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![Pyrazolo[3,4-d]pyrimidines inhibiting H. pylori infections](/abs-image/US/2007/10/23/US07285558B2/abs.jpg.150x150.jpg)
公开(公告)号：US07285558B2
公开(公告)日：2007-10-23
申请号：US10481178
申请日：2002-06-28
申请人： Gregory Basarab , Joseph Eyermann , Madhusudhan Gowravaram , Oluyinka Green , Lawrence MacPherson , Marshall Morningstar , Thanh Nguyen
发明人： Gregory Basarab , Joseph Eyermann , Madhusudhan Gowravaram , Oluyinka Green , Lawrence MacPherson , Marshall Morningstar , Thanh Nguyen
IPC分类号： C07D271/02 , C07D473/00 , A61K31/519
CPC分类号： C07D239/545 , C07D409/12 , C07D487/04
摘要： Compounds having the general formula and pharmaceutical compositions containing them, and their use in the treatment or prophylaxis of H. pylori infection.
摘要翻译： 具有通式的化合物和含有它们的药物组合物，以及它们在治疗或预防幽门螺杆菌感染中的用途。
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![Pyrazolo [3,4-d] pyrimidine derivatives and their use in the treatment of h.pylori infection](/abs-image/US/2007/01/04/US20070004761A1/abs.jpg.150x150.jpg)
2.发明申请Pyrazolo [3,4-d] pyrimidine derivatives and their use in the treatment of h.pylori infection 审中-公开吡唑并[3,4-d]嘧啶衍生物及其在治疗幽门螺杆菌感染中的应用公开(公告)号：US20070004761A1
公开(公告)日：2007-01-04
申请号：US10539936
申请日：2003-12-19
申请人： Gregory Basarab , Joseph Eyermann , Madhusudhan Gowravaram , Ohryinka Green , Lawrence MacPherson , Marshall Morningstar , Thanh Nguyen
发明人： Gregory Basarab , Joseph Eyermann , Madhusudhan Gowravaram , Ohryinka Green , Lawrence MacPherson , Marshall Morningstar , Thanh Nguyen
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04
摘要： This invention relates to novel compounds having the structural diagram (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of H. pylori infection.
摘要翻译： 本发明涉及具有结构图（I）及其药物组合物及其使用方法的新型化合物。 这些新型化合物提供治疗或预防幽门螺杆菌感染。
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公开(公告)号：US07371757B2
公开(公告)日：2008-05-13
申请号：US10567797
申请日：2004-08-12
申请人： Marshall Morningstar , Gregory Basarab , Charles Joseph Eyermann , Madhu Gowravaram , Oluyinka Green , Andrew Kiely , Lawrence MacPherson , Nguyen Thanh
发明人： Marshall Morningstar , Gregory Basarab , Charles Joseph Eyermann , Madhu Gowravaram , Oluyinka Green , Andrew Kiely , Lawrence MacPherson , Nguyen Thanh
IPC分类号： A01N43/54 , A61K31/505 , C07D239/00 , C07D471/00 , C07D487/00 , C07D491/00
CPC分类号： C07D487/14
摘要： This invention relates to novel compounds having formula: (I) or (II) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of H. pylori infection.
摘要翻译： 本发明涉及具有式（I）或（II）的新化合物及其药物组合物及其使用方法。 这些新型化合物提供治疗或预防幽门螺杆菌感染。
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公开(公告)号：US20070275954A1
公开(公告)日：2007-11-29
申请号：US11569112
申请日：2005-05-19
申请人： Gregory Basarab , Charles Eyermann , Bolin Geng , Madhusudhan Gowravaram , James Loch III , Lawrence MacPherson , Marshall Morningstar , George Mullen , Alex Staz , Andrew Kiely
发明人： Gregory Basarab , Charles Eyermann , Bolin Geng , Madhusudhan Gowravaram , James Loch III , Lawrence MacPherson , Marshall Morningstar , George Mullen , Alex Staz , Andrew Kiely
IPC分类号： A61K31/5513 , A61P1/04 , A61P31/04 , C07D243/14 , C07D491/02
CPC分类号： A61K31/551 , A61K31/5513 , C07D243/20 , C07D403/04 , C07D409/04 , C07D409/14 , C07D471/04
摘要： This invention relates to novel compounds having the Formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of H. pylori infection.
