公开(公告)号：US4990601A

公开(公告)日：1991-02-05

申请号：US206345

申请日：1988-08-16

申请人： Gudmund Skjak-Braek ,  Trygve Eklund ,  Kurt O. Von Husby ,  Bjarne J. Kvam ,  Olav Smidsrod

发明人： Gudmund Skjak-Braek ,  Trygve Eklund ,  Kurt O. Von Husby ,  Bjarne J. Kvam ,  Olav Smidsrod

IPC分类号： C08B1/00 ,  C08B20060101 ,  C08B37/00 ,  C08B37/04 ,  C08B37/08

CPC分类号： C08B37/0084 ,  C08B37/0063 ,  Y02P20/544

摘要： A method for modification of alginates or other uronic acid containing compounds to give improved physical properties, wherein the alginates in solid form are treated with CO.sub.2 under supercritical conditions thereby achieving at least partial epimerization of said uronic acid containing compound. The critical point of CO.sub.2 is pcrit=73.83 bar and tcrit=31.degree. C.

摘要翻译： PCT No.PCT / NO87 / 00065 Sec。 371日期1988年8月16日 102（e）日期1988年8月16日PCT提交1987年10月6日PCT公布。 出版物WO88 / 02758 日本1994年4月21日。一种用于改性藻酸盐或其它含糖醛酸化合物以提供改善的物理性质的方法，其中固体形式的藻酸盐在超临界条件下用CO 2处理，从而达到所述含糖醛酸化合物的至少部分差向异构化 。 CO2的临界点为pcrit = 73.83巴，tcrit = 31℃

公开(公告)号：US5166137A

公开(公告)日：1992-11-24

申请号：US676756

申请日：1991-03-27

申请人： Marit Otterlei ,  Terje Espevik ,  Gudmund Skjak-Braek ,  Olav Smidsrod

发明人： Marit Otterlei ,  Terje Espevik ,  Gudmund Skjak-Braek ,  Olav Smidsrod

IPC分类号： A61K31/70 ,  A61K31/715 ,  A61P7/00 ,  A61P9/00 ,  A61P31/04 ,  C08B37/00

CPC分类号： A61K31/715 ,  Y10S514/886 ,  Y10S514/887 ,  Y10S514/921

摘要： A family of compounds effective in inhibiting interleukin-1 (IL-1) production, interleukin-6 (IL-6), tumor necrosis factor (TNF) production, and the production of other leukocyte derived cytokines is comprised of oligomers and polymers of .alpha.1-4 linked L-guluronic acid residues which may be administered to a human or mammal in an amount sufficient to inhibit the production effect of leukocyte-derived cytokines. The inhibition of IL-1, IL-6 and TNF, and other cytokines in mammals is implicated in alleviation of a wide variety of disease conditions.

公开(公告)号：US20100105633A1

公开(公告)日：2010-04-29

申请号：US12448466

申请日：2007-12-20

申请人： Kjell Morton Varum ,  Kurt Ingar Draget ,  Olav Smidsrod

发明人： Kjell Morton Varum ,  Kurt Ingar Draget ,  Olav Smidsrod

IPC分类号： A61K31/722 ,  C08B37/08 ,  A61P43/00

CPC分类号： C08B37/003 ,  A23L29/275

摘要： The invention relates to a process for the preparation of water-soluble chitosan salts, to chitosan products produced by this process and to their uses, e.g. in pharmaceutical or veterinary compositions or as a food or cosmetic additive. More specifically, the invention relates to a process for preparing a water-soluble chitosan salt which comprises: (a) contacting a solid chitosan with at least one protic acid whereby to produce a water-soluble chitosan salt; and (b) optionally recovering said salt, wherein said chitosan is converted into said salt whilst remaining substantially in the solid state. Gaseous or liquid protic acids may be used, including hydrochloric, acetic and propionic acids.

摘要翻译： 本发明涉及一种制备水溶性壳聚糖盐的方法，涉及通过该方法制备的壳聚糖产品及其用途，例如， 在药物或兽医组合物中或作为食品或化妆品添加剂。 更具体地说，本发明涉及一种制备水溶性壳聚糖盐的方法，其包括：（a）使固体壳聚糖与至少一种质子酸接触，从而产生水溶性壳聚糖盐; 和（b）任选地回收所述盐，其中所述壳聚糖转化成所述盐，同时保持基本上处于固态。 可以使用气态或液态的质子酸，包括盐酸，乙酸和丙酸。

公开(公告)号：US5169840A

公开(公告)日：1992-12-08

申请号：US676103

申请日：1991-03-27

申请人： Marit Otterlei ,  Terje Espevik ,  Gudmund Skjak-Brock ,  Olav Smidsrod

发明人： Marit Otterlei ,  Terje Espevik ,  Gudmund Skjak-Brock ,  Olav Smidsrod

IPC分类号： A61K38/21 ,  A61K31/00 ,  A61K31/715 ,  A61P17/02 ,  A61P31/00 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P37/00 ,  C08B37/00 ,  C12P21/02 ,  C12R1/91

CPC分类号： A61K31/00 ,  A61K31/715 ,  Y10S514/908 ,  Y10S514/929

摘要： The present invention is directed to a material and method for the stimulation of the production of cytokines. Several polysaccharides, including polymers of different size of .sym.1-4 linked D-mannuronic acid (poly-M and M-blocks), chitosan and cellulose oxidized in C-6 position C60XY) induce human monocytes to produce the cytokines. Preferably, the molecular weights of poly-M and chitosan are above 50,000 and 20,000 respectively. Pretreatment of the monocytes with IFN-.gamma. increases the cytokine production from monocytes stimulated with all polysaccharides tested. The subject polysaccharides worked in vivo and in vitro.The present invention has therapeutic utility as vaccine adjuvants and components. Therapeutic compositions comprising biologically active quantities of the compositions of the present invention may be employed to potentiate antibody production in response to vaccine antigens. Anti-tumor, anti-bacteriological, anti-fungal and anti-viral effects may be expected.

公开(公告)号：US20060240168A1

公开(公告)日：2006-10-26

申请号：US10544521

申请日：2004-02-06

申请人： Jo Klaveness ,  Einar Mustaparta ,  Bjarne Brudeli ,  Olav Smidsrod ,  Kjell Varum

发明人： Jo Klaveness ,  Einar Mustaparta ,  Bjarne Brudeli ,  Olav Smidsrod ,  Kjell Varum

IPC分类号： A23L1/212

CPC分类号： C08B37/003 ,  A23L5/273 ,  A23L17/40 ,  A23L19/19 ,  A23L29/275 ,  A23L33/22 ,  A61K31/722 ,  A61K47/36

摘要： The invention provides a foodstuff comprising a nutritional food substance and a chitosan having an FA value of at least 0.25.

摘要翻译： 本发明提供一种食品，其包含营养食品物质和至少0.25的F A A值的壳聚糖。

公开(公告)号：US20070036864A1

公开(公告)日：2007-02-15

申请号：US10577306

申请日：2004-10-27

申请人： Knut Börsheim ,  Simon Ballance ,  Bjorn Christensen ,  Olav Smidsrod

发明人： Knut Börsheim ,  Simon Ballance ,  Bjorn Christensen ,  Olav Smidsrod

IPC分类号： A61K9/14

CPC分类号： A61K8/97 ,  A61Q11/00

摘要： An oral hygiene product, such as tooth paste, is described. A methos for controlling undesirable bacterial flora in the oral cavity, as well as the use of the plant Sphagnum, are also described.

摘要翻译： 描述了诸如牙膏的口腔卫生产品。 还描述了用于控制口腔中不期望的细菌菌群的方法以及植物Sphagnum的使用。