公开(公告)号：US20150353959A1

公开(公告)日：2015-12-10

申请号：US14760250

申请日：2014-01-17

Applicant: GLYCOTOPE GMBH

Inventor： Steffen GOLETZ ,  Antje DANIELCZYK ,  Doreen JAHN

IPC: C12N15/85 ,  C07K14/505 ,  C07K14/47

CPC classification number: C12N15/85 ,  C07K14/47 ,  C07K14/505 ,  C07K2319/35 ,  C07K2319/50

Abstract: The present invention pertains to the field of recombinant protein production. Novel peptides derived from the extracellular region of a glycophorin protein are provided which enhance the expression rate of proteins or peptides of interest when expressed as fusion protein together with said novel peptides.

Abstract translation: 本发明涉及重组蛋白质生产领域。 提供衍生自血型糖蛋白的细胞外区的新肽，其当与所述新肽一起表达为融合蛋白时增强目的蛋白质或肽的表达速率。

公开(公告)号：US20180216093A1

公开(公告)日：2018-08-02

申请号：US15747911

申请日：2016-08-05

Applicant: Glycotope GmbH

Inventor： Steffen GOLETZ ,  Doreen JAHN

IPC: C12N9/64 ,  C07K14/59

Abstract: The present invention pertains to fusion constructs of dimeric proteins, wherein the portions of the protein are fused to either to the CH1 domain of the CL domain of an antibody. These fusion constructs improve stability, solubility, circulation half-life and production yield of the dimeric protein.

公开(公告)号：US20180094279A1

公开(公告)日：2018-04-05

申请号：US15559272

申请日：2016-03-30

Applicant: Glycotope GmbH

Inventor： Steffen GOLETZ ,  Doreen JAHN ,  Antje DANIELCZYK

IPC: C12N15/85 ,  C12N15/66 ,  C07K14/47 ,  G01N33/50

CPC classification number: C12N15/85 ,  C07K14/473 ,  C07K14/59 ,  C07K14/7151 ,  C12N15/66 ,  G01N33/5047

Abstract: The present invention pertains to the field of recombinant protein production. Novel expression cassettes comprising elements of the human globin gene clusters are provided which show enhanced expression rates of proteins or polypeptides of interest.