公开(公告)号：US5370642A

公开(公告)日：1994-12-06

申请号：US102851

申请日：1993-08-02

申请人： Gregory S. Keller

发明人： Gregory S. Keller

IPC分类号： A61B17/00 ,  A61B18/22 ,  A61B17/36

CPC分类号： A61B18/22 ,  A61B2017/00761

摘要： Laser surgery is utilized to perform cosmetic surgery. A quartz fiber is used to direct the laser energy to the target area for the incision, division or resection of tissue. An endoscope may be utilized in conjunction with the quartz fiber to perform the cosmetic surgical techniques. One application utilizes laser energy to eliminate glabellar frown lines and/or forehead wrinkles. Another application employs laser energy to rectify brow descent. A further application uses laser energy to perform a neck lift. In yet another application, laser energy is utilized to reduce nasolabial folds. The use of laser energy in cosmetic surgical procedures greatly reduces the size of the incision required in the skin to perform cosmetic surgical procedures, and as a result greatly reduces the risks of potential complications.

摘要翻译： 利用激光手术进行整容手术。 使用石英纤维将激光能量引导到目标区域用于切割，分割或切除组织。 内窥镜可以与石英纤维一起使用以执行整容手术技术。 一种应用使用激光能量来消除皱纹皱纹和/或前额皱纹。 另一个应用程序采用激光能量来纠正眉毛下降。 另外的应用使用激光能量来执行颈部提升。 在另一个应用中，利用激光能量来减少鼻唇褶皱。 在化妆品外科手术中使用激光能量大大降低了皮肤所需的切口尺寸以进行美容外科手术，从而大大降低了潜在并发症的风险。

公开(公告)号：US20080311089A1

公开(公告)日：2008-12-18

申请号：US12194316

申请日：2008-08-19

申请人： Gregory S. Keller

发明人： Gregory S. Keller

IPC分类号： A61P11/04 ,  A01N63/00 ,  A61B19/00

CPC分类号： A61L27/3804 ,  A61K35/12 ,  A61K38/00 ,  A61L27/24 ,  A61L27/3633 ,  A61L27/3641 ,  A61L27/3683 ,  A61L27/3839 ,  A61L27/3895 ,  C12N5/0068 ,  C12N5/0653 ,  C12N5/0656 ,  C12N2533/54

摘要： The present invention provides a method for corrective surgery in a human subject of a vocal cord defect being amenable to rectification by the augmentation of tissue subjacent to the vocal cord defect comprising the steps of: a) retrieving a plurality of viable cells from the subject; b) culturing the viable cells in vitro; and c) placing an effective volume of the in vitro cultured cells into a tissue of the subject, the tissue being located in a position subjacent to the vocal cord defect to be rectified. The present invention further provides a method for corrective surgery in a human subject of a vocal cord defect being amenable to rectification by the augmentation of tissue subjacent to the vocal cord defect comprising the steps of: a) retrieving a plurality of viable cells from the subject; b) culturing the cells in vitro in a culture vessel for a time sufficient for the cells to produce extracellular matrix; c) separating the extracellular matrix produced by the cells from the culture vessel; d) collecting the extracellular matrix; and e) placing the collected extracellular matrix into a tissue subjacent to the vocal cord defect.

摘要翻译： 本发明提供了一种用于矫正手术的方法，所述方法包括以下步骤：a）从所述受试者中检索多个活细胞，所述方法包括以下步骤：通过增加声带缺损附近的组织来矫正声带缺损的矫正手术， b）体外培养活细胞; 以及c）将有效体积的体外培养的细胞置于受试者的组织中，所述组织位于与声带缺损相邻的位置以进行矫正。 本发明还提供了一种用于矫形手术的方法，其用于通过增加与声带缺损相邻的组织的增大来矫正声带缺损，所述方法包括以下步骤：a）从所述对象中检索多个活细胞 ; b）在培养容器中体外培养细胞足以使细胞产生细胞外基质的时间; c）从培养容器中分离细胞产生的细胞外基质; d）收集细胞外基质; 和e）将收集的细胞外基质置于与声带缺损相邻的组织中。

公开(公告)号：US5807385A

公开(公告)日：1998-09-15

申请号：US477333

申请日：1995-06-07

申请人： Gregory S. Keller

发明人： Gregory S. Keller

IPC分类号： A61B17/00 ,  A61B18/22 ,  A61N5/06

CPC分类号： A61B18/22 ,  A61B2017/00761

摘要： Laser surgery is utilized to perform cosmetic surgery. A quartz fiber is used to direct the laser energy to the target area for the incision, division or resection of tissue. An endoscope may be utilized in conjunction with the quartz fiber to perform the cosmetic surgical techniques. One application utilizes laser energy to eliminate glabellar frown lines and/or forehead wrinkles. Another application employs laser energy to rectify brow descent. A further application uses laser energy to perform a neck lift. In yet another application, laser energy is utilized to reduce nasolabial folds. The use of laser energy in cosmetic surgical procedures greatly reduces the size of the incision required in the skin to perform cosmetic surgical procedures, and as a result greatly reduces the risks of potential complications.

公开(公告)号：US5505727A

公开(公告)日：1996-04-09

申请号：US473495

申请日：1995-06-07

申请人： Gregory S. Keller

发明人： Gregory S. Keller

IPC分类号： A61B17/00 ,  A61B18/22 ,  A61B17/36

CPC分类号： A61B18/22 ,  A61B2017/00761

摘要： Laser surgery is utilized to perform cosmetic surgery. A quartz fiber is used to direct the laser energy to the target area for the incision, division or resection of tissue. An endoscope may be utilized in conjunction with the quartz fiber to perform the cosmetic surgical techniques. One application utilizes laser energy to eliminate glabellar frown lines and/or forehead wrinkles. Another application employs laser energy to rectify brow descent. A further application uses laser energy to perform a neck lift. In yet another application, laser energy is utilized to reduce nasolabial folds. The use of laser energy in cosmetic surgical procedures greatly reduces the size of the incision required in the skin to perform cosmetic surgical procedures, and as a result greatly reduces the risks of potential complications.

公开(公告)号：US08261749B2

公开(公告)日：2012-09-11

申请号：US12194316

申请日：2008-08-19

申请人： Gregory S. Keller

发明人： Gregory S. Keller

IPC分类号： A61B19/00

CPC分类号： A61L27/3804 ,  A61K35/12 ,  A61K38/00 ,  A61L27/24 ,  A61L27/3633 ,  A61L27/3641 ,  A61L27/3683 ,  A61L27/3839 ,  A61L27/3895 ,  C12N5/0068 ,  C12N5/0653 ,  C12N5/0656 ,  C12N2533/54

摘要： A method for corrective surgery in a human subject of a vocal cord defect amenable to rectification by the augmentation of tissue subadjacent to the vocal cord defect, the method comprising: injecting an effective amount of autologous in vitro cultured fibroblast cells into the lamina propia, Reinke's space, the lateral tissue or the lateral edge of the vocal cord tissue of the subject in a position subadjacent to the vocal cord defect, wherein the in vitro fibroblast cultured cells are retrieved from the subject.

摘要翻译： 一种用于矫正手术的方法，该方法包括：将有效量的自体体外培养的成纤维细胞注射到椎板内的Rein染色体 空间，侧组织或受试者的声带组织的侧边缘处于与声带缺损相邻的位置，其中体外成纤维细胞培养的细胞从受试者中回收。

公开(公告)号：US5445634A

公开(公告)日：1995-08-29

申请号：US314659

申请日：1994-09-29

申请人： Gregory S. Keller

发明人： Gregory S. Keller

IPC分类号： A61B17/00 ,  A61B18/22 ,  A61B17/36

CPC分类号： A61B18/22 ,  A61B2017/00761

摘要： Laser surgery is utilized to perform cosmetic surgery. A quartz fiber is used to direct the laser energy to the target area for the incision, division or resection of tissue. An endoscope may be utilized in conjunction with the quartz fiber to perform the cosmetic surgical techniques. One application utilizes laser energy to eliminate glabellar frown lines and/or forehead wrinkles. Another application employs laser energy to rectify brow descent. A further application uses laser energy to perform a neck lift. In yet another application, laser energy is utilized to reduce nasolabial folds. The use of laser energy in cosmetic surgical procedures greatly reduces the size of the incision required in the skin to perform cosmetic surgical procedures, and as a result greatly reduces the risks of potential complications.

公开(公告)号：US07846465B1

公开(公告)日：2010-12-07

申请号：US09980150

申请日：2000-05-26

申请人： Gregory S. Keller ,  Elena Revazova

发明人： Gregory S. Keller ,  Elena Revazova

IPC分类号： A61F2/02

CPC分类号： C12N5/0656 ,  A61K35/12

摘要： The invention provides a method or promoting healing of a wound, e.g., an epithelial wound, in an animal. The method involves administering cultured autologous fibroblasts to the wound.

摘要翻译： 本发明提供在动物中的方法或促进伤口（例如上皮创伤）的愈合。 该方法包括将培养的自体成纤维细胞给予伤口。

公开(公告)号：US07412978B1

公开(公告)日：2008-08-19

申请号：US09634038

申请日：2000-08-08

申请人： Gregory S. Keller

发明人： Gregory S. Keller

IPC分类号： A61B19/00

CPC分类号： A61L27/3804 ,  A61K35/12 ,  A61K38/00 ,  A61L27/24 ,  A61L27/3633 ,  A61L27/3641 ,  A61L27/3683 ,  A61L27/3839 ,  A61L27/3895 ,  C12N5/0068 ,  C12N5/0653 ,  C12N5/0656 ,  C12N2533/54

摘要： A method for corrective surgery in a human subject of a vocal cord defect amenable to rectification by the augmentation of tissue subadjacent to the vocal cord defect, the method comprising: placing an effective amount of autologous in vitro cultured cells into a vocal cord tissue of the subject in a position subadjacent to the vocal cord defect, wherein the vocal cord tissue is selected from the group consisting of a scar, Reinke's space, a muscle of the vocal cord, and the lamina propria, wherein the in vitro cultured cells are obtained by culturing a plurality of viable cells retrieved from the subject, and wherein the cultured cells are suspended in a collagen or modified collagen solution prior to injection of the cultured cells. The in vitro cultured cells can be fibroblasts, e.g., fibroblasts derived from dermis, fascia, connective tissue, or lamina propria.

摘要翻译： 一种用于通过增加与声带缺损相邻的组织增加来矫正声带缺损的人类受试者的矫正手术的方法，所述方法包括：将有效量的自体体外培养的细胞置于所述声带组织中 受试者位于与声带缺损相邻的位置，其中声带组织选自疤痕，Reinke的空间，声带的肌肉和固有层，其中体外培养的细胞通过 培养从受试者取回的多个活细胞，并且其中培养的细胞在注射培养的细胞之前悬浮在胶原或改性胶原溶液中。 体外培养的细胞可以是成纤维细胞，例如衍生自真皮，筋膜，结缔组织或固有层的成纤维细胞。

公开(公告)号：US07115274B2

公开(公告)日：2006-10-03

申请号：US11040419

申请日：2005-01-21

申请人： Gregory S. Keller ,  Elena Revazova

发明人： Gregory S. Keller ,  Elena Revazova

IPC分类号： A61F2/02

CPC分类号： C12N5/0656 ,  A61K35/12

摘要： The present invention provides a method of using autologous fibroblasts to promote wound or fistula healing in an animal.

摘要翻译： 本发明提供使用自体成纤维细胞促进动物中的伤口或瘘修复的方法。

公开(公告)号：USRE36903E

公开(公告)日：2000-10-03

申请号：US360708

申请日：1999-07-26

申请人： Gregory S. Keller

发明人： Gregory S. Keller

IPC分类号： A61B17/00 ,  A61B18/22 ,  A61N5/06

CPC分类号： A61B18/22 ,  A61B2017/00761

摘要： Laser surgery is utilized to perform cosmetic surgery. A quartz fiber is used to direct the laser energy to the target area for the incision, division or resection of tissue. An endoscope may be utilized in conjunction with the quartz fiber to perform the cosmetic surgical techniques. One application utilizes laser energy to eliminate glabellar frown lines and/or forehead wrinkles. Another application employs laser energy to rectify brow descent. A further application uses laser energy to perform a neck lift. In yet another application, laser energy is utilized to reduce nasolabial folds. The use of laser energy in cosmetic surgical procedures greatly reduces the size of the incision required in the skin to perform cosmetic surgical procedures, and as a result greatly reduces the risks of potential complications.

摘要翻译： 利用激光手术进行整容手术。 使用石英纤维将激光能量引导到目标区域用于切割，分割或切除组织。 内窥镜可以与石英纤维一起使用以执行整容手术技术。 一种应用使用激光能量来消除皱纹皱纹和/或前额皱纹。 另一个应用程序采用激光能量来纠正眉毛下降。 另外的应用使用激光能量来执行颈部提升。 在另一个应用中，利用激光能量来减少鼻唇褶皱。 在化妆品外科手术中使用激光能量大大降低了皮肤所需的切口尺寸以进行美容外科手术，从而大大降低了潜在并发症的风险。