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1.发明授权公开(公告)号：US08124602B2
公开(公告)日：2012-02-28
申请号：US12964366
申请日：2010-12-09
IPC分类号： A61K31/438 , A61K31/498 , C07D401/06 , C07D403/06
CPC分类号： C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/06 , C07D491/04 , C07D513/04
摘要： The present invention relates to compounds of Formula V(A): that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds of Formula V(A) useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.
摘要翻译： 本发明涉及式V（A）的化合物：其表现出抗菌活性，其制备方法，含有它们作为活性成分的药物组合物，其用作药物及其在制备药物中的用途 治疗温血动物如人类的细菌感染。 特别地，本发明涉及用于治疗温血动物如人的细菌感染的式V（A）化合物，更具体地说涉及这些化合物在制备用于治疗细菌感染的药物中的用途 在温血动物如人类。
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公开(公告)号：US07371757B2
公开(公告)日：2008-05-13
申请号：US10567797
申请日：2004-08-12
申请人： Marshall Morningstar , Gregory Basarab , Charles Joseph Eyermann , Madhu Gowravaram , Oluyinka Green , Andrew Kiely , Lawrence MacPherson , Nguyen Thanh
发明人： Marshall Morningstar , Gregory Basarab , Charles Joseph Eyermann , Madhu Gowravaram , Oluyinka Green , Andrew Kiely , Lawrence MacPherson , Nguyen Thanh
IPC分类号： A01N43/54 , A61K31/505 , C07D239/00 , C07D471/00 , C07D487/00 , C07D491/00
CPC分类号： C07D487/14
摘要： This invention relates to novel compounds having formula: (I) or (II) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of H. pylori infection.
摘要翻译： 本发明涉及具有式（I）或（II）的新化合物及其药物组合物及其使用方法。 这些新型化合物提供治疗或预防幽门螺杆菌感染。
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公开(公告)号：US06573295B2
公开(公告)日：2003-06-03
申请号：US09990637
申请日：2001-11-21
申请人： William C. Shakespeare , Michael G. Yang , Rajeswari Sundaramoorthi , Regine Bohacek , Charles Joseph Eyermann , Tomi K. Sawyer
发明人： William C. Shakespeare , Michael G. Yang , Rajeswari Sundaramoorthi , Regine Bohacek , Charles Joseph Eyermann , Tomi K. Sawyer
IPC分类号： A61K31335
CPC分类号： C07F9/65527 , C07C237/48 , C07C2601/14 , C07C2602/12 , C07D313/08 , C07F9/12 , C07F9/3834 , C07F9/3873 , C07F9/3882 , C07F9/4021
摘要： This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediated by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to pharmaceutical compositions containing the compounds and prophylactic and therapeutic methods involving pharmaceutical and veterinary administration of the compounds. The compounds are of the formula as defined herein.
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4.发明授权Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors 失效取代的环状羰基及其衍生物可用作逆转录病毒蛋白酶抑制剂
公开(公告)号：US5811422A
公开(公告)日：1998-09-22
申请号：US770546
申请日：1996-11-22
申请人： Patrick Yuk-Sun Lam , Prabhakar Kondaji Jadhav , Charles Joseph Eyermann , Carl Nicholas Hodge , George Vincent De Lucca , James David Rodgers
发明人： Patrick Yuk-Sun Lam , Prabhakar Kondaji Jadhav , Charles Joseph Eyermann , Carl Nicholas Hodge , George Vincent De Lucca , James David Rodgers
IPC分类号： C12N9/99 , A61K31/12 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/451 , A61K31/505 , A61K31/55 , A61K31/554 , A61P31/12 , A61P43/00 , C07C49/723 , C07C49/737 , C07C49/747 , C07D211/74 , C07D211/76 , C07D223/10 , C07D223/12 , C07D239/10 , C07D243/04 , C07D245/02 , C07D247/02 , C07D267/06 , C07D279/02 , C07D281/02 , C07D285/16 , C07D285/36 , C07D313/04 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/06 , C07D409/10 , C07D409/14 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07D521/00 , C07F9/6584
CPC分类号： C07D239/10 , C07C49/723 , C07C49/747 , C07D211/76 , C07D223/10 , C07D223/12 , C07D231/12 , C07D233/56 , C07D243/04 , C07D245/02 , C07D249/08 , C07D267/06 , C07D279/02 , C07D281/02 , C07D285/16 , C07D285/36 , C07D313/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/06 , C07D409/10 , C07D409/14 , C07D413/10 , C07D413/14 , C07D417/14 , C07D487/04 , C07F9/65848
摘要： This invention relates to substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors, to pharmaceutical compositions comprising such compounds, and to methods of using these compounds for treating viral infection. A representative compound of the invention is the compound of formula: ##STR1## wherein R.sup.22 and R.sup.23 are allyl.
摘要翻译： 本发明涉及用作逆转录病毒蛋白酶抑制剂的取代的环状羰基及其衍生物，包含这些化合物的药物组合物，以及使用这些化合物治疗病毒感染的方法。 本发明的代表性化合物是下式的化合物：其中R 22和R 23是烯丙基。
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5.发明授权公开(公告)号：US06503898B1
公开(公告)日：2003-01-07
申请号：US09113905
申请日：1998-07-10
申请人： Patrick Yuk-Sun Lam , Prabhakar Kondaji Jadhav , Charles Joseph Eyermann , Carl Nicholas Hodge , George Vincent De Lucca , James David Rodgers
发明人： Patrick Yuk-Sun Lam , Prabhakar Kondaji Jadhav , Charles Joseph Eyermann , Carl Nicholas Hodge , George Vincent De Lucca , James David Rodgers
IPC分类号： A61K3155
CPC分类号： C07D239/10 , C07C49/723 , C07C49/747 , C07D211/76 , C07D223/10 , C07D223/12 , C07D231/12 , C07D233/56 , C07D243/04 , C07D245/02 , C07D249/08 , C07D267/06 , C07D279/02 , C07D281/02 , C07D285/16 , C07D285/36 , C07D313/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/06 , C07D409/10 , C07D409/14 , C07D413/10 , C07D413/14 , C07D417/14 , C07D487/04 , C07F9/65848
摘要： This invention relates to substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors, to pharmaceutical compositions comprising such compounds, and to methods of using these compounds for treating viral infection. A representative compound of the invention is the compound of formula: wherein R22 and R23 are allyl.
