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1.发明申请USE OF QUINOLINE DERIVATIVES IN THE TREATMENT OF PAIN AND IRRITABLE BOWEL SYNDROME 审中-公开喹诺酮衍生物在治疗疼痛和刺激性牙龈综合征中的应用公开(公告)号：US20100041672A1
公开(公告)日：2010-02-18
申请号：US12531896
申请日：2008-03-19
IPC分类号： A61K31/496 , A61P1/00
CPC分类号： A61K31/496
摘要： The use of 5-HT6 serotonin receptor antagonists of formula (I): or pharmaceutically acceptable salts thereof, is described for the treatment of Irritable Bowel Syndrome and pain in mammals, more particularly inflammatory, neuropathic or visceral pain.
摘要翻译： 描述了式（I）的5-HT 6 5-羟色胺受体拮抗剂或其药学上可接受的盐的用途，用于治疗肠易激综合征和哺乳动物疼痛，特别是炎性，神经性或内脏痛。
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2.发明申请PIPERAZINYL-SULFONAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF GPR38 RECEPTOR MEDIATED DISEASES 失效用于治疗GPR38受体介导的疾病的哌嗪 - 磺酰胺衍生物公开(公告)号：US20100256364A1
公开(公告)日：2010-10-07
申请号：US12744367
申请日：2008-11-26
申请人： Darren Jason Mitchell , Jonathan Thomas Seal , Geoffrey Stemp , Mervyn Thompson , Susan Marie Westaway
发明人： Darren Jason Mitchell , Jonathan Thomas Seal , Geoffrey Stemp , Mervyn Thompson , Susan Marie Westaway
IPC分类号： C07D413/14 , C07D401/12 , C07D401/14
CPC分类号： C07D401/12 , C07D241/02
摘要： Disclosed are motilin agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
摘要翻译： 公开了胃动素激动剂，其制备方法，含有它们的药物组合物及其在治疗各种疾病中的用途。
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公开(公告)号：US20100099752A1
公开(公告)日：2010-04-22
申请号：US12486567
申请日：2009-06-17
IPC分类号： A61K31/352 , C07D311/04 , C07D409/12 , A61K31/381 , A61P25/00
CPC分类号： C07D409/06 , C07D311/68 , C07D409/12 , C07D498/04
摘要： The present invention relates to pharmaceutical compositions containing bicyclic type compounds and to methods of using same, for example, in the treatment or prevention of anxiety, mania, depression, disorders associated with a subarachnoid haemorrhage or neural shock, the effects associated with withdrawal from substances of abuse, Parkinson's Disease, psychosis, migraine and/or cerebral ischaemia.
摘要翻译： 本发明涉及含有双环型化合物的药物组合物及其使用方法，例如治疗或预防焦虑症，躁狂症，抑郁症，与蛛网膜下腔出血或神经性休克相关的疾病，与物质戒断有关的作用 滥用，帕金森病，精神病，偏头痛和/或脑缺血。
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公开(公告)号：US20090036442A1
公开(公告)日：2009-02-05
申请号：US11926375
申请日：2007-10-29
申请人： Clive Leslie BRANCH , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp
发明人： Clive Leslie BRANCH , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp
IPC分类号： A61K31/454 , A61P3/04 , A61P43/00 , C07D417/14 , C07D401/14 , C07D401/06 , A61K31/4725 , A61K31/506 , A61K31/5377 , A61K31/4709 , A61K31/4545 , A61K31/4525
CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/04
摘要： Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.
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公开(公告)号：US07470710B2
公开(公告)日：2008-12-30
申请号：US10481133
申请日：2002-06-25
申请人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp
发明人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp
IPC分类号： A61K31/4525 , A61K31/4535 , A61K31/454 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D407/14
CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/04
摘要： This invention relates to N-aroyl cyclic amine derivatives of formula (I), wherein X represents a bond, oxygen, NR3 or a group (CH2), wherein n represents 1, 2 or 3; Y represents CH2, CO, CH(OH), or CH2CH(OH); Het is an optionally substituted bicyclic heteroaryl group containing up to 4 heteroatoms selected from N, O and S; Ar2 represents an optionally substituted phenyl or a 5- or 6-membered heterocyclyl group containing up to 3 heteroatoms selected from N, O and S and their use as pharmaceuticals, specifically as orexin receptor antagonists.
