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1.发明授权Identification of novel factors that block programmed cell death or apoptosis by targeting JNK 失效鉴定通过靶向JNK阻断程序性细胞死亡或凋亡的新因子公开(公告)号：US07354898B2
公开(公告)日：2008-04-08
申请号：US11032794
申请日：2005-01-10
CPC分类号： A61K31/00 , A61K31/704 , A61K31/7105 , A61K31/711 , A61K38/1709 , A61K48/00 , A61K49/0008 , C07K14/47 , C07K14/4747 , C12N9/1205 , G01N33/5041 , G01N33/573 , G01N2510/00
摘要： Methods and compositions for modulating apoptosis by acting on the c-Jun-N-terminal kinase (JNK) pathway and assays for the isolation of agents capable of modulating apoptosis, including modulators of the JNK pathway are disclosed. A method of modulating JNK pathway independent of Gadd46β is disclosed. Methods and compositions are presented for the preparation and use of novel therapeutic compositions for modulating diseases and conditions associated with elevated or decreased apoptosis.
摘要翻译： 公开了通过作用于c-Jun-N末端激酶（JNK）途径调节凋亡的方法和组合物，以及用于分离能够调节凋亡的试剂（包括JNK途径的调节剂）的分析。 公开了一种独立于Gadd46beta调节JNK途径的方法。 提出了用于制备和使用用于调节与升高或降低的细胞凋亡相关的疾病和病症的新型治疗组合物的方法和组合物。
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2.发明申请Identification of novel factors that block programmed cell death or apoptosis by targeting JNK 失效鉴定通过靶向JNK阻断程序性细胞死亡或凋亡的新因子公开(公告)号：US20050267022A1
公开(公告)日：2005-12-01
申请号：US11000365
申请日：2004-11-29
IPC分类号： G01N33/50 , A61K31/704 , A61K31/7105 , A61K31/711 , A61K33/24 , A61K38/00 , A61K38/17 , A61K45/00 , A61K48/00 , A61K49/00 , A61P35/00 , A61P37/04 , A61P43/00 , C07K14/47 , C12N9/12 , C12N15/09 , C12N15/12 , C12Q1/02 , G01N33/15 , G01N33/573
CPC分类号： A61K31/704 , A61K31/7105 , A61K31/711 , A61K38/00 , A61K49/0008 , C07K14/4747 , C12N9/1205 , G01N33/573 , G01N2510/00
摘要： Methods and compositions for modulating apoptosis by acting on the c-Jun-N-terminal kinase (JNK) pathway and assays for the isolation of agents capable of modulating apoptosis, including modulators of the JNK pathway are disclosed. A method of modulating JNK pathway independent of Gadd46β is disclosed. Methods and compositions are presented for the preparation and use of novel therapeutic compositions for modulating diseases and conditions associated with elevated or decreased apoptosis.
摘要翻译： 公开了通过作用于c-Jun-N末端激酶（JNK）途径调节凋亡的方法和组合物，以及用于分离能够调节凋亡的试剂（包括JNK途径的调节剂）的分析。 公开了一种独立于Gadd46beta调节JNK途径的方法。 提出了用于制备和使用用于调节与升高或降低的细胞凋亡相关的疾病和病症的新型治疗组合物的方法和组合物。
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3.发明授权公开(公告)号：US07326418B2
公开(公告)日：2008-02-05
申请号：US11000365
申请日：2004-11-29
CPC分类号： A61K31/704 , A61K31/7105 , A61K31/711 , A61K38/00 , A61K49/0008 , C07K14/4747 , C12N9/1205 , G01N33/573 , G01N2510/00
摘要： Methods and compositions for modulating apoptosis by acting on the c-Jun-N-terminal kinase (JNK) pathway and assays for the isolation of agents capable of modulating apoptosis, including modulators of the JNK pathway are disclosed. A method of modulating JNK pathway independent of Gadd46β is disclosed. Methods and compositions are presented for the preparation and use of novel therapeutic compositions for modulating diseases and conditions associated with elevated or decreased apoptosis.
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4.发明申请IDENTIFICATION OF NOVEL FACTORS THAT BLOCK PROGRAMMED CELL DEATH OR APOPTOSIS BY TARGETING JNK 审中-公开通过定位JNK识别块编程细胞死亡或病毒的新因子的鉴定公开(公告)号：US20080247956A1
公开(公告)日：2008-10-09
申请号：US12030558
申请日：2008-02-13
CPC分类号： A61K31/00 , A61K31/704 , A61K31/7105 , A61K31/711 , A61K38/1709 , A61K48/00 , A61K49/0008 , C07K14/47 , C07K14/4747 , C12N9/1205 , G01N33/5041 , G01N33/573 , G01N2510/00
摘要： Methods and compositions for modulating apoptosis by acting on the c-Jun-N-terminal kinase (JNK) pathway and assays for the isolation of agents capable of modulating apoptosis, including modulators of the JNK pathway are disclosed. A method of modulating JNK pathway independent of Gadd46β is disclosed. Methods and compositions are presented for the preparation and use of novel therapeutic compositions for modulating diseases and conditions associated with elevated or decreased apoptosis.
摘要翻译： 公开了通过作用于c-Jun-N末端激酶（JNK）途径调节凋亡的方法和组合物，以及用于分离能够调节凋亡的试剂（包括JNK途径的调节剂）的分析。 公开了一种独立于Gadd46beta调节JNK途径的方法。 提出了用于制备和使用用于调节与升高或降低的细胞凋亡相关的疾病和病症的新型治疗组合物的方法和组合物。
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5.发明申请公开(公告)号：US20050265970A1
公开(公告)日：2005-12-01
申请号：US11032794
申请日：2005-01-10
CPC分类号： A61K31/00 , A61K31/704 , A61K31/7105 , A61K31/711 , A61K38/1709 , A61K48/00 , A61K49/0008 , C07K14/47 , C07K14/4747 , C12N9/1205 , G01N33/5041 , G01N33/573 , G01N2510/00
摘要： Methods and compositions for modulating apoptosis by acting on the c-Jun-N-terminal kinase (JNK) pathway and assays for the isolation of agents capable of modulating apoptosis, including modulators of the JNK pathway are disclosed. A method of modulating JNK pathway independent of Gadd46β is disclosed. Methods and compositions are presented for the preparation and use of novel therapeutic compositions for modulating diseases and conditions associated with elevated or decreased apoptosis.
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