,  Brijesh Kumar ,  Vijay Kumar Sethi ,  Samar Singh Andotra ,  Ghulam Nabi Qazi

IPC分类号： C07D207/12 ,  C07D471/02

CPC分类号： C07D207/12

摘要： The present invention relates to a facile, highly efficient and economical process for the preparation of optically active N-benzyl-3-hydroxypyrrolidine in high yield from a naturally occurring alkaloid vasicine. The natural alkaloid vasicine is used as a precursor of (S)—N-benzyl-3-hydroxypyrrolidine and (R)—N-benzyl-3-hydroxypyrrolidines which can easily be sourced from the medicinal plant Adatoda vasica by the method known in the art and transformed to optical isomers (R) and (S)—N-benzyl-3-hydroxypyrrolidine by the method described in the present invention.

摘要翻译： 本发明涉及从天然存在的生物碱催化剂以高产率制备光学活性N-苄基-3-羟基吡咯烷的简便，高效和经济的方法。 使用天然生物碱维生素作为（S）-N-苄基-3-羟基吡咯烷和（R）-N-苄基-3-羟基吡咯烷的前体，其可以通过以下方法容易地从药用植物金丝桃源中获得 并通过本发明所述的方法转化成光学异构体（R）和（S）-N-苄基-3-羟基吡咯烷。

公开(公告)号：US20120101285A1

公开(公告)日：2012-04-26

申请号：US13130702

申请日：2009-11-24

申请人： Subhash Chandra Taneja ,  Mushtaq Ahmad Aga ,  Brijesh Kumar ,  Vijay Kumar Sethi ,  Samar Singh Andotra ,  Ghulam Nabi Qazi

发明人： Subhash Chandra Taneja ,  Mushtaq Ahmad Aga ,  Brijesh Kumar ,  Vijay Kumar Sethi ,  Samar Singh Andotra ,  Ghulam Nabi Qazi

IPC分类号： C07D207/12

CPC分类号： C07D207/12

摘要： The present invention relates to a facile, highly efficient and economical process for the preparation of optically active N-benzyl-3-hydroxypyrrolidine in high yield from a naturally occurring alkaloid vasicine. The natural alkaloid vasicine is used as a precursor of (S)—N-benzyl-3-hydroxypyrrolidine and (R)—N-benzyl-3-hydroxypyrrolidines which can easily be sourced from the medicinal plant Adatoda vasica by the method known in the art and transformed to optical isomers (R) and (S)—N-benzyl-3-hydroxypyrrolidine by the method described in the present invention.

摘要翻译： 本发明涉及从天然存在的生物碱催化剂以高产率制备光学活性N-苄基-3-羟基吡咯烷的简便，高效和经济的方法。 使用天然生物碱维生素作为（S）-N-苄基-3-羟基吡咯烷和（R）-N-苄基-3-羟基吡咯烷的前体，其可以通过以下方法容易地从药用植物金丝桃源中获得 并通过本发明所述的方法转化成光学异构体（R）和（S）-N-苄基-3-羟基吡咯烷。

公开(公告)号：US08609858B2

公开(公告)日：2013-12-17

申请号：US12921061

申请日：2009-03-05

申请人： Mahabalarao Sampath Kumar Halmuthur ,  Ajit Kumar Saxena ,  Subhash Chandra Taneja ,  Shashank Kumar Singh ,  Vijay Kumar Sethi ,  Naveed Ahmed Qazi ,  Sanghapal Damodhar Sawant ,  Mahendhar Reddy Doma ,  Abid Hussain Banday ,  Monika Verma ,  Ghularn Nabi Qazi

发明人： Mahabalarao Sampath Kumar Halmuthur ,  Ajit Kumar Saxena ,  Subhash Chandra Taneja ,  Shashank Kumar Singh ,  Vijay Kumar Sethi ,  Naveed Ahmed Qazi ,  Sanghapal Damodhar Sawant ,  Mahendhar Reddy Doma ,  Abid Hussain Banday ,  Monika Verma ,  Ghularn Nabi Qazi

IPC分类号： C07D498/10 ,  C07D491/107

CPC分类号： C07D491/107 ,  C07D498/10

摘要： The present invention relates to novel spiro derivatives of parthenin prepared by the dipolar cycloaddition of various dipoles viz, benzonitrile oxides, nitrones, azides, nitrile ylide diazoalkane, nitrile imide, ozone, azomethine imides, azomethine ylides etc. with exocyclic double bond of C ring (α-methylene-γ-butyrolactone). Representative compounds have been screened for their anticancer activity against different cancer cell lines. ICs0 value of these analogues varies between 4.3 μM to 93 μM. A mechanistic correlation of their anticancer activity has been described. The results of the cytotoxicity test of the compounds studies indicated that the α,β-unsaturated ketonic moiety in parthenin plays an important role in the maintenance of the high level of cytotoxicity.

