公开(公告)号：US20250049908A1

公开(公告)日：2025-02-13

申请号：US18743701

申请日：2024-06-14

Applicant: Gilead Sciences, Inc.

Inventor： Jiani Li ,  Xinan Liu ,  Azure T. Makadzange ,  Stephen R. Martin ,  Sarah Schmidt ,  Hesham Shehata ,  Felix Stemeseder ,  Evguenia Svarovskaia ,  Archana V. Boopathy

IPC: A61K39/12 ,  A61K39/00 ,  A61P31/18 ,  C07K14/005 ,  C07K16/10 ,  C07K16/28 ,  C12N15/10 ,  C12N15/86

Abstract: Provided are HIV-1 fusion polypeptides, polynucleotides encoding such fusion polypeptides, vectors expressing such fusion polypeptides for use in eliciting an immune response against HIV-1; pharmaceutical and immunogenic compositions and kits comprising such fusion polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HIV-1. Further provided are methods for design of antiviral vaccines, including vaccines to elicit an immune response against HIV-1.

公开(公告)号：US20220218813A1

公开(公告)日：2022-07-14

申请号：US17574465

申请日：2022-01-12

Applicant: Gilead Sciences, Inc.

Inventor： Jiani Li ,  Xinan Liu ,  Azure T. Makadzange ,  Stephen R. Martin ,  Sarah Schmidt ,  Hesham Shehata ,  Felix Stemeseder ,  Evguenia Svarovskaia ,  Archana V. Boopathy

IPC: A61K39/12 ,  A61P31/18 ,  C07K14/005 ,  C07K16/10 ,  C07K16/28 ,  C12N15/10 ,  C12N15/86

Abstract: Provided are HIV-1 fusion polypeptides, polynucleotides encoding such fusion polypeptides, vectors expressing such fusion polypeptides for use in eliciting an immune response against HIV-1; pharmaceutical and immunogenic compositions and kits comprising such fusion polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HIV-1. Further provided are methods for design of antiviral vaccines, including vaccines to elicit an immune response against HIV-1.