公开(公告)号：US06827899B2

公开(公告)日：2004-12-07

申请号：US09943647

申请日：2001-08-30

申请人： Graeme Antony Maisey ,  James Aitken ,  Andrew James Woodhead ,  Stuart Richard May ,  Michael Pearson ,  Murdo M. Black ,  James George Elcoaté Smith

发明人： Graeme Antony Maisey ,  James Aitken ,  Andrew James Woodhead ,  Stuart Richard May ,  Michael Pearson ,  Murdo M. Black ,  James George Elcoaté Smith

IPC分类号： G01N3349

CPC分类号： G01N33/48757 ,  Y10S436/808 ,  Y10S436/811 ,  Y10T436/110833 ,  Y10T436/144444

摘要： A test device for testing of analyte concentration in a fluid comprises: a housing (2) having an opening and containing a stack of sensors (16); a transport member (4) rotatably mounted in the opening of the housing, having an axis of rotation which spans the opening; a spring (24) which urges the stack against the transport member; and sealing means (20, 34) for making a moisture tight seal between the transport member and the sensors when the transport member is in a specified rotational position. An outer surface of the transport member has a recessed region (12) which is adapted to receive a single sensor from the stack. Rotation of the transport member with a sensor in the recessed region transports the sensor to a location where it can be connected to a meter (6, 8) and receive a drop of fluid to be tested.

摘要翻译： 用于测试流体中分析物浓度的测试装置包括：壳体（2），其具有开口并且包含一叠传感器（16）; 可旋转地安装在所述壳体的开口中的传送构件（4），具有跨越所述开口的旋转轴线; 弹簧（24），其将所述叠堆推向所述运送构件; 以及密封装置（20,34），用于当所述传送构件处于指定的旋转位置时，在所述传送构件和所述传感器之间进行防潮密封。 传送构件的外表面具有适于从堆叠接收单个传感器的凹陷区域（12）。 运输构件在凹陷区域中的传感器的转动将传感器传送到可以连接到仪表（6,8）的位置，并接收一滴待测试的流体。

公开(公告)号：US07138089B2

公开(公告)日：2006-11-21

申请号：US09909427

申请日：2001-07-19

申请人： James Aitken ,  Andrew James Woodhead ,  Stuart Richard May ,  Murdo M. Black

发明人： James Aitken ,  Andrew James Woodhead ,  Stuart Richard May ,  Murdo M. Black

IPC分类号： G01N27/00

CPC分类号： G01N33/48757 ,  Y10T436/144444

摘要： A test device for testing of analyte concentration in a fluid to be applied thereto, the device comprising a plurality of test members arranged in at least one stack and electrodes for engaging with electrode tracks on a test member. A pusher pushes a single test member from the stack so that it can engage with the electrodes. An actuation member is connected to the pusher, and moves it when operated by a user. The at least one stack of test members is enclosed in a magazine which is initially sealed by a moisture impermeable seal. A cutter is provided for slitting the seal and permitting a test member to be pushed from the magazine by the pusher when the first test member from the magazine is to be used.

摘要翻译： 一种用于测试要施加到其上的流体中的分析物浓度的测试装置，所述装置包括布置在至少一个堆叠中的多个测试构件和用于与测试构件上的电极轨迹接合的电极。 推动器从堆叠器推动单个测试构件，使得其可以与电极接合。 致动构件连接到推动器，并且在由使用者操作时移动。 至少一个测试构件堆叠被封装在最初由不透水的密封件密封的料盒中。 提供切割器，用于切割密封件，并且当使用来自盒的第一测试构件时允许测试构件由推动器从盒体推动。

公开(公告)号：US07250095B2

公开(公告)日：2007-07-31

申请号：US10617262

申请日：2003-07-10

申请人： Murdo M. Black ,  Colin Butters ,  Wah O. Ho ,  John Rippeth

发明人： Murdo M. Black ,  Colin Butters ,  Wah O. Ho ,  John Rippeth

IPC分类号： G01N27/327

CPC分类号： C12Q1/005

摘要： A non-mediated enzyme electrode comprises a base substrate (2) on which is provided an electrically conductive base layer (8) comprising finely divided platinum group metal or oxide bonded together by a resin; a top layer on the base layer (8), the top layer comprising a buffer. A catalytically active quantity of an oxidoreductase enzyme is provided in at least one of the base layer and the top layer. The invention also provides a biosensor (20) which includes an enzyme electrode, and methods of manufacturing the enzyme electrode and biosensor.

摘要翻译： 非介导的酶电极包括基底（2），在其上设置有包含细分的铂族金属或通过树脂粘合在一起的氧化物的导电性基底层（8） 在基层（8）上的顶层，顶层包括缓冲液。 催化活性量的氧化还原酶被提供在基层和顶层中的至少一个中。 本发明还提供了包括酶电极的生物传感器（20），以及制造酶电极和生物传感器的方法。

公开(公告)号：US06509169B2

公开(公告)日：2003-01-21

申请号：US09903902

申请日：2001-07-12

申请人： Norman M. Ratcliffe ,  Clive Teare ,  Christopher Dunn ,  David C. Cowell ,  Caroline Penault ,  Paul Chambers ,  Murdo M. Black

发明人： Norman M. Ratcliffe ,  Clive Teare ,  Christopher Dunn ,  David C. Cowell ,  Caroline Penault ,  Paul Chambers ,  Murdo M. Black

IPC分类号： C12Q104

CPC分类号： A61B5/4216 ,  A61B5/097 ,  G01N27/12 ,  G01N33/0054 ,  G01N33/497 ,  Y02A50/246

摘要： A method for detecting Helicobacter pylori in a subject's gastroenteral tract involves measuring a change in resistance of an electronic or electrochemical sensor, notably a polypyrrole film, on exposure to gas from the subject's lungs and/or stomach. Depending on the magnitude of the change (if any) a positive or negative result is indicated visually by electronics means. Two sensors are used, one of which receives a sample of gas which has passed through an amonia-absorbing means to provide a corrected baseline value for the ammonia. The invention also provides apparatus suitable for carrying out the method.

摘要翻译： 用于检测受试者胃肠道中的幽门螺杆菌的方法包括在暴露于来自受试者的肺和/或胃的气体时测量电子或电化学传感器，特别是聚吡咯膜的电阻变化。 根据变化的大小（如果有的话），电子手段可以直观地指出正或负的结果。 使用两个传感器，其中一个接收已经通过氨基酸吸收装置的气体样品，以提供校正的氨的基准值。 本发明还提供适用于实施该方法的设备。

公开(公告)号：US06833110B2

公开(公告)日：2004-12-21

申请号：US09909456

申请日：2001-07-19

申请人： Murdo M. Black

发明人： Murdo M. Black

IPC分类号： G01N3100

CPC分类号： G01N27/3271

摘要： A test member suitable for use in a test device for testing of analyte concentration in a fluid to be applied thereto comprises a base member (2) having a working area (4) to which the fluid is to be applied, containing a reagent which is reactive to the said analyte to produce an electrical signal or a color change, and a non-working area (8) adjacent to the working area (4). The total thickness of the test member in at least a portion of the non-working area (8) is at least as great as the total thickness of the test member in the working area (4).

摘要翻译： 适合用于测试待施加流体中的分析物浓度的测试装置的测试构件包括具有工作区域（4）的基底构件（2），待加入流体的工作区域包含试剂 对所述分析物反应以产生电信号或颜色变化，以及与工作区域（4）相邻的非工作区域（8）。 在非工作区域（8）的至少一部分中的测试构件的总厚度至少与工作区域（4）中测试构件的总厚度一样大。