摘要翻译： 本发明涉及通过各种偶极子，苄腈氧化物，硝酮，叠氮化物，腈基内鎓，重氮烷，腈酰亚胺，臭氧，偶氮甲碱酰亚胺，偶氮甲碱基内鎓等与环C的环外双键的偶极环加成制备的新戊二烯衍生物 （α-亚甲基-γ-丁内酯）。 已经筛选了代表性化合物对抗不同癌细胞系的抗癌活性。 这些类似物的ICs0值在4.3μM至93μM之间变化。 已经描述了其抗癌活性的机械相关性。 化合物研究的细胞毒性试验的结果表明，单分散素中的α，β-不饱和酮部分在维持高水平的细胞毒性中起重要作用。

公开(公告)号：US20110201661A1

公开(公告)日：2011-08-18

申请号：US12921061

申请日：2009-03-05

申请人： Mahabalarao Sampath Kumar Halmuthur ,  Ajit Kumar Saxena ,  Subhash Chandra Taneja ,  Shashank Kumar Singh ,  Vijay Kumar Sethi ,  Naveed Ahmed Qazi ,  Sanghapal Damodhar Sawant ,  Mahendhar Reddy Doma ,  Abid Hussain Banday ,  Monika Verma ,  Ghularn Nabi Qazi

发明人： Mahabalarao Sampath Kumar Halmuthur ,  Ajit Kumar Saxena ,  Subhash Chandra Taneja ,  Shashank Kumar Singh ,  Vijay Kumar Sethi ,  Naveed Ahmed Qazi ,  Sanghapal Damodhar Sawant ,  Mahendhar Reddy Doma ,  Abid Hussain Banday ,  Monika Verma ,  Ghularn Nabi Qazi

IPC分类号： A61K31/424 ,  C07D498/10 ,  C07D491/107 ,  A61K31/396 ,  A61P35/00

CPC分类号： C07D491/107 ,  C07D498/10

摘要： The present invention relates to novel spiro derivatives of parthenin prepared by the dipolar cycloaddition of various dipoles viz, benzonitrile oxides, nitrones, azides, nitrile ylide diazoalkane, nitrile imide, ozone, azomethine imides, azomethine ylides etc. with exocyclic double bond of C ring (α-methylene-γ-butyrolactone). Representative compounds have been screened for their anticancer activity against different cancer cell lines. ICs0 value of these analogues varies between 4.3 μM to 93 μM. A mechanistic correlation of their anticancer activity has been described. The results of the cytotoxicity test of the compounds studies indicated that the α,β-unsaturated ketonic moiety in parthenin plays an important role in the maintenance of the high level of cytotoxicity.

摘要翻译： 本发明涉及通过各种偶极子，苄腈氧化物，硝酮，叠氮化物，腈基内鎓，重氮烷，腈酰亚胺，臭氧，偶氮甲碱酰亚胺，偶氮甲碱基内鎓等与环C的环外双键的偶极环加成制备的新戊二烯衍生物 （α-亚甲基-γ-丁内酯）。 已经筛选了代表性化合物对抗不同癌细胞系的抗癌活性。 这些类似物的ICs0值在4.3μM至93μM之间变化。 已经描述了其抗癌活性的机械相关性。 化合物研究的细胞毒性试验结果表明，在维持高水平的细胞毒性方面，单分散素中α，bgr-不饱和酮部分起重要作用。

公开(公告)号：US07166728B2

公开(公告)日：2007-01-23

申请号：US11023904

申请日：2004-12-28

申请人： Vijay Kumar Sethi ,  Samar Singh Andotra ,  Subhash Chandra Taneja ,  Pankaj Gupta ,  Ghulam Nabi Qazi

发明人： Vijay Kumar Sethi ,  Samar Singh Andotra ,  Subhash Chandra Taneja ,  Pankaj Gupta ,  Ghulam Nabi Qazi

IPC分类号： C07D309/18

CPC分类号： C08K5/1545

摘要： The present invention relates to a process for the synthesis of racemic nerol oxide i.e. 3,6-dihydro-4-methyl-2-[2-methyl-1-propenyl)-2H-pyran from monoterpene alcohol nerol i.e. cis-3,7-dimethylocta-2,6-diene-1-ol.

