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    Method and apparatus for treating tissues with HIFU
    1.
    发明授权
    Method and apparatus for treating tissues with HIFU 有权
    用HIFU治疗组织的方法和装置

    公开(公告)号：US08845559B2

    公开(公告)日：2014-09-30

    申请号：US12573840

    申请日：2009-10-05

    申请人： Gregory P. Darlington ,  Michael J. Connolly ,  Justin A. Reed ,  Jessica E. Parsons ,  Roland Horth ,  John Murkowski

    发明人： Gregory P. Darlington ,  Michael J. Connolly ,  Justin A. Reed ,  Jessica E. Parsons ,  Roland Horth ,  John Murkowski

    IPC分类号： A61H1/00 ,  A61H1/02 ,  A61H5/00 ,  A61N7/02 ,  A61N7/00 ,  A61B19/00

    CPC分类号： A61N7/02 ,  A61B2090/378 ,  A61N2007/0082

    摘要： A method for treating a desired volume of tissue using HIFU or other energy modality to ablate a pattern of elemental treatment volumes each having a volume that is greater than that of the focal zone of the HIFU transducer but smaller than the overall volume of the desired treatment volume. In one embodiment, the pattern of elemental treatment volumes are arranged to form a shell which partially or wholly encapsulates the desired volume of tissue, which then necroses in situ due to effects other than direct HIFU damage (including some combination of ischemia, thermal conduction, inflammation, apoptosis, etc.). The necrosed tissue remains in the body and is subsequently resorbed and/or healed via normal body mechanisms.

    摘要翻译： 一种使用HIFU或其他能量模式来治疗期望体积的组织的方法，以消融每个具有大于HIFU换能器的焦点区域的体积的体积的元素处理体积的图案，但小于所需治疗的总体积 卷。 在一个实施方案中，元件处理体积的图案被布置成形成部分地或完全地包封所需体积的组织的壳，其由于除了直接HIFU损伤之外的作用（包括局部缺血，热传导， 炎症，凋亡等）。 坏死的组织保留在体内，随后通过正常的身体机制吸收和/或愈合。

    METHOD AND APPARATUS FOR TREATING TISSUES WITH HIFU
    4.
    发明申请
    METHOD AND APPARATUS FOR TREATING TISSUES WITH HIFU 有权
    用HIFU治疗组织的方法和装置

    公开(公告)号：US20100210976A1

    公开(公告)日：2010-08-19

    申请号：US12573840

    申请日：2009-10-05

    申请人： Gregory P. Darlington ,  Michael J. Connolly ,  Justin A. Reed ,  Jessica E. Parsons ,  Roland Horth ,  John Murkowski

    发明人： Gregory P. Darlington ,  Michael J. Connolly ,  Justin A. Reed ,  Jessica E. Parsons ,  Roland Horth ,  John Murkowski

    IPC分类号： A61N7/00

    CPC分类号： A61N7/02 ,  A61B2090/378 ,  A61N2007/0082

    摘要： A method for treating a desired volume of tissue using HIFU or other energy modality to ablate a pattern of elemental treatment volumes each having a volume that is greater than that of the focal zone of the HIFU transducer but smaller than the overall volume of the desired treatment volume. In one embodiment, the pattern of elemental treatment volumes are arranged to form a shell which partially or wholly encapsulates the desired volume of tissue, which then necroses in situ due to effects other than direct HIFU damage (including some combination of ischemia, thermal conduction, inflammation, apoptosis, etc.). The necrosed tissue remains in the body and is subsequently resorbed and/or healed via normal body mechanisms.

    摘要翻译： 一种使用HIFU或其他能量模式来治疗期望体积的组织的方法，以消融每个具有大于HIFU换能器的焦点区域的体积的体积的元素处理体积的图案，但小于所需治疗的总体积 卷。 在一个实施方案中，元件处理体积的图案被布置成形成部分地或完全地包封所需体积的组织的壳，其由于除了直接HIFU损伤之外的作用（包括局部缺血，热传导， 炎症，凋亡等）。 坏死的组织保留在体内，随后通过正常的身体机制吸收和/或愈合。

    METHOD AND APPARATUS FOR FEEDBACK CONTROL OF HIFU TREATMENTS
    5.
    发明申请
    METHOD AND APPARATUS FOR FEEDBACK CONTROL OF HIFU TREATMENTS 有权
    HIFU治疗反馈控制的方法与装置

    公开(公告)号：US20100106019A1

    公开(公告)日：2010-04-29

    申请号：US12606129

    申请日：2009-10-26

    申请人： Barry Friemel ,  Jessica E. Parsons ,  Charles D. Emery ,  Gregory P. Darlington ,  Justin A. Reed ,  Tim Etchells

    发明人： Barry Friemel ,  Jessica E. Parsons ,  Charles D. Emery ,  Gregory P. Darlington ,  Justin A. Reed ,  Tim Etchells

