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公开(公告)号:US20060014673A1
公开(公告)日:2006-01-19
申请号:US11174996
申请日:2005-07-06
申请人: Richard Layer , Karen Pemberton , Robert Jones , James Garrett , Baldomero Olivera , J. McIntosh , David Hillyard , Michelle Grilley , Maren Watkins , Ameurfina Santos , Glenn Zafaralla , A. Craig
发明人: Richard Layer , Karen Pemberton , Robert Jones , James Garrett , Baldomero Olivera , J. McIntosh , David Hillyard , Michelle Grilley , Maren Watkins , Ameurfina Santos , Glenn Zafaralla , A. Craig
IPC分类号: A61K38/16 , C07K14/435
CPC分类号: A61K38/17 , C07K14/43504
摘要: The present invention is directed to kappaA (κA) conopeptides and the use of these peptides for blocking the flow of potassium ions through voltage-gated potassium channels. The κA conopeptides include unglycosylated and O-glycosylated peptides.
摘要翻译: 本发明涉及kappaA(kappaA)肽以及这些肽用于阻断通过电压门控钾通道的钾离子流动的用途。 κA肽包括非糖基化和O-糖基化肽。
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公开(公告)号:US20060247173A1
公开(公告)日:2006-11-02
申请号:US11482148
申请日:2006-07-07
申请人: Baldomero Olivera , Richard Layer , Maren Watkins , David Hillyard , J. McIntosh , Robert Schoenfeld , Jacob Nielsen , Robert Jones
发明人: Baldomero Olivera , Richard Layer , Maren Watkins , David Hillyard , J. McIntosh , Robert Schoenfeld , Jacob Nielsen , Robert Jones
IPC分类号: A61K38/17 , C07K14/435
CPC分类号: C07K14/435 , A61K38/00 , C07K14/43504
摘要: The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The α-conotoxins, as described herein, are useful for as neuromuscular blocking agents, such as muscle relaxants.
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公开(公告)号:US20050214903A1
公开(公告)日:2005-09-29
申请号:US10839227
申请日:2004-05-06
申请人: Baldomero Olivera , G. Cartier , Maren Watkins , David Hillyard , J. McIntosh , Richard Layer , Robert Jones
发明人: Baldomero Olivera , G. Cartier , Maren Watkins , David Hillyard , J. McIntosh , Richard Layer , Robert Jones
IPC分类号: G01N33/50 , A61K38/00 , A61P3/10 , A61P9/00 , A61P9/06 , A61P11/06 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/20 , A61P25/28 , A61P25/36 , A61P29/00 , A61P35/00 , A61P37/06 , A61P39/00 , A61P43/00 , C07K14/435 , C12N15/09 , G01N33/15 , G01N33/53 , G01N33/566 , C07H21/04
CPC分类号: C07K14/43504 , A61K38/00
摘要: The invention relates to relatively short peptides (termed O-Superfamily conotoxins herein), about 20-40 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译: 本发明涉及相对较短的肽(本文中称为O超家族芋螺毒素),长度约20-40个残基,其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽,并且其优选包括 两个二硫键。
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公开(公告)号:US20050203003A1
公开(公告)日:2005-09-15
申请号:US10067857
申请日:2002-02-08
申请人: A. Craig , David Griffin , Baldomero Olivera , Maren Watkins , David Hillyard , Julita Imperial , Lourdes Cruz , John Wagstaff , Richard Layer , Robert Jones , R. McCabe
发明人: A. Craig , David Griffin , Baldomero Olivera , Maren Watkins , David Hillyard , Julita Imperial , Lourdes Cruz , John Wagstaff , Richard Layer , Robert Jones , R. McCabe
IPC分类号: C12N15/09 , A61K38/00 , A61P1/00 , A61P1/04 , A61P1/12 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P29/00 , A61P35/00 , A61P43/00 , C07K7/08 , C07K9/00 , C07K14/435 , C07K14/575 , C12N15/12 , A61K38/14 , A61K38/10
CPC分类号: C07K7/08 , A61K38/00 , C07K9/001 , C07K14/575
摘要: The present invention is directed to contulakin-G (which is the native glycosylated peptide), a des-glycosylated contulakin-G (termed Thr10-contulakin-G), and derivatives thereof, to a cDNA clone encoding a precursor of this mature peptide and to a precursor peptide. The invention is further directed to the use of this peptide as a therapeutic for anti-seizure, anti-inflammatory, anti-shock, anti-thrombus, hypotensive, analgesia, anti-psychotic, Parkinson's disease, gastrointestinal disorders, depressive states, cognitive dysfunction, anxiety, tardive dyskinesia, drug dependency, panic attack, mania, irritable bowel syndrome, diarrhea, ulcer, GI tumors, Tourette's syndrome, Huntington's chorea, vascular leakage, anti-arteriosclerosis, vascular and vasodilation disorders, as well as neurological, neuropharmalogical and neuropsychopharmacological disorders.
摘要翻译: 本发明涉及对于cDNA克隆的contulakin-G(其是天然糖基化肽),去糖基化的唾液蛋白-G(称为Thr 10 -contulakin-G)及其衍生物 编码该成熟肽的前体和前体肽。 本发明进一步涉及该肽作为抗癫痫发作,抗炎,抗休克,抗血栓,降血压,止痛,抗精神病,帕金森病,胃肠道疾病,抑郁状态,认知功能障碍 焦虑症,迟发性运动障碍,药物依赖性,恐慌发作,躁狂症,肠易激综合征,腹泻,溃疡,胃肠道肿瘤,杜氏综合征,亨廷顿氏舞蹈病,血管渗漏,抗动脉硬化,血管和血管舒张障碍,以及神经系统,神经功能和 神经精神药理学障碍。
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公开(公告)号:US20060040312A1
公开(公告)日:2006-02-23
申请号:US11259039
申请日:2005-10-27
申请人: Ann Cornell-Bell , Karen Pemberton , Davis Temple , Richard Layer , R. McCabe , Robert Jones
发明人: Ann Cornell-Bell , Karen Pemberton , Davis Temple , Richard Layer , R. McCabe , Robert Jones
CPC分类号: A61K38/17 , C07K14/43504
摘要: The invention relates to uses of kappa-conotoxin PVIIA (κ-PVIIA), analogs and derivatives for activating ATP-sensitive K+ channels. The activation of ATP-sensitive K+ channels is useful for opening KATP channels which can be used to treat a wide range of disease and injury states, including cerebral and cardiac ischemia and asthma.
摘要翻译: 本发明涉及κ-芋螺毒素PVIIA(kappa-PVIIA),类似物和衍生物用于激活ATP敏感性K +通道的用途。 ATP敏感的K + +通道的激活可用于打开可用于治疗广泛范围的疾病和损伤状态的K ATP通道,包括脑和心脏缺血 和哮喘。
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