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公开(公告)号:US20140128370A1
公开(公告)日:2014-05-08
申请号:US14151796
申请日:2014-01-09
申请人: Nigel Graham COOKE , Frédéric ZECRI , Nicolas SOLDERMANN , Romain WOLF , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Anette VON MATT , Ross Sinclair STRANG , Alexander Baxter SMITH , Paulo FERNANDES GOMES DOS SANTOS , Nadege GRAVELEAU , Frank STOWASSER , Nicola TUFILLI
发明人: Nigel Graham COOKE , Frédéric ZECRI , Nicolas SOLDERMANN , Romain WOLF , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Anette VON MATT , Ross Sinclair STRANG , Alexander Baxter SMITH , Paulo FERNANDES GOMES DOS SANTOS , Nadege GRAVELEAU , Frank STOWASSER , Nicola TUFILLI
IPC分类号: C07D471/04
CPC分类号: C07D471/04 , A61K31/519 , A61K31/5377 , C07B2200/05
摘要: The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.
摘要翻译: 本发明涉及式(I)的取代的四氢 - 吡啶并 - 嘧啶衍生物,其中Y,R 1,R 2和m如说明书中所定义。 这些化合物适用于治疗由PI3K酶的活性介导的病症或疾病。
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公开(公告)号:US09840498B2
公开(公告)日:2017-12-12
申请号:US14907225
申请日:2014-07-24
申请人: NOVARTIS AG , Zhenxing Du , Samuel Hintermann , Konstanze Hurth , Sebastien Jacquier , Hansjoerg Lehmann , Henrik Moebitz , Nicolas Soldermann , Aleksandar Stojanovic
发明人: Zhenxing Du , Samuel Hintermann , Konstanze Hurth , Sébastien Jacquier , Hansjoerg Lehmann , Henrik Moebitz , Nicolas Soldermann , Aleksandar Stojanovic
IPC分类号: C07D403/14 , C07D401/14 , C07D417/14 , C07D473/16 , A61K31/517 , A61K31/52
CPC分类号: C07D403/14 , A61K31/517 , A61K31/52 , C07D401/14 , C07D417/14 , C07D473/16
摘要: Provided are substituted quinazolin-4-one compounds of the formula (I) and/or pharmaceutically acceptable salts and/or solvates thereof, wherein R1, R2, R3, R5, R6 and L are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the class I PI3K kinases.
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公开(公告)号:US20170267678A1
公开(公告)日:2017-09-21
申请号:US15613560
申请日:2017-06-05
申请人: Nigel Graham COOKE , Paulo Fernandes Gomes Dos Santos , Nadege GRAVELEAU , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Alexander Baxter SMITH , Nicolas SOLDERMANN , Frank STOWASSER , Ross Sinclair STRANG , Nicola TUFILLI , Anette von MATT , Romain WOLF , Frederic ZECRI
发明人: Nigel Graham COOKE , Paulo Fernandes Gomes Dos Santos , Nadege GRAVELEAU , Christina HEBACH , Klemens HOEGENAUER , Gregory John HOLLINGWORTH , Alexander Baxter SMITH , Nicolas SOLDERMANN , Frank STOWASSER , Ross Sinclair STRANG , Nicola TUFILLI , Anette von MATT , Romain WOLF , Frederic ZECRI
IPC分类号: C07D471/04 , A61K31/519 , A61K31/5377
CPC分类号: C07D471/04 , A61K31/519 , A61K31/5377 , C07B2200/05
摘要: The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.
