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公开(公告)号：US07638631B2
公开(公告)日：2009-12-29
申请号：US11575311
申请日：2005-09-16
IPC分类号： C07D401/00 , C07D211/08
CPC分类号： C07D413/14 , C07D401/14
摘要： The present invention relates to novel methylene dipiperidine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
摘要翻译： 本发明涉及具有药理活性的新型亚甲基二哌啶衍生物，其制备方法，含有它们的组合物及其在治疗神经和精神疾病中的用途。
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公开(公告)号：US20080108624A1
公开(公告)日：2008-05-08
申请号：US11575311
申请日：2005-09-16
IPC分类号： A61K31/4545 , C07D401/14 , A61K31/497 , A61K31/501 , A61P25/00 , A61K31/506 , C07D401/06 , C07D413/14
CPC分类号： C07D413/14 , C07D401/14
摘要： The present invention relates to novel methylene dipiperidine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
摘要翻译： 本发明涉及具有药理活性的新型亚甲基二哌啶衍生物，其制备方法，含有它们的组合物及其在治疗神经和精神疾病中的用途。
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3.发明授权Quinoline derivatives, process for preparing them and use for the treatment of diseases mediated by s-CD23 失效喹啉衍生物，其制备方法和用于治疗由s-CD23介导的疾病公开(公告)号：US07045626B2
公开(公告)日：2006-05-16
申请号：US10496193
申请日：2002-11-25
IPC分类号： C07D221/18 , C07D215/12 , A61K31/47
CPC分类号： C07D405/12
摘要： A compound of formula (I): useful in the treatment and prophylaxis of conditions mediated by s-CD23
摘要翻译： 式（I）化合物：可用于治疗和预防由s-CD23介导的病症
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4.发明申请USE OF QUINOLINE DERIVATIVES IN THE TREATMENT OF PAIN AND IRRITABLE BOWEL SYNDROME 审中-公开喹诺酮衍生物在治疗疼痛和刺激性牙龈综合征中的应用公开(公告)号：US20100041672A1
公开(公告)日：2010-02-18
申请号：US12531896
申请日：2008-03-19
IPC分类号： A61K31/496 , A61P1/00
CPC分类号： A61K31/496
摘要： The use of 5-HT6 serotonin receptor antagonists of formula (I): or pharmaceutically acceptable salts thereof, is described for the treatment of Irritable Bowel Syndrome and pain in mammals, more particularly inflammatory, neuropathic or visceral pain.
摘要翻译： 描述了式（I）的5-HT 6 5-羟色胺受体拮抗剂或其药学上可接受的盐的用途，用于治疗肠易激综合征和哺乳动物疼痛，特别是炎性，神经性或内脏痛。
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5.发明申请1-Benzoyl Substituted Diazepine Derivatives As Selective Histamine H3 Receptor Agonists 失效1-苯甲酰基取代的二氮杂衍生物作为选择性组胺H3受体激动剂公开(公告)号：US20080045505A1
公开(公告)日：2008-02-21
申请号：US10576492
申请日：2004-10-14
IPC分类号： A61K31/551 , C07D403/02
CPC分类号： C07D401/10 , C07D243/08 , C07D403/10 , C07D403/12 , C07D405/12 , C07D413/10 , C07D417/10
摘要： The present invention relates to novel diazepanyl derivatives of formula (I) having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
摘要翻译： 本发明涉及具有药理学活性的式（I）的新的二氮杂环庚烷基衍生物，其制备方法，含有它们的组合物及其在治疗神经和精神疾病中的用途。
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6.发明授权Sulfone derivatives and their use in the treatment of autoimmune diseases and allergies 失效砜衍生物及其在治疗自身免疫性疾病和过敏中的应用公开(公告)号：US07038055B2
公开(公告)日：2006-05-02
申请号：US10496159
申请日：2002-11-25
IPC分类号： C07D215/36 , A61K31/47