    IPC分类号： A61N7/00 ,  A61B8/00

    CPC分类号： A61B8/08 ,  A61B17/42 ,  A61B2017/00119 ,  A61B2090/378 ,  A61N7/02

    摘要： HIFU therapy to a desired tissue site is controlled based on detected changes in one or more characteristics of a received backscatter signal resulting from exposure of the tissue to HIFU or other interrogation signals. In one embodiment, the bloom of backscatter signals outward from a treatment region (e.g., towards the HIFU transducer) is detected and monitored. Once the bloom reaches a predetermined location, treatment is stopped. Other signal characteristics such as angular distribution of frequency components in the backscatter signal, changes in reflection, power required to saturate a tissue characteristic, changes in attenuation and changes in a cumulative energy distribution function of the backscatter signal that change as a result of the application of HIFU power are also used to control the delivery of HIFU signals in accordance with other embodiments of the disclosed technology.

    摘要翻译： 基于通过将组织暴露于HIFU或其他询问信号而导致的接收的反向散射信号的一个或多个特性的检测变化来控制对所需组织部位的HIFU治疗。 在一个实施例中，检测和监视来自处理区域（例如，朝向HIFU换能器）向外的反向散射信号的绽放。 一旦绽放到达预定位置，治疗就停止。 其他信号特性，例如反向散射信号中的频率分量的角度分布，反射变化，饱和组织特征所需的功率，衰减的变化以及作为应用的结果而改变的反向散射信号的累积能量分布函数的变化 的HIFU功率也用于根据所公开技术的其他实施例来控制HIFU信号的传送。

    Method and apparatus for feedback control of HIFU treatments
    6.
    发明授权
    Method and apparatus for feedback control of HIFU treatments 有权
    HIFU治疗反馈控制方法及装置

    公开(公告)号：US08480600B2

    公开(公告)日：2013-07-09

    申请号：US12606129

    申请日：2009-10-26

    申请人： Barry Friemel ,  Jessica E. Parsons ,  Charles D. Emery ,  Gregory P. Darlington ,  Justin A. Reed ,  Tim Etchells

    发明人： Barry Friemel ,  Jessica E. Parsons ,  Charles D. Emery ,  Gregory P. Darlington ,  Justin A. Reed ,  Tim Etchells

    IPC分类号： A61B8/00

    CPC分类号： A61B8/08 ,  A61B17/42 ,  A61B2017/00119 ,  A61B2090/378 ,  A61N7/02

    摘要： HIFU therapy to a desired tissue site is controlled based on detected changes in one or more characteristics of a received backscatter signal resulting from exposure of the tissue to HIFU or other interrogation signals. In one embodiment, the bloom of backscatter signals outward from a treatment region (e.g., towards the HIFU transducer) is detected and monitored. Once the bloom reaches a predetermined location, treatment is stopped. Other signal characteristics such as angular distribution of frequency components in the backscatter signal, changes in reflection, power required to saturate a tissue characteristic, changes in attenuation and changes in a cumulative energy distribution function of the backscatter signal that change as a result of the application of HIFU power are also used to control the delivery of HIFU signals in accordance with other embodiments of the disclosed technology.

    摘要翻译： 基于通过将组织暴露于HIFU或其他询问信号而导致的接收的反向散射信号的一个或多个特性的检测变化来控制对所需组织部位的HIFU治疗。 在一个实施例中，检测和监视来自处理区域（例如，朝向HIFU换能器）向外的反向散射信号的绽放。 一旦绽放到达预定位置，治疗就停止。 其他信号特性，例如反向散射信号中的频率分量的角度分布，反射变化，饱和组织特征所需的功率，衰减的变化以及作为应用的结果而改变的反向散射信号的累积能量分布函数的变化 的HIFU功率也用于根据所公开技术的其他实施例来控制HIFU信号的传送。

    OPTIMIZATION AND FEEDBACK CONTROL OF HIFU POWER DEPOSITION THROUGH THE ANALYSIS OF DETECTED SIGNAL CHARACTERISTICS
    7.
    发明申请
    OPTIMIZATION AND FEEDBACK CONTROL OF HIFU POWER DEPOSITION THROUGH THE ANALYSIS OF DETECTED SIGNAL CHARACTERISTICS 有权
    通过检测信号特性分析，HIFU功率沉积的优化和反馈控制

    公开(公告)号：US20100036292A1

    公开(公告)日：2010-02-11

    申请号：US12537217

    申请日：2009-08-06

    申请人： Gregory P. Darlington ,  Charles D. Emery ,  Justin A. Reed ,  Barry Friemel

    发明人： Gregory P. Darlington ,  Charles D. Emery ,  Justin A. Reed ,  Barry Friemel

    IPC分类号： A61N7/00

    CPC分类号： A61N7/00 ,  A61B2017/00106 ,  A61B2090/378 ,  A61N7/02 ,  A61N2007/0052

    摘要： A system and method for adjusting or selecting the treatment parameters for HIFU signals to treat a target treatment site, and/or to aid in visualizing the likely degree and location of HIFU effects on patient tissue. The system transmits one or more test signals into patient tissue and receives signals created in response to the test signals. The signals are analyzed to determine a response curve of how a characteristic of the signal varies with the one or more test signals. The response curve of the detected signals is used to select a treatment parameter.

