公开(公告)号：US20140095206A1

公开(公告)日：2014-04-03

申请号：US14039125

申请日：2013-09-27

申请人： Glenn Fung ,  Balaji Krishnapuram ,  Faisal Farooq ,  Shipeng Yu ,  Mark Overhange ,  John Haley ,  Jan DeHaan ,  Vikram Anand

发明人： Glenn Fung ,  Balaji Krishnapuram ,  Faisal Farooq ,  Shipeng Yu ,  Mark Overhange ,  John Haley ,  Jan DeHaan ,  Vikram Anand

IPC分类号： G06F19/00

CPC分类号： G16H50/30 ,  G16H10/60 ,  G16H50/20

摘要： Adaptive medical data collection for medical entities may involve triggering an analysis of electronic records in response to information input into an Electronic Medical Record (EMR) of a patient. Determining a potential condition for the patient based on the analysis. Identifying additional information indicated as relevant to the potential condition of the patient, and generating a request for the identified additional information.

摘要翻译： 用于医疗实体的适应性医疗数据收集可以涉及触发对输入到患者的电子病历（EMR）的信息的电子记录的分析。 根据分析确定患者的潜在病情。 识别与患者的潜在状况相关的附加信息，并产生对所识别的附加信息的请求。

公开(公告)号：US20060143093A1

公开(公告)日：2006-06-29

申请号：US11285807

申请日：2005-11-23

申请人： Samuel Brandt ,  Jan DeHaan ,  John Haley ,  Zhijing Liu

发明人： Samuel Brandt ,  Jan DeHaan ,  John Haley ,  Zhijing Liu

IPC分类号： G06Q30/00 ,  G07G1/00 ,  G06Q10/00

CPC分类号： G06Q50/22 ,  G06F3/0482 ,  G06Q30/02 ,  G06Q30/0202 ,  G06Q30/0601 ,  G16H10/20 ,  G16H40/20 ,  G16H50/20

摘要： A user interface system decreases the number of user interactions with a computer user interface, used to select items in multiple related menus, through a comprehensive heuristic menu arrangement control by providing several discrete, yet complementary, features. The system enables user selection of related parameters identifying an order for providing an item. A repository includes information identifying candidate items for order and associated corresponding related order parameters. An individual item for order is associated with multiple related order parameters. A user interface processor provides data representing a display image identifying an initial complete candidate order including multiple related parameters, in response to user entry of order-associated data. In response to user selection of an individual parameter of the initial complete candidate order, the user interface processor provides data representing multiple, different individually user selectable complete candidate orders incorporating corresponding sets of different related order parameters. The complete candidate orders are derived using the repository and based on user ordering history. The user interface processor selects one of the multiple, different individually user selectable complete candidate orders in response to a user command.

摘要翻译： 用户界面系统通过提供多个离散但互补的特征，通过综合启发式菜单排列控制，减少用于通过多个相关菜单中选择项目的计算机用户界面的用户交互次数。 该系统使用户可以选择相关参数来识别用于提供物品的订单。 存储库包括识别订单的候选项目和相关联的对应相关订单参数的信息。 订单的单个项目与多个相关订单参数相关联。 响应于用户输入订单相关数据，用户界面处理器提供表示识别包括多个相关参数的初始完成候选顺序的显示图像的数据。 响应于用户选择初始完成候选顺序的单独参数，用户界面处理器提供表示包含不同相关订单参数的相应组的多个不同的单独用户可选择的完整候选订单的数据。 完整的候选订单是使用存储库导出的，并且基于用户订单历史记录。 用户接口处理器响应于用户命令选择多个不同的单独用户可选择的完整候选订单中的一个。

公开(公告)号：US20070065858A1

公开(公告)日：2007-03-22

申请号：US11523259

申请日：2006-09-19

申请人： John Haley

发明人： John Haley

IPC分类号： C12Q1/68 ,  G01N33/574

CPC分类号： G01N33/57423 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/574 ,  G01N2333/71 ,  G01N2333/91215 ,  G01N2500/04 ,  G01N2800/52

摘要： The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with an IGF-1R kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an IGF-1R kinase inhibitor, comprising assessing whether the tumor cell has undergone an epithelial to mesenchymal transition (EMT), by determining the expression level of epithelial and/or mesenchymal biomarkers, wherein tumor cells that have undergone an EMT are substantially less sensitive to inhibition by IGF-1R kinase inhibitors. Improved methods for treating cancer patients with IGF-1R kinase inhibitors that incorporate the above methodology are also provided. Additionally, methods are provided for the identification of new biomarkers that are predictive of responsiveness of tumors to IGF-1R kinase inhibitors. Furthermore, methods for the identification of agents that restore the sensitivity of tumor cells that have undergone EMT to inhibition by IGF-1R kinase inhibitors are also provided.

