公开(公告)号：US07259163B2

公开(公告)日：2007-08-21

申请号：US10494127

申请日：2002-10-30

申请人： Gianpaolo Bravi ,  Rossella Guidetti ,  David Haigh ,  Charles David Hartley ,  Peter David Howes ,  Deborah Lynette Jackson ,  Victoria Lucy Helen Lovegrove ,  Pritom Shah ,  Martin John Slater ,  Katrina Jane Wareing

发明人： Gianpaolo Bravi ,  Rossella Guidetti ,  David Haigh ,  Charles David Hartley ,  Peter David Howes ,  Deborah Lynette Jackson ,  Victoria Lucy Helen Lovegrove ,  Pritom Shah ,  Martin John Slater ,  Katrina Jane Wareing

IPC分类号： A61K31/4965 ,  A01N43/54 ,  C07D239/42 ,  C07D241/00 ,  C07D241/02

CPC分类号： C07D401/14 ,  C07D403/04 ,  C07D409/14 ,  C07D417/14

摘要： Novel anti-viral agents of Formula wherein: A represents OR1, NR1R2, or R1 wherein R1 and R2 are hydrogen, C1-6alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; or R1 and R2 together with the nitrogen atom to which they are attached form a 5 or 6 membered saturated cyclic group; B represents C(O)R3 wherein R3 is C1-6alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; C represents C1-6alkyl, aryl, heteroaryl or heterocyclyl; D represents a saturated or unsaturated optionally substituted 6-membered heterocyclic ring; E represents hydrogen or C1-6alkyl; F represents hydrogen, C1-6alkyl, aryl or heteroaryl; and G represents hydrogen, C1-6alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts, solvates and esters thereof, processes for their preparation and methods of using them in HCV treatment are provided.

摘要翻译： 新型的下式的抗病毒剂，其中：A表示OR 1，NR 1，R 2，或R 1， 其中R 1和R 2是氢，C 1-6烷基，芳基，杂芳基，芳基烷基或杂芳基烷基; 或R 1和R 2与它们所连接的氮原子一起形成5或6元饱和环状基团; B表示C（O）R 3，其中R 3是C 1-6烷基，芳基，杂芳基，芳烷基或杂芳基烷基; C表示C 1-6烷基，芳基，杂芳基或杂环基; D表示饱和或不饱和的任选取代的6元杂环; E表示氢或C 1-6烷基; F表示氢，C 1-6烷基，芳基或杂芳基; 和G表示氢，C 1-6烷基，杂环基烷基，芳基烷基或杂芳基烷基; 提供其盐，溶剂合物和酯，其制备方法及其用于HCV治疗的方法。

公开(公告)号：US07304087B2

公开(公告)日：2007-12-04

申请号：US10531884

申请日：2003-10-22

申请人： David Haigh ,  Charles David Hartley ,  Peter David Howes ,  Deborah Lynette Jackson ,  Pritom Shah ,  Martin John Slater

发明人： David Haigh ,  Charles David Hartley ,  Peter David Howes ,  Deborah Lynette Jackson ,  Pritom Shah ,  Martin John Slater

IPC分类号： A61K31/4025 ,  C07D405/04 ,  C07D207/08

CPC分类号： C07D401/04 ,  C07D207/16 ,  C07D403/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04

摘要： Anti-viral agents of Formula (I) wherein: A represents hydroxy; D represents aryl or heteroaryl; E represents hydrogen, C1-6alkyl, aryl, heteroaryl or heterocyclyl; G represents hydrogen or optionally substituted C1-6alkyl; J represents C1-6alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts, solvates and esters thereof; provided that when A is esterified to form —OR where R is selected from straight or branched chain alkyl, aralkyl, aryloxyalkyl, or aryl, then R is other than tert-butyl; processes for their preparation, pharmaceutical compositions comprising them, and methods of using them in HCV treatment are provided.

摘要翻译： 式（I）的抗病毒剂

公开(公告)号：US20090227600A1

公开(公告)日：2009-09-10

申请号：US11577940

申请日：2005-10-24

申请人： Rossella Guidetti ,  David Haigh ,  Charles David Hartley ,  Peter David Howes ,  Fabrizio Nerozzi ,  Stephen Allan Smith

发明人： Rossella Guidetti ,  David Haigh ,  Charles David Hartley ,  Peter David Howes ,  Fabrizio Nerozzi ,  Stephen Allan Smith

IPC分类号： A61K31/497 ,  C07D417/14 ,  A61P31/12

CPC分类号： C07D417/14

摘要： Anti-viral agents of Formula (Ia) wherein: A represents hydroxy; B represents C(O)R3 wherein R3 is 4-tert-butyl-3-methoxyphenyl; D represents 1,3-thiazol-2-yl or 5-methyl-1,3-thiazol-2-yl; E represents pyrazin-2-yl; G represents 1,3-thiazol-2-ylmethyl, 1,3-thiazol-4-ylmethyl, 1,2-thiazol-3-ylmethyl, or 1H-pyrazol-1-ylmethyl; and salts, solvates and esters thereof; provided that when A is esterified to form —OR where R is selected from straight or branched chain alkyl, aralkyl, aryloxyalkyl, or aryl, then R is other than tert-butyl, processes for their preparation and their use in HCV treatment are provided.

摘要翻译： 式（Ia）的抗病毒剂，其中：A表示羟基; B表示C（O）R 3，其中R 3是4-叔丁基-3-甲氧基苯基; D代表1,3-噻唑-2-基或5-甲基-1,3-噻唑-2-基; E表示吡嗪-2-基; G表示1,3-噻唑-2-基甲基，1,3-噻唑-4-基甲基，1,2-噻唑-3-基甲基或1H-吡唑-1-基甲基; 及其盐，溶剂化物和酯; 条件是当A被酯化形成-OR时，其中R选自直链或支链烷基，芳烷基，芳氧基烷基或芳基，则R不是叔丁基，提供其制备方法及其在HCV治疗中的用途。

公开(公告)号：US20090136448A1

公开(公告)日：2009-05-28

申请号：US12097840

申请日：2006-12-20

申请人： John Andrew Corfield ,  Richard Martin Grimes ,  David Harrison ,  Charles David Hartley ,  Peter David Howes ,  Joelle Le ,  Malcolm Lees Meeson ,  Jacqueline Elizabeth Mordaunt ,  Pritom Shah ,  Martin John Slater ,  Gemma Victoria White

发明人： John Andrew Corfield ,  Richard Martin Grimes ,  David Harrison ,  Charles David Hartley ,  Peter David Howes ,  Joelle Le ,  Malcolm Lees Meeson ,  Jacqueline Elizabeth Mordaunt ,  Pritom Shah ,  Martin John Slater ,  Gemma Victoria White

IPC分类号： A61K38/21 ,  C07D491/02 ,  A61K31/4355 ,  C07D487/02 ,  A61K31/519 ,  C07D471/02 ,  A61K31/437 ,  C07D513/02 ,  A61P31/12 ,  A61K31/7056 ,  A61K31/429 ,  C07D263/54 ,  A61K31/423 ,  A61K31/5025 ,  C07D209/04 ,  A61K31/404

CPC分类号： C07D409/10 ,  C07D333/70 ,  C07D413/10 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D513/04

摘要： Anti-viral agents of compounds of Formula (I): wherein A, R1, R2 and R3 are as defined in the specification, processes for their preparation and their use in HCV treatment are provided.

摘要翻译： 式（I）化合物的抗病毒剂：其中A，R1，R2和R3如说明书中所定义，提供其制备方法及其在HCV治疗中的用途。