摘要翻译： 本发明涉及从单萜醇橙花醇合成外消旋橙花蜜的方法，即3,6-二氢-4-甲基-2- [2-甲基-1-丙烯基）-2H-吡喃，即顺式-3,7 - 二甲基-2,6-二烯-1-醇。

公开(公告)号：US06787674B1

公开(公告)日：2004-09-07

申请号：US10401128

申请日：2003-03-27

申请人： Subhash Chandra Taneja ,  Ashok Kumar Shahi ,  Vijeshwar Verma ,  Vijay Kumar Sethi ,  Samar Singh Andotra ,  Abid Zaffar Hashmi ,  Prabhu Dutt ,  Sanotosh Kumar Bakshi ,  Maharaj Krishan Koul ,  Satya Narayan Sharma ,  Suresh Chandra ,  Ghulam Nabi Qazi

发明人： Subhash Chandra Taneja ,  Ashok Kumar Shahi ,  Vijeshwar Verma ,  Vijay Kumar Sethi ,  Samar Singh Andotra ,  Abid Zaffar Hashmi ,  Prabhu Dutt ,  Sanotosh Kumar Bakshi ,  Maharaj Krishan Koul ,  Satya Narayan Sharma ,  Suresh Chandra ,  Ghulam Nabi Qazi

IPC分类号： C07C4500

CPC分类号： C07C403/02 ,  A23L3/3499 ,  C07B2200/07 ,  C07C2601/16 ,  C11B9/0034

摘要： The present invention relates to anti-microbial activity of the essential oil of Cymbopogon flexuosus (Nees ex Steud) Wats and the process of isolation of novel sesquiterpene compound which is mainly responsible for the strong anti-microbial/anti-bacterial activity. The present invention particularly relates to anti-bacterial activity of the essential oil and a pure isolate identified as (+)-1-bisabolone of formula 1 against gram positive bacteria from a strain of a grass identified as Cymbopogon flexuosus.

摘要翻译： 本发明涉及Cymbopogon flexuosus（Nees ex Steud）Wats的精油的抗微生物活性和主要负责强抗微生物/抗菌活性的新型倍半萜烯化合物的分离过程。 本发明特别涉及精油的抗细菌活性，以及​​鉴定为式（1）的（+） - 1 - 双代谢素的革兰氏阳性细菌的鉴定为Cymbopogon flexuosus的草的菌株的抗菌活性。

公开(公告)号：US08580752B2

公开(公告)日：2013-11-12

申请号：US11391391

申请日：2006-03-29

申请人： Surrinder Koul ,  Jawahir Lal Koul ,  Subhash Chandra Taneja ,  Pankaj Gupta ,  Inshad Ali Khan ,  Zahid Mehmood Mirza ,  Ashwani Kumar ,  Rakesh Kamal Johri ,  Monika Pandita ,  Anita Khosa ,  Ashok Kumar Tikoo ,  Subhash Chander Sharma ,  Vijeshwar Verma ,  Ghulam Nabi Qazi

发明人： Surrinder Koul ,  Jawahir Lal Koul ,  Subhash Chandra Taneja ,  Pankaj Gupta ,  Inshad Ali Khan ,  Zahid Mehmood Mirza ,  Ashwani Kumar ,  Rakesh Kamal Johri ,  Monika Pandita ,  Anita Khosa ,  Ashok Kumar Tikoo ,  Subhash Chander Sharma ,  Vijeshwar Verma ,  Ghulam Nabi Qazi

IPC分类号： A61K31/70

CPC分类号： C07D211/46 ,  A61K31/351 ,  A61K31/445 ,  A61K31/4525 ,  A61K31/453 ,  A61K31/496 ,  A61K31/7036 ,  C07D295/108 ,  C07D311/58 ,  C07D317/60 ,  C07D319/16 ,  C07D319/18 ,  Y02A50/473 ,  Y02A50/481

摘要： The present invention relates to an aromatic substituted pentadienoic acid amides and there use in combination of specific amounts of aromatic amides i.e. 4-alkyl-5-(substituted phenyl)-2(E),4(E)-pentadienoic acid amides, its geometrical isomers or their dihydro or tetrahydro derivatives and an anti-infective drug useful in potentiating the bioefficacy of antiinfective drug. The combination of the present invention is useful in the treatment of certain infections and disease at lower concentration of anti-infectives necessary to inhibit the growth of microbial strains and may also find applications in reducing the resistance in microorganisms.

