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1.发明授权公开(公告)号：US08961426B2
公开(公告)日：2015-02-24
申请号：US13180315
申请日：2011-07-11
申请人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
发明人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
CPC分类号： A61B5/721 , A61B5/0048 , A61B5/02007 , A61B5/021 , A61B5/0225 , A61B5/7207 , A61B5/7264 , A61B5/7282 , A61B5/7285
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism, when such parameters are potentially affected by other concurrent events. In one exemplary embodiment, apparatus and methods for compensating for occlusive events (e.g., pressure cuff inflation) occurring ipsilateral to the location of parameter measurement are disclosed. Upon passive detection of signal degradation resulting from the event, the apparatus selectively enters a “wait state” wherein further processing of the hemodynamic data is suspended until the degrading event subsides. This behavior mitigates any adverse effects the event might have on the accuracy of the representation of the measured hemodynamic parameter generated by the system. In another exemplary embodiment, the measured data is analyzed in order to classify the type of event (e.g., occlusive or other), such classification allowing the system to appropriately tailor its response to the event.
摘要翻译： 改进的方法和装置，用于非侵入性地评估与流体系统相关联的一个或多个参数，例如活体的循环系统，当这些参数可能受到其他并发事件的影响时。 在一个示例性实施例中，公开了用于补偿与参数测量位置同侧出现的闭塞事件（例如，压力袖带充气）的装置和方法。 在被动检测由事件导致的信号劣化时，该装置选择性地进入“等待状态”，其中暂停血液动力学数据的进一步处理，直到降解事件消退。 该行为减轻了事件可能对由系统产生的测量的血液动力学参数的表示的准确性的任何不利影响。 在另一个示例性实施例中，分析测量数据以便将事件的类型（例如，闭塞或其他）分类，允许系统适当地定制其对事件的响应。
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2.发明授权公开(公告)号：US07976471B2
公开(公告)日：2011-07-12
申请号：US11982975
申请日：2007-11-05
申请人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
发明人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
IPC分类号： A61B5/02
CPC分类号： A61B5/721 , A61B5/0048 , A61B5/02007 , A61B5/021 , A61B5/0225 , A61B5/7207 , A61B5/7264 , A61B5/7282 , A61B5/7285
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism, when such parameters are potentially affected by other concurrent events. In one exemplary embodiment, apparatus and methods for compensating for occlusive events (e.g., pressure cuff inflation) occurring ipsilateral to the location of parameter measurement are disclosed. Upon passive detection of signal degradation resulting from the event, the apparatus selectively enters a “wait state” wherein further processing of the hemodynamic data is suspended until the degrading event subsides. This behavior mitigates any adverse effects the event might have on the accuracy of the representation of the measured hemodynamic parameter generated by the system. In another exemplary embodiment, the measured data is analyzed in order to classify the type of event (e.g., occlusive or other), such classification allowing the system to appropriately tailor its response to the event.
摘要翻译： 改进的方法和装置，用于非侵入性地评估与流体系统相关联的一个或多个参数，例如活体的循环系统，当这些参数可能受到其他并发事件的影响时。 在一个示例性实施例中，公开了用于补偿与参数测量位置同侧出现的闭塞事件（例如，压力袖带充气）的装置和方法。 在被动检测由事件导致的信号劣化时，该装置选择性地进入“等待状态”，其中暂停血液动力学数据的进一步处理，直到降解事件消退。 该行为减轻了事件可能对由系统产生的测量的血液动力学参数的表示的准确性的任何不利影响。 在另一个示例性实施例中，分析测量数据以便将事件的类型（例如，闭塞或其他）分类，允许系统适当地定制其对事件的响应。
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3.发明申请公开(公告)号：US20110263991A1
公开(公告)日：2011-10-27
申请号：US13180315
申请日：2011-07-11
申请人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
发明人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
CPC分类号： A61B5/721 , A61B5/0048 , A61B5/02007 , A61B5/021 , A61B5/0225 , A61B5/7207 , A61B5/7264 , A61B5/7282 , A61B5/7285
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism, when such parameters are potentially affected by other concurrent events. In one exemplary embodiment, apparatus and methods for compensating for occlusive events (e.g., pressure cuff inflation) occurring ipsilateral to the location of parameter measurement are disclosed. Upon passive detection of signal degradation resulting from the event, the apparatus selectively enters a “wait state” wherein further processing of the hemodynamic data is suspended until the degrading event subsides. This behavior mitigates any adverse effects the event might have on the accuracy of the representation of the measured hemodynamic parameter generated by the system. In another exemplary embodiment, the measured data is analyzed in order to classify the type of event (e.g., occlusive or other), such classification allowing the system to appropriately tailor its response to the event.
