公开(公告)号：US20090298938A1

公开(公告)日：2009-12-03

申请号：US12401337

申请日：2009-03-10

Applicant: Ghulam Nabi Qazi ,  Subhash Chandra Taneja ,  Jaswant Singh ,  Ajit Kumar Saxena ,  Vijay Kumar Sethi ,  Bhahwal Ali Shah ,  Bal Krishan Kapahi ,  Samar Singh Andotra ,  Ajay Kumar ,  Shashi Bhushan ,  Fayaz Malik ,  Dilip Manikrao Mondhe ,  Shanmugavel Muthiah ,  Surjeet Singh ,  Monika Verma ,  Shashank Kumar Singh

Inventor： Ghulam Nabi Qazi ,  Subhash Chandra Taneja ,  Jaswant Singh ,  Ajit Kumar Saxena ,  Vijay Kumar Sethi ,  Bhahwal Ali Shah ,  Bal Krishan Kapahi ,  Samar Singh Andotra ,  Ajay Kumar ,  Shashi Bhushan ,  Fayaz Malik ,  Dilip Manikrao Mondhe ,  Shanmugavel Muthiah ,  Surjeet Singh ,  Monika Verma ,  Shashank Kumar Singh

IPC: A61K31/19 ,  C07C62/30

CPC classification number: A61K31/19

Abstract: The present invention relates to use of compounds of general formula 1 for anticancerous activity, wherein the said compound being derived semi-synthetically from natural triterpenoic acids known as boswellic acids by the induction of apoptosis thereof cytotoxicity and anti-cancer activity displayed by semi-synthetic analogues of natural triterpenes, known as Boswellic acids. These compounds may be used for the treatment of cancer, alone or in combination with pharmaceutically acceptable or other carriers, displaying cytotoxicity and anti-cancer activity for colon, prostrate, liver, breast, central nervous system (CNS), leukemia and malignancy of other tissues, including ascites and solid tumors. The cancer cell death is mediated by induction of apoptosis and inhibition of cell proliferation at specific doses.

Abstract translation: 本发明涉及通式1的化合物用于抗癌活性的用途，其中所述化合物通过诱导其细胞凋亡的细胞毒性和半合成显示的抗癌活性而被天然三萜烯酸被称为保乳酸半合成衍生 天然三萜类似物，称为乳香酸。 这些化合物可以单独使用或与药学上可接受的或其它载体组合用于治疗癌症，显示对结肠，前列腺癌，肝癌，乳腺癌，中枢神经系统（CNS），白血病和其他恶性肿瘤的细胞毒性和抗癌活性 组织，包括腹水和实体瘤。 癌细胞死亡是通过细胞凋亡的诱导和特定剂量的细胞增殖抑制来介导的。

公开(公告)号：US06913772B2

公开(公告)日：2005-07-05

申请号：US10735437

申请日：2003-12-11

Applicant: Ghulam Nabi Qazi ,  Bupinder Singh Jaggi ,  Bal Krishan Chandan ,  Krishan Avtar Suri ,  Naresh Kumar Satti ,  Rakesh Maurya ,  Lila Ram Manhas ,  Ashwani Kumar ,  Bal Krishan Kapahi

Inventor： Ghulam Nabi Qazi ,  Bupinder Singh Jaggi ,  Bal Krishan Chandan ,  Krishan Avtar Suri ,  Naresh Kumar Satti ,  Rakesh Maurya ,  Lila Ram Manhas ,  Ashwani Kumar ,  Bal Krishan Kapahi

IPC: A01N25/00 ,  A01N27/00 ,  A01N65/00 ,  A61K31/4745 ,  A61K31/70 ,  A61K36/27 ,  A61K35/78

CPC classification number: A61K36/27 ,  Y10S514/885 ,  Y10S514/893 ,  Y10S514/894

Abstract: The present invention relates to a composition useful for hepatoprotection, said composition comprising polar extract of plant Cryptolepis Buchanani and/or fractions of the said extract, and optionally pharmaceutically acceptable additives and a method of producing said composition and also a method of treating a subject using said composition.

