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公开(公告)号：US20050014737A1
公开(公告)日：2005-01-20
申请号：US10856340
申请日：2004-05-28
CPC分类号： C07J41/00
摘要： Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering compounds of the general formula: wherein the variables are defined in the specification.
摘要翻译： 用于治疗哺乳动物疾病的组合物和方法，其特征在于不期望的血管生成，其通过施用以下通式的化合物：其中变量在说明书中定义。
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公开(公告)号：US20070010505A1
公开(公告)日：2007-01-11
申请号：US11519570
申请日：2006-09-12
CPC分类号： C07J41/00
摘要： Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering compounds of the general formula: wherein the variables are defined in the specification.
摘要翻译： 用于治疗哺乳动物疾病的组合物和方法，其特征在于不期望的血管生成，其通过施用以下通式的化合物：其中变量在说明书中定义。
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公开(公告)号：US20050192258A1
公开(公告)日：2005-09-01
申请号：US11118852
申请日：2005-04-29
申请人： Gregory Agoston , Jamshed Shah , Kimberly Hunsucker , Victor Pribluda , Theresa LaVallee , Shawn Green , Christopher Herbstritt , Xiaoguo Zhan , Anthony Treston
发明人： Gregory Agoston , Jamshed Shah , Kimberly Hunsucker , Victor Pribluda , Theresa LaVallee , Shawn Green , Christopher Herbstritt , Xiaoguo Zhan , Anthony Treston
CPC分类号： C07J1/00
摘要： Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering derivatives of 2-methoxyestradiol of the general formula: wherein the variables are defined in the specification.
摘要翻译： 用于治疗哺乳动物疾病的组合物和方法，其特征在于通过施用以下通式的2-甲氧基雌二醇的衍生物的不期望的血管生成：其中变量在说明书中定义。
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公开(公告)号：US20070135400A1
公开(公告)日：2007-06-14
申请号：US11701809
申请日：2007-02-02
CPC分类号： C07J41/00
摘要： Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering compounds of the general formula: wherein the variables are defined in the specification.
摘要翻译： 用于治疗哺乳动物疾病的组合物和方法，其特征在于不期望的血管生成，其通过施用以下通式的化合物：其中变量在说明书中定义。
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5.发明申请Compositions and methods comprising proteinase activated receptor antagonists 审中-公开包含蛋白酶活化受体拮抗剂的组合物和方法公开(公告)号：US20060063930A1
公开(公告)日：2006-03-23
申请号：US11208460
申请日：2005-08-19
申请人： Gregory Agoston , Todd Hembrough , Theresa LaVallee , Jamshed Shah , Lita Suwandi , Anthony Treston
发明人： Gregory Agoston , Todd Hembrough , Theresa LaVallee , Jamshed Shah , Lita Suwandi , Anthony Treston
IPC分类号： C07D261/18 , C07D235/30 , C07D403/02
CPC分类号： C07D295/185 , C07D205/04 , C07D207/34 , C07D213/56 , C07D213/82 , C07D231/40 , C07D233/64 , C07D235/26 , C07D235/30 , C07D241/26 , C07D249/04 , C07D261/18 , C07D275/03 , C07D277/46 , C07D403/06 , C07D487/04
摘要： Compositions and methods comprising proteinase activated receptor antagonists are provided. More particularly, the present invention relates to the use of proteins, peptides and molecules that bind to proteinase activated receptor 2, and inhibit the processes associated with the activation of that receptor. More specifically, the present invention provides novel compositions and methods for the treatment of disorders and diseases such as those associated with abnormal cellular proliferation, angiogenesis, inflammation and cancer.
摘要翻译： 提供了包含蛋白酶激活的受体拮抗剂的组合物和方法。 更具体地，本发明涉及结合蛋白酶活化受体2的蛋白质，肽和分子的用途，并且抑制与该受体活化相关的过程。 更具体地，本发明提供了用于治疗疾病和疾病的新型组合物和方法，例如与异常细胞增殖，血管生成，炎症和癌症相关的疾病和疾病。
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公开(公告)号：US20070004689A1
公开(公告)日：2007-01-04
申请号：US11489263
申请日：2006-07-19
摘要： Compositions and methods for treating mammalian diseases or conditions characterized by undesirable angiogenesis by administering an effective amount of a compound of the formulae: wherein Ra is selected from —OCH3, —OCH2CH3 or —CCCH3; and Z is selected from >C(H)—OH, >C(H)—O-alkyl, >C(H)—O-sulfamate, or >C(H)-dioxolane, where alkyl is a linear, branched and/or cyclic hydrocarbon chain comprising 1 to 10 carbons.
摘要翻译： 通过施用有效量的下式化合物来治疗哺乳动物疾病或特征在于不期望的血管生成的病症的组合物和方法：其中R a a选自-OCH 3 - ， - OCH 2 CH 3或-CCH 3 3; 并且Z选自C（H）-OH，> C（H）-O-烷基，> C（H）-O-氨基磺酸酯或C（H） - 二氧戊环，其中烷基是直链，支链和 /或包含1至10个碳的环状烃链。
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公开(公告)号：US20050203075A1
公开(公告)日：2005-09-15
申请号：US11077977
申请日：2005-03-11
CPC分类号： C07J1/00
摘要： Compositions and methods for treating mammalian diseases or conditions characterized by undesirable angiogenesis by administering an effective amount of a compound of the formulae: wherein Ra is selected from —OCH3, —OCH2CH3 or —CCCH3; and Z is selected from >C(H)—OH, >C(H)—O-alkyl, >C(H)—O-sulfamate, where alkyl is a linear, branched and/or cyclic hydrocarbon chain comprising 1 to 10 carbons.
摘要翻译： 通过施用有效量的下式化合物来治疗哺乳动物疾病或特征在于不期望的血管生成的病症的组合物和方法：其中R a a选自-OCH 3 - ， - OCH 2 CH 3或-CCH 3 3; 并且Z选自> C（H）-OH，> C（H）-O-烷基，> C（H）-O-氨基磺酸酯，其中烷基是包含1至10个的直链，支链和/或环状烃链 碳。
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8.发明申请Anti-angiogenic activity of 2-methoxyestradiol in combination with anti-cancer agents 审中-公开2-甲氧基雌二醇与抗癌剂的抗血管生成活性公开(公告)号：US20070185069A1
公开(公告)日：2007-08-09
申请号：US11599997
申请日：2006-11-14
申请人： Stacy Plum , Steven Strawn , Theresa LaVallee , Carolyn Sidor , William Fogler , Anthony Treston
发明人： Stacy Plum , Steven Strawn , Theresa LaVallee , Carolyn Sidor , William Fogler , Anthony Treston
IPC分类号： A61K31/56
CPC分类号： A61K31/56 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0034 , A61K9/20 , A61K31/53 , A61K45/06 , A61K2300/00
摘要： The present invention relates generally to methods and compositions of treating disease characterized by abnormal cell proliferation and/or abnormal or undesirable angiogenesis by administering antiangiogenic agents in combination with chemotherapeutic agents. More specifically, the present invention relates to a methods and compositions of treating diseases characterized by abnormal cell proliferation and/or abnormal or undesirable angiogenesis by administering 2-methoxyestradiol, in combination with chemotherapeutic agents.
摘要翻译： 本发明一般涉及通过与化学治疗剂组合施用抗血管生成剂来治疗以异常细胞增殖和/或异常或不期望的血管生成为特征的疾病的方法和组合物。 更具体地，本发明涉及通过与化疗剂组合施用2-甲氧基雌二醇来治疗以异常细胞增殖和/或异常或不期望的血管生成为特征的疾病的方法和组合物。
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