摘要翻译： 本发明提供用于预测用IGF-1R激酶抑制剂治疗癌症患者的有效性的诊断和预后方法。 提供了用于预测肿瘤细胞生长对IGF-1R激酶抑制剂抑制的敏感性的方法，包括评估肿瘤细胞是否经历了上皮与间质转化（EMT），通过确定上皮和/或间质生物标志物的表达水平 其中已经经历EMT的肿瘤细胞对IGF-1R激酶抑制剂的抑制基本上较不敏感。 还提供了用于治疗结合上述方法的IGF-1R激酶抑制剂的癌症患者的改进方法。 另外，提供了用于鉴定预测肿瘤对IGF-1R激酶抑制剂的反应性的新生物标志物的方法。 此外，还提供了用于鉴定恢复已经经过EMT的肿瘤细胞对IGF-1R激酶抑制剂抑制的敏感性的药剂的方法。

公开(公告)号：US20070212738A1

公开(公告)日：2007-09-13

申请号：US11787044

申请日：2007-04-13

申请人： John Haley ,  Stuart Thomson ,  Filippo Petti

发明人： John Haley ,  Stuart Thomson ,  Filippo Petti

IPC分类号： G01N33/574

CPC分类号： G01N33/6893 ,  G01N33/5011 ,  G01N33/57407 ,  G01N33/57484 ,  G01N2800/52

摘要： The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with an EGFR kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an EGFR kinase inhibitor, comprising assessing whether the tumor cell has undergone an epithelial to mesenchymal transition (EMT), by determining the expression level of epithelial and/or mesenchymal biomarkers, wherein tumor cells that have undergone an EMT are substantially less sensitive to inhibition by EGFR kinase inhibitors. Improved methods for treating cancer patients with EGFR kinase inhibitors that incorporate the above methodology are also provided. Additionally, methods are provided for the identification of new biomarkers that are predictive of responsiveness of tumors to EGFR kinase inhibitors. Furthermore, methods for the identification of agents that restore the sensitivity of tumor cells that have undergone EMT to inhibition by EGFR kinase inhibitors are also provided.

摘要翻译： 本发明提供用于预测EGFR激酶抑制剂治疗癌症患者的有效性的诊断和预后方法。 提供了用于预测肿瘤细胞生长对EGFR激酶抑制剂抑制的敏感性的方法，包括通过测定上皮和/或间质生物标志物的表达水平来评估肿瘤细胞是否经历了上皮与间质转化（EMT），其中 已经经历EMT的肿瘤细胞对EGFR激酶抑制剂的抑制基本上较不敏感。 还提供了用于治疗结合上述方法的EGFR激酶抑制剂的癌症患者的改进方法。 另外，提供了用于鉴定预测肿瘤对EGFR激酶抑制剂的反应性的新生物标志物的方法。 此外，还提供了用于鉴定恢复已经经历EMT的肿瘤细胞对EGFR激酶抑制剂抑制的敏感性的药剂的方法。

公开(公告)号：US20070151923A1

公开(公告)日：2007-07-05

申请号：US11614700

申请日：2006-12-21

申请人： John Haley

发明人： John Haley

IPC分类号： C02F3/00

CPC分类号： C02F3/103 ,  B01D39/083 ,  B01D39/086 ,  B01D2239/02 ,  B01D2239/0609 ,  B01D2239/065 ,  B01D2239/10 ,  C02F3/04 ,  C02F2103/28 ,  Y02W10/15 ,  Y10T428/2929 ,  Y10T428/2931 ,  Y10T428/2933 ,  Y10T428/2976

摘要： A biomedia apparatus comprising an elongated central core and a plurality of loops positioned along the central core adapted to collect organisms from water. The biomedia apparatus may further comprise at least one reinforcing member associated with the central core. In one embodiment, the biomedia apparatus is utilized in a trickle tower to treat wastewater. In another embodiment, the biomedia apparatus is utilized outside a power plant to minimize spat that is drawn into the plant through water intake valves.

摘要翻译： 一种生物媒介装置，包括细长的中心核心和沿中心核心定位的多个环，适于从水中收集生物体。 生物媒体装置还可以包括与中心核心相关联的至少一个加强构件。 在一个实施例中，生物媒体装置用于涓流塔来处理废水。 在另一个实施例中，生物媒体装置在发电厂外部被利用，以通过进水阀最小化吸入工厂的唾液。

公开(公告)号：US20070250225A1

公开(公告)日：2007-10-25

申请号：US11408973

申请日：2006-04-24

申请人： Stephen Nickles ,  John Haley

发明人： Stephen Nickles ,  John Haley

IPC分类号： G05D1/00

CPC分类号： B61L25/021 ,  B61L3/006 ,  B61L3/008 ,  B61L25/025 ,  B61L27/0038 ,  B61L2205/04

摘要： A method of speed forecasting a train over a track including determining location of the train on the track, the speed of the train and brake and throttle setting of the train. Speeds and suggested throttle and brake settings for spaced points along the track are calculated based on the determinations. The calculated speeds and throttle and brake setting are displayed for the spaced points along the track.

