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公开(公告)号：US11655285B2
公开(公告)日：2023-05-23
申请号：US17110876
申请日：2020-12-03
发明人： Mini Balakrishnan , Brian A. Carr , John Corbin , Craig S. Pace , Nathan D. Thomsen , Xue Zhang
CPC分类号： C07K16/1063 , A61K2039/505 , C07K2317/33 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides novel anti-HIV antibodies with improved therapeutic properties, related pharmaceutical compositions, and methods of use thereof.
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2.发明申请公开(公告)号：US20200368347A1
公开(公告)日：2020-11-26
申请号：US16877292
申请日：2020-05-18
发明人： Brian Moldt , Craig S. Pace
IPC分类号： A61K39/21 , A61K31/519 , A61K31/4745 , C12Q1/70 , C07K16/10 , A61P31/18
摘要： Provided are methods for identifying patient populations infected with HIV that can be targeted by antibodies that bind to HIV gp120 V3 glycan region.
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公开(公告)号：US20190211083A1
公开(公告)日：2019-07-11
申请号：US16273753
申请日：2019-02-12
发明人： Mini Balakrishnan , Brian A. Carr , John Corbin , Craig S. Pace , Nathan D. Thomsen , Xue Zhang
IPC分类号： C07K16/10
CPC分类号： C07K16/1063 , A61K2039/505 , C07K2317/33 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides novel anti-HIV antibodies with improved therapeutic properties, related pharmaceutical compositions, and methods of use thereof.
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公开(公告)号：US11597759B2
公开(公告)日：2023-03-07
申请号：US16867924
申请日：2020-05-06
发明人： Tomas Cihlar , Joshua Goldsmith , George Kukolj , Craig S. Pace , Doug Rehder , Matthew R. Schenauer , Derek Dean Sloan , Heather Theresa Stephenson , Nathan D. Thomsen
IPC分类号： C07K16/10 , A61K47/68 , A61K51/10 , A61P31/18 , C07K16/28 , G01N33/53 , A61K39/395 , A61K39/42 , A61K39/00
摘要： Multispecific antibodies (e.g., bispecific antibodies) that bind to HIV gp120 and CD3 are disclosed. Also disclosed are methods of using such antibodies to treat or prevent HIV infection.
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公开(公告)号：US20220089698A1
公开(公告)日：2022-03-24
申请号：US17496250
申请日：2021-10-07
发明人： Mini Balakrishnan , Brian A. Carr , Magdeleine S. Hung , Manu Kanwar , Craig S. Pace , Doug Rehder , Matthew Robert Schenauer , Loredana Serafini , Heather Theresa Stephenson , Nathan D. Thomsen , Helen Yu , Xue Zhang
摘要： Antibodies that bind to HIV gp120 and neutralize HIV are disclosed. Also disclosed are methods of using such antibodies alone or in combination with other therapeutic agents to treat or prevent HIV infection.
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公开(公告)号：US10882898B2
公开(公告)日：2021-01-05
申请号：US16273753
申请日：2019-02-12
发明人： Mini Balakrishnan , Brian A. Carr , John Corbin , Craig S. Pace , Nathan D. Thomsen , Xue Zhang
摘要： The present invention provides novel anti-HIV antibodies with improved therapeutic properties, related pharmaceutical compositions, and methods of use thereof.
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公开(公告)号：US20180371086A1
公开(公告)日：2018-12-27
申请号：US16014153
申请日：2018-06-21
发明人： Tomas Cihlar , Joshua Goldsmith , Craig S. Pace , Derek Sloan , Heather Stephenson , Nathan D. Thomsen , George Kukolj , Doug Rehder
摘要： Multispecific antibodies (e.g., bispecific antibodies) that bind to HIV gp120 and CD3 are disclosed. Also disclosed are methods of using such antibodies to treat or prevent HIV infection.
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公开(公告)号：US20240034774A1
公开(公告)日：2024-02-01
申请号：US18365869
申请日：2023-08-04
发明人： Mini Balakrishnan , Brian A. Carr , Magdeleine S. Hung , Manu Kanwar , Craig S. Pace , Doug Rehder , Matthew Robert Schenauer , Loredana Serafini , Heather Theresa Stephenson , Nathan D. Thomsen , Helen Yu , Xue Zhang
CPC分类号： C07K16/1063 , A61P31/18 , A61K45/06
摘要： Antibodies that bind to HIV gp120 and neutralize HIV are disclosed. Also disclosed are methods of using such antibodies alone or in combination with other therapeutic agents to treat or prevent HIV infection.
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公开(公告)号：US11168130B2
公开(公告)日：2021-11-09
申请号：US16460094
申请日：2019-07-02
发明人： Mini Balakrishnan , Brian A. Carr , Craig S. Pace , Doug Rehder , Matthew Robert Schenauer , Loredana Serafini , Heather Theresa Stephenson , Nathan D. Thomsen , Helen Yu , Xue Zhang
摘要： Antibodies that bind to HIV gp120 and neutralize HIV are disclosed. Also disclosed are methods of using such antibodies alone or in combination with other therapeutic agents to treat or prevent HIV infection.
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公开(公告)号：US20210155676A1
公开(公告)日：2021-05-27
申请号：US17110876
申请日：2020-12-03
发明人： Mini Balakrishnan , Brian A. Carr , John Corbin , Craig S. Pace , Nathan D. Thomsen , Xue Zhang
IPC分类号： C07K16/10
摘要： The present invention provides novel anti-HIV antibodies with improved therapeutic properties, related pharmaceutical compositions, and methods of use thereof.
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