摘要翻译： 本发明涉及具有式（I）的新化合物及其药物组合物及其使用方法。 这些新型化合物提供治疗或预防幽门螺杆菌感染。
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公开(公告)号：US20060252781A1
公开(公告)日：2006-11-09
申请号：US10567797
申请日：2004-08-12
申请人： Gregory Basarab , Charles Eyermann , Madhusudhhan Gowravaram , Oluyinka Green , Andrew Kiely , Lawrence Macpherson , Marshall Morningstar , Nguyen Thanh
发明人： Gregory Basarab , Charles Eyermann , Madhusudhhan Gowravaram , Oluyinka Green , Andrew Kiely , Lawrence Macpherson , Marshall Morningstar , Nguyen Thanh
IPC分类号： A61K31/519 , C07D487/14
CPC分类号： C07D487/14
摘要： This invention relates to novel compounds having formula: (I) or (II) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of H. pylori infection.
摘要翻译： 本发明涉及具有式（I）或（II）的新化合物及其药物组合物及其使用方法。 这些新型化合物提供治疗或预防幽门螺杆菌感染。
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6.发明授权公开(公告)号：US07875715B2
公开(公告)日：2011-01-25
申请号：US11917394
申请日：2006-06-16
IPC分类号： C07D498/04
CPC分类号： C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/06 , C07D491/04 , C07D513/04
摘要： The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.
摘要翻译： 本发明涉及表现出抗菌活性的化合物，其制备方法，含有它们作为活性成分的药物组合物，它们作为药物的用途，以及它们在制备用于治疗温暖的细菌感染的药物中的用途， 血液动物如人类。 特别地，本发明涉及可用于治疗温血动物如人的细菌感染的化合物，更具体地涉及这些化合物在制备用于治疗温血动物细菌感染的药物中的用途，例如 作为人类
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7.发明授权公开(公告)号：US08124602B2
公开(公告)日：2012-02-28
申请号：US12964366
申请日：2010-12-09
IPC分类号： A61K31/438 , A61K31/498 , C07D401/06 , C07D403/06
CPC分类号： C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/06 , C07D491/04 , C07D513/04
摘要： The present invention relates to compounds of Formula V(A): that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds of Formula V(A) useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.
摘要翻译： 本发明涉及式V（A）的化合物：其表现出抗菌活性，其制备方法，含有它们作为活性成分的药物组合物，其用作药物及其在制备药物中的用途 治疗温血动物如人类的细菌感染。 特别地，本发明涉及用于治疗温血动物如人的细菌感染的式V（A）化合物，更具体地说涉及这些化合物在制备用于治疗细菌感染的药物中的用途 在温血动物如人类。
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8.发明申请公开(公告)号：US20120108577A1
公开(公告)日：2012-05-03
申请号：US13348143
申请日：2012-01-11
IPC分类号： A61K31/436 , A61P31/04 , A61K31/538 , A61K31/4709 , A61K31/5415
CPC分类号： C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/06 , C07D491/04 , C07D513/04
摘要： The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.
摘要翻译： 本发明涉及表现出抗菌活性的化合物，其制备方法，含有它们作为活性成分的药物组合物，它们作为药物的用途，以及它们在制备用于治疗温暖的细菌感染的药物中的用途， 血液动物如人类。 特别地，本发明涉及可用于治疗温血动物如人的细菌感染的化合物，更具体地涉及这些化合物在制备用于治疗温血动物细菌感染的药物中的用途，例如 作为人类。
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9.发明申请公开(公告)号：US20110092495A1
公开(公告)日：2011-04-21
申请号：US12964366
申请日：2010-12-09
IPC分类号： A61K31/5383 , C07D471/04 , A61K31/4375 , C07D401/14 , A61K31/4709 , C07D498/04 , A61K31/4985 , A61P31/04
CPC分类号： C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/06 , C07D491/04 , C07D513/04
摘要： The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.
摘要翻译： 本发明涉及表现出抗菌活性的化合物，其制备方法，含有它们作为活性成分的药物组合物，它们作为药物的用途，以及它们在制备用于治疗温暖的细菌感染的药物中的用途， 血液动物如人类。 特别地，本发明涉及可用于治疗温血动物如人的细菌感染的化合物，更具体地涉及这些化合物在制备用于治疗温血动物细菌感染的药物中的用途，例如 作为人类
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10.发明申请公开(公告)号：US20100152441A1
公开(公告)日：2010-06-17
申请号：US11917394
申请日：2006-06-16
IPC分类号： C07D498/04
CPC分类号： C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/06 , C07D491/04 , C07D513/04
摘要： The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.
摘要翻译： 本发明涉及表现出抗菌活性的化合物，其制备方法，含有它们作为活性成分的药物组合物，它们作为药物的用途，以及它们在制备用于治疗温暖的细菌感染的药物中的用途， 血液动物如人类。 特别地，本发明涉及可用于治疗温血动物如人的细菌感染的化合物，更具体地涉及这些化合物在制备用于治疗温血动物细菌感染的药物中的用途，例如 作为人类
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