公开(公告)号：US20130017244A1

公开(公告)日：2013-01-17

申请号：US13613636

申请日：2012-09-13

申请人： Glenn T. Huang ,  Thïerry Nivaggioli

发明人： Glenn T. Huang ,  Thïerry Nivaggioli

IPC分类号： A61K9/00 ,  A61P27/02 ,  A61K31/56

CPC分类号： A61K9/0051 ,  A61K9/0092 ,  A61K31/573 ,  A61K31/58 ,  A61K45/06 ,  A61K2300/00

摘要： Biocompatible intraocular implants include a steroid and a polymer associated with each other to facilitate release of the steroid into an eye for a period of time greater than about two months. The steroid may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants may be placed in an eye to treat one or more ocular conditions. The steroid is released from the implant for more than about two months, and may be release for more than several years.

公开(公告)号：US09814773B2

公开(公告)日：2017-11-14

申请号：US14124631

申请日：2012-06-11

申请人： Vernon G. Wong ,  Louis L. Wood ,  Carol Wood ,  Glenn T. Huang

发明人： Vernon G. Wong ,  Louis L. Wood ,  Glenn T. Huang

IPC分类号： A61K39/395 ,  A61K9/00 ,  A61K47/14 ,  A61K47/20 ,  A61K47/34 ,  A61K38/17 ,  A61K9/08

CPC分类号： A61K39/39541 ,  A61K9/0024 ,  A61K9/0051 ,  A61K9/08 ,  A61K38/1709 ,  A61K47/14 ,  A61K47/20 ,  A61K47/34

摘要： The present invention provides for injectable pharmaceutical sustained release formulations for delivery of active agents, particularly therapeutic proteins, to the eye. The formulations are biocompatible, biodegradable sustained release formulations comprising low-solubility liquid excipients and relatively small amounts (less than about 10%) of biocompatible, biodegradable polymer such as PLA or PLGA polymers. A unit dose of 5 μL to 100 μL of the formulation provides for sustained release of the agent for at least 14 days.

公开(公告)号：US08962009B2

公开(公告)日：2015-02-24

申请号：US13840535

申请日：2013-03-15

申请人： Glenn T. Huang ,  Thierry Nivaggioli

发明人： Glenn T. Huang ,  Thierry Nivaggioli

IPC分类号： A61F2/14 ,  A61K9/00 ,  A61K31/573 ,  A61K45/06 ,  A61K31/58

CPC分类号： A61K9/0051 ,  A61K9/0092 ,  A61K31/573 ,  A61K31/58 ,  A61K45/06 ,  A61K2300/00

摘要： Biocompatible intraocular implants include a steroid and a polymer associated with each other to facilitate release of the steroid into an eye for a period of time greater than about two months. The steroid may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants may be placed in an eye to treat one or more ocular conditions. The steroid is released from the implant for more than about two months, and may be release for more than several years.

摘要翻译： 生物相容性眼内植入物包括彼此相关的类固醇和聚合物，以促进类固醇进入眼睛大于约两个月的时间。 类固醇可以与可生物降解的聚合物基质相关联，例如两种可生物降解聚合物的基质。 或者，类固醇可以与具有一个或多个开口有效以允许类固醇释放到外部环境中的聚合物涂层相关联。 植入物可以放置在眼睛中以治疗一种或多种眼睛状况。 类固醇从植入物中释放超过约两个月，可能会释放超过几年。

公开(公告)号：US08440216B2

公开(公告)日：2013-05-14

申请号：US13613636

申请日：2012-09-13

申请人： Glenn T. Huang ,  Thierry Nivaggioli

发明人： Glenn T. Huang ,  Thierry Nivaggioli

IPC分类号： A61F2/14

CPC分类号： A61K9/0051 ,  A61K9/0092 ,  A61K31/573 ,  A61K31/58 ,  A61K45/06 ,  A61K2300/00

摘要： Biocompatible intraocular implants include a steroid and a polymer associated with each other to facilitate release of the steroid into an eye for a period of time greater than about two months. The steroid may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants may be placed in an eye to treat one or more ocular conditions. The steroid is released from the implant for more than about two months, and may be release for more than several years.

公开(公告)号：US20080131485A1

公开(公告)日：2008-06-05

申请号：US11927613

申请日：2007-10-29

申请人： Glenn T. Huang ,  James Burke ,  Patrick M. Hughes ,  Kai-Ming Zhang ,  Ton Lin ,  Larry A. Wheeler ,  Rosy Sheng Donn

发明人： Glenn T. Huang ,  James Burke ,  Patrick M. Hughes ,  Kai-Ming Zhang ,  Ton Lin ,  Larry A. Wheeler ,  Rosy Sheng Donn

IPC分类号： A61K9/00 ,  A61K31/498

CPC分类号： A61K31/498 ,  A61K9/0051 ,  A61K47/34

摘要： Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants may be placed in an eye to prevent the occurrence of one or more ocular conditions, or to reduce one or more symptoms of an ocular condition, such as an ocular neurosensory disorder and the like.

公开(公告)号：US20130236525A1

公开(公告)日：2013-09-12

申请号：US13840535

申请日：2013-03-15

申请人： Glenn T. Huang ,  Thierry Nivaggioli

发明人： Glenn T. Huang ,  Thierry Nivaggioli

IPC分类号： A61K9/00 ,  A61K31/58

CPC分类号： A61K9/0051 ,  A61K9/0092 ,  A61K31/573 ,  A61K31/58 ,  A61K45/06 ,  A61K2300/00

摘要： Biocompatible intraocular implants include a steroid and a polymer associated with each other to facilitate release of the steroid into an eye for a period of time greater than about two months. The steroid may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants may be placed in an eye to treat one or more ocular conditions. The steroid is released from the implant for more than about two months, and may be release for more than several years.

