公开(公告)号：US4748161A

公开(公告)日：1988-05-31

申请号：US739183

申请日：1985-05-30

申请人： Goro Kimura ,  Yoshihiko Hirose ,  Kumi Yoshida ,  Fumio Kuzuya ,  Katsunari Fujita

发明人： Goro Kimura ,  Yoshihiko Hirose ,  Kumi Yoshida ,  Fumio Kuzuya ,  Katsunari Fujita

IPC分类号： C07J53/00 ,  C07J9/00

CPC分类号： C07J53/004

摘要： A triterpenyl ester of organic acid other than triterpenyl esters of ferulic acid and of monobasic and dibasic saturated fatty acids. A process for producing a triterpenyl ester of organic acid other than esters of ferulic acid and of monobasic and dibasic saturated fatty acids, which comprises the reaction of a triterpenyl alcohol with an acid halide of the corresponding organic acid. A pharmaceutical composition for treatment of hyperlipidemia comprising a pharmaceutical carrier and an effective amount of a triterpenyl ester of organic acid other than triterpenyl esters of dibasic saturated fatty acids. A pharmaceutical composition for treating hyperlipidemia which comprises a pharmaceutical carrier and an effective amount of cyclobranol as an active ingredient.

摘要翻译： 除了阿魏酸和一元和二元饱和脂肪酸的三萜烯酯以外的有机酸的三萜烯酯。 一种制备除阿魏酸和一元和二元饱和脂肪酸以外的有机酸三萜烯酯的方法，其包括三萜烯醇与相应有机酸的酰卤反应。 一种用于治疗高脂血症的药物组合物，其包含药物载体和有效量的除二元饱和脂肪酸的三萜烯酯之外的有机酸的三萜烯基酯。 一种用于治疗高脂血症的药物组合物，其包含药物载体和有效量的环唑啉作为活性成分。

公开(公告)号：US4057684A

公开(公告)日：1977-11-08

申请号：US588893

申请日：1975-06-20

申请人： Goro Kimura ,  Junzo Sekine

发明人： Goro Kimura ,  Junzo Sekine

IPC分类号： C07H15/04 ,  A61K31/70 ,  A61K31/7008 ,  A61K31/7028 ,  A61P35/00 ,  C07H13/12

CPC分类号： C07H13/12

摘要： Certain alkyl amino-glucopyranoside are disclosed, including alkyl N-carbamyl-N'-(2-chloroethyl)-N'-nitroso-6-amino-6-deoxy-D-glucopyranoside, alkyl N-carbamyl-N'-(2-chloroethyl)-N'-nitroso-2-amino-2-deoxy-D-glucopyranoside, and alkyl di-N,N'-[N-(2-chloroethyl)-N-nitroso-carbamyl]-2,6-di-amino-2,6-di-deoxy-D-glucopyranoside. The alkyl amino-glucopryanoside exhibits marked antitumor activity while not having diabetogenic activity and bone marrow toxicity. The alkyl amino-glucopryanoside is further water soluble and free from antibacterial activity.

摘要翻译： 公开了某些烷基氨基 - 吡喃葡萄糖苷，包括N-氨基甲酰基-N' - （2-氯乙基）-N'-亚硝基-6-氨基-6-脱氧-D-吡喃葡萄糖胺基，N-氨基甲酰基-N' - （ 2-氯乙基）-N'-亚硝基-2-氨基-2-脱氧-D-吡喃葡萄酰侧，烷基二-N，N' - [N-（2-氯乙基）-N-亚硝基甲酰基] 6-二氨基-2,6-二脱氧-D-吡喃葡萄糖苷。 烷基氨基葡糖苷显示出明显的抗肿瘤活性，而不具有致糖性活性和骨髓毒性。 烷基氨基葡萄糖苷进一步水溶性且没有抗菌活性。

公开(公告)号：US5186944A

公开(公告)日：1993-02-16

申请号：US807406

申请日：1991-12-12

申请人： Yoichi Ishii ,  Hisashi Mihara ,  Lee M. Ho ,  Goro Kimura

发明人： Yoichi Ishii ,  Hisashi Mihara ,  Lee M. Ho ,  Goro Kimura

IPC分类号： A61K35/56 ,  A61K35/62

CPC分类号： A61K35/62 ,  Y10S514/866 ,  Y10S530/855

摘要： An efficient therapeutic medicament in a powdery form for thrombosis and related diseases is prepared by the steps of: removing dirty matters on the body surface and fecal mud in the digestive tracts from live earthworms by keeping them in a slightly acidified water bath at a specified temperature; mashing the cleaned earthworms into a mushy paste; and vacuum-drying the mushy paste of the earthworms by the stepwise temperature elevation up to 70.degree. to 80.degree. C. The results of the clinical tests of the medicament are presented.

摘要翻译： 通过以下步骤制备用于血栓形成和相关疾病的粉末形式的有效治疗药物：通过将它们保持在特定温度的稍微酸化的水浴中，从活蚯蚓去除身体表面上的脏物质并消化消化道中的粪便 ; 将清洁的蚯蚓糖化成糊状糊状物; 并通过逐步升温至70℃至80℃对蚯蚓糊状物进行真空干燥。介绍了药物临床试验结果。

公开(公告)号：US4156777A

公开(公告)日：1979-05-29

申请号：US872384

申请日：1978-01-26

申请人： Goro Kimura

发明人： Goro Kimura

IPC分类号： A61K31/70 ,  A61K31/7024 ,  A61K31/7028 ,  A61P35/00 ,  C07H13/12 ,  C07H15/04 ,  C07H19/00 ,  C07H21/00

CPC分类号： C07H13/12 ,  Y10S514/866

摘要： Glucopyranose-nitrosourea compounds having lower alkyl group and/or 2-chloroethyl group as substituent(s), are produced at high yield by reacting amino-glucopyranose compounds having lower alkoxy group and/or amino group(s) (or an acid-added amino group) as substituent(s), with o-nitro- or o-cyano-phenyl N-substituted-N-nitrosocarbamate compounds having lower alkyl group or 2-chloroethyl group as substituent. 1-(Lower alkyl or 2-chloroethyl)-3-(D-glucopyranos-6-yl)-1-nitrosourea compounds included within the scope of the nitrosourea compounds are novel. The nitrosourea compounds produced by this invention all show antitumor activity, among which the novel compounds exhibit excellent physical and pharmacological properties.

摘要翻译： 具有低级烷基和/或2-氯乙基作为取代基的吡喃葡萄糖 - 亚硝基脲化合物通过使具有低级烷氧基和/或氨基的氨基 - 吡喃葡萄糖化合物（或酸加成盐） 氨基）作为取代基，具有低级烷基或2-氯乙基作为取代基的邻 - 硝基 - 或邻 - 氰基 - 苯基N-取代-N-亚硝基氨基甲酸酯化合物。 包括在亚硝基脲化合物范围内的1-（低级烷基或2-氯乙基）-3-（D-吡喃葡萄糖-6-基）-1-亚硝基脲化合物是新颖的。 本发明生产的亚硝基脲化合物均显示出抗肿瘤活性，其中新化合物具有优异的物理和药理性质。