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公开(公告)号:US20160106753A1
公开(公告)日:2016-04-21
申请号:US14976998
申请日:2015-12-21
申请人: Giorgio CARAVATTI , Sylvie CHAMOIN , Pascal FURET , Klemens HOGENAUER , Konstanze HURTH , Christoph KALIS , Karen KAMMERTOENS , Ian LEWIS , Henrik MOEBITZ , Alexander Baxter SMITH , Nicolas SOLDERMANN , Romain WOLF , Frederic ZECRI
发明人: Giorgio CARAVATTI , Sylvie CHAMOIN , Pascal FURET , Klemens HOGENAUER , Konstanze HURTH , Christoph KALIS , Karen KAMMERTOENS , Ian LEWIS , Henrik MOEBITZ , Alexander Baxter SMITH , Nicolas SOLDERMANN , Romain WOLF , Frederic ZECRI
IPC分类号: A61K31/5383 , A61K31/538
CPC分类号: A61K31/5383 , A61K31/538 , C07D413/14 , C07D498/04 , C12N9/12 , C12Q1/25 , C12Q1/686 , Y02A50/409 , Y02A50/411
摘要: The invention relates to dihydro-benzo-oxazine and dihydro-pyrido-oxazine compounds of the formula (I) and/or pharmaceutically acceptable salts and/or solvates thereof, wherein Y, V, W, U, Q, R1, R5, R7 and R30 are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.
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公开(公告)号:US20120263712A1
公开(公告)日:2012-10-18
申请号:US13488589
申请日:2012-06-05
IPC分类号: A61K31/4439 , A61K31/427 , A61K31/506 , A61K31/497 , A61K39/00 , A61K31/7088 , A61K39/395 , A61K31/565 , A61P35/00 , A61P35/02 , A61P7/00 , A61P11/08 , A61P37/08 , A61P7/02 , A61P9/12 , A61P29/00 , A61P31/12 , A61P25/00 , A61P25/28 , A61P19/10 , A61P37/06 , A61P37/04 , C07D417/14
CPC分类号: A61K31/4439 , A61K45/06 , C07D417/14
摘要: The present invention relates to a compound of formula (I) or a salt thereof, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.
摘要翻译: 本发明涉及式(I)化合物或其盐,其中取代基如说明书中所定义,化合物在治疗通过抑制磷脂酰肌醇3-激酶而变态化的疾病中的组合物和用途。
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公开(公告)号:US20130012704A1
公开(公告)日:2013-01-10
申请号:US13617881
申请日:2012-09-14
申请人: Qiang DING , Nathanael Schiander GRAY , Bing LI , Yi LIU , Taebo SIM , Tetsuo UNO , Guobao ZHANG , Carole Pissot Soldermann , Werner BREITENSTEIN , Guido BOLD , Giorgio CARAVATTI , Pascal FURET , Vito GUAGNANO , Marc LANG , Paul W. MANLEY , Joseph SCHOEPFER , Carsten SPANKA
发明人: Qiang DING , Nathanael Schiander GRAY , Bing LI , Yi LIU , Taebo SIM , Tetsuo UNO , Guobao ZHANG , Carole Pissot Soldermann , Werner BREITENSTEIN , Guido BOLD , Giorgio CARAVATTI , Pascal FURET , Vito GUAGNANO , Marc LANG , Paul W. MANLEY , Joseph SCHOEPFER , Carsten SPANKA
IPC分类号: C07D403/12 , C07C265/12 , C07D413/12 , C07D405/12 , C07D409/14 , C07D401/12 , C07D401/14 , C07C217/84 , C07D239/48
CPC分类号: C07D239/48 , C07D251/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要: The invention relates to compounds of formula (I) wherein the substituents X1, R1, R2, R3 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, and a method for the treatment of such a disease.
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公开(公告)号:US20140378450A1
公开(公告)日:2014-12-25
申请号:US14478523
申请日:2014-09-05
申请人: Giorgio CARAVATTI , Robin Alec FAIRHURST , Pascal FURET , Clive MCCARTHY , Heinrich RUEEGER , Frank Hans SEILER , Frédéric STAUFFER
发明人: Giorgio CARAVATTI , Robin Alec FAIRHURST , Pascal FURET , Clive MCCARTHY , Heinrich RUEEGER , Frank Hans SEILER , Frédéric STAUFFER
IPC分类号: C07D498/04 , A61K31/5377 , C07D413/14
CPC分类号: C07D498/04 , A61K31/5377 , A61K45/06 , C07D413/14
摘要: The present invention relates to oxazolidin-2-one substituted pyrimidine compounds that act as PI3K (phosphatidylinositol-3-kinase) inhibitors, as well as pharmaceutical compositions thereof, methods for their manufacture and uses for the treatment of conditions, diseases and disorders dependent on PI3K.
摘要翻译: 本发明涉及作为PI3K(磷脂酰肌醇-3-激酶)抑制剂的恶唑烷-2-酮取代的嘧啶化合物及其药物组合物,其制备方法和用于治疗依赖于 PI3K。
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公开(公告)号:US20130012476A1
公开(公告)日:2013-01-10
申请号:US13617733
申请日:2012-09-14
申请人: Qiang DING , Nathanael Schiander GRAY , Bing LI , Yi LIU , Taebo SIM , Tetsuo UNO , Guobao ZHANG , Carole Pissot Soldermann , Werner BREITENSTEIN , Guido BOLD , Giorgio CARAVATTI , Pascal FURET , Vito GUAGNANO , Marc LANG , Paul W. MANLEY , Joseph SCHOEPFER , Carsten SPANKA
发明人: Qiang DING , Nathanael Schiander GRAY , Bing LI , Yi LIU , Taebo SIM , Tetsuo UNO , Guobao ZHANG , Carole Pissot Soldermann , Werner BREITENSTEIN , Guido BOLD , Giorgio CARAVATTI , Pascal FURET , Vito GUAGNANO , Marc LANG , Paul W. MANLEY , Joseph SCHOEPFER , Carsten SPANKA
IPC分类号: A61K31/496 , A61K31/695 , A61K31/505 , A61P35/00 , A61K31/5377
CPC分类号: C07D239/48 , C07D251/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要: The invention relates to compounds of formula (I) wherein the substituents X1, R1, R2, R3 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, and a method for the treatment of such a disease.
摘要翻译: 本发明涉及式(I)化合物,其中取代基X1,R1,R2,R3和R4具有本发明说明书中阐述和解释的含义,制备这些化合物的方法,含有它们的药物组合物 ,其任选与一种或多种其它药学活性化合物组合用于治疗对蛋白激酶活性的抑制作出反应的疾病的用途,以及治疗这种疾病的方法。
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