摘要翻译： 本发明涉及式（I）的N-芳酰基环胺衍生物，其中X表示键，氧，NR 3或基团（CH 2），其中n表示1,2或3; Y表示CH 2，CO，CH（OH）或CH 2 CH（OH）; Het是含有至多4个选自N，O和S的杂原子的任选取代的双环杂芳基; Ar2表示任选取代的苯基或含有至多3个选自N，O和S的杂原子的5-或6-元杂环基，以及它们作为药物的用途，特别是作为食欲素受体拮抗剂。
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公开(公告)号：US07405217B2
公开(公告)日：2008-07-29
申请号：US11557998
申请日：2006-11-09
IPC分类号： A61K31/495 , A61K31/496 , C07D241/04 , C07D417/12
CPC分类号： C07D413/10 , C07D241/04 , C07D417/06
摘要： This invention relates to N-aroyl cyclic amino derivatives and their use as pharmaceuticals.
摘要翻译： 本发明涉及N-芳酰基环状氨基衍生物及其作为药物的用途。
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公开(公告)号：US20070167457A1
公开(公告)日：2007-07-19
申请号：US11557998
申请日：2006-11-09
申请人： Clive BRANCH , Christopher Johnson , David Nash , Geoffrey Stemp
发明人： Clive BRANCH , Christopher Johnson , David Nash , Geoffrey Stemp
IPC分类号： A61K31/501 , A61K31/496 , A61K31/495 , C07D403/02 , C07D413/02 , C07D417/02
CPC分类号： C07D413/10 , C07D241/04 , C07D417/06
摘要： This invention relates to N-aroyl cyclic amino derivatives and their use as pharmaceuticals.
摘要翻译： 本发明涉及N-芳酰基环状氨基衍生物及其作为药物的用途。
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8.发明授权Piperazinyl-sulfonamide derivatives useful in the treatment of GPR38 receptor mediated diseases 失效可用于治疗GPR38受体介导的疾病的哌嗪基 - 磺酰胺衍生物公开(公告)号：US07964597B2
公开(公告)日：2011-06-21
申请号：US12744367
申请日：2008-11-26
申请人： Darren Jason Mitchell , Jonathan Thomas Seal , Geoffrey Stemp , Mervyn Thompson , Susan Marie Westaway
发明人： Darren Jason Mitchell , Jonathan Thomas Seal , Geoffrey Stemp , Mervyn Thompson , Susan Marie Westaway
IPC分类号： A61K31/5377 , A61K31/496 , C07D295/12 , C07D401/12 , C07D401/14 , C07D413/14
CPC分类号： C07D401/12 , C07D241/02
摘要： Disclosed are motilin agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
摘要翻译： 公开了胃动素激动剂，其制备方法，含有它们的药物组合物及其在治疗各种疾病中的用途。
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公开(公告)号：US07893090B2
公开(公告)日：2011-02-22
申请号：US11928072
申请日：2007-10-30
申请人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp
发明人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp
IPC分类号： A61K31/4525 , C07D401/06
CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/04
摘要： Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.
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公开(公告)号：US20090093478A1
公开(公告)日：2009-04-09
申请号：US11925036
申请日：2007-10-26
申请人： Clive Leslie BRANCH , Steven Coulton , Amanda Johns , Christopher Norbert Johnson , Roderick Alan Porter , Geoffrey Stemp , Kevin Thewlis
发明人： Clive Leslie BRANCH , Steven Coulton , Amanda Johns , Christopher Norbert Johnson , Roderick Alan Porter , Geoffrey Stemp , Kevin Thewlis
IPC分类号： A61K31/454 , C07D417/12 , C07D241/38 , A61K31/5377 , A61P25/00 , A61K31/498 , C07D413/12
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Disclosed are N-aroyl cyclic amine derivatives having the formula: wherein the substituent variables are as defined herein, and their use as pharmaceuticals.
摘要翻译： 公开了具有下式的N-芳酰基环胺衍生物：其中取代基变量如本文所定义，及其作为药物的用途。
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