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公开(公告)号：US07883474B1
公开(公告)日：2011-02-08
申请号：US08640259
申请日：1996-04-30
IPC分类号： A61M25/00
CPC分类号： A61M25/09 , A61M2025/09175
摘要： This is a composite guidewire for use with a catheter for accessing a targeted site in a lumen system of a patient's body. The guidewire core or guidewire section may be of a stainless steel or a high elasticity metal alloy, preferably a Ni—Ti alloy, also preferably having specified physical parameters. The composite guidewire assembly is especially useful for accessing peripheral or soft tissue targets. The invention includes multi-section guidewire assemblies having super-elastic alloy or stainless steel ribbon braided reinforcements along a least a portion of the core. A variation of the inventive guidewire includes a braid and a tie layer (and one or more lubricious polymers on the tie layer exterior) to enhance the guidewire's suitability for use within catheters and within the interior of vascular lumen.
摘要翻译： 这是一种用于与用于进入患者身体的管腔系统中的目标部位的导管一起使用的复合导丝。 导丝芯或导丝部分可以是不锈钢或高弹性金属合金，优选Ni-Ti合金，也优选具有特定的物理参数。 复合导丝组件对于接近外周或软组织靶是特别有用的。 本发明包括具有沿着芯的至少一部分的超弹性合金或不锈钢丝带编织增强件的多段导丝组件。 本发明的导丝的变体包括编织物和连接层（以及在连接层外部的一种或多种润滑聚合物），以增强导丝线在导管内和血管内腔内的适用性。
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公开(公告)号：US20110144625A1
公开(公告)日：2011-06-16
申请号：US13022360
申请日：2011-02-07
IPC分类号： A61M25/09
CPC分类号： A61M25/09 , A61M2025/09175
摘要： This is a composite guidewire for use with a catheter for accessing a targeted site in a lumen system of a patient's body. The guidewire core or guidewire section may be of a stainless steel or a high elasticity metal alloy, preferably a Ni—Ti alloy, also preferably having specified physical parameters. The composite guidewire assembly is especially useful for accessing peripheral or soft tissue targets. The invention includes multi-section guidewire assemblies having super-elastic alloy or stainless steel ribbon braided reinforcements along a least a portion of the core. A variation of the inventive guidewire includes a braid and a tie layer (and one or more lubricious polymers on the tie layer exterior) to enhance the guidewire's suitability for use within catheters and within the interior of vascular lumen.
摘要翻译： 这是一种用于与用于进入患者身体的管腔系统中的目标部位的导管一起使用的复合导丝。 导丝芯或导丝部分可以是不锈钢或高弹性金属合金，优选Ni-Ti合金，也优选具有特定的物理参数。 复合导丝组件对于接近外周或软组织靶是特别有用的。 本发明包括具有沿着芯的至少一部分的超弹性合金或不锈钢丝带编织增强件的多段导丝组件。 本发明的导丝的变体包括编织物和连接层（以及在连接层外部的一种或多种润滑聚合物），以增强导丝线在导管内和血管内腔内的适用性。
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公开(公告)号：US5769796A
公开(公告)日：1998-06-23
申请号：US789607
申请日：1997-01-22
申请人： Thomas J. Palermo , Gene Samson , Gregory E. Mirigian , U. Hiram Chee , Erik T. Engelson , Edward Snyder
发明人： Thomas J. Palermo , Gene Samson , Gregory E. Mirigian , U. Hiram Chee , Erik T. Engelson , Edward Snyder
IPC分类号： A61B5/00
CPC分类号： A61M25/09 , A61M2025/09091 , A61M2025/09175
摘要： This is a composite guidewire for use in a catheter and is used for accessing a targeted site in a lumen system of a patient's body. The guidewire core or guidewire section may be of a stainless steel or a high elasticity metal alloy, preferably a Ni--Ti alloy, also preferably having specified physical parameters. The composite guidewire assembly is especially useful for accessing peripheral or soft tissue targets. Variations include multi-section guidewire assemblies having (at least) super-elastic distal portions and super-elastic braided reinforcements along the mid or distal sections. A variation of the inventive guidewire includes the coating of the wire with a tie layer and then with a one or more lubricious polymers to enhance its suitability for use within catheters and with the interior of vascular lumen.
