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30 条记录 (耗时 0.06 秒)

    2-oxy-benzoxazinone derivatives for the treatment of obesity
    7.
    发明授权
    2-oxy-benzoxazinone derivatives for the treatment of obesity 有权
    2-氧基 - 苯并嗪酮衍生物用于治疗肥胖症

    公开(公告)号：US08877750B2

    公开(公告)日：2014-11-04

    申请号：US12952972

    申请日：2010-11-23

    申请人： Harold Francis Hodson ,  Robert Downham ,  Timothy John Mitchell ,  Beverley Jane Carr ,  Christopher Robert Dunk ,  Richard Michael John Palmer

    发明人： Harold Francis Hodson ,  Robert Downham ,  Timothy John Mitchell ,  Beverley Jane Carr ,  Christopher Robert Dunk ,  Richard Michael John Palmer

    IPC分类号： A61K31/535 ,  C07D265/26 ,  C07C271/28

    CPC分类号： C07D265/26 ,  C07C271/28

    摘要： The use of a compound comprising formula (I): or a salt, ester, amide or prodrug thereof in the inhibition of an enzyme whose preferred mode of action is to catalyse the hydrolysis of an ester functionality, e.g. in the control and inhibition of unwanted enzymes in products and processes. The compounds are also useful in medicine e.g. in the treatment of obesity and related conditions. The invention also relates to novel compounds within formula (I), to processes for preparing them and pharmaceutical compositions containing them. In formula (I) A is a 6-membered aromatic or heteroaromatic ring; and R1 is a branched or unbranched alkyl (optionally interrupted by one or more oxygen atoms), alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, reduced arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, reduced aryl, reduced heteroaryl, reduced heteroarylalkyl or a substituted derivative of any of the foregoing groups.

    摘要翻译： 包含式（I）的化合物或其盐，酯，酰胺或前药在抑制其优选作用模式是催化酯官能团水解的酶的用途，例如， 在产品和过程中控制和抑制不需要的酶。 这些化合物也可用于医学，例如 在治疗肥胖和相关情况。 本发明还涉及式（I）中的新化合物，其制备方法和含有它们的药物组合物。 在式（I）中，A是6元芳族或杂芳族环; 烯基，炔基，环烷基，环烯基，芳基，芳基烷基，还原芳基烷基，芳基烯基，杂芳基，杂芳基烷基，杂芳基烯基，还原芳基，还原杂芳基，还原的杂芳基烷基（可以被一个或多个氧原子间隔的烷基） 或任何上述基团的取代衍生物。

    2-thio-4h-3, 1-benzoxazin-4-one derivatives for use as enzyme inhibitors
    10.
    发明授权
    2-thio-4h-3, 1-benzoxazin-4-one derivatives for use as enzyme inhibitors 失效
    2-硫代-4h-3,1-苯并恶嗪-4-酮衍生物，用作酶抑制剂

    公开(公告)号：US06916808B2

    公开(公告)日：2005-07-12

    申请号：US10181868

    申请日：2001-01-17

    申请人： Robert Downham ,  Richard Michael John Palmer ,  Harold Francis Hodson ,  Christopher Robert Dunk

    发明人： Robert Downham ,  Richard Michael John Palmer ,  Harold Francis Hodson ,  Christopher Robert Dunk

    IPC分类号： A23L1/30 ,  A23L3/3544 ,  A61K8/49 ,  A61K31/536 ,  A61K31/5365 ,  A61P1/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P43/00 ,  C07D265/24 ,  C07D498/04 ,  C07D403/14 ,  C07D405/12

    CPC分类号： C07D265/24 ,  A61K31/536 ,  A61K31/5365

    摘要： The use of a compound, comprising formula (I) or a salt, ester, amide of prodrug thereof in the inhibition of an enzyme whose preferred mode of action is to catalyse the hydrolysis of an ester functionality e.g. in the control and inhibition of unwanted enzymes in products and processes. The compounds are also useful in medicine e.g. in the treatment of obesity and related conditions. The invention also relates to novel compounds within formula (I), to processes for preparing them and pharmaceutical compositions containing them. In formula (I) A is an optionally substituted 6-membered aromatic or heteroaromatic ring; and R1 is a branched or unbranched alkyl (optionally interrupted by one or more oxygen atoms), alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, reduced arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, reduced aryl, reduced heteroaryl, reduced heteroarylalkyl or a substituted derivative of any of the foregoing groups

    摘要翻译： 使用包含式（I）的化合物或其前体药物的盐，酯，酰胺在抑制其优选作用模式是催化酯官能团水解的酶的酶。 在产品和过程中控制和抑制不需要的酶。 这些化合物也可用于医学，例如 在治疗肥胖和相关情况。 本发明还涉及式（I）中的新化合物，其制备方法和含有它们的药物组合物。 在式（I）中，A是任选取代的6元芳族或杂芳族环; 并且R 1是支链或非支链烷基（任选被一个或多个氧原子间隔开），烯基，炔基，环烷基，环烯基，芳基，芳基烷基，还原芳基烷基，芳基烯基，杂芳基，杂芳基烷基，杂芳基烯基， 还原的芳基，还原的杂芳基，还原的杂芳基烷基或任何前述基团的取代的衍生物