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公开(公告)号：US12076385B2
公开(公告)日：2024-09-03
申请号：US17934781
申请日：2022-09-23
发明人： Jan Theunis Poolman , Bert Jacquemyn , Darren Robert Abbanat , Patricia Ibarra Yon , Peter Wilhelmus Maria Hermans , Michael Thomas Kowarik , Michael Lukas Wetter , Stefan Jochen Kemmler , Micha Andres Häuptle , Veronica Gambillara Fonck , Manuela Mally
IPC分类号： A61K39/02 , A61K39/108 , A61K39/385 , A61K47/64 , A61P31/04 , C08B37/00 , A61K39/00
CPC分类号： A61K39/0258 , A61K39/385 , A61K47/6415 , A61K47/646 , A61P31/04 , C08B37/0063 , A61K2039/545 , A61K2039/55583 , A61K2039/6037 , A61K2039/6087 , A61K2039/70 , Y02A50/30
摘要： Compositions and methods are described for inducing an immune response against extra-intestinal pathogenic Escherichia coli (ExPEC) to thereby provide immune protection against diseases associated with ExPEC. In particular, compositions and methods are described for using conjugates of E. coli polysaccharide antigens O25B, O1A, O2, and O6A covalently bound to a detoxified exotoxin A of Pseudomonas aeruginosa (EPA) carrier protein as vaccines for the prevention of invasive ExPEC disease caused by ExPEC serotypes O1A, O2, O6A and O25B.
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2.发明授权公开(公告)号：US11484582B2
公开(公告)日：2022-11-01
申请号：US16781526
申请日：2020-02-04
发明人： Jan Theunis Poolman , Bert Jacquemyn , Darren Robert Abbanat , Patricia Ibarra Yon , Peter Wilhelmus Maria Hermans , Michael Thomas Kowarik , Michael Lukas Wetter , Stefan Jochen Kemmler , Micha Andres Häuptle , Veronica Gambillara Fonck , Manuela Mally
IPC分类号： A61K39/02 , A61K47/64 , C08B37/00 , A61P31/04 , A61K39/385 , A61K39/108 , A61K39/00
摘要： Compositions and methods are described for inducing an immune response against extra-intestinal pathogenic Escherichia coli (ExPEC) to thereby provide immune protection against diseases associated with ExPEC. In particular, compositions and methods are described for using conjugates of E. coli polysaccharide antigens O25B, O1A, O2, and O6A covalently bound to a detoxified exotoxin A of Pseudomonas aeruginosa (EPA) carrier protein as vaccines for the prevention of invasive ExPEC disease caused by ExPEC serotypes O1A, O2, O6A and O25B.
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公开(公告)号：US11491220B2
公开(公告)日：2022-11-08
申请号：US16822403
申请日：2020-03-18
发明人： Jeroen Geurtsen , Pieter Jan Burghout , Eveline Marleen Weerdenburg , Jan Theunis Poolman , Kellen Cristhina Fae , Patricia Ibarra Yon , Darren Robert Abbanat , Stefan Jochen Kemmler , Michael Thomas Kowarik , Manuela Mally , Veronica Gambillara Fonck , Martin Edward Braun , Maria Paula Carranza Sandmeier
IPC分类号： A61K39/095 , A61K39/085 , A61K39/102 , A61K39/104 , A61K39/09 , A61K39/02 , A61K47/64 , A61K39/00 , A61K39/385 , A61K39/108
摘要： Methods of producing bioconjugates of O-antigen polysaccharides covalently linked to a carrier protein using recombinant host cells are provided. The recombinant host cells used in the methods described herein encode a particular oligosaccharyl transferase enzyme depending on the O-antigen polysaccharide bioconjugate to be produced. The oligosaccharyl transferase enzymes can be PglB oligosaccharyl transferase or variants thereof. Also provided are compositions containing the bioconjugates, and methods of using the bioconjugates and compositions described herein to vaccinate a subject against extra-intestinal pathogenic E. coli. (ExPEC).