摘要翻译： 改进的方法和装置，用于非侵入性地评估与流体系统相关联的一个或多个参数，例如活体的循环系统，当这些参数可能受到其他并发事件的影响时。 在一个示例性实施例中，公开了用于补偿与参数测量位置同侧出现的闭塞事件（例如，压力袖带充气）的装置和方法。 在被动检测由事件导致的信号劣化时，该装置选择性地进入“等待状态”，其中暂停血液动力学数据的进一步处理，直到降解事件消退。 该行为减轻了事件可能对由系统产生的测量的血液动力学参数的表示的准确性的任何不利影响。 在另一个示例性实施例中，分析测量数据以便将事件的类型（例如，闭塞或其他）分类，允许系统适当地定制其对事件的响应。
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4.发明授权公开(公告)号：US07291112B2
公开(公告)日：2007-11-06
申请号：US10393660
申请日：2003-03-20
申请人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
发明人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
IPC分类号： A61B5/02
CPC分类号： A61B5/022 , A61B5/02007 , A61B5/02028 , A61B5/024 , A61B5/684 , A61B5/6843 , A61B5/7203 , A61B5/7207 , A61B5/7264
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism, when such parameters are potentially affected by other concurrent events. In one exemplary embodiment, apparatus and methods for compensating for occlusive events (e.g., pressure cuff inflation) occurring ipsilateral to the location of parameter measurement are disclosed. Upon passive detection of signal degradation resulting from the event, the apparatus selectively enters a “wait state” wherein further processing of the hemodynamic data is suspended until the degrading event subsides. This behavior mitigates any adverse effects the event might have on the accuracy of the representation of the measured hemodynamic parameter generated by the system. In another exemplary embodiment, the measured data is analyzed in order to classify the type of event (e.g., occlusive or other), such classification allowing the system to appropriately tailor its response to the event.
摘要翻译： 改进的方法和装置，用于非侵入性地评估与流体系统相关联的一个或多个参数，例如活体的循环系统，当这些参数可能受到其他并发事件的影响时。 在一个示例性实施例中，公开了用于补偿与参数测量位置同侧出现的闭塞事件（例如，压力袖带充气）的装置和方法。 在被动检测由事件导致的信号劣化时，该装置选择性地进入“等待状态”，其中暂停血液动力学数据的进一步处理，直到降解事件消退。 该行为减轻了事件可能对由系统产生的测量的血液动力学参数的表示的准确性的任何不利影响。 在另一个示例性实施例中，分析测量数据以便将事件的类型（例如，闭塞或其他）分类，允许系统适当地定制其对事件的响应。
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公开(公告)号：US07955267B2
公开(公告)日：2011-06-07
申请号：US11300019
申请日：2005-12-13
IPC分类号： A61B5/02
CPC分类号： A61B5/022 , A61B5/02007 , A61B5/02028 , A61B5/024 , A61B5/684 , A61B5/6843 , A61B5/7203 , A61B5/7207 , A61B5/7264
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism. In a first aspect, an improved method of continuously measuring pressure from a compressible vessel is disclosed, wherein a substantially optimal level of compression for the vessel is achieved and maintained using perturbations (e.g., modulation) of the compression level of the vessel. In one exemplary embodiment, the modulation is conducted according to a pseudo-random binary sequence (PBRS). In a second aspect, an improved apparatus for determining the blood pressure of a living subject is disclosed, the apparatus generally comprising a pressure sensor and associated processor with a computer program defining a plurality of operating states related to the sensed pressure data. Methods for pressure waveform correction and reacquisition, as well as treatment using the present invention, are also disclosed.
