公开(公告)号：US20230248781A1

公开(公告)日：2023-08-10

申请号：US18004828

申请日：2021-07-08

申请人： BEIJING RONGXIANG INSTITUTE OF REGENERATIVE MEDICINE CO., LTD.

发明人： Li LI

IPC分类号： A61K35/644 ,  A61K31/575 ,  A61K31/7048 ,  A61K47/44 ,  A61K31/366 ,  A61K31/4748 ,  A61K31/4375 ,  A61K31/472 ,  A61K35/62 ,  A61P17/02

CPC分类号： A61K35/644 ,  A61K31/575 ,  A61K31/7048 ,  A61K47/44 ,  A61K31/366 ,  A61K31/4748 ,  A61K31/4375 ,  A61K31/472 ,  A61K35/62 ,  A61P17/02

摘要： A method for regulating an expression level of Musashi1 in cells. In particular, the present application relates to a cell-regulating composition capable of regulating the expression or activity, in cells, of any one selected from the followings: K19, α2β1 integrin, and Musashi1. The regulating composition can promote proliferation, growth, and migration of epidermal cells, promote proliferation, growth, and migration of vascular endothelial cells, and promote proliferation, growth, and migration of fibroblasts.

公开(公告)号：US20190192578A1

公开(公告)日：2019-06-27

申请号：US16327670

申请日：2017-08-25

申请人： California Institute of Technology ,  Boyce Thompson Institute for Plant Research

发明人： Andrea Choe ,  Paul W. Sternberg ,  Frank C. Schroeder

IPC分类号： A61K35/62 ,  A61K31/4439 ,  A61K31/7042 ,  A61K31/56 ,  A61P1/04 ,  A61K31/4178 ,  A61K31/7028 ,  A61K47/26

CPC分类号： A61K35/62 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/56 ,  A61K31/573 ,  A61K31/7028 ,  A61K31/7042 ,  A61K45/06 ,  A61K47/26 ,  A61P1/04 ,  A61P3/10 ,  A61P37/06 ,  G01N33/6869 ,  Y02A50/414 ,  A61K2300/00

摘要： A method of preventing or treating eosinophilic esophagitis (EoE) comprising administering a composition comprising ascr#7 is described.

公开(公告)号：US20180207206A1

公开(公告)日：2018-07-26

申请号：US15852443

申请日：2017-12-22

申请人： Rutgers, The State University of New Jersey

发明人： William C. Gause ,  Fei Chen ,  Zhugong Liu ,  Pankaj Mishra

IPC分类号： A61K35/62 ,  A61K39/00

CPC分类号： A61K35/62 ,  A61K39/0003

摘要： The invention relates to a field of tissue repair and regeneration. More particularly, the invention relates to a composition for promoting cutaneous wound healing. In one embodiment, the composition is composed of one or more metazoan parasites or a mimic thereof sufficient to promote helminth-induced type-2 immune response. Preferably, the composition contains N. brasiliensis excretory/secretory antigen (NES) or an immune triggering portion thereof. The invention also relates to a method of accelerating wound healing in a subject in need of such treatment.

公开(公告)号：US09931361B2

公开(公告)日：2018-04-03

申请号：US14218189

申请日：2014-03-18

申请人： Rutgers, The State University of New Jersey

发明人： William C. Gause ,  Fei Chen ,  Zhugong Liu ,  Pankaj Mishra

IPC分类号： A61K35/62 ,  A61K39/00

CPC分类号： A61K35/62 ,  A61K39/0003

摘要： The invention relates to a field of tissue repair and regeneration. More particularly, the invention relates to a composition for promoting cutaneous wound healing. In one embodiment, the composition is composed of one or more metazoan parasites or a mimic thereof sufficient to promote helminth-induced type-2 immune response. Preferably, the composition contains N. brasiliensis excretory/secretory antigen (NES) or an immune triggering portion thereof. The invention also relates to a method of accelerating wound healing in a subject in need of such treatment.

公开(公告)号：US20170239301A1

公开(公告)日：2017-08-24

申请号：US15426576

申请日：2017-02-07

申请人： Biopep Solutions, Inc.

发明人： Abbas Mohammad Ghawi ,  Ahmed Merzouk ,  Abdualrahman M. Abdualkader ,  Mohamed Alaama

IPC分类号： A61K35/62 ,  A61K9/00 ,  A01K67/033 ,  A61K9/19

CPC分类号： A61K35/62 ,  A01K67/033 ,  A01N63/00 ,  A61K9/0014 ,  A61K31/282 ,  A61K31/4745 ,  A61K31/555 ,  A61K38/21 ,  A61K45/06 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/393 ,  Y02A50/40 ,  Y02A50/401 ,  Y02A50/402 ,  Y02A50/406 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/415 ,  Y02A50/419 ,  Y02A50/422 ,  Y02A50/423 ,  Y02A50/463 ,  Y02A50/465 ,  Y02A50/467 ,  Y02A50/469 ,  Y02A50/47 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/479 ,  Y02A50/481 ,  Y02A50/483 ,  Y02A50/491 ,  A61K2300/00

摘要： Methods are also provided for isolating and using a whole-saliva leech extract in the treatment of a bacterial skin infection. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about −20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.

