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公开(公告)号：US07572455B2
公开(公告)日：2009-08-11
申请号：US11132686
申请日：2005-05-19
CPC分类号： C12N7/00 , A61K2039/5252 , C07K14/005 , C12N2770/24322 , C12N2770/24361
摘要： Attenuated pestiviruses, in particular attenuated BVDV, wherein at least one mutation is in the coding sequence for glycoprotein Erns and at least another mutation in the coding sequence for Npro which preferably leads to combined inactivation of the RNase activity residing in glycoprotein Erns in addition to the inactivation of the (hypothesized) immunomodulating activity residing in Npro. Methods for attenuating pestiviruses such as BVDV, nucleic acids encoding the pestiviruses, in particular BVDV, compositions and vaccines comprising the attenuated pestiviruses, in particular BVDV, of the invention.
摘要翻译： 减毒瘟病毒，特别是减毒BVDV，其中至少一个突变位于糖蛋白Erns的编码序列中，并且在Npro的编码序列中至少有一个突变，其优选导致除了存在于糖蛋白Erns中的糖蛋白Erns之外的RNase活性的组合失活 灭活Npro的（假设的）免疫调节活性。 用于减毒瘟病毒如BVDV，编码瘟病毒的核酸，特别是BVDV，包含本发明的减毒瘟病毒，特别是BVDV的组合物和疫苗的方法。
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公开(公告)号：US20050287171A1
公开(公告)日：2005-12-29
申请号：US11132686
申请日：2005-05-19
CPC分类号： C12N7/00 , A61K2039/5252 , C07K14/005 , C12N2770/24322 , C12N2770/24361
摘要： Attenuated pestiviruses, in particular attenuated BVDV, wherein at least one mutation is in the coding sequence for glycoprotein Erns and at least another mutation in the coding sequence for Npro which preferably leads to combined inactivation of the RNase activity residing in glycoprotein Erns in addition to the inactivation of the (hypothesized) immunomodulating activity residing in Npro. Methods for attenuating pestiviruses such as BVDV, nucleic acids encoding the pestiviruses, in particular BVDV, compositions and vaccines comprising the attenuated pestiviruses, in particular BVDV, of the invention.
摘要翻译： 减毒瘟病毒，特别是减毒BVDV，其中至少一个突变位于糖蛋白E编码序列和至少另一个突变的编码序列中， 导致存在于糖蛋白ENA中的RNase活性的组合失活除了灭活N（pro）的（假设的）免疫调节活性。 用于减毒瘟病毒如BVDV，编码瘟病毒的核酸，特别是BVDV，包含本发明的减毒瘟病毒，特别是BVDV的组合物和疫苗的方法。
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