摘要翻译： 一种用于在轨道上速度预测列车的方法，包括确定列车在轨道上的位置，列车的速度以及列车的制动和节气门设置。 基于确定，计算沿着轨道的间隔点的速度和建议的油门和制动器设置。 对于轨道上的间隔点，显示计算出的速度和节气门和制动设置。

公开(公告)号：US20050051138A1

公开(公告)日：2005-03-10

申请号：US10657443

申请日：2003-09-08

申请人： John Haley ,  Maria Nowland

发明人： John Haley ,  Maria Nowland

IPC分类号： F02M35/10 ,  F02M35/116 ,  F02M51/00 ,  F02M55/02 ,  F02M61/14

CPC分类号： F02M35/10347 ,  F02M35/10026 ,  F02M35/10032 ,  F02M35/10111 ,  F02M35/10216 ,  F02M35/10321 ,  F02M35/1036 ,  F02M35/116 ,  F02M51/005 ,  F02M55/025 ,  F02M61/145

摘要： An intake manifold assembly includes an intake manifold having an intake passageway and a fuel injector in communication with the intake passageway. At least a portion of the fuel injector is molded into the intake manifold such that liquid fuel and hydrocarbon emissions are substantially prevented from leaking outside of the intake manifold.

摘要翻译： 进气歧管组件包括具有进气通道和与进气通道连通的燃料喷射器的进气歧管。 燃料喷射器的至少一部分被模制到进气歧管中，使得基本上防止液体燃料和碳氢化合物排放物泄漏到进气歧管外部。

公开(公告)号：US20060211060A1

公开(公告)日：2006-09-21

申请号：US11377530

申请日：2006-03-16

申请人： John Haley ,  Graeme Griffin ,  Lukas Amler ,  David Eberhard ,  Robert Yauch

发明人： John Haley ,  Graeme Griffin ,  Lukas Amler ,  David Eberhard ,  Robert Yauch

IPC分类号： G01N33/574

CPC分类号： A61K31/517 ,  G01N33/5011 ,  G01N33/57407 ,  G01N33/57484 ,  G01N2800/52

摘要： The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with an EGFR kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an EGFR kinase inhibitor, comprising assessing whether the tumor cell has undergone an epithelial to mesenchymal transition (EMT), by determining the expression level of epithelial and/or mesenchymal biomarkers, wherein tumor cells that have undergone an EMT are substantially less sensitive to inhibition by EGFR kinase inhibitors. Improved methods for treating cancer patients with EGFR kinase inhibitors that incorporate the above methodology are also provided. Additionally, methods are provided for the identification of new biomarkers that are predictive of responsiveness of tumors to EGFR kinase inhibitors. Furthermore, methods for the identification of agents that restore the sensitivity of tumor cells that have undergone EMT to inhibition by EGFR kinase inhibitors are also provided.

公开(公告)号：US20050229109A1

公开(公告)日：2005-10-13

申请号：US11125364

申请日：2005-05-09

申请人： John Haley

发明人： John Haley

IPC分类号： G06F3/00 ,  G06F9/00 ,  G06F9/44 ,  G09G5/00

CPC分类号： G06F9/451 ,  Y10S707/99936 ,  Y10S707/99945

摘要： A system for dynamically configuring a user interface display, including image elements for prompting user data entry, includes an input data processor for receiving input data via a prompt element for display in the user interface. A database is readily updated and modified to include a dynamically variable condition and associates a condition with input data received via the prompt element An image element processor determines whether the received input data satisfies the condition and at least either activates or inactivates an image element in the user interface display in response to the determination.

摘要翻译： 用于动态地配置用户界面显示的系统，包括用于提示用户数据输入的图像元素，包括用于经由用户界面中显示的提示元素接收输入数据的输入数据处理器。 数据库被容易地更新和修改以包括动态可变条件，并且将条件与经由提示元素接收的输入数据相关联。图像元素处理器确定所接收的输入数据是否满足条件，并且至少激活或者使图像元素在 用户界面显示响应确定。

公开(公告)号：US20050021771A1

公开(公告)日：2005-01-27

申请号：US10783133

申请日：2004-02-20

申请人： Keith Kaehn ,  Xiping Song ,  John Haley

发明人： Keith Kaehn ,  Xiping Song ,  John Haley

IPC分类号： H04L29/08 ,  G06F15/167 ,  G06F15/16

CPC分类号： H04L67/14 ,  H04L67/02 ,  H04L67/142 ,  H04L69/329

摘要： A data switching system, having a switch processor, directs requests to initiate a new operation session of an executable application. The switch processor parses received data representing a received universal resource locator (URL) to identify whether the received URL is associated with a request to initiate an operation session of an executable application. If the received URL is associated with a request to initiate an operation session, the switch processor initiates a data access request at a second URL address hosted by a particular server. In response to receiving a response indicating success of the data access request at the second URL address hosted by the particular server, the switch processor directs the request to initiate the operation session of the executable application to the particular server.

摘要翻译： 具有交换处理器的数据交换系统指示发起可执行应用程序的新操作会话的请求。 交换机处理器解析接收的表示接收到的通用资源定位符（URL）的数据，以识别所接收的URL是否与发起可执行应用的操作会话的请求相关联。 如果接收到的URL与发起操作会话的请求相关联，则交换处理器在由特定服务器托管的第二URL地址处发起数据访问请求。 响应于在由特定服务器托管的第二URL地址处接收到指示数据访问请求的成功的响应，交换处理器引导该请求以将可执行应用的操作会话发起到特定服务器。