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1.发明授权Identification of novel factors that block programmed cell death or apoptosis by targeting JNK 失效鉴定通过靶向JNK阻断程序性细胞死亡或凋亡的新因子公开(公告)号：US07354898B2
公开(公告)日：2008-04-08
申请号：US11032794
申请日：2005-01-10
CPC分类号： A61K31/00 , A61K31/704 , A61K31/7105 , A61K31/711 , A61K38/1709 , A61K48/00 , A61K49/0008 , C07K14/47 , C07K14/4747 , C12N9/1205 , G01N33/5041 , G01N33/573 , G01N2510/00
摘要： Methods and compositions for modulating apoptosis by acting on the c-Jun-N-terminal kinase (JNK) pathway and assays for the isolation of agents capable of modulating apoptosis, including modulators of the JNK pathway are disclosed. A method of modulating JNK pathway independent of Gadd46β is disclosed. Methods and compositions are presented for the preparation and use of novel therapeutic compositions for modulating diseases and conditions associated with elevated or decreased apoptosis.
摘要翻译： 公开了通过作用于c-Jun-N末端激酶（JNK）途径调节凋亡的方法和组合物，以及用于分离能够调节凋亡的试剂（包括JNK途径的调节剂）的分析。 公开了一种独立于Gadd46beta调节JNK途径的方法。 提出了用于制备和使用用于调节与升高或降低的细胞凋亡相关的疾病和病症的新型治疗组合物的方法和组合物。
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公开(公告)号：US10697019B2
公开(公告)日：2020-06-30
申请号：US14113518
申请日：2012-04-27
IPC分类号： C12Q1/68 , C12Q1/6886
摘要： A method of measuring Gadd45β expression comprising the step of measuring Gadd45β expression levels in a sample of cells, for example CD 138 expressing cells, obtained from a subject known to have or suspected of having a haematological malignancy. Expression levels may be used in diagnosis, for example of multiple myeloma, in providing a prognosis, for example in a patient having multiple myeloma or in guiding selection of an appropriate treatment agent, especially a treatment agent comprising Gadd45β and or MKK7 inhibitors. Also datasets comprising measured expression levels from multiple subjects.
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3.发明申请Identification of novel factors that block programmed cell death or apoptosis by targeting JNK 失效鉴定通过靶向JNK阻断程序性细胞死亡或凋亡的新因子公开(公告)号：US20050267022A1
公开(公告)日：2005-12-01
申请号：US11000365
申请日：2004-11-29
IPC分类号： G01N33/50 , A61K31/704 , A61K31/7105 , A61K31/711 , A61K33/24 , A61K38/00 , A61K38/17 , A61K45/00 , A61K48/00 , A61K49/00 , A61P35/00 , A61P37/04 , A61P43/00 , C07K14/47 , C12N9/12 , C12N15/09 , C12N15/12 , C12Q1/02 , G01N33/15 , G01N33/573
CPC分类号： A61K31/704 , A61K31/7105 , A61K31/711 , A61K38/00 , A61K49/0008 , C07K14/4747 , C12N9/1205 , G01N33/573 , G01N2510/00
摘要： Methods and compositions for modulating apoptosis by acting on the c-Jun-N-terminal kinase (JNK) pathway and assays for the isolation of agents capable of modulating apoptosis, including modulators of the JNK pathway are disclosed. A method of modulating JNK pathway independent of Gadd46β is disclosed. Methods and compositions are presented for the preparation and use of novel therapeutic compositions for modulating diseases and conditions associated with elevated or decreased apoptosis.
摘要翻译： 公开了通过作用于c-Jun-N末端激酶（JNK）途径调节凋亡的方法和组合物，以及用于分离能够调节凋亡的试剂（包括JNK途径的调节剂）的分析。 公开了一种独立于Gadd46beta调节JNK途径的方法。 提出了用于制备和使用用于调节与升高或降低的细胞凋亡相关的疾病和病症的新型治疗组合物的方法和组合物。
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公开(公告)号：US20140128330A1
公开(公告)日：2014-05-08
申请号：US14113518
申请日：2012-04-27
IPC分类号： C12Q1/68
摘要： A method of measuring Gadd45β expression comprising the step of measuring Gadd45β expression levels in a sample of cells, for example CD 138 expressing cells, obtained from a subject known to have or suspected of having a haematological malignancy. Expression levels may be used in diagnosis, for example of multiple myeloma, in providing a prognosis, for example in a patient having multiple myeloma or in guiding selection of an appropriate treatment agent, especially a treatment agent comprising Gadd45β and or MKK7 inhibitors. Also datasets comprising measured expression levels from multiple subjects.
