公开(公告)号：US20170281532A1

公开(公告)日：2017-10-05

申请号：US15490220

申请日：2017-04-18

申请人： Glaxo Group Limited ,  Shionogi and Co., Ltd

发明人： Toshiaki AOKI ,  Hiroki KUSANO ,  Xiangmin LIAO ,  Neil David PEARSON ,  Israil PENDRAK ,  Jun SATO ,  Reema K. THALJI ,  Kenji YAMAWAKI ,  Katsuki YOKOO

IPC分类号： C07D501/48 ,  C07D501/50 ,  C07D505/24 ,  A61K9/00

CPC分类号： C07D501/48 ,  A61K9/0019 ,  C07D501/50 ,  C07D505/24 ,  Y02A50/473

摘要： The compounds of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical compositions comprising the same.

公开(公告)号：US20150299223A1

公开(公告)日：2015-10-22

申请号：US14439219

申请日：2013-10-29

申请人： GLAXO GROUP LIMITED ,  SHIONOGI & CO., LTD.

发明人： Toshiaki AOKI ,  Hiroki KUSANO ,  Xiangmin LIAO ,  Neil David PEARSON ,  Israil PENDRAK ,  Jun SATO ,  Reema THALGI ,  Kenji YAMAWAKI ,  Katsuki YOKOO

IPC分类号： C07D501/48

摘要： The present invention relates to 2-substituted cephem compounds of Formula (I) having a quaternary ammonium group on the 3-side chain, preferably together with a cathechol group, or pharmaceutically acceptable salts thereof, which exhibit potent antimicrobial spectrum against a variety of bacteria including Gram negative bacteria and/or Gram positive bacteria, corresponding pharmaceutical compositions, methods of making, treatment methods for bacterial infections or uses thereof.

摘要翻译： 本发明涉及在3-侧链上具有季铵基团的式（I）的2-取代头孢烯化合物，优选与导管胆固醇基团或其药学上可接受的盐，其表现出针对各种细菌的有效的抗菌谱 包括革兰氏阴性细菌和/或革兰氏阳性细菌，相应的药物组合物，制备方法，细菌感染的治疗方法或其用途。