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公开(公告)号:US20110092505A1
公开(公告)日:2011-04-21
申请号:US12996901
申请日:2009-06-12
申请人: Robin Burgis , Michael Paul Capparelli , Lucian Dipietro , Gabriel G. Gamber , Charles Francis Jewell, JR. , Erik Meredith , Karl Miranda , Lauren G. Monovich , Chang Rao , Nicolas Soldermann , Taeyoung Yoon , Qingming Zhu
发明人: Robin Burgis , Michael Paul Capparelli , Lucian Dipietro , Gabriel G. Gamber , Charles Francis Jewell, JR. , Erik Meredith , Karl Miranda , Lauren G. Monovich , Chang Rao , Nicolas Soldermann , Taeyoung Yoon , Qingming Zhu
IPC分类号: A61K31/535 , A61K31/4985 , A61K31/501 , A61K31/497 , A61K31/437 , A61K31/4545 , C07D417/14 , C07D487/04 , C07D413/14 , C07D471/04 , C07D401/14 , A61P17/00 , A61P9/00 , A61P35/00 , A61P37/00
CPC分类号: C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D519/00
摘要: The present invention provides novel organic compounds of Formula I: methods of use, and pharmaceutical compositions thereof.
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公开(公告)号:US20100130469A1
公开(公告)日:2010-05-27
申请号:US12594724
申请日:2008-04-04
申请人: Maurice van Eis , Walter Schuler , Anette Von Matt , Nicolas Soldermann , Lauren G. Monovich , Christoph Gaul
发明人: Maurice van Eis , Walter Schuler , Anette Von Matt , Nicolas Soldermann , Lauren G. Monovich , Christoph Gaul
IPC分类号: A61K31/397 , A61K31/551 , A61K31/499 , A61K31/496 , A61K31/4375 , A61K31/4725 , C07D471/04 , C07D401/14 , C07D217/12 , C07D205/04 , A61P37/00 , A61P29/00
CPC分类号: C07D471/04
摘要: The present invention relates to novel organic compounds comprising a naphthyridine which may be mediators of a selective subset of kinases belonging to the AGC kinase family, such as for example PKC, PKD, PKN-1/2, CDK-9, MRCK-beat, PASK, PRKX, ROCK-I/II or mediators of other kinases, the selectivity of which would be depending on the structural variation thereof.
摘要翻译: 本发明涉及包含萘啶的新型有机化合物,其可以是属于AGC激酶家族的激酶的选择性子集的介体,例如PKC,PKD,PKN-1,CDK-9,MRCK-beat, PASK,PRKX,ROCK-I / II或其他激酶的介质,其选择性取决于其结构变化。
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公开(公告)号:US08653092B2
公开(公告)日:2014-02-18
申请号:US13175050
申请日:2011-07-01
申请人: Nigel Graham Cooke , Paulo Fernandes Gomes Dos Santos , Nadege Graveleau , Christina Hebach , Klemens Högenauer , Gregory Hollingworth , Alexander Baxter Smith , Nicolas Soldermann , Frank Stowasser , Ross Strang , Nicola Tufilli , Anette Von Matt , Romain Wolf , Frédéric Zecri
发明人: Nigel Graham Cooke , Paulo Fernandes Gomes Dos Santos , Nadege Graveleau , Christina Hebach , Klemens Högenauer , Gregory Hollingworth , Alexander Baxter Smith , Nicolas Soldermann , Frank Stowasser , Ross Strang , Nicola Tufilli , Anette Von Matt , Romain Wolf , Frédéric Zecri
IPC分类号: C07D471/04 , A61K31/519 , A61P37/08 , A61P25/28 , A61P35/00 , A61P37/06
CPC分类号: C07D471/04 , A61K31/519 , A61K31/5377 , C07B2200/05
摘要: The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.
摘要翻译: 本发明涉及式(I)的取代的四氢 - 吡啶并 - 嘧啶衍生物,其中Y,R 1,R 2和m如说明书中所定义。 这些化合物适用于治疗由PI3K酶的活性介导的病症或疾病。
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公开(公告)号:US08299085B2
公开(公告)日:2012-10-30
申请号:US11572007
申请日:2005-07-26
申请人: Hans Allgeier , Wolfgang Froestl , Manuel Koller , Henri Mattes , Joachim Nozulak , Silvio Ofner , David Orain , Vittorio Rasetti , Johanne Renaud , Nicolas Soldermann , Philipp Floersheim
发明人: Hans Allgeier , Wolfgang Froestl , Manuel Koller , Henri Mattes , Joachim Nozulak , Silvio Ofner , David Orain , Vittorio Rasetti , Johanne Renaud , Nicolas Soldermann , Philipp Floersheim
IPC分类号: A01N43/54 , A61K31/517
CPC分类号: C07D409/12 , C07D239/96 , C07D401/12 , C07D403/04
摘要: The present invention relates to 1H-Quinazoline-2,4-dione derivatives of formula(I) wherein the substituents are defined as in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them.
