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1.发明申请ALKOXY-THIENOPYRIMIDINES AS TGF-BETA RECEPTOR KINASE MODULATORS 审中-公开作为TGF-β受体激酶调节剂的ALKOXY-THIENOPYRIMININES公开(公告)号：US20120101095A1
公开(公告)日：2012-04-26
申请号：US13379773
申请日：2010-05-27
IPC分类号： A61K31/5377 , A61K31/519 , A61P35/00 , A61P35/04 , A61P9/00 , A61P25/28 , A61P9/10 , C12N9/99 , A61P43/00 , C07D495/04 , A61P31/18
CPC分类号： C07D495/04
摘要： Novel alkoxy-thienopyrimidine derivatives of formula (I) wherein R1 and R2 have the meaning according to claim 1, are inhibitors of TGF-beta receptor I kinase, and can be employed, inter alia, for the treatment of tumors.
摘要翻译： 式（I）的新型烷氧基 - 噻吩并嘧啶衍生物，其中R 1和R 2具有权利要求1的含义，是TGF-β受体I激酶的抑制剂，并且可以用于治疗肿瘤。
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![2,4-diaryl-substituted [1,8] naphthyridines as kinase inhibitors for use against cancer](/abs-image/US/2014/07/29/US08791113B2/abs.jpg.150x150.jpg)
2.发明授权2,4-diaryl-substituted [1,8] naphthyridines as kinase inhibitors for use against cancer 有权2,4-二芳基取代的[1,8]萘啶作为抗癌剂的激酶抑制剂公开(公告)号：US08791113B2
公开(公告)日：2014-07-29
申请号：US13807119
申请日：2011-05-31
IPC分类号： A61K31/535 , C07D413/00
CPC分类号： C07D491/048 , A61K31/4375 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D471/04 , C07D519/00
摘要： The present invention relates to novel [1,8]naphthyridine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors.
摘要翻译： 本发明涉及式（I）的新颖的[1,8]萘啶衍生物，以及这样的化合物的用途，其中ATP消耗蛋白质如激酶的信号转导的抑制，调节和/或调节起着重要的作用，特别是 TGF-β受体激酶的抑制剂，以及这些化合物用于治疗激酶诱导的疾病，特别是用于治疗肿瘤的用途。
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![PYRIDO [2, 3 - B] PYRAZINE DERIVATIVES AND THEIR THERAPEUTICAL USES](/abs-image/US/2013/12/26/US20130345227A1/abs.jpg.150x150.jpg)
3.发明申请公开(公告)号：US20130345227A1
公开(公告)日：2013-12-26
申请号：US14002991
申请日：2012-02-13
IPC分类号： C07D471/04 , A61K31/4985 , C07D491/048 , A61K45/06
CPC分类号： C07D471/04 , A61K31/4985 , A61K45/06 , C07D491/048
摘要： The present invention relates to novel pyrido[2,3-b]pyrazine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors.
摘要翻译： 本发明涉及式（I）的新颖的吡啶并[2,3-b]吡嗪衍生物，以及其中抑制，调节和/或调节ATP消耗蛋白质如激酶的信号转导的化合物的用途 ，特别是TGF-β受体激酶的抑制剂，以及这些化合物用于治疗激酶诱导的疾病，特别是用于治疗肿瘤的用途。
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![Hetaryl-[1,8]naphthyridine derivatives](/abs-image/US/2013/12/24/US08614226B2/abs.jpg.150x150.jpg)
公开(公告)号：US08614226B2
公开(公告)日：2013-12-24
申请号：US13574282
申请日：2010-12-17
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02
CPC分类号： C07D471/04 , A61K31/4375 , C07D401/14 , C07D413/14 , C07D519/00
摘要： Novel hetaryl-[1,8]naphthyridine derivatives of formula (I) wherein R1, R2, W1, W3, W5 and W6 have the meaning according to claim 1, are inhibitors of ATP consuming proteins, and can be employed, inter alia, for the treatment of tumors.
摘要翻译： 其中R 1，R 2，W 1，W 3，W 5和W 6具有权利要求1的含义的式（I）的新型杂芳基 - [1,8]二氮杂萘衍生物是ATP消耗蛋白质的抑制剂， 用于治疗肿瘤。
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公开(公告)号：US20130102608A1
公开(公告)日：2013-04-25
申请号：US13808369
申请日：2011-06-07
IPC分类号： C07D401/14 , A61K45/06 , A61K31/496 , A61K31/4545 , A61K31/5377 , A61K31/444
CPC分类号： C07D401/14 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D471/04
摘要： The present invention relates to novel bipyridyl derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors.
摘要翻译： 本发明涉及式（I）的新型联吡啶衍生物和其中ATP消耗蛋白质如激酶的信号转导的抑制，调节和/或调节起到特别是TGF-β抑制剂的作用的用途 受体激酶，以及这些化合物用于治疗激酶诱导的疾病，特别是用于治疗肿瘤的用途。
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![Pyrido [2, 3-B] pyrazine compounds and their therapeutical uses such as for inhibiting ATP consuming proteins and treating diseases associated therewith](/abs-image/US/2015/06/09/US09051318B2/abs.jpg.150x150.jpg)
6.发明授权Pyrido [2, 3-B] pyrazine compounds and their therapeutical uses such as for inhibiting ATP consuming proteins and treating diseases associated therewith 有权吡啶并[2,3-B]吡嗪化合物及其治疗用途，例如用于抑制ATP消耗蛋白质并治疗与之相关的疾病公开(公告)号：US09051318B2
公开(公告)日：2015-06-09
申请号：US14002991
申请日：2012-02-13
IPC分类号： A61K31/4985 , C07D471/04 , A61K45/06 , C07D491/048
CPC分类号： C07D471/04 , A61K31/4985 , A61K45/06 , C07D491/048
摘要： The present invention relates to novel pyrido[2,3-b]pyrazine compounds of formula (I): and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors.
摘要翻译： 本发明涉及式（I）的新型吡啶并[2,3-b]吡嗪化合物：以及使用这样的化合物，其中抑制，调节和/或调节ATP消耗蛋白质如激酶的信号转导 特别是TGF-β受体激酶抑制剂的作用，以及这些化合物用于治疗激酶诱导的疾病，特别是用于治疗肿瘤的用途。
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公开(公告)号：US08846931B2
公开(公告)日：2014-09-30
申请号：US13808369
申请日：2011-06-07
IPC分类号： C07D401/14 , A61K45/06 , C07D213/74 , A61K31/496 , C07D471/04 , A61K31/5377 , A61K31/444 , A61K31/4545
CPC分类号： C07D401/14 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K45/06 , C07D213/74 , C07D471/04
摘要： The present invention relates to novel bipyridyl derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors.
摘要翻译： 本发明涉及式（I）的新型联吡啶衍生物和其中ATP消耗蛋白质如激酶的信号转导的抑制，调节和/或调节起到特别是TGF-β抑制剂的作用的用途 受体激酶，以及这些化合物用于治疗激酶诱导的疾病，特别是用于治疗肿瘤的用途。
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![Hetaryl-[1,8]naphthyridine derivatives](/abs-image/US/2014/02/06/US20140038960A1/abs.jpg.150x150.jpg)
公开(公告)号：US20140038960A1
公开(公告)日：2014-02-06
申请号：US14046703
申请日：2013-10-04
IPC分类号： C07D401/14 , C07D471/04 , C07D413/14
CPC分类号： C07D471/04 , A61K31/4375 , C07D401/14 , C07D413/14 , C07D519/00
摘要： Novel hetaryl-[1,8]naphthyridine derivatives of formula (I) wherein R1, R2, W1, W3, W5 and W6 have the meaning according to claim 1, are inhibitors of ATP consuming proteins, and can be employed, inter alia, for the treatment of tumors.
摘要翻译： 其中R 1，R 2，W 1，W 3，W 5和W 6具有权利要求1的含义的式（I）的新型杂芳基 - [1,8]二氮杂萘衍生物是ATP消耗蛋白质的抑制剂， 用于治疗肿瘤。
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![2,4-DIARYL - SUBSTITUTED [1,8] NAPHTHYRIDINES AS KINASE INHIBITORS FOR USE AGAINST CANCER](/abs-image/US/2013/04/25/US20130102603A1/abs.jpg.150x150.jpg)
9.发明申请2,4-DIARYL - SUBSTITUTED [1,8] NAPHTHYRIDINES AS KINASE INHIBITORS FOR USE AGAINST CANCER 有权2,4-DIARYL - 取代[1,8]萘啶类作为激酶使用抗癌剂公开(公告)号：US20130102603A1
公开(公告)日：2013-04-25
申请号：US13807119
申请日：2011-05-31
IPC分类号： C07D491/048 , A61K31/5377 , A61K31/517 , A61K31/519 , C07D471/04 , A61K31/4375
CPC分类号： C07D491/048 , A61K31/4375 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D471/04 , C07D519/00
摘要： The present invention relates to novel [1,8]naphthyridine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors.
摘要翻译： 本发明涉及式（I）的新颖的[1,8]萘啶衍生物，以及这样的化合物的用途，其中ATP消耗蛋白质如激酶的信号转导的抑制，调节和/或调节起着重要的作用，特别是 TGF-β受体激酶的抑制剂，以及这些化合物用于治疗激酶诱导的疾病，特别是用于治疗肿瘤的用途。
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![Hetaryl-[1,8]naphthyridine derivatives](/abs-image/US/2012/11/22/US20120295902A1/abs.jpg.150x150.jpg)
公开(公告)号：US20120295902A1
公开(公告)日：2012-11-22
申请号：US13574282
申请日：2010-12-17
IPC分类号： C07D471/04 , A61K31/444 , A61K31/4545 , A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/4375 , A61K31/501 , A61K31/538 , A61K31/4725 , C07D213/75 , C07D213/81 , C07F5/02 , C12N9/99 , A61P35/00 , A61P35/04 , A61P43/00 , A61P9/00 , A61P31/18 , A61P25/28 , A61P9/10 , A61P29/00 , A61P17/02 , A61P19/08 , A61P25/00 , A61K31/4709
CPC分类号： C07D471/04 , A61K31/4375 , C07D401/14 , C07D413/14 , C07D519/00
摘要： Novel hetaryl-[1,8]naphthyridine derivatives of formula (I) wherein R1, R2, W1, W3, W5 and W6 have the meaning according to claim 1, are inhibitors of ATP consuming proteins, and can be employed, inter alia, for the treatment of tumors.
摘要翻译： 其中R 1，R 2，W 1，W 3，W 5和W 6具有权利要求1的含义的式（I）的新型杂芳基 - [1,8]二氮杂萘衍生物是ATP消耗蛋白质的抑制剂， 用于治疗肿瘤。
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