    摘要翻译： 用于调整或选择HIFU信号的治疗参数以治疗目标治疗部位的系统和方法，和/或帮助将HIFU效应的可能程度和位置可视化到患者组织上。 系统将一个或多个测试信号传输到患者组织中并接收响应于测试信号产生的信号。 分析信号以确定信号的特性如何随着一个或多个测试信号而变化的响应曲线。 检测信号的响应曲线用于选择治疗参数。

    Optimization and feedback control of HIFU power deposition through the frequency analysis of backscattered HIFU signals
    9.
    发明授权
    Optimization and feedback control of HIFU power deposition through the frequency analysis of backscattered HIFU signals 有权
    通过后向散射HIFU信号的频率分析优化和反馈控制HIFU功率沉积

    公开(公告)号：US08216161B2

    公开(公告)日：2012-07-10

    申请号：US12187318

    申请日：2008-08-06

    申请人： Gregory P. Darlington ,  Charles D. Emery ,  Justin A. Reed

    发明人： Gregory P. Darlington ,  Charles D. Emery ,  Justin A. Reed

    IPC分类号： A61H1/00

    CPC分类号： A61N7/02 ,  A61B2017/00106 ,  A61B2090/378

    摘要： A system and method for dynamically adjusting the energy of HIFU signals delivered to a patient, and/or to aid in visualizing the likely degree and location of HIFU effects on patient tissue. The system transmits a HIFU signal into a patient and receives echoes therefrom. The echo signals are analyzed to determine the energy of the signals in a first range, such as at one or more harmonics and/or sub-harmonics of the fundamental frequency of the HIFU signal, and energy of the echo signals in a second range such as at the fundamental frequency of the HIFU signal. Based on the comparison, the energy and/or focus of the HIFU signals delivered to the patient is adjusted. An image of the compared echo signal powers in two or more frequency ranges may also be displayed for a user or used to adjust the focus point of the HIFU signals.

    摘要翻译： 用于动态地调节传递给患者的HIFU信号的能量的系统和方法，和/或帮助将HIFU效应的可能程度和位置可视化在患者组织上。 系统将HIFU信号发送到患者体内并从其接收回波。 分析回波信号以确定在第一范围内的信号的能量，例如在HIFU信号的基频的一个或多个谐波和/或次谐波处，以及在第二范围内的回波信号的能量 如HIFU信号的基频。 基于比较，调节传送给患者的HIFU信号的能量和/或焦点。 也可以为用户显示比较的回波信号在两个或更多个频率范围内的功率的图像，或用于调整HIFU信号的焦点。

    OPTIMIZATION AND FEEDBACK CONTROL OF HIFU POWER DEPOSITION THROUGH THE FREQUENCY ANALYSIS OF BACKSCATTERED HIFU SIGNALS
    10.
    发明申请
    OPTIMIZATION AND FEEDBACK CONTROL OF HIFU POWER DEPOSITION THROUGH THE FREQUENCY ANALYSIS OF BACKSCATTERED HIFU SIGNALS 有权
    通过后置式HIFU信号的频率分析对高功率放电的优化和反馈控制

    公开(公告)号：US20100036291A1

    公开(公告)日：2010-02-11

    申请号：US12187318

    申请日：2008-08-06

    申请人： Gregory P. Darlington ,  Charles D. Emery ,  Justin A. Reed

    发明人： Gregory P. Darlington ,  Charles D. Emery ,  Justin A. Reed

    IPC分类号： A61N7/00

    CPC分类号： A61N7/02 ,  A61B2017/00106 ,  A61B2090/378

    摘要： A system and method for dynamically adjusting the energy of HIFU signals delivered to a patient, and/or to aid in visualizing the likely degree and location of HIFU effects on patient tissue. The system transmits a HIFU signal into a patient and receives echoes therefrom. The echo signals are analyzed to determine the energy of the signals in a first range, such as at one or more harmonics and/or sub-harmonics of the fundamental frequency of the HIFU signal, and energy of the echo signals in a second range such as at the fundamental frequency of the HIFU signal. Based on the comparison, the energy and/or focus of the HIFU signals delivered to the patient is adjusted. An image of the compared echo signal powers in two or more frequency ranges may also be displayed for a user or used to adjust the focus point of the HIFU signals.

    摘要翻译： 用于动态地调节传递给患者的HIFU信号的能量的系统和方法，和/或帮助将HIFU效应的可能程度和位置可视化在患者组织上。 系统将HIFU信号发送到患者体内并从其接收回波。 分析回波信号以确定在第一范围内的信号的能量，例如在HIFU信号的基频的一个或多个谐波和/或次谐波处，以及在第二范围内的回波信号的能量 如HIFU信号的基频。 基于比较，调节传送给患者的HIFU信号的能量和/或焦点。 也可以为用户显示比较的回波信号在两个或更多个频率范围内的功率的图像，或用于调整HIFU信号的焦点。