摘要翻译： 这是用于导管的复合导丝，并用于进入患者体内的管腔系统中的目标部位。 导丝芯或导丝部分可以是不锈钢或高弹性金属合金，优选Ni-Ti合金，也优选具有特定的物理参数。 复合导丝组件对于接近外周或软组织靶是特别有用的。 变型包括具有（至少）超弹性远端部分的多段导丝组件和沿着中部或远端部分的超弹性编织加强件。 本发明的导丝的变体包括用连接层涂覆线材，然后使用一种或多种润滑聚合物来增强其在导管内和血管腔内部使用的适用性。
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公开(公告)号：US08048060B2
公开(公告)日：2011-11-01
申请号：US11505119
申请日：2006-08-16
申请人： Stephen Griffin , Elaine Lim , Gregory E. Mirigian
发明人： Stephen Griffin , Elaine Lim , Gregory E. Mirigian
IPC分类号： A61M25/00
CPC分类号： A61M25/0054 , A61L29/02 , A61M25/001 , A61M25/0045 , A61M25/0051 , A61M25/0053 , A61M25/0068 , A61M25/0097 , A61M25/0108 , A61M2025/0046 , A61M2205/0216 , A61M2205/0227 , A61M2205/0266
摘要： A medical device including a shaft having an elongated inner member and an elongated tubular reinforcing member disposed over at least a portion of the inner member. In some embodiments, at least a portion of the outer surface of the inner member is spaced from the inner surface of the reinforcing member, defining a space substantially free of any other structures of the device. In some embodiments, the shaft can include a tip structure disposed on a distal portion of the inner member. In some such embodiments, the reinforcing member has a distal end, and the tip structure is disposed on the distal portion of the inner member adjacent the distal end of the reinforcing member. Additionally, in some embodiments, the reinforcing member can include a plurality of apertures defined therein, for example, to enhance the flexibility or other such characteristics of all or portions of the reinforcing member.
摘要翻译： 一种医疗装置，包括具有细长内部构件的轴和设置在内部构件的至少一部分上的细长管状加强构件。 在一些实施例中，内部构件的外表面的至少一部分与加强构件的内表面间隔开，限定了基本上没有设备的任何其他结构的空间。 在一些实施例中，轴可以包括设置在内部构件的远侧部分上的末端结构。 在一些这样的实施例中，加强构件具有远端，并且尖端结构设置在邻近加强构件的远端的内部构件的远侧部分上。 此外，在一些实施例中，加强构件可以包括限定在其中的多个孔，例如以增强加强构件的全部或部分的柔性或其它这些特性。
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公开(公告)号：US20090177261A1
公开(公告)日：2009-07-09
申请号：US12319255
申请日：2009-01-05
申请人： Clifford Teoh , Michael Williams , Gregory E. Mirigian , Kirsten Carroll , James M. Anderson , Jay Rassat , Benjamin Arcand , Derek Sutermeister
发明人： Clifford Teoh , Michael Williams , Gregory E. Mirigian , Kirsten Carroll , James M. Anderson , Jay Rassat , Benjamin Arcand , Derek Sutermeister
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B2017/12068 , A61B2017/12077 , A61B2017/1209
摘要： Disclosed herein are detachment mechanisms for vaso-occlusive devices that allow for rapid operator-controlled release of the vaso-occlusive device into the selected site. Also disclosed are vaso-occlusive assemblies comprising these detachment mechanisms and methods of using these detachment mechanisms and vaso-occlusive assemblies.
摘要翻译： 本文公开了一种用于血管闭塞装置的分离机构，其允许快速操作者控制将血管闭塞装置释放到选定部位。 还公开了包括这些分离机构的血管闭塞组件和使用这些分离机构和血管闭塞组件的方法。
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公开(公告)号：US08277438B2
公开(公告)日：2012-10-02
申请号：US12797374
申请日：2010-06-09
IPC分类号： A61M25/00
CPC分类号： A61M25/01 , A61M25/104 , A61M2025/0004 , A61M2025/0059 , A61M2025/0681
摘要： Catheters such as guide catheters can be configured for delivery of devices to vasculature portions such as intracranial spaces while retaining a desired level of flexibility. A catheter having an elongate shaft can include removable support means that can provide column support to the elongate shaft. The elongate shaft can include anchoring means that releasably secure the removable support means. The catheter can be deployed within a patient's vasculature, followed by deploying the removable support means.
摘要翻译： 诸如引导导管的导管可以被配置为将装置输送到脉管系部分，例如颅内空间，同时保持期望的柔性水平。 具有细长轴的导管可以包括可移除的支撑装置，其可以向细长轴提供柱支撑。 细长轴可以包括可释放地固定可移除支撑装置的锚固装置。 导管可以部署在患者的脉管系统内，随后部署可移除的支撑装置。
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公开(公告)号：US07918806B2
公开(公告)日：2011-04-05
申请号：US11352753
申请日：2006-02-13
IPC分类号： A61M25/00
CPC分类号： A61M25/09 , A61M2025/0915 , A61M2025/09175
摘要： A guide wire with a distal portion having adjustable flexibility. The guide wire may include a distal polymeric member and a heat source. The heat source may be activated to cause the polymeric member to increase in temperature and increase in flexibility. The increase in flexibility of the distal portion of the guide wire enhances the ability of the guide wire to navigate tortuous vasculature to a target site. After the guide wire has been navigated to the target site, the heat source may be deactivated to cause the polymeric member to decrease in temperature and increase in stiffness. The increase in stiffness of the distal portion of the guide wire enhances support provided for devices (e.g., catheters) advanced thereon.