摘要翻译: 本发明涉及式(I)的1H-喹唑啉-2,4-二酮衍生物,其中取代基如说明书中所定义,它们的制备,它们作为药物的用途以及含有它们的药物组合物。
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公开(公告)号:US09499536B2
公开(公告)日:2016-11-22
申请号:US14151796
申请日:2014-01-09
申请人: Nigel Graham Cooke , Frédèric Zecri , Nicolas Soldermann , Romain Wolf , Christina Hebach , Klemens Hoegenauer , Gregory John Hollingworth , Anette Von Matt , Ross Sinclair Strang , Alexander Baxter Smith , Paulo Fernandes Gomes Dos Santos , Nadege Graveleau , Frank Stowasser , Nicola Tufilli
发明人: Nigel Graham Cooke , Frédèric Zecri , Nicolas Soldermann , Romain Wolf , Christina Hebach , Klemens Hoegenauer , Gregory John Hollingworth , Anette Von Matt , Ross Sinclair Strang , Alexander Baxter Smith , Paulo Fernandes Gomes Dos Santos , Nadege Graveleau , Frank Stowasser , Nicola Tufilli
IPC分类号: A61K31/519 , A61P35/02 , A61P19/02 , C07D471/04
CPC分类号: C07D471/04 , A61K31/519 , A61K31/5377 , C07B2200/05
摘要: The invention relates to substituted tetrahydro-pyrido-pyrimidine derivatives of the formula (I), wherein Y, R1, R2 and m are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.
摘要翻译: 本发明涉及式(I)的取代的四氢 - 吡啶并 - 嘧啶衍生物,其中Y,R 1,R 2和m如说明书中所定义。 这些化合物适用于治疗由PI3K酶的活性介导的病症或疾病。
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公开(公告)号:US20160106753A1
公开(公告)日:2016-04-21
申请号:US14976998
申请日:2015-12-21
申请人: Giorgio CARAVATTI , Sylvie CHAMOIN , Pascal FURET , Klemens HOGENAUER , Konstanze HURTH , Christoph KALIS , Karen KAMMERTOENS , Ian LEWIS , Henrik MOEBITZ , Alexander Baxter SMITH , Nicolas SOLDERMANN , Romain WOLF , Frederic ZECRI
发明人: Giorgio CARAVATTI , Sylvie CHAMOIN , Pascal FURET , Klemens HOGENAUER , Konstanze HURTH , Christoph KALIS , Karen KAMMERTOENS , Ian LEWIS , Henrik MOEBITZ , Alexander Baxter SMITH , Nicolas SOLDERMANN , Romain WOLF , Frederic ZECRI
IPC分类号: A61K31/5383 , A61K31/538
CPC分类号: A61K31/5383 , A61K31/538 , C07D413/14 , C07D498/04 , C12N9/12 , C12Q1/25 , C12Q1/686 , Y02A50/409 , Y02A50/411
摘要: The invention relates to dihydro-benzo-oxazine and dihydro-pyrido-oxazine compounds of the formula (I) and/or pharmaceutically acceptable salts and/or solvates thereof, wherein Y, V, W, U, Q, R1, R5, R7 and R30 are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.
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公开(公告)号:US20080306064A1
公开(公告)日:2008-12-11
申请号:US11996222
申请日:2006-07-19
IPC分类号: A61K31/5377 , C07D235/30 , A61K31/4184 , C07D401/12 , A61K31/4439 , C07D413/10
CPC分类号: C07D405/12 , C07D235/30 , C07D401/12 , C07D403/04
摘要: Benzimidazole derivatives, methods of preparing the same and their pharmaceutical uses for the treatment of inflammatory diseases including COPD.
摘要翻译: 苯并咪唑衍生物,其制备方法及其用于治疗包括COPD的炎性疾病的药物用途。
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