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公开(公告)号：US11446370B2
公开(公告)日：2022-09-20
申请号：US16822340
申请日：2020-03-18
发明人： Jeroen Geurtsen , Jan Theunis Poolman , Kellen Cristhina Fae , Pieter Jan Burghout , Eveline Marleen Weerdenburg , Patricia Ibarra Yon , Darren Robert Abbanat , Stefan Jochen Kemmler , Michael Thomas Kowarik , Manuela Mally , Veronica Gambillara Fonck , Martin Edward Braun , Maria Paula Carranza Sandmeier
摘要： A bioconjugate of an E. coli glucosylated O4 antigen polysaccharide covalently linked to a carrier protein and compositions thereof are provided. Also provided are recombinant host cells for producing the bioconjugate, and methods of producing the bioconjugate using the recombinant host cells. The recombinant host cells contain a nucleic acid encoding a glucosyl transferase capable of modifying the E. coli O4 antigen with glucose branching to produce the glucosylated O4 antigen polysaccharide. Bioconjugates of an E. coli glucosylated O4 antigen polysaccharide described herein can be used alone or in combination with one or more additional E. coli O-antigen polysaccharides to induce antibodies against an E. coli glucosylated antigen, and to vaccinate a subject against extra-intestinal pathogenic E. coli (ExPEC).
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公开(公告)号：US11931405B2
公开(公告)日：2024-03-19
申请号：US17815705
申请日：2022-07-28
发明人： Jeroen Geurtsen , Jan Theunis Poolman , Kellen Cristhina Fae , Pieter Jan Burghout , Eveline Marleen Weerdenburg , Patricia Ibarra Yon , Darren Robert Abbanat , Stefan Jochen Kemmler , Michael Thomas Kowarik , Manuela Mally , Veronica Gambillara Fonck , Martin Edward Braun , Maria Paula Carranza Sandmeier
CPC分类号： A61K39/0258 , A61P31/04 , A61P37/04 , C07K14/21 , C07K19/00 , C12N9/1051 , C12Y204/01 , A61K2039/575 , A61K2039/6037
摘要： A bioconjugate of an E. coli glucosylated O4 antigen polysaccharide covalently linked to a carrier protein and compositions thereof are provided. Also provided are recombinant host cells for producing the bioconjugate, and methods of producing the bioconjugate using the recombinant host cells. The recombinant host cells contain a nucleic acid encoding a glucosyl transferase capable of modifying the E. coli O4 antigen with glucose branching to produce the glucosylated O4 antigen polysaccharide. Bioconjugates of an E. coli glucosylated O4 antigen polysaccharide described herein can be used alone or in combination with one or more additional E. coli O-antigen polysaccharides to induce antibodies against an E. coli glucosylated antigen, and to vaccinate a subject against extra-intestinal pathogenic E. coli (ExPEC).
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6.发明授权公开(公告)号：US10583185B2
公开(公告)日：2020-03-10
申请号：US15754867
申请日：2016-08-24
发明人： Jan Theunis Poolman , Bert Jacquemyn , Darren Robert Abbanat , Patricia Ibarra Yon , Peter Wilhelmus Maria Hermans , Michael Thomas Kowarik , Michael Lukas Wetter , Stefan Jochen Kemmler , Micha Andres Häuptle , Veronica Gambillara Fonck , Manuela Mally
IPC分类号： A61K39/108 , A61K47/64 , A61P31/04 , A61K39/385 , C08B37/00 , A61K39/00
摘要： Compositions and methods are described for inducing an immune response against extra-intestinal pathogenic Escherichia coli (ExPEC) to thereby provide immune protection against diseases associated with ExPEC. In particular, compositions and methods are described for using conjugates of E. coli polysaccharide antigens O25B, O1A, O2, and O6A covalently bound to a detoxified exotoxin A of Pseudomonas aeruginosa (EPA) carrier protein as vaccines for the prevention of invasive ExPEC disease caused by ExPEC serotypes O1A, O2, O6A and O25B.
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公开(公告)号：US11406696B2
公开(公告)日：2022-08-09
申请号：US15769646
申请日：2016-10-19
发明人： Christiane Marie-Paule Simone Jeanne Feron , Stefan Jochen Kemmler , Michael Thomas Kowarik , Julien Laurent Quebatte
IPC分类号： A61K39/02 , A61K39/104 , A61K39/385 , C07K14/21 , A61K47/64 , A61K45/06 , A61P31/04 , C12N9/10 , A61K39/00
摘要： The present invention discloses a conjugate comprising an antigen (for example a saccharide antigen) covalently linked to a Pseudomonas aeruginosa PcrV carrier protein comprising an amino acid sequence which is at least 80% identical to the sequence of SEQ ID NO:1-4, wherein the antigen is linked (either directly or through a linker) to an amino acid residue of the P. aeruginosa PcrV carrier protein. The invention also discloses Pseudomonas aeruginosa PcrV proteins that contain glycosylation site consensus sequences.
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