Abstract translation: 本发明涉及一种可用于肝保护的组合物，所述组合物包含植物Cryptolepis Buchanani的极性提取物和/或所述提取物的级分，和任选的药学上可接受的添加剂和制备所述组合物的方法，以及使用 所说的组合。

公开(公告)号：US20080138452A1

公开(公告)日：2008-06-12

申请号：US12004403

申请日：2007-12-21

Applicant: Rakesh Kamal Johri ,  Sheikh Tasaduq Abdullah ,  Kuldeep Singh ,  Devinder Kumar Gupta ,  Bal Krishan Kapahi ,  Dilip Manikrao Mondhe ,  Satinder Mohan Jain ,  Om Parkash Suri ,  Kasturi Lal Bedi ,  Ghulam Nabi Qazi

Inventor： Rakesh Kamal Johri ,  Sheikh Tasaduq Abdullah ,  Kuldeep Singh ,  Devinder Kumar Gupta ,  Bal Krishan Kapahi ,  Dilip Manikrao Mondhe ,  Satinder Mohan Jain ,  Om Parkash Suri ,  Kasturi Lal Bedi ,  Ghulam Nabi Qazi

IPC: A61K36/47 ,  A61P43/00

CPC classification number: A61K36/47 ,  A61K2300/00

Abstract: The present invention relates to a composition useful for hepatocurative effect against CYP 450 bio-activation hepatotoxicity induced by drugs, said composition comprising an extract from Emblica officinalis and optionally pharmaceutically acceptable additives and method of treating drug induced hepatotoxicity

Abstract translation: 本发明涉及一种可用于对由药物诱导的CYP 450生物活化肝毒性的肝脏作用的组合物，所述组合物包含来自Emblica officinalis的提取物和任选的药学上可接受的添加剂和治疗药物诱导的肝毒性的方法

公开(公告)号：US07001619B2

公开(公告)日：2006-02-21

申请号：US10106119

申请日：2002-03-27

Applicant: Rakesh Kamal Johri ,  Sheikh Tasaduq Abdullah ,  Kuldeep Singh ,  Devinder Kumar Gupta ,  Bal Krishan Kapahi ,  Dilip Manikrao Mondhe ,  Satinder Mohan Jain ,  Om Parkash Suri ,  Kasturi Lal Bedi ,  Ghulam Nabi Qazi

Inventor： Rakesh Kamal Johri ,  Sheikh Tasaduq Abdullah ,  Kuldeep Singh ,  Devinder Kumar Gupta ,  Bal Krishan Kapahi ,  Dilip Manikrao Mondhe ,  Satinder Mohan Jain ,  Om Parkash Suri ,  Kasturi Lal Bedi ,  Ghulam Nabi Qazi

IPC: A61K9/00 ,  A61K9/20 ,  A61K35/00 ,  A61K35/78

CPC classification number: A61K36/47 ,  A61K2300/00

Abstract: The present invention relates to a composition useful for hepatocurative effect against CYP 450 bio-activation hepatotoxicity induced by drugs, said composition comprising an extract from Emblica officinalis and optionally pharmaceutically acceptable additives and method of treating drug induced hepatotoxicity.

Abstract translation: 本发明涉及一种可用于对由药物诱导的CYP 450生物活化肝毒性的肝脏作用的组合物，所述组合物包含来自Emblica officinalis的提取物和任选的药学上可接受的添加剂和治疗药物诱导的肝毒性的方法。

公开(公告)号：US07514105B2

公开(公告)日：2009-04-07

申请号：US11360653

申请日：2006-02-23

Applicant: Ghulam Nabi Qazi ,  Kasturi Lal Bedi ,  Rakesh Kamal Johri ,  Manoj Kumar Tikoo ,  Ashok Kumar Tikoo ,  Subhash Chander Sharma ,  Sheikh Tasaduq Abdullah ,  Om Parkash Suri ,  Bishan Datt Gupta ,  Krishan Avtar Suri ,  Naresh Kumar Satti ,  Ravi Kant Khajuria ,  Surjit Singh ,  Anamika Khajuria ,  Bal Krishan Kapahi

