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公开(公告)号:US20060014673A1
公开(公告)日:2006-01-19
申请号:US11174996
申请日:2005-07-06
申请人: Richard Layer , Karen Pemberton , Robert Jones , James Garrett , Baldomero Olivera , J. McIntosh , David Hillyard , Michelle Grilley , Maren Watkins , Ameurfina Santos , Glenn Zafaralla , A. Craig
发明人: Richard Layer , Karen Pemberton , Robert Jones , James Garrett , Baldomero Olivera , J. McIntosh , David Hillyard , Michelle Grilley , Maren Watkins , Ameurfina Santos , Glenn Zafaralla , A. Craig
IPC分类号: A61K38/16 , C07K14/435
CPC分类号: A61K38/17 , C07K14/43504
摘要: The present invention is directed to kappaA (κA) conopeptides and the use of these peptides for blocking the flow of potassium ions through voltage-gated potassium channels. The κA conopeptides include unglycosylated and O-glycosylated peptides.
摘要翻译: 本发明涉及kappaA(kappaA)肽以及这些肽用于阻断通过电压门控钾通道的钾离子流动的用途。 κA肽包括非糖基化和O-糖基化肽。
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公开(公告)号:US20050203003A1
公开(公告)日:2005-09-15
申请号:US10067857
申请日:2002-02-08
申请人: A. Craig , David Griffin , Baldomero Olivera , Maren Watkins , David Hillyard , Julita Imperial , Lourdes Cruz , John Wagstaff , Richard Layer , Robert Jones , R. McCabe
发明人: A. Craig , David Griffin , Baldomero Olivera , Maren Watkins , David Hillyard , Julita Imperial , Lourdes Cruz , John Wagstaff , Richard Layer , Robert Jones , R. McCabe
IPC分类号: C12N15/09 , A61K38/00 , A61P1/00 , A61P1/04 , A61P1/12 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P9/14 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P29/00 , A61P35/00 , A61P43/00 , C07K7/08 , C07K9/00 , C07K14/435 , C07K14/575 , C12N15/12 , A61K38/14 , A61K38/10
CPC分类号: C07K7/08 , A61K38/00 , C07K9/001 , C07K14/575
摘要: The present invention is directed to contulakin-G (which is the native glycosylated peptide), a des-glycosylated contulakin-G (termed Thr10-contulakin-G), and derivatives thereof, to a cDNA clone encoding a precursor of this mature peptide and to a precursor peptide. The invention is further directed to the use of this peptide as a therapeutic for anti-seizure, anti-inflammatory, anti-shock, anti-thrombus, hypotensive, analgesia, anti-psychotic, Parkinson's disease, gastrointestinal disorders, depressive states, cognitive dysfunction, anxiety, tardive dyskinesia, drug dependency, panic attack, mania, irritable bowel syndrome, diarrhea, ulcer, GI tumors, Tourette's syndrome, Huntington's chorea, vascular leakage, anti-arteriosclerosis, vascular and vasodilation disorders, as well as neurological, neuropharmalogical and neuropsychopharmacological disorders.
摘要翻译: 本发明涉及对于cDNA克隆的contulakin-G(其是天然糖基化肽),去糖基化的唾液蛋白-G(称为Thr 10 -contulakin-G)及其衍生物 编码该成熟肽的前体和前体肽。 本发明进一步涉及该肽作为抗癫痫发作,抗炎,抗休克,抗血栓,降血压,止痛,抗精神病,帕金森病,胃肠道疾病,抑郁状态,认知功能障碍 焦虑症,迟发性运动障碍,药物依赖性,恐慌发作,躁狂症,肠易激综合征,腹泻,溃疡,胃肠道肿瘤,杜氏综合征,亨廷顿氏舞蹈病,血管渗漏,抗动脉硬化,血管和血管舒张障碍,以及神经系统,神经功能和 神经精神药理学障碍。
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