摘要翻译： 本发明涉及芳族取代的戊二烯酸酰胺，并且其中使用特定量的芳族酰胺，即4-烷基-5-（取代的苯基）-2（E），4（E） - 戊二烯酸酰胺，其几何形状 异构体或其二氢或四氢衍生物和用于增强抗感染药物生物功效的抗感染药物。 本发明的组合可用于治疗抑制微生物菌株生长所必需的较低浓度抗感染剂的某些感染和疾病，并且还可用于降低微生物的抗性。

公开(公告)号：USPP15595P3

公开(公告)日：2005-03-01

申请号：US10067808

申请日：2002-02-08

申请人： Ashok Kumar Shahi ,  Satya Narayan Sharma ,  Swadesh Pal ,  Suresh Chandra ,  Prabhu Dutt ,  Surendra Singh Balyan ,  Maharaj Krishen Bhan ,  Subhash Chandra Taneja ,  Ravinder Kumar Raina ,  Vijeshwar Verma ,  Shazia Zahoor ,  Maharaj Krishen Kaul ,  Ghulam Nabi Qazi

发明人： Ashok Kumar Shahi ,  Satya Narayan Sharma ,  Swadesh Pal ,  Suresh Chandra ,  Prabhu Dutt ,  Surendra Singh Balyan ,  Maharaj Krishen Bhan ,  Subhash Chandra Taneja ,  Ravinder Kumar Raina ,  Vijeshwar Verma ,  Shazia Zahoor ,  Maharaj Krishen Kaul ,  Ghulam Nabi Qazi

IPC分类号： A01H5/12 ,  A01H5/00

CPC分类号： A01H5/12 ,  Y02A40/132

摘要： A new and distinct variety of Cymbopogon commutatus grass is provided. The new variety was discovered during a mass selection program that was carried out in India in a cultivated area, and offers significant advantages over a typical plant of the species. More specifically, the new variety exhibits superior drought tolerance, a vigorous perennial growth habit, and lighter green leaves than typically exhibited by the species. The plant produces an essential oil having an enhanced geraniol and geranyl acetate content that is useful to form perfumes and in flavor applications. Asexual reproduction can be readily carried out by the rooting of slips.

摘要翻译： 提供了一种新的和独特的Cymbopogon commutatus草。 新品种在印度在耕地上进行的群众选择计划中被发现，与典型植物种类相比，具有显着的优势。 更具体地说，新品种表现出优异的耐旱性，强壮的多年生生长习性，以及比该物种通常表现出的较轻的绿色叶。 该植物产生具有增强的香叶醇和乙酸香叶酯含量的精油，其可用于形成香料和香料应用。 无性繁殖可以很容易地通过纸条的生根进行。

公开(公告)号：US06242243B1

公开(公告)日：2001-06-05

申请号：US09050011

申请日：1998-03-30

申请人： Ghulam Nabi Qazi ,  Rajinder Parshad ,  Surrinder Koul ,  Subhash Chandra Taneja ,  Kanaya Lal Dhar ,  Ravi Ji Kotru ,  Sukhdev Swami Handa

发明人： Ghulam Nabi Qazi ,  Rajinder Parshad ,  Surrinder Koul ,  Subhash Chandra Taneja ,  Kanaya Lal Dhar ,  Ravi Ji Kotru ,  Sukhdev Swami Handa

IPC分类号： C12N118

CPC分类号： C12R1/645 ,  C12P41/002 ,  Y10S435/911

摘要： This invention discloses a process for the use of a novel organism belonging to the genus Trichosporon sp. as whole wet or dry cell culture or cell free extract or crude enzyme or pure isolated enzyme The strain of Trichosporon sp. used in the process is designated as RRLY-15 and has been deposited in Deutsche Sammlung von Mikroorganismen und Zellekulturen GmbH (DSMZ). The invention also discloses the preparation of S(+)-6-methoxy-2-naphthalene acetic acid (naproxen) of formula (2) through enantioselective hydrolysis of a racemic mixture of alkyl esters of (±)-6-methoxy-&agr;-methyl-2-naphthalene acetic acid of formula (1) where R represents —CH3,—C2H5,—C3H7,—C4H9 and the like and S(+)- Naproxen is a medicinally important non steroidal anti-inflammatory drug.

摘要翻译： 本发明公开了一种使用属于Trichosporon sp。的新生物的方法。 作为整个湿或干细胞培养或无细胞提取物或粗酶或纯分离的酶Trichosporon sp。 在该过程中使用的产品被指定为RRLY-15，并已存放在德意志银行（Mikroorganismen und Zellekulturen GmbH）（DSMZ）。 本发明还公开了通过对映选择性水解（±）-6-甲氧基-α-甲氧基-2-甲基苯基的烷基酯的外消旋混合物制备式（2）的S（+） - 6-甲氧基-2-萘乙酸（萘普生） 式（1）的甲基-2-萘乙酸，其中R表示-CH 3，-C 2 H 5，-C 3 H 7，-C 4 H 9等，而S（+） - 萘普生是药物重要的非甾体抗炎药。