Inventor： Ghulam Nabi Qazi ,  Kasturi Lal Bedi ,  Rakesh Kamal Johri ,  Manoj Kumar Tikoo ,  Ashok Kumar Tikoo ,  Subhash Chander Sharma ,  Sheikh Tasaduq Abdullah ,  Om Parkash Suri ,  Bishan Datt Gupta ,  Krishan Avtar Suri ,  Naresh Kumar Satti ,  Ravi Kant Khajuria ,  Surjit Singh ,  Anamika Khajuria ,  Bal Krishan Kapahi

IPC: A61K36/00 ,  A61K36/752

CPC classification number: A61K45/06 ,  A23L33/105 ,  A23L33/15 ,  A23L33/16 ,  A23L33/175 ,  A61K31/43 ,  A61K31/4453 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/545 ,  A61K31/704 ,  A61K31/7048 ,  A61K33/04 ,  A61K36/185 ,  A61K36/19 ,  A61K36/23 ,  A61K36/28 ,  A61K36/47 ,  A61K36/59 ,  A61K36/67 ,  A61K36/75 ,  A61K36/80 ,  A61K36/81 ,  A61K36/8965 ,  A61K2300/00

Abstract: The present invention relates to a bioenhancing/bioavailability-facilitating composition comprising: an effective amount of an extract and/or at least one bioactive fraction from Cuminum cyminum; one or more additive selected from drugs, nutrients, vitamins, nutraceuticals, herbal drugs/products, micro nutrients, antioxidants along with pharmaceuticaly acceptable additives/excipient, and optionally, an effective amount of piperine or extract/fraction of piper nigrum or piper longum; and a process for the preparation of such extracts and active fractions from plant Cuminum cyminum.

Abstract translation: 本发明涉及生物增强/生物利用度促进组合物，其包含：有效量的来自孜然的提取物和/或至少一种生物活性级分; 一种或多种选自药物，营养素，维生素，营养品，草药/产品，微量营养素，抗氧化剂以及药用可接受的添加剂/赋形剂的添加剂，以及任选的有效量的胡椒碱或胡椒或胡椒的提取物/级分; 以及从植物孜然中制备这些提取物和活性级分的方法。

公开(公告)号：US07070814B2

公开(公告)日：2006-07-04

申请号：US10386395

申请日：2003-03-11

Applicant: Ghulam Nabi Qazi ,  Kasturi Lal Bedi ,  Rakesh Kamal Johri ,  Manoj Kumar Tikoo ,  Ashok Kumar Tikoo ,  Subhash Chander Sharma ,  Sheikh Tasaduq Absullah ,  Om Parkash Suri ,  Bishan Datt Gupta ,  Krishan Avtar Suri ,  Naresh Kumar Satti ,  Ravi Kant Khajuria ,  Surjit Singh ,  Anamika Khajuria ,  Bal Krishan Kapahi

Inventor： Ghulam Nabi Qazi ,  Kasturi Lal Bedi ,  Rakesh Kamal Johri ,  Manoj Kumar Tikoo ,  Ashok Kumar Tikoo ,  Subhash Chander Sharma ,  Sheikh Tasaduq Absullah ,  Om Parkash Suri ,  Bishan Datt Gupta ,  Krishan Avtar Suri ,  Naresh Kumar Satti ,  Ravi Kant Khajuria ,  Surjit Singh ,  Anamika Khajuria ,  Bal Krishan Kapahi

IPC: A61K35/78

CPC classification number: A61K45/06 ,  A23L33/105 ,  A23L33/15 ,  A23L33/16 ,  A23L33/175 ,  A61K31/43 ,  A61K31/4453 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/545 ,  A61K31/704 ,  A61K31/7048 ,  A61K33/04 ,  A61K36/185 ,  A61K36/19 ,  A61K36/23 ,  A61K36/28 ,  A61K36/47 ,  A61K36/59 ,  A61K36/67 ,  A61K36/75 ,  A61K36/80 ,  A61K36/81 ,  A61K36/8965 ,  A61K2300/00

Abstract: The present invention relates to a bioenhancing/bioavailability-facilitating composition comprising: an effective amount of an extract and/or at least one bioactive fraction from Cuminum cyminum; one or more additive selected from drugs, nutrients, vitamins, nutraceuticals, herbal drugs/products, micro nutrients, antioxidants along with pharmaceutically acceptable additives/excipient, and optionally, an effective amount of piperine or extract/fraction of piper nigrum or piper longum; and a process for the preparation of such extracts and active fractions from plant Cuminum cyminum.