摘要翻译： 导丝，其具有可调节的柔性的远端部分。 导丝可以包括远端聚合物构件和热源。 可以激活热源以使聚合物部件的温度升高并且柔性增加。 引导线的远端部分的柔性的增加增强了引导线将弯曲脉管系统导航到目标部位的能力。 在引导线已经导航到目标部位之后，热源可以被去活，以使聚合物部件降低温度并增加刚度。 引导线的远端部分的刚度的增加增强了对在其上推进的装置（例如，导管）提供的支撑。
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公开(公告)号：US5549624A
公开(公告)日：1996-08-27
申请号：US265188
申请日：1994-06-24
申请人： Gregory E. Mirigian , Nga T. Van
发明人： Gregory E. Mirigian , Nga T. Van
CPC分类号： A61B17/12145 , A61B17/12022 , A61B17/1215
摘要： This invention is a vasoocclusive device. It is placed in the vasculature of an animal to form thrombus in a selected site such as an aneurysm or AVM. The device uses a central coil having thrombogenic fibers placed on the coil in a specified fashion. The coil will pass through the lumen of a vascular catheter and form a convolution when ejected from the catheter's distal end. The fibers are attached to the coil and cooperate with the coil so that upon ejection from the catheter, the convoluted coil forms a shape in which the central region contains the majority of these fibers.
摘要翻译： 本发明是血管闭塞装置。 将其置于动物的脉管系统中，以在选定的部位如动脉瘤或AVM中形成血栓。 该装置使用具有以特定方式放置在线圈上的血栓形成纤维的中心线圈。 线圈将穿过血管导管的内腔，并在从导管的远端喷射时形成卷积。 纤维连接到线圈并与线圈配合，使得当从导管喷射时，卷积的线圈形成中心区域包含大多数这些纤维的形状。
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公开(公告)号：US08636716B2
公开(公告)日：2014-01-28
申请号：US13477755
申请日：2012-05-22
IPC分类号： A61M25/00
CPC分类号： A61M25/0054 , A61L29/02 , A61M25/001 , A61M25/0045 , A61M25/0051 , A61M25/0053 , A61M25/0068 , A61M25/0097 , A61M25/0108 , A61M2025/0046 , A61M2205/0216 , A61M2205/0227 , A61M2205/0266
摘要： A medical device including a shaft having an elongated inner member and an elongated tubular reinforcing member disposed over at least a portion of the inner member. In some embodiments, at least a portion of the outer surface of the inner member is spaced from the inner surface of the reinforcing member, defining a space substantially free of any other structures of the device. In some embodiments, the shaft can include a tip structure disposed on a distal portion of the inner member. In some such embodiments, the reinforcing member has a distal end, and the tip structure is disposed on the distal portion of the inner member adjacent the distal end of the reinforcing member. Additionally, in some embodiments, the reinforcing member can include a plurality of apertures defined therein, for example, to enhance the flexibility or other such characteristics of all or portions of the reinforcing member.
摘要翻译： 一种医疗装置，包括具有细长内部构件的轴和设置在所述内部构件的至少一部分上的细长管状加强构件。 在一些实施例中，内部构件的外表面的至少一部分与加强构件的内表面间隔开，限定了基本上没有设备的任何其他结构的空间。 在一些实施例中，轴可以包括设置在内部构件的远侧部分上的末端结构。 在一些这样的实施例中，加强构件具有远端，并且尖端结构设置在邻近加强构件的远端的内部构件的远侧部分上。 此外，在一些实施例中，加强构件可以包括限定在其中的多个孔，例如以增强加强构件的全部或部分的柔性或其它这些特性。
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公开(公告)号：US08182465B2
公开(公告)日：2012-05-22
申请号：US12470261
申请日：2009-05-21
申请人： Stephen Griffin , Elaine Lim , Gregory E. Mirigian
发明人： Stephen Griffin , Elaine Lim , Gregory E. Mirigian
IPC分类号： A61M25/00
CPC分类号： A61M25/0054 , A61L29/02 , A61M25/001 , A61M25/0045 , A61M25/0051 , A61M25/0053 , A61M25/0068 , A61M25/0097 , A61M25/0108 , A61M2025/0046 , A61M2205/0216 , A61M2205/0227 , A61M2205/0266
摘要： A medical device including a shaft having an elongated inner member and an elongated tubular reinforcing member disposed over at least a portion of the inner member. In some embodiments, at least a portion of the outer surface of the inner member is spaced from the inner surface of the reinforcing member, defining a space substantially free of any other structures of the device. In some embodiments, the shaft can include a tip structure disposed on a distal portion of the inner member. In some such embodiments, the reinforcing member has a distal end, and the tip structure is disposed on the distal portion of the inner member adjacent the distal end of the reinforcing member. Additionally, in some embodiments, the reinforcing member can include a plurality of apertures defined therein, for example, to enhance the flexibility or other such characteristics of all or portions of the reinforcing member.
摘要翻译： 一种医疗装置，包括具有细长内部构件的轴和设置在内部构件的至少一部分上的细长管状加强构件。 在一些实施例中，内部构件的外表面的至少一部分与加强构件的内表面间隔开，限定了基本上没有设备的任何其他结构的空间。 在一些实施例中，轴可以包括设置在内部构件的远侧部分上的末端结构。 在一些这样的实施例中，加强构件具有远端，并且尖端结构设置在邻近加强构件的远端的内部构件的远侧部分上。 此外，在一些实施例中，加强构件可以包括限定在其中的多个孔，例如以增强加强构件的全部或部分的柔性或其它这些特性。
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