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公开(公告)号：US11236085B2
公开(公告)日：2022-02-01
申请号：US16660219
申请日：2019-10-22
发明人： Zhimin Du , Michael Graupe , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Eric Q. Parkhill , Barton W. Phillips , Scott P. Simonovich , Peiyuan Wang , Jie Xu , Christopher A. Ziebenhaus
IPC分类号： C07D471/04 , C07D217/04 , C07D401/12 , C07D401/14 , C07D413/10 , C07D471/08 , C07D487/04 , C07D495/04 , C07D513/04 , C07K16/28 , C07K16/40
摘要： Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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公开(公告)号：US20200157094A1
公开(公告)日：2020-05-21
申请号：US16660219
申请日：2019-10-22
发明人： Zhimin Du , Michael Graupe , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Eric Q. Parkhill , Barton W. Phillips , Scott P. Simonovich , Peiyuan Wang , Jie Xu , Christopher A. Ziebenhaus
IPC分类号： C07D471/04 , C07D513/04 , C07D401/12 , C07D413/10 , C07D217/04 , C07D401/14 , C07D471/08 , C07D487/04 , C07D495/04
摘要： Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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公开(公告)号：US11453681B2
公开(公告)日：2022-09-27
申请号：US16880134
申请日：2020-05-21
发明人： Evangelos Aktoudianakis , Jayaraman Chandrasekhar , Julian A. Codelli , John H. Conway , Kristyna M. Elbel , Rao V. Kalla , Samuel E. Metobo , Scott A. Mitchell , Thao D. Perry , Scott P. Simonovich , Christopher A. Ziebenhaus
IPC分类号： C07D498/04 , C07D413/14 , C07D471/04 , C07D519/00
摘要： The present disclosure relates generally to certain ene-oxindole compounds, pharmaceutical compositions comprising thereof. Also disclosed are methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
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公开(公告)号：US12037342B2
公开(公告)日：2024-07-16
申请号：US17820374
申请日：2022-08-17
发明人： Evangelos Aktoudianakis , Jayaraman Chandrasekhar , Julian A. Codelli , John H. Conway , Kristyna M. Elbel , Rao V. Kalla , Samuel E. Metobo , Scott A. Mitchell , Thao D. Perry , Scott P. Simonovich , Christopher A. Ziebenhaus
IPC分类号： C07D498/04 , C07D413/14 , C07D471/04 , C07D519/00
CPC分类号： C07D498/04 , C07D413/14 , C07D471/04 , C07D519/00
摘要： The present disclosure relates generally to certain ene-oxindole compounds, pharmaceutical compositions comprising thereof. Also disclosed are methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
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公开(公告)号：US20230183262A1
公开(公告)日：2023-06-15
申请号：US17820374
申请日：2022-08-17
发明人： Evangelos Aktoudianakis , Jayaraman Chandrasekhar , Julian A. Codelli , John H. Conway , Kristyna M. Elbel , Rao V. Kalla , Samuel E. Metobo , Scott A. Mitchell , Thao D. Perry , Scott P. Simonovich , Christopher A. Ziebenhaus
IPC分类号： C07D498/04 , C07D413/14 , C07D471/04 , C07D519/00
CPC分类号： C07D498/04 , C07D413/14 , C07D471/04 , C07D519/00
摘要： The present disclosure relates generally to certain ene-oxindole compounds, pharmaceutical compositions comprising thereof. Also disclosed are methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
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