公开(公告)号：US08257730B2

公开(公告)日：2012-09-04

申请号：US11118288

申请日：2005-04-29

申请人： Glenn T. Huang ,  Thierry Nivaggioli ,  Lon T. Spada ,  Hiroshi Sugimoto ,  Wendy M Blanda ,  James N. Chang ,  Orest Olejnik

发明人： Glenn T. Huang ,  Thierry Nivaggioli ,  Lon T. Spada ,  Hiroshi Sugimoto ,  Wendy M Blanda ,  James N. Chang ,  Orest Olejnik

IPC分类号： A61F2/00

CPC分类号： A61K9/0051 ,  A61K9/0092 ,  A61K31/573 ,  A61K31/58 ,  A61K45/06 ,  A61K2300/00

摘要： Biocompatible intraocular implants include a steroid and a polymer associated with each other to facilitate release of the steroid into an eye for a period of time greater than about two months. The steroid may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants may be placed in an eye to treat one or more ocular conditions. The steroid is released from the implant for more than about two months, and may be release for more than several years.

摘要翻译： 生物相容性眼内植入物包括彼此相关的类固醇和聚合物，以促进类固醇进入眼睛大于约两个月的时间。 类固醇可以与可生物降解的聚合物基质相关联，例如两种可生物降解聚合物的基质。 或者，类固醇可以与具有一个或多个开口有效以允许类固醇释放到外部环境中的聚合物涂层相关联。 植入物可以放置在眼睛中以治疗一种或多种眼睛状况。 类固醇从植入物中释放超过约两个月，可能会释放超过几年。

公开(公告)号：US08119154B2

公开(公告)日：2012-02-21

申请号：US10837356

申请日：2004-04-30

申请人： Glenn T. Huang ,  Thierry Nivaggioli

发明人： Glenn T. Huang ,  Thierry Nivaggioli

IPC分类号： A61F2/14

CPC分类号： A61K9/0051 ,  A61K9/0092 ,  A61K31/573 ,  A61K31/58 ,  A61K45/06 ,  A61K2300/00

摘要： Biocompatible intraocular implants include a steroid and a polymer associated with each other to facilitate release of the steroid into an eye for a period of time greater than about two months. The steroid may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants may be placed in an eye to treat one or more ocular conditions. The steroid is released from the implant for more than about two months, and may be release for more than several years.

公开(公告)号：US20080145407A1

公开(公告)日：2008-06-19

申请号：US11932373

申请日：2007-10-31

申请人： Glenn T. Huang ,  Thierry Nivaggioli ,  Lon T. Spada ,  Hiroshi Sugimoto ,  Wendy M. Blanda ,  James N. Chang ,  Orest Olejnik

发明人： Glenn T. Huang ,  Thierry Nivaggioli ,  Lon T. Spada ,  Hiroshi Sugimoto ,  Wendy M. Blanda ,  James N. Chang ,  Orest Olejnik

IPC分类号： A61F2/16 ,  A61K31/56 ,  A61P27/02

CPC分类号： A61K9/0051 ,  A61F9/0017 ,  A61K9/0024 ,  A61K9/0092 ,  A61K9/1647 ,  A61K9/204 ,  A61K31/5377 ,  A61K31/56 ,  A61K31/573 ,  A61K31/58 ,  A61K45/06 ,  A61K47/593 ,  A61L27/18 ,  A61L27/54 ,  A61L27/58 ,  A61L31/06 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/222 ,  A61L2300/436 ,  A61L2300/45 ,  A61L2300/604 ,  A61L2430/16 ,  A61K2300/00 ,  C08L67/04

摘要： Biocompatible intraocular implants include a steroid and an auxiliary agent, where the auxiliary agent is present in an amount sufficient to lessen the severity of at least one side effect compared to the use of an otherwise identical implant lacking said auxiliary agent. The steroid and the auxiliary agent may be present on the same intraocular implant or on different implants. The steroid and auxiliary agent may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants containing the steroid and an auxiliary agent may be placed in an eye to treat one or more ocular conditions while reducing the side effects otherwise accompanying steroid use.

摘要翻译： 生物相容性眼内植入物包括类固醇和辅助剂，其中与使用缺乏所述辅助剂的其它相同的植入物相比，辅助剂的存在量足以减轻至少一种副作用的严重性。 类固醇和辅助剂可以存在于相同的眼内植入物或不同的植入物上。 类固醇和辅助剂可以与可生物降解的聚合物基质相结合，例如两种可生物降解的聚合物的基质。 或者，类固醇可以与具有一个或多个开口有效以允许类固醇释放到外部环境中的聚合物涂层相关联。 包含类固醇和辅助剂的植入物可以放置在眼睛中以治疗一种或多种眼部病症，同时减少否则伴随类固醇使用的副作用。

公开(公告)号：US20140213646A1

公开(公告)日：2014-07-31

申请号：US14168139

申请日：2014-01-30

申请人： Vernon G. Wong ,  Mae W. Hu ,  Glenn T. Huang

发明人： Vernon G. Wong ,  Mae W. Hu ,  Glenn T. Huang

IPC分类号： A61K31/216

CPC分类号： A61K31/5575 ,  A61K9/0019 ,  A61K9/0048 ,  A61K47/14

摘要： The present embodiments provide for methods of treating elevated intraocular pressure or glaucoma using a sustained release medicament consisting of prostaglandin in benzyl benzoate that is injected intraocularly no more frequently than once every two months.

摘要翻译： 本实施例提供了使用由前列腺素组成的持续释放药物治疗眼内压或青光眼的方法，所述缓释药物由苯甲酸苄酯组成，其眼内注射的频率不得超过每两个月一次。