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6.发明申请公开(公告)号：US20120108577A1
公开(公告)日：2012-05-03
申请号：US13348143
申请日：2012-01-11
IPC分类号： A61K31/436 , A61P31/04 , A61K31/538 , A61K31/4709 , A61K31/5415
CPC分类号： C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/06 , C07D491/04 , C07D513/04
摘要： The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.
摘要翻译： 本发明涉及表现出抗菌活性的化合物，其制备方法，含有它们作为活性成分的药物组合物，它们作为药物的用途，以及它们在制备用于治疗温暖的细菌感染的药物中的用途， 血液动物如人类。 特别地，本发明涉及可用于治疗温血动物如人的细菌感染的化合物，更具体地涉及这些化合物在制备用于治疗温血动物细菌感染的药物中的用途，例如 作为人类。
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7.发明申请公开(公告)号：US20110092495A1
公开(公告)日：2011-04-21
申请号：US12964366
申请日：2010-12-09
IPC分类号： A61K31/5383 , C07D471/04 , A61K31/4375 , C07D401/14 , A61K31/4709 , C07D498/04 , A61K31/4985 , A61P31/04
CPC分类号： C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/06 , C07D491/04 , C07D513/04
摘要： The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.
摘要翻译： 本发明涉及表现出抗菌活性的化合物，其制备方法，含有它们作为活性成分的药物组合物，它们作为药物的用途，以及它们在制备用于治疗温暖的细菌感染的药物中的用途， 血液动物如人类。 特别地，本发明涉及可用于治疗温血动物如人的细菌感染的化合物，更具体地涉及这些化合物在制备用于治疗温血动物细菌感染的药物中的用途，例如 作为人类
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8.发明申请公开(公告)号：US20100152441A1
公开(公告)日：2010-06-17
申请号：US11917394
申请日：2006-06-16
IPC分类号： C07D498/04
CPC分类号： C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/06 , C07D491/04 , C07D513/04
摘要： The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.
摘要翻译： 本发明涉及表现出抗菌活性的化合物，其制备方法，含有它们作为活性成分的药物组合物，它们作为药物的用途，以及它们在制备用于治疗温暖的细菌感染的药物中的用途， 血液动物如人类。 特别地，本发明涉及可用于治疗温血动物如人的细菌感染的化合物，更具体地涉及这些化合物在制备用于治疗温血动物细菌感染的药物中的用途，例如 作为人类
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9.发明授权Bicyclic signal transduction inhibitors, compositions containing them & uses thereof 有权双环信号转导抑制剂，含有它们的组合物及其用途公开(公告)号：US06482852B2
公开(公告)日：2002-11-19
申请号：US09854027
申请日：2001-05-11
申请人： William C. Shakespeare , Michael G. Yang , Rajeswari Sundaramoorthi , Regine Bohacek , Charles Joseph Eyermann , Tomi K. Sawyer
发明人： William C. Shakespeare , Michael G. Yang , Rajeswari Sundaramoorthi , Regine Bohacek , Charles Joseph Eyermann , Tomi K. Sawyer
IPC分类号： A61K3121
CPC分类号： C07F9/65527 , C07C237/48 , C07C2601/14 , C07C2602/12 , C07D313/08 , C07F9/12 , C07F9/3834 , C07F9/3873 , C07F9/3882 , C07F9/4021
摘要： This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediated by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to pharmaceutical compositions containing the compounds and prophylactic and therapeutic methods involving pharmaceutical and veterinary administration of the compounds. The compounds are of the formula as defined herein.
摘要翻译： 本发明涉及用于抑制细胞内信号转导的化合物，特别是通过涉及含磷酸酪氨酸的蛋白质的一种或多种分子相互作用介导的细胞内信号转导。 本发明还涉及包含化合物的药物组合物和涉及化合物的药物和兽药施用的预防和治疗方法。 这些化合物是本文定义的式。
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10.发明授权公开(公告)号：US07875715B2
公开(公告)日：2011-01-25
申请号：US11917394
申请日：2006-06-16
IPC分类号： C07D498/04
CPC分类号： C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/06 , C07D491/04 , C07D513/04
摘要： The present invention relates to compounds that demonstrate antibacterial activity, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans. In particular this invention relates to compounds useful for the treatment of bacterial infections in warm-blooded animals such as humans, more particularly to the use of these compounds in the manufacture of medicaments for use in the treatment of bacterial infections in warm-blooded animals such as humans.
摘要翻译： 本发明涉及表现出抗菌活性的化合物，其制备方法，含有它们作为活性成分的药物组合物，它们作为药物的用途，以及它们在制备用于治疗温暖的细菌感染的药物中的用途， 血液动物如人类。 特别地，本发明涉及可用于治疗温血动物如人的细菌感染的化合物，更具体地涉及这些化合物在制备用于治疗温血动物细菌感染的药物中的用途，例如 作为人类
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