Abstract translation: 本发明涉及生物增强/生物利用度促进组合物，其包含：有效量的来自孜然的提取物和/或至少一种生物活性级分; 一种或多种选自药物，营养素，维生素，营养品，草药/产品，微量营养素，抗氧化剂以及药学上可接受的添加剂/赋形剂的添加剂，以及任选的有效量的胡椒碱或胡椒或胡椒的提取物/级分; 以及从植物孜然中制备这些提取物和活性级分的方法。

公开(公告)号：US06989162B2

公开(公告)日：2006-01-24

申请号：US10403700

申请日：2003-03-31

Applicant: Ghulam Nabi Qazi ,  Om Parkash Suri ,  Kasturi Lal Bedi ,  Krishan Avtar Suri ,  Bishan Datt Gupta ,  Bupinder Singh Jaggi ,  Bal Krishan Kapahi ,  Naresh Kumar Satti ,  Musarat Amina ,  Bal Krishan Chandan ,  Neelam Sharma ,  Gurdarshan Singh

Inventor： Ghulam Nabi Qazi ,  Om Parkash Suri ,  Kasturi Lal Bedi ,  Krishan Avtar Suri ,  Bishan Datt Gupta ,  Bupinder Singh Jaggi ,  Bal Krishan Kapahi ,  Naresh Kumar Satti ,  Musarat Amina ,  Bal Krishan Chandan ,  Neelam Sharma ,  Gurdarshan Singh

IPC: A61K35/78 ,  A61K31/70 ,  A61K31/33 ,  A61K31/555 ,  A61K31/05

CPC classification number: A61K36/53 ,  Y10S514/893

Abstract: A process of isolation of pure Acteoside of high hepatoprotection from plant Colerbrookea oppositifolia, said process comprising steps of drying aerial parts of the plant, grounding the dried parts into powder, percolating the powder with water or ethanol for 3-4 times to obtain an extract, filtering the extract for clearing of suspended particles to obtain supernatant, drying the supernatant at about 45 to 55° C. to obtain a residue, fractionating the residue with chloroform, ethyl acetate, and butanol successively, subjecting butanol fraction to adsorption chromatography of SiO2 after adding methanol to the fraction, charging the adsorbed fraction to glass column, eluting the column with solvents of increasing polarity of methanol:chloroform to obtain further fractions and repeating the process one more time, subjecting the fractions to column chromatography to obtain fractions, concentrating the fractions under reduced pressure to obtain acteoside as residue; and a method of effectively hepatoprotecting a subject using pure Acteoside from plant Colerbrookea oppositifolia, said method comprising steps of administering appropriate low-dose of the acteoside to the subject.

Abstract translation: 从植物Colerbrookea oppositifolia中分离出高保护酶的纯Acteoside的过程，所述方法包括干燥植物的地上部分，将干燥部分粉碎成粉末，用水或乙醇渗滤粉末3-4次以获得提取物 过滤提取物以清除悬浮颗粒以获得上清液，在约45至55℃下干燥上清液，得到残余物，依次用氯仿，乙酸乙酯和丁醇分馏残余物，将丁醇级分进行吸附层析 在将甲醇加入到级分中后，将吸附的级分装入玻璃柱，用极性升高的甲醇：氯仿溶剂洗脱柱，得到更多的级分并重复该过程一次， 进行柱色谱分离，得到级分，减压浓缩，得到作为残留物的acteoside; 该方法包括以下步骤：向受试者施用合适的低剂量的acteoside。