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公开(公告)号：US08936780B2
公开(公告)日：2015-01-20
申请号：US11468721
申请日：2006-08-30
申请人： Gina Zhang , Jessica Renee DesNoyer , Gordon Stewart , Maricela Kezis , Syed Faiyaz Ahmed Hossainy
发明人： Gina Zhang , Jessica Renee DesNoyer , Gordon Stewart , Maricela Kezis , Syed Faiyaz Ahmed Hossainy
IPC分类号： A61K31/785 , A61F2/00 , A61K9/00 , A61L24/00 , A61L24/04
CPC分类号： A61K47/48207 , A61K9/0019 , A61K31/436 , A61K47/595 , A61L24/001 , A61L24/046 , A61L2430/36 , C08G69/44 , Y10S977/906 , C08L77/12
摘要： A composition including a solution suitable for introduction into a blood vessel comprising particles including a treatment agent and a tunable stimuli-responsive polymer. A method including introducing a delivery device into a blood vessel; and introducing a solution into the blood vessel, the solution including particles comprising a treatment agent and a tunable stimuli-responsive polymer. A method including combining a treatment agent and a tunable stimuli-responsive polymer; and forming particles of the combination suitable for delivery through a blood vessel.
摘要翻译： 一种包含适于引入血管的溶液的组合物，其包含包含处理剂和可调节刺激响应性聚合物的颗粒。 一种包括将输送装置引入血管的方法; 并且将溶液引入血管中，所述溶液包括包含处理剂和可调节刺激响应性聚合物的颗粒。 一种包括处理剂和可调谐刺激响应性聚合物的组合的方法; 以及形成适于通过血管输送的组合颗粒。
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公开(公告)号：US20080057024A1
公开(公告)日：2008-03-06
申请号：US11468721
申请日：2006-08-30
申请人： Gina Zhang , Jessica Renee DesNoyer , Gordon Stewart , Maricela Kezis , Syed Faiyaz Ahmed Hossainy
发明人： Gina Zhang , Jessica Renee DesNoyer , Gordon Stewart , Maricela Kezis , Syed Faiyaz Ahmed Hossainy
IPC分类号： A61K31/785
CPC分类号： A61K47/48207 , A61K9/0019 , A61K31/436 , A61K47/595 , A61L24/001 , A61L24/046 , A61L2430/36 , C08G69/44 , Y10S977/906 , C08L77/12
摘要： A composition including a solution suitable for introduction into a blood vessel comprising particles including a treatment agent and a tunable stimuli-responsive polymer. A method including introducing a delivery device into a blood vessel; and introducing a solution into the blood vessel, the solution including particles comprising a treatment agent and a tunable stimuli-responsive polymer. A method including combining a treatment agent and a tunable stimuli-responsive polymer; and forming particles of the combination suitable for delivery through a blood vessel.
摘要翻译： 一种包含适于引入血管的溶液的组合物，其包含包含处理剂和可调节刺激响应性聚合物的颗粒。 一种包括将输送装置引入血管的方法; 并且将溶液引入血管中，所述溶液包括包含处理剂和可调节刺激响应性聚合物的颗粒。 一种包括处理剂和可调谐刺激响应性聚合物的组合的方法; 以及形成适于通过血管输送的组合颗粒。
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3.发明授权Poly(ester amide)-based drug delivery systems with controlled release rate and morphology 有权具有控制释放速率和形态的基于聚（酯酰胺）的药物递送系统公开(公告)号：US08389044B2
公开(公告)日：2013-03-05
申请号：US13037173
申请日：2011-02-28
申请人： Lothar Walter Kleiner , Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Ahmed Hossainy
发明人： Lothar Walter Kleiner , Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Ahmed Hossainy
IPC分类号： A61K33/00
CPC分类号： A61L27/34 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2420/02
摘要： A method of forming a coating on a medical device having a controlled morphology is described. A method of treating a disorder in a patient using the medical device is described.
摘要翻译： 描述了在具有受控形态的医疗装置上形成涂层的方法。 描述了使用医疗装置治疗患者的病症的方法。
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4.发明授权Poly(ester amide)-based drug delivery systems with controlled release rate and morphology 有权具有控制释放速率和形态的基于聚（酯酰胺）的药物递送系统公开(公告)号：US08377107B2
公开(公告)日：2013-02-19
申请号：US13037169
申请日：2011-02-28
申请人： Lothar Walter Kleiner , Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Ahmed Hossainy
发明人： Lothar Walter Kleiner , Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Ahmed Hossainy
IPC分类号： A61F2/06
CPC分类号： A61L27/34 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2420/02
摘要： A method of forming a coating on a medical device having a controlled morphology is described. A medical device having a controlled morphology is described.