摘要翻译： 测量Gadd45＆bgr的方法 包括测量Gadd45＆bgr的步骤; 从已知具有或怀疑具有血液恶性肿瘤的受试者获得的细胞样品中的表达水平，例如CD138表达细胞。 表达水平可以用于例如多发性骨髓瘤的诊断中，例如在具有多发性骨髓瘤的患者中或在指导选择适当的治疗剂，特别是包含Gadd45和bgr的治疗剂时提供预后。 和/或MKK7抑制剂。 还包括来自多个受试者的测量表达水平的数据集。
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公开(公告)号：US20120277164A1
公开(公告)日：2012-11-01
申请号：US13502781
申请日：2010-10-22
申请人： Guido Franzoso , Albert Andrzej Jaxa-Chamiec , Caroline Minli Rachel Low , Simona Maria Monti , Menotti Ruvo , Laura Tornatore , Catherine Jane Tralau-Stewart
发明人： Guido Franzoso , Albert Andrzej Jaxa-Chamiec , Caroline Minli Rachel Low , Simona Maria Monti , Menotti Ruvo , Laura Tornatore , Catherine Jane Tralau-Stewart
IPC分类号： A61K38/07 , A61P35/02 , A61P29/00 , C07K5/107 , A61K38/06 , C07K5/087 , C07K5/12 , A61K38/05 , A61K38/12 , A61P35/00 , C07K5/117
CPC分类号： C07K5/08 , A61K38/00 , C07K5/06078 , C07K5/06104 , C07K5/06113 , C07K5/0812 , C07K5/1016
摘要： Compounds based around tetrapeptide, tripeptide and dipeptide moeties and corresponding peptiod moeties. Related methods and pharmaceutical compositions for use in treatment of cancer, inflammatory diseases, and other disorders.
摘要翻译： 基于四肽，三肽和二肽的化合物和相应的肽酶。 用于治疗癌症，炎性疾病和其他疾病的相关方法和药物组合物。
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6.发明授权公开(公告)号：US07326418B2
公开(公告)日：2008-02-05
申请号：US11000365
申请日：2004-11-29
CPC分类号： A61K31/704 , A61K31/7105 , A61K31/711 , A61K38/00 , A61K49/0008 , C07K14/4747 , C12N9/1205 , G01N33/573 , G01N2510/00
摘要： Methods and compositions for modulating apoptosis by acting on the c-Jun-N-terminal kinase (JNK) pathway and assays for the isolation of agents capable of modulating apoptosis, including modulators of the JNK pathway are disclosed. A method of modulating JNK pathway independent of Gadd46β is disclosed. Methods and compositions are presented for the preparation and use of novel therapeutic compositions for modulating diseases and conditions associated with elevated or decreased apoptosis.
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公开(公告)号：US08993717B2
公开(公告)日：2015-03-31
申请号：US13502781
申请日：2010-10-22
申请人： Guido Franzoso , Albert Andrzej Jaxa-Chamiec , Caroline Minli Rachel Low , Simona Maria Monti , Menotti Ruvo , Laura Tornatore , Catherine Jane Tralau-Stewart
发明人： Guido Franzoso , Albert Andrzej Jaxa-Chamiec , Caroline Minli Rachel Low , Simona Maria Monti , Menotti Ruvo , Laura Tornatore , Catherine Jane Tralau-Stewart
IPC分类号： A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , C07K5/107 , C07K5/065 , C07K5/072 , C07K5/087
CPC分类号： C07K5/08 , A61K38/00 , C07K5/06078 , C07K5/06104 , C07K5/06113 , C07K5/0812 , C07K5/1016
摘要： Compounds based around tetrapeptide, tripeptide and dipeptide moeties and corresponding peptiod moeties. Related methods and pharmaceutical compositions for use in treatment of cancer, inflammatory diseases, and other disorders.
摘要翻译： 基于四肽，三肽和二肽的化合物和相应的肽酶。 用于治疗癌症，炎性疾病和其他疾病的相关方法和药物组合物。
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8.发明申请IDENTIFICATION OF NOVEL FACTORS THAT BLOCK PROGRAMMED CELL DEATH OR APOPTOSIS BY TARGETING JNK 审中-公开通过定位JNK识别块编程细胞死亡或病毒的新因子的鉴定公开(公告)号：US20080247956A1
公开(公告)日：2008-10-09
申请号：US12030558
申请日：2008-02-13
CPC分类号： A61K31/00 , A61K31/704 , A61K31/7105 , A61K31/711 , A61K38/1709 , A61K48/00 , A61K49/0008 , C07K14/47 , C07K14/4747 , C12N9/1205 , G01N33/5041 , G01N33/573 , G01N2510/00
摘要： Methods and compositions for modulating apoptosis by acting on the c-Jun-N-terminal kinase (JNK) pathway and assays for the isolation of agents capable of modulating apoptosis, including modulators of the JNK pathway are disclosed. A method of modulating JNK pathway independent of Gadd46β is disclosed. Methods and compositions are presented for the preparation and use of novel therapeutic compositions for modulating diseases and conditions associated with elevated or decreased apoptosis.
摘要翻译： 公开了通过作用于c-Jun-N末端激酶（JNK）途径调节凋亡的方法和组合物，以及用于分离能够调节凋亡的试剂（包括JNK途径的调节剂）的分析。 公开了一种独立于Gadd46beta调节JNK途径的方法。 提出了用于制备和使用用于调节与升高或降低的细胞凋亡相关的疾病和病症的新型治疗组合物的方法和组合物。
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9.发明申请公开(公告)号：US20050265970A1
公开(公告)日：2005-12-01
申请号：US11032794
申请日：2005-01-10
CPC分类号： A61K31/00 , A61K31/704 , A61K31/7105 , A61K31/711 , A61K38/1709 , A61K48/00 , A61K49/0008 , C07K14/47 , C07K14/4747 , C12N9/1205 , G01N33/5041 , G01N33/573 , G01N2510/00
摘要： Methods and compositions for modulating apoptosis by acting on the c-Jun-N-terminal kinase (JNK) pathway and assays for the isolation of agents capable of modulating apoptosis, including modulators of the JNK pathway are disclosed. A method of modulating JNK pathway independent of Gadd46β is disclosed. Methods and compositions are presented for the preparation and use of novel therapeutic compositions for modulating diseases and conditions associated with elevated or decreased