公开(公告)号：US20160271235A1

公开(公告)日：2016-09-22

申请号：US15036982

申请日：2014-11-19

申请人： THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.

发明人： Edward E. Mitre ,  Marina Torrero ,  Belinda Jackson

IPC分类号： A61K39/00 ,  A61K35/62

CPC分类号： A61K39/0003 ,  A61K35/62 ,  A61K39/0008 ,  A61K39/35 ,  A61K39/39 ,  A61K2039/55516

摘要： Methods of using axenic C. elegans homogenate for treating allergies or an autoimmune disease are disclosed. Also disclosed is a composition comprising a homogenate of C. elegans wherein the homogenate is obtained from C. elegans cultured in axenic media, for use in treating an allergy or autoimmune disease.

摘要翻译： 公开了用于治疗过敏或自身免疫性疾病的线虫线虫匀浆物的方法。 还公开了包含秀丽隐杆线粒体的组合物的组合物，其中匀浆获自在无菌培养基中培养的线虫，用于治疗过敏或自身免疫性疾病。

公开(公告)号：US09265803B2

公开(公告)日：2016-02-23

申请号：US14837281

申请日：2015-08-27

申请人： Biopep Solutions, Inc.

发明人： Abbas Mohammad Ghawi ,  Ahmed Merzouk ,  Abdualrahman Abdualkader ,  Mohamed Alaama

IPC分类号： A61K35/37 ,  A61K38/00 ,  A61K35/62

CPC分类号： A61K35/62 ,  A01K67/033 ,  A01N63/00 ,  A61K9/0014 ,  A61K31/282 ,  A61K31/4745 ,  A61K31/555 ,  A61K38/21 ,  A61K45/06 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/393 ,  Y02A50/40 ,  Y02A50/401 ,  Y02A50/402 ,  Y02A50/406 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/415 ,  Y02A50/419 ,  Y02A50/422 ,  Y02A50/423 ,  Y02A50/463 ,  Y02A50/465 ,  Y02A50/467 ,  Y02A50/469 ,  Y02A50/47 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/479 ,  Y02A50/481 ,  Y02A50/483 ,  Y02A50/491 ,  A61K2300/00

摘要： Methods are also provided for isolating and using a whole-saliva leech extract in the treatment of a melanoma. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about −20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.

摘要翻译： 还提供了用于分离和使用全唾液水蛭提取物治疗黑素瘤的方法。 所述方法可以包括向水蛭喂养吞噬剂; 诱导水蛭反流，诱导包括将水蛭放置在温度低于约0℃的环境中; 并在冷水蛭的反流中收集未精制的全唾液。 所述方法可以包括通过在约5℃至约40℃的温度范围内升温来振兴水蛭。还提供了稳定的，冻干的全唾液提取物，所述提取物在储存时具有稳定的活性 在低于约-20℃的温度下使用，提取物保持至少6个月的活性的至少70％。 提取物可用于治疗实体瘤，治疗液体肿瘤，治疗糖尿病，治疗病毒性疾病，治疗寄生虫病，治疗抗菌疾病或用作抗氧化剂。

公开(公告)号：US09149498B2

公开(公告)日：2015-10-06

申请号：US14657671

申请日：2015-03-13

申请人： Biopep Solutions, Inc.

发明人： Abdualrahman Abdualkader ,  Mohamed Alaama ,  Abbas Mohammad Ghawi ,  Ahmed Merzouk

IPC分类号： A61K35/37 ,  A61K38/00 ,  A61K35/62 ,  A61K45/06

CPC分类号： A61K35/62 ,  A01K67/033 ,  A01N63/00 ,  A61K9/0014 ,  A61K31/282 ,  A61K31/4745 ,  A61K31/555 ,  A61K38/21 ,  A61K45/06 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/393 ,  Y02A50/40 ,  Y02A50/401 ,  Y02A50/402 ,  Y02A50/406 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/415 ,  Y02A50/419 ,  Y02A50/422 ,  Y02A50/423 ,  Y02A50/463 ,  Y02A50/465 ,  Y02A50/467 ,  Y02A50/469 ,  Y02A50/47 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/479 ,  Y02A50/481 ,  Y02A50/483 ,  Y02A50/491 ,  A61K2300/00

摘要： Methods are provided for isolating and using a whole-saliva leech extract. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° C.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech. The methods can include revitalizing the leech by warming it at a temperature ranging from about 5° C. to about 40° C. Stable, lyophilized, whole-saliva extracts of a leech are also provided, the extract having a stable activity when stored for use at a temperature below about −20° C., the extract maintaining at least 70% of the activity for at least 6 months. The extracts can be used to treat solid tumors, treat liquid tumors, treat diabetes, treat a viral disease, treat a parasitic disease, treat an antibacterial disease, or serve as an anti-oxidant.

