公开(公告)号：US20170267694A1

公开(公告)日：2017-09-21

申请号：US15387318

申请日：2016-12-21

申请人： Gilead Sciences, Inc.

发明人： Dustin Bringley ,  Johann Chan ,  Peter Fung ,  Katie Keaton ,  Olga Lapina ,  Henry Morrison ,  Dominika Pcion

IPC分类号： C07D498/16 ,  A61K45/06 ,  A61K31/4985 ,  C07K5/083

CPC分类号： C07D498/16 ,  A61K31/4985 ,  A61K45/06 ,  C07K5/0808

摘要： Crystalline forms of the anti-HCV compound (1aR,5S,8S,9S,10R,22aR)-5-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-9-ethyl-18,18-difluoro-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxamide (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.

公开(公告)号：US09562058B2

公开(公告)日：2017-02-07

申请号：US14575966

申请日：2014-12-18

申请人： GILEAD SCIENCES, INC.

发明人： Dustin Bringley ,  Johann Chan ,  Peter Fung ,  Katie Keaton ,  Olga Lapina ,  Henry Morrison ,  Dominika Pcion

IPC分类号： A61K31/4985 ,  C07D498/16 ,  A61K45/06 ,  C07K5/083

CPC分类号： C07D498/16 ,  A61K31/4985 ,  A61K45/06 ,  C07K5/0808

摘要： Crystalline forms of the anti-HCV compound (1aR,5S,8S,9S,10R,22aR)-5-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-9-ethyl-18,18-difluoro-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxamide (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.

摘要翻译： 抗HCV化合物（1aR，5S，8S，9S，10R，22aR）-5-叔丁基-N - [（1R，2R）-2-（二氟甲基）-1 - {[（1- 甲基环丙基）磺酰基]氨基甲酰基}环丙基] -9-乙基-18,18-二氟-14-甲氧基-3,6-二氧代-1,1a，3,4,5,6,9,10,18,19,20 ，21,22,22a-十四氢-8H-7,10-亚甲基环丙烷[18,19] [1,10,3,6]二氧杂二氮杂环十二烷[11,12-b]喹喔啉-8-甲酰胺（化合物I） 其特征在于固态：还提供了制造方法和使用结晶形式的方法。

公开(公告)号：US09862728B2

公开(公告)日：2018-01-09

申请号：US15387318

申请日：2016-12-21

申请人： Gilead Sciences, Inc.

发明人： Dustin Bringley ,  Johann Chan ,  Peter Fung ,  Katie Keaton ,  Olga Lapina ,  Henry Morrison ,  Dominika Pcion

IPC分类号： C07D498/16 ,  C07K5/083 ,  A61K45/06 ,  A61K31/4985

CPC分类号： C07D498/16 ,  A61K31/4985 ,  A61K45/06 ,  C07K5/0808

摘要： Crystalline forms of the anti-HCV compound (1aR,5S,8S,9S,10R,22aR)-5-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-9-ethyl-18,18-difluoro-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxamide (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.

公开(公告)号：US20150175625A1

公开(公告)日：2015-06-25

申请号：US14575966

申请日：2014-12-18

申请人： GILEAD SCIENCES, INC.

发明人： Dustin Bringley ,  Johann Chan ,  Peter Fung ,  Katie Keaton ,  Olga Lapina ,  Henry Morrison ,  Dominika Pcion

IPC分类号： C07D498/16 ,  A61K45/06 ,  A61K31/4985

CPC分类号： C07D498/16 ,  A61K31/4985 ,  A61K45/06 ,  C07K5/0808

摘要： Crystalline forms of the anti-HCV compound (1aR,5S,8S,9S,10R,22aR)-5-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-9-ethyl-18,18-difluoro-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxamide (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the crystalline forms.

摘要翻译： 抗HCV化合物（1aR，5S，8S，9S，10R，22aR）-5-叔丁基-N - [（1R，2R）-2-（二氟甲基）-1 - {[（1- 甲基环丙基）磺酰基]氨基甲酰基}环丙基] -9-乙基-18,18-二氟-14-甲氧基-3,6-二氧代-1,1a，3,4,5,6,9,10,18,19,20 ，21,22,22a-十四氢-8H-7,10-亚甲基环丙烷[18,19] [1,10,3,6]二氧杂二氮杂环十二烷[11,12-b]喹喔啉-8-甲酰胺（化合物I） 其特征在于固态：还提供了制造方法和使用结晶形式的方法。