摘要翻译： 描述了在具有受控形态的医疗装置上形成涂层的方法。 描述具有受控形态的医疗装置。
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公开(公告)号：US20110144741A1
公开(公告)日：2011-06-16
申请号：US13027126
申请日：2011-02-14
CPC分类号： A61L31/10 , A61L2420/02 , A61L2420/08 , Y10T428/3154 , C08L77/12 , C08L27/12 , C08L27/18
摘要： The present invention provides a method of forming a coating on a medical device having a topcoat and a basecoat and an improved compatibility between a topcoat and a basecoat on the medical device.
摘要翻译： 本发明提供了一种在具有面漆和底涂层的医疗装置上形成涂层的方法，并且改善了医用装置上的顶涂层和底涂层之间的相容性。
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6.发明授权Methods of forming Poly(ester amide)-based drug delivery systems with controlled release rate and morphology 有权形成具有控制释放速率和形态的基于聚（酯酰胺）的药物递送系统的方法公开(公告)号：US08377499B2
公开(公告)日：2013-02-19
申请号：US13037166
申请日：2011-02-28
申请人： Lothar Walter Kleiner , Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Ahmed Hossainy , O. Mikael Trollsas , Michael Huy Ngo
发明人： Lothar Walter Kleiner , Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Ahmed Hossainy , O. Mikael Trollsas , Michael Huy Ngo
IPC分类号： A61L33/00
CPC分类号： A61L27/34 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2300/606 , A61L2420/02
摘要： A method of forming a coating on a medical device having a controlled morphology is described.
摘要翻译： 描述了在具有受控形态的医疗装置上形成涂层的方法。
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公开(公告)号：US20080095918A1
公开(公告)日：2008-04-24
申请号：US11453419
申请日：2006-06-14
CPC分类号： A61L31/10 , A61L2420/02 , A61L2420/08 , Y10T428/3154 , C08L77/12 , C08L27/12 , C08L27/18
摘要： The present invention provides a method of forming a coating on a medical device having a topcoat and a basecoat and an improved compatibility between a topcoat and a basecoat on the medical device.
摘要翻译： 本发明提供了一种在具有面漆和底涂层的医疗装置上形成涂层的方法，并且改善了医用装置上的顶涂层和底涂层之间的相容性。
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8.发明授权公开(公告)号：US07749263B2
公开(公告)日：2010-07-06
申请号：US11970490
申请日：2008-01-07
申请人： Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Shmed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
发明人： Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Shmed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
CPC分类号： C09D177/12 , A61L31/06 , A61L31/10 , Y10S623/90 , Y10T428/31725 , Y10T428/31786 , C08L77/12
摘要： Provided herein is a PEA polymer blend and coatings or implantable devices formed therefrom.
摘要翻译： 本文提供了由其形成的PEA聚合物共混物和涂层或可植入装置。
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9.发明申请公开(公告)号：US20080167712A1
公开(公告)日：2008-07-10
申请号：US11970490
申请日：2008-01-07
申请人： Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Shmed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
发明人： Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Shmed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
CPC分类号： C09D177/12 , A61L31/06 , A61L31/10 , Y10S623/90 , Y10T428/31725 , Y10T428/31786 , C08L77/12
摘要： Provided herein is a PEA polymer blend and coatings or implantable devices formed therefrom.
摘要翻译： 本文提供了由其形成的PEA聚合物共混物和涂层或可植入装置。
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10.发明授权公开(公告)号：US07390497B2
公开(公告)日：2008-06-24
申请号：US10976551
申请日：2004-10-29
申请人： Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Shmed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
发明人： Jessica Renee DesNoyer , Stephen Dirk Pacetti , Syed Faiyaz Shmed Hossainy , Lothar Kleiner , Yiwen Tang , Gina Zhang
CPC分类号： C09D177/12 , A61L31/06 , A61L31/10 , Y10S623/90 , Y10T428/31725 , Y10T428/31786 , C08L77/12
摘要： Provided herein is a PEA polymer blend and coatings or implantable devices formed therefrom. The PEA polymer blend is formed of a PEA polymer and a material capable of hydrogen bonding with the PEA. The PEA polymer blend can form a coating on an implantable device, one example of which is a stent. The coating can optionally include a biobeneficial material and/or optionally with a bioactive agent. The implantable device can be used to treat or prevent a disorder such as one of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
摘要翻译： 本文提供了由其形成的PEA聚合物共混物和涂层或可植入装置。 PEA聚合物共混物由PEA聚合物和能够与PEA氢键合的材料形成。 PEA聚合物共混物可以在可植入装置上形成涂层，其一个实例是支架。 涂层可任选地包括生物有益材料和/或任选地含有生物活性剂。 可植入装置可用于治疗或预防动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔之一，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍 导管阻塞，输尿管阻塞，肿瘤阻塞及其组合。
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