摘要翻译： 用于非侵入性评估与诸如活体的循环系统的流体系统相关联的一个或多个参数的改进的方法和装置。 在第一方面，公开了一种从可压缩容器连续测量压力的改进方法，其中使用容器的压缩水平的扰动（例如，调制）来实现和维持容器的基本上最佳的压缩水平。 在一个示例性实施例中，根据伪随机二进制序列（PBRS）进行调制。 在第二方面，公开了一种用于确定活体的血压的改进装置，所述装置通常包括压力传感器和与计算机程序相关联的处理器，所述计算机程序定义与感测的压力数据有关的多个操作状态。 还公开了压力波形校正和再吸收的方法以及使用本发明的处理。
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6.发明申请公开(公告)号：US20110237961A1
公开(公告)日：2011-09-29
申请号：US13154315
申请日：2011-06-06
IPC分类号： A61B5/021
CPC分类号： A61B5/022 , A61B5/02007 , A61B5/02028 , A61B5/024 , A61B5/684 , A61B5/6843 , A61B5/7203 , A61B5/7207 , A61B5/7264
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism. In a first aspect, an improved method of continuously measuring pressure from a compressible vessel is disclosed, wherein a substantially optimal level of compression for the vessel is achieved and maintained using perturbations (e.g., modulation) of the compression level of the vessel. In one exemplary embodiment, the modulation is conducted according to a pseudo-random binary sequence (PBRS). In a second aspect, an improved apparatus for determining the blood pressure of a living subject is disclosed, the apparatus generally comprising a pressure sensor and associated processor with a computer program defining a plurality of operating states related to the sensed pressure data. Methods for pressure waveform correction and reacquisition, as well as treatment using the present invention, are also disclosed.
摘要翻译： 用于非侵入性评估与诸如活体的循环系统的流体系统相关联的一个或多个参数的改进的方法和装置。 在第一方面，公开了一种从可压缩容器连续测量压力的改进方法，其中使用容器的压缩水平的扰动（例如，调制）来实现和维持容器的基本上最佳的压缩水平。 在一个示例性实施例中，根据伪随机二进制序列（PBRS）进行调制。 在第二方面，公开了一种用于确定活体的血压的改进的装置，该装置通常包括压力传感器和与计算机程序相关联的处理器，该计算机程序定义与感测的压力数据相关的多个操作状态。 还公开了压力波形校正和再吸收的方法以及使用本发明的处理。
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7.发明授权公开(公告)号：US08945016B2
公开(公告)日：2015-02-03
申请号：US13154315
申请日：2011-06-06
CPC分类号： A61B5/022 , A61B5/02007 , A61B5/02028 , A61B5/024 , A61B5/684 , A61B5/6843 , A61B5/7203 , A61B5/7207 , A61B5/7264
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism. In a first aspect, an improved method of continuously measuring pressure from a compressible vessel is disclosed, wherein a substantially optimal level of compression for the vessel is achieved and maintained using perturbations (e.g., modulation) of the compression level of the vessel. In one exemplary embodiment, the modulation is conducted according to a pseudo-random binary sequence (PBRS). In a second aspect, an improved apparatus for determining the blood pressure of a living subject is disclosed, the apparatus generally comprising a pressure sensor and associated processor with a computer program defining a plurality of operating states related to the sensed pressure data. Methods for pressure waveform correction and reacquisition, as well as treatment using the present invention, are also disclosed.
摘要翻译： 用于非侵入性评估与诸如活体的循环系统的流体系统相关联的一个或多个参数的改进的方法和装置。 在第一方面，公开了一种从可压缩容器连续测量压力的改进方法，其中使用容器的压缩水平的扰动（例如，调制）来实现和维持容器的基本上最佳的压缩水平。 在一个示例性实施例中，根据伪随机二进制序列（PBRS）进行调制。 在第二方面，公开了一种用于确定活体的血压的改进装置，所述装置通常包括压力传感器和与计算机程序相关联的处理器，所述计算机程序定义与感测的压力数据有关的多个操作状态。 还公开了压力波形校正和再吸收的方法以及使用本发明的处理。
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8.发明授权公开(公告)号：US06974419B1
公开(公告)日：2005-12-13
申请号：US10211115
申请日：2002-08-01
IPC分类号： A61B5/02
CPC分类号： A61B5/022 , A61B5/02007 , A61B5/02028 , A61B5/024 , A61B5/684 , A61B5/6843 , A61B5/7203 , A61B5/7207 , A61B5/7264
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism. In a first aspect, an improved method of continuously measuring pressure from a compressible vessel is disclosed, wherein a substantially optimal level of compression for the vessel is achieved and maintained using perturbations (e.g., modulation) of the compression level of the vessel. In one exemplary embodiment, the modulation is conducted according to a pseudo-random binary sequence (PBRS). In a second aspect, an improved apparatus for determining the blood pressure of a living subject is disclosed, the apparatus generally comprising a pressure sensor and associated processor with a computer program defining a plurality of operating states related to the sensed pressure data. Methods for pressure waveform correction and reacquisition, as well as treatment using the present invention, are also disclosed.
摘要翻译： 用于非侵入性评估与诸如活体的循环系统的流体系统相关联的一个或多个参数的改进的方法和装置。 在第一方面，公开了一种从可压缩容器连续测量压力的改进方法，其中使用容器的压缩水平的扰动（例如，调制）来实现和维持容器的基本上最佳的压缩水平。 在一个示例性实施例中，根据伪随机二进制序列（PBRS）进行调制。 在第二方面，公开了一种用于确定活体的血压的改进装置，所述装置通常包括压力传感器和与计算机程序相关联的处理器，所述计算机程序定义与感测的压力数据有关的多个操作状态。 还公开了压力波形校正和再吸收的方法以及使用本发明的处理。
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公开(公告)号：US08506497B2
公开(公告)日：2013-08-13
申请号：US11803559
申请日：2007-05-14
申请人： Andrew S. Katayama , Todd A. Keitel , Manouchehr Goharlaee , Stuart L. Gallant , Warren B. Craycroft
发明人： Andrew S. Katayama , Todd A. Keitel , Manouchehr Goharlaee , Stuart L. Gallant , Warren B. Craycroft
IPC分类号： A61B5/02
CPC分类号： A61B5/0225 , A61B5/021 , A61B5/02233 , A61B5/6843 , A61B5/72
摘要： Improved apparatus and methods for non-invasively assessing one or more parameters associated with systems such as fluidic circulating systems (e.g., the circulatory system of a living organism). In a first aspect, an improved method of continuously measuring pressure from a compressible vessel is disclosed, wherein a substantially optimal level of compression for the vessel is achieved and maintained using dynamically applied dither perturbations (e.g., modulation) on the various axes associated with the vessel. In a second aspect, an improved apparatus and method are provided for monitoring hemodynamic parameters, such as blood pressure, in a continuous and non-invasive manner while operating under a single unifying scheme. One variant of this scheme using a simulated annealing (SA) type approach to determining and maintaining an optimal operating state.
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10.发明申请公开(公告)号：US20080064968A1
公开(公告)日：2008-03-13
申请号：US11982975
申请日：2007-11-05
IPC分类号： A61B5/0225
CPC分类号： A61B5/721 , A61B5/0048 , A61B5/02007 , A61B5/021 , A61B5/0225 , A61B5/7207 , A61B5/7264 , A61B5/7282 , A61B5/7285
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism, when such parameters are potentially affected by other concurrent events. In one exemplary embodiment, apparatus and methods for compensating for occlusive events (e.g., pressure cuff inflation) occurring ipsilateral to the location of parameter measurement are disclosed. Upon passive detection of signal degradation resulting from the event, the apparatus selectively enters a “wait state” wherein further processing of the hemodynamic data is suspended until the degrading event subsides. This behavior mitigates any adverse effects the event might have on the accuracy of the representation of the measured hemodynamic parameter generated by the system. In another exemplary embodiment, the measured data is analyzed in order to classify the type of event (e.g., occlusive or other), such classification allowing the system to appropriately tailor its response to the event.
摘要翻译： 改进的方法和装置，用于非侵入性地评估与流体系统相关联的一个或多个参数，例如活体的循环系统，当这些参数可能受到其他并发事件的影响时。 在一个示例性实施例中，公开了用于补偿与参数测量位置同侧出现的闭塞事件（例如，压力袖带充气）的装置和方法。 在被动检测由事件导致的信号劣化时，该装置选择性地进入“等待状态”，其中暂停血液动力学数据的进一步处理，直到降解事件消退。 该行为减轻了事件可能对由系统产生的测量的血液动力学参数的表示的准确性的任何不利影响。 在另一个示例性实施例中，分析测量数据以便将事件的类型（例如，闭塞或其他）分类，允许系统适当地定制其对事件的响应。
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