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    Modified Poloxamers for Gene Expression and Associated Methods
    5.
    发明申请
    Modified Poloxamers for Gene Expression and Associated Methods 审中-公开
    用于基因表达和相关方法的改良的泊洛沙姆

    公开(公告)号：US20100004313A1

    公开(公告)日：2010-01-07

    申请号：US12395240

    申请日：2009-02-27

    申请人： Gregory Slobodkin ,  Majed Matar ,  Brian Jeffery Sparks ,  Jason Fewell ,  Khursheed Anwer

    发明人： Gregory Slobodkin ,  Majed Matar ,  Brian Jeffery Sparks ,  Jason Fewell ,  Khursheed Anwer

    IPC分类号： A61K48/00 ,  C08G65/00

    CPC分类号： C08G65/329 ,  A61K9/0019 ,  A61K47/34

    摘要： Nucleotide delivery polymers, compositions, and associated methods for the enhancement of gene delivery and expression in solid tissues are provided. In one aspect, for example, a nucleotide delivery polymer may include a poloxamer backbone having a metal chelator covalently coupled to at least one terminal end of the poloxamer backbone. In another aspect, the nucleotide expression polymer has a metal chelator coupled to at least two terminal ends of the poloxamer backbone.

    摘要翻译： 提供了用于增强固体组织中基因递送和表达的核苷酸递送聚合物，组合物和相关方法。 在一个方面，例如，核苷酸递送聚合物可以包括具有与泊洛沙姆主链的至少一个末端共价连接的金属螯合剂的泊洛沙姆骨架。 另一方面，核苷酸表达聚合物具有与泊洛沙姆主链的至少两个末端偶联的金属螯合剂。

    Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof
    8.
    发明授权
    Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof 有权
    用于基因递送的可生物降解的交联阳离子多嵌段共聚物及其制备方法

    公开(公告)号：US08445017B2

    公开(公告)日：2013-05-21

    申请号：US13237168

    申请日：2011-09-20

    申请人： Gregory Slobodkin ,  Majed Matar ,  Jason Fewell ,  Khursheed Anwer

    发明人： Gregory Slobodkin ,  Majed Matar ,  Jason Fewell ,  Khursheed Anwer

    IPC分类号： A61K48/00

    CPC分类号： C08G73/0206 ,  A61K47/34 ,  A61K48/00

    摘要： A biodegradable cross-linked cationic multi-block copolymer of linear polyethylenimine (LPEI) wherein the LPEI blocks are linked together by hydrophilic linkers with a biodegradable disulfide bond and methods of making thereof. The biodegradable cross-linked cationic multi-block copolymer may also contain pendant functional moieties which are preferably receptor ligands, membrane permeating agents, endosomolytic agents, nuclear localization sequences, pH sensitive endosomolytic peptides, chromogenic or fluorescent dyes.

    摘要翻译： 线性聚乙烯亚胺（LPEI）的可生物降解的交联阳离子多嵌段共聚物，其中LPEI嵌段通过具有可生物降解的二硫键的亲水接头连接在一起及其制备方法。 可生物降解的交联阳离子多嵌段共聚物还可以含有侧链官能部分，其优选为受体配体，膜渗透剂，内体分解剂，核定位序列，pH敏感性内分解酶，显色或荧光染料。

    Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof
    9.
    发明授权
    Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof 有权
    用于基因递送的可生物降解的交联阳离子多嵌段共聚物及其制备方法

    公开(公告)号：US08057821B2

    公开(公告)日：2011-11-15

    申请号：US10981135

    申请日：2004-11-03

    申请人： Gregory Slobodkin ,  Majed Matar ,  Jason Fewell ,  Khursheed Anwer

    发明人： Gregory Slobodkin ,  Majed Matar ,  Jason Fewell ,  Khursheed Anwer

    IPC分类号： A61K48/00

    CPC分类号： C08G73/0206 ,  A61K47/34 ,  A61K48/00

    摘要： A biodegradable cross-linked cationic multi-block copolymer of linear polyethylenimine (LPEI) wherein the LPEI blocks are linked together by hydrophilic linkers with a biodegradable disulfide bond and methods of making thereof. The biodegradable cross-linked cationic multi-block copolymer may also contain pendant functional moieties which are preferably receptor ligands, membrane permeating agents, endosomolytic agents, nuclear localization sequences, pH sensitive endosomolytic peptides, chromogenic or fluorescent dyes.

    摘要翻译： 线性聚乙烯亚胺（LPEI）的可生物降解的交联阳离子多嵌段共聚物，其中LPEI嵌段通过具有可生物降解的二硫键的亲水接头连接在一起及其制备方法。 可生物降解的交联阳离子多嵌段共聚物还可以含有优选受体配体，膜渗透剂，内体分解剂，核定位序列，pH敏感性内分解酶，显色或荧光染料的侧链官能部分。