公开(公告)号：US20230151016A1

公开(公告)日：2023-05-18

申请号：US18155304

申请日：2023-01-17

申请人： Global Blood Therapeutics, Inc.

发明人： Lina Q. Setti ,  Shahul Nilar ,  Zhe Li ,  Ming Yu ,  Manuel Zancanella

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.

公开(公告)号：US11566030B2

公开(公告)日：2023-01-31

申请号：US17665942

申请日：2022-02-07

申请人： Global Blood Therapeutics, Inc.

发明人： Lina Q. Setti ,  Shahul Nilar ,  Zhe Li ,  Ming Yu ,  Manuel Zancanella

IPC分类号： A61K31/4162 ,  C07D487/04

摘要： The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I: and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.

公开(公告)号：US20230278984A1

公开(公告)日：2023-09-07

申请号：US18019379

申请日：2021-08-03

申请人： Global Blood Therapeutics, Inc.

发明人： Lina Q. Setti ,  Brian Cathers ,  Zhe Li ,  Shahul Nilar ,  James Partridge ,  Chul Yu ,  Ming Yu ,  Manuel Zancanella

IPC分类号： C07D401/14 ,  C07D257/04 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14 ,  C07D249/08

CPC分类号： C07D401/14 ,  C07D257/04 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14 ,  C07D249/08

摘要： The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.

公开(公告)号：US11746100B2

公开(公告)日：2023-09-05

申请号：US17242731

申请日：2021-04-28

申请人： GLOBAL BLOOD THERAPEUTICS, INC.

发明人： Qing Xu ,  Carsten Alt ,  Zhe Li ,  Shahul Nilar ,  Peter Michael Rademacher ,  Calvin Wesley Yee

IPC分类号： C07D401/14 ,  C07D401/04 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D491/056 ,  C07D498/08

CPC分类号： C07D401/14 ,  C07D401/04 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D491/056 ,  C07D498/08

摘要： The subject matter described herein is directed to ferroportin inhibitor compounds of Formula I or I′ and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis, and also kidney injuries.

公开(公告)号：US20230159553A1

公开(公告)日：2023-05-25

申请号：US17921905

申请日：2021-04-28

申请人： Global Blood Therapeutics, Inc

发明人： Qing Xu ,  Zhe Li ,  Shahul Nilar

IPC分类号： C07D495/04 ,  C07D519/00

CPC分类号： C07D495/04 ,  C07D519/00

摘要： The subject matter described herein is directed to ferroportin inhibitor compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis, and also kidney injuries.

公开(公告)号：US20220267337A1

公开(公告)日：2022-08-25

申请号：US17665942

申请日：2022-02-07

申请人： Global Blood Therapeutics, Inc.

发明人： Lina Q. Setti ,  Shahul Nilar ,  Zhe Li ,  Ming Yu ,  Manuel Zancanella

IPC分类号： C07D487/04

摘要： The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.