CPC分类号： C07D215/12
摘要： A compound of formula (I) useful in the treatment and prophylaxis of conditions mediated by s-CD23
摘要翻译： 用于治疗和预防由s-CD23介导的病症的式（I）化合物
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7.发明授权1-benzoyl substituted diazepine derivatives as selective histamine H3 receptor agonists 失效1-苯甲酰基取代的二氮杂衍生物作为选择性组胺H3受体激动剂公开(公告)号：US08492375B2
公开(公告)日：2013-07-23
申请号：US12912026
申请日：2010-10-26
IPC分类号： A61P25/00 , A61K31/551 , C07D241/12 , C07D231/14 , C07D239/26 , C07D237/08 , C07D213/81 , C07D263/32 , C07D257/04 , C07D295/18
CPC分类号： C07D401/10 , C07D243/08 , C07D403/10 , C07D403/12 , C07D405/12 , C07D413/10 , C07D417/10
摘要： The present invention relates to novel diazepanyl derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
摘要翻译： 本发明涉及具有药理学活性的新的二氮茚基衍生物，其制备方法，含有它们的组合物及其在治疗神经和精神疾病中的用途。
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8.发明授权1-benzoyl substituted diazepine derivatives as selective histamine H3 receptor agonists 失效1-苯甲酰基取代的二氮杂衍生物作为选择性组胺H3受体激动剂公开(公告)号：US07846922B2
公开(公告)日：2010-12-07
申请号：US10576492
申请日：2004-10-14
IPC分类号： A61P25/00 , A61K31/551 , C07D241/12 , C07D231/14 , C07D239/26 , C07D237/08 , C07D213/81 , C07D263/32 , C07D257/04 , C07D295/18
CPC分类号： C07D401/10 , C07D243/08 , C07D403/10 , C07D403/12 , C07D405/12 , C07D413/10 , C07D417/10
摘要： The present invention relates to novel diazepanyl derivatives of formula (I) having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
摘要翻译： 本发明涉及具有药理学活性的式（I）的新的二氮杂环庚烷基衍生物，其制备方法，含有它们的组合物及其在治疗神经和精神疾病中的用途。
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9.发明授权Piperazine derivates and their use for the treatment of neurological and psychiatric diseases 失效哌嗪衍生物及其用于治疗神经和精神疾病的用途公开(公告)号：US07592347B2
公开(公告)日：2009-09-22
申请号：US10553803
申请日：2004-04-21
IPC分类号： A61P25/28 , A61K31/496 , A61K31/501 , A61K31/506 , C07D211/62 , C07D401/00 , C07D405/00 , C07D413/00 , C07D417/00
CPC分类号： C07D401/04 , C07D211/62 , C07D401/06 , C07D401/10 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/14
摘要： The present invention relates to novel piperidine carbonyl piperazine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.
摘要翻译： 本发明涉及具有药理活性的新型哌啶羰基哌嗪衍生物，其制备方法，含有它们的组合物及其在治疗神经和精神疾病中的用途。
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公开(公告)号：US20060247271A1
公开(公告)日：2006-11-02
申请号：US10543974
申请日：2004-01-30
申请人： Gordon Bruton
发明人： Gordon Bruton
IPC分类号： A61K31/47 , C07D215/12 , A61K31/19
CPC分类号： C07D215/12 , C07C317/44
摘要： Compounds of formula (I): wherein R is hydrogen, alkyl, alkoxy, alkenyl, alkynyl, aryl, heteroaryl or heterocyclyl; and R1 is bicyclyl or heterobicyclyl; are useful in the treatment and prophylaxis of conditions mediated by s-CD23.
摘要翻译： 式（I）化合物：其中R是氢，烷基，烷氧基，烯基，炔基，芳基，杂芳基或杂环基; R 1是双环基或杂双环基; 可用于治疗和预防由s-CD23介导的病症。
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