摘要翻译： 提供了分离和使用全唾液水蛭提取物的方法。 所述方法可以包括向水蛭喂养吞噬剂; 诱导水蛭反流，诱导包括将水蛭放置在温度低于约0℃的环境中; 并在冷水蛭的反流中收集未精制的全唾液。 所述方法可以包括通过在约5℃至约40℃的温度范围内升温来振兴水蛭。还提供了稳定的，冻干的全唾液提取物，所述提取物在储存时具有稳定的活性 在低于约-20℃的温度下使用，提取物保持至少6个月的活性的至少70％。 提取物可用于治疗实体瘤，治疗液体肿瘤，治疗糖尿病，治疗病毒性疾病，治疗寄生虫病，治疗抗菌疾病或用作抗氧化剂。

公开(公告)号：US20150224149A1

公开(公告)日：2015-08-13

申请号：US14694290

申请日：2015-04-23

申请人： Nikolay Vladimirovich SOLOVYEV

发明人： Nikolay Vladimirovich SOLOVYEV

IPC分类号： A61K35/62 ,  A61K35/612 ,  C12P21/06 ,  A61K35/618

CPC分类号： A61K35/62 ,  A61K35/56 ,  A61K35/612 ,  A61K35/618 ,  C12P21/06

摘要： The present invention relates to a field of veterinary and human medicine. In particular, the invention relates to a composition suitable for parenteral administration, based on hydrolyzate obtained from natural bioresources, a composition for use in treating and/or preventing a pathological condition in a mammal in need thereof, and various other uses thereof. More particularly the invention relates to a composition having immunomodulatory properties being based on a hydrolyzate obtained from bioresources, which composition is used for parenteral administration to a mammal in need thereof.

摘要翻译： 本发明涉及兽医和人类医学领域。 特别地，本发明涉及一种适合肠胃外给药的组合物，其基于天然生物资源获得的水解产物，用于治疗和/或预防有需要的哺乳动物病理状况的组合物及其各种其它用途。 更具体地说，本发明涉及具有免疫调节特性的组合物，其基于从生物资源获得的水解产物，该组合物用于向有需要的哺乳动物肠胃外给药。

公开(公告)号：US09095595B2

公开(公告)日：2015-08-04

申请号：US13331249

申请日：2011-12-20

申请人： Christian Mollin Outzen Kapel ,  Allan Roepstorff ,  Stig Milan Thamsborg

发明人： Christian Mollin Outzen Kapel ,  Allan Roepstorff ,  Stig Milan Thamsborg

IPC分类号： A61K35/56 ,  C12N1/04 ,  A61K35/62 ,  C12N5/07

CPC分类号： A61K35/62 ,  C12N5/0601

摘要： The invention relates to a composition for storage and development of eggs from helminthic parasites, where the composition further comprises a liquid carrier having a pH value of below 7 at a temperature of from 10C to ambient temperature. The liquid carrier can be sulphuric acid, H2SO4 with a pH in the range of from 0 to 2, and antibiotics can be added. The invention further relates to a method for treating, ameliorating, prophylactic or curative, an autoimmune or allergic disease in an individual, animal or man, using eggs being separated from the composition. The present invention also relates to methods for isolation, embryonation and preservation of eggs of helminthic parasite, and to a method for producing a pharmaceutical composition comprising a helminthic parasite preparation. The helminthic parasite eggs may be from the pig whipworm; Trichuris suis ova (TSO).

摘要翻译： 本发明涉及一种用于储存和发育来自蠕虫寄生虫的卵的组合物，其中组合物还在10℃至室温的温度下包含pH值低于7的液体载体。 液体载体可以是硫酸，pH在0至2范围内的H 2 SO 4，并且可以加入抗生素。 本发明还涉及使用与组合物分离的卵来治疗，改善，预防或治疗个体，动物或人的自身免疫或过敏性疾病的方法。 本发明还涉及用于分离，培养和保存蠕虫寄生虫卵的方法，以及用于生产包含蠕虫寄生虫制剂的药物组合物的方法。 蠕虫寄生虫卵可能来自猪鞭虫; Trichuris suis ova（TSO）。