公开(公告)号：US20250049908A1

公开(公告)日：2025-02-13

申请号：US18743701

申请日：2024-06-14

Applicant: Gilead Sciences, Inc.

Inventor： Jiani Li ,  Xinan Liu ,  Azure T. Makadzange ,  Stephen R. Martin ,  Sarah Schmidt ,  Hesham Shehata ,  Felix Stemeseder ,  Evguenia Svarovskaia ,  Archana V. Boopathy

IPC: A61K39/12 ,  A61K39/00 ,  A61P31/18 ,  C07K14/005 ,  C07K16/10 ,  C07K16/28 ,  C12N15/10 ,  C12N15/86

Abstract: Provided are HIV-1 fusion polypeptides, polynucleotides encoding such fusion polypeptides, vectors expressing such fusion polypeptides for use in eliciting an immune response against HIV-1; pharmaceutical and immunogenic compositions and kits comprising such fusion polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HIV-1. Further provided are methods for design of antiviral vaccines, including vaccines to elicit an immune response against HIV-1.

公开(公告)号：US11497808B2

公开(公告)日：2022-11-15

申请号：US17034706

申请日：2020-09-28

Applicant: Gilead Sciences, Inc.

Inventor： Scott J. Balsitis ,  Sarah M. Ahmadi-Erber ,  Timo Schippers ,  Sarah Schmidt

IPC: A61K39/29 ,  A61P37/04 ,  C12N9/12 ,  A61K39/00

Abstract: Provided are HBV immunogenic polypeptides, polynucleotides encoding such polypeptides, vectors expressing such immunogenic polypeptides for use in eliciting an immune response against HBV; pharmaceutical and immunogenic compositions and kits comprising such polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HBV.

公开(公告)号：US20220218813A1

公开(公告)日：2022-07-14

申请号：US17574465

申请日：2022-01-12

Applicant: Gilead Sciences, Inc.

Inventor： Jiani Li ,  Xinan Liu ,  Azure T. Makadzange ,  Stephen R. Martin ,  Sarah Schmidt ,  Hesham Shehata ,  Felix Stemeseder ,  Evguenia Svarovskaia ,  Archana V. Boopathy

IPC: A61K39/12 ,  A61P31/18 ,  C07K14/005 ,  C07K16/10 ,  C07K16/28 ,  C12N15/10 ,  C12N15/86

Abstract: Provided are HIV-1 fusion polypeptides, polynucleotides encoding such fusion polypeptides, vectors expressing such fusion polypeptides for use in eliciting an immune response against HIV-1; pharmaceutical and immunogenic compositions and kits comprising such fusion polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HIV-1. Further provided are methods for design of antiviral vaccines, including vaccines to elicit an immune response against HIV-1.

公开(公告)号：US20210093712A1

公开(公告)日：2021-04-01

申请号：US17034706

申请日：2020-09-28

Applicant: Gilead Sciences, Inc.

Inventor： Scott J. Balsitis ,  Stephane Daffis ,  Sarah M. Ahmadi-Erber ,  Timo Schippers ,  Sarah Schmidt

IPC: A61K39/29 ,  C12N9/12 ,  A61P37/04

Abstract: Provided are HBV immunogenic polypeptides, polynucleotides encoding such polypeptides, vectors expressing such immunogenic polypeptides for use in eliciting an immune response against HBV; pharmaceutical and immunogenic compositions and kits comprising such polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HBV.

公开(公告)号：US20240066117A1

公开(公告)日：2024-02-29

申请号：US18335810

申请日：2023-06-15

Applicant: Gilead Sciences, Inc.

Inventor： Scott J. Balsitis ,  Sarah M. Ahmadi-Erber ,  Timo Schippers ,  Sarah Schmidt

IPC: A61K39/29 ,  A61P37/04 ,  C12N9/12

CPC classification number: A61K39/292 ,  A61P37/04 ,  C12N9/1252 ,  C12Y207/07007 ,  A61K2039/5256

Abstract: Provided are HBV immunogenic polypeptides, polynucleotides encoding such polypeptides, vectors expressing such immunogenic polypeptides for use in eliciting an immune response against HBV; pharmaceutical and immunogenic compositions and kits comprising such polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HBV.

公开(公告)号：US11730808B2

公开(公告)日：2023-08-22

申请号：US17937567

申请日：2022-10-03

Applicant: Gilead Sciences, Inc.

Inventor： Scott J. Balsitis ,  Sarah M. Ahmadi-Erber ,  Timo Schippers ,  Sarah Schmidt

IPC: A61K39/29 ,  A61P37/04 ,  C12N9/12 ,  A61K39/00

CPC classification number: A61K39/292 ,  A61P37/04 ,  C12N9/1252 ,  C12Y207/07007 ,  A61K2039/5256 ,  C12N2730/10122 ,  C12N2730/10134 ,  C12N2760/10034 ,  C12N2760/10043

Abstract: Provided are HBV immunogenic polypeptides, polynucleotides encoding such polypeptides, vectors expressing such immunogenic polypeptides for use in eliciting an immune response against HBV; pharmaceutical and immunogenic compositions and kits comprising such polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HBV.

公开(公告)号：US20230114007A1

公开(公告)日：2023-04-13

申请号：US17937567

申请日：2022-10-03

Applicant: Gilead Sciences, Inc.

Inventor： Scott J. Balsitis ,  Stephane Daffis ,  Sarah M. Ahmadi-Erber ,  Timo Schippers ,  Sarah Schmidt

IPC: A61K39/29 ,  A61P37/04 ,  C12N9/12

Abstract: Provided are HBV immunogenic polypeptides, polynucleotides encoding such polypeptides, vectors expressing such immunogenic polypeptides for use in eliciting an immune response against HBV; pharmaceutical and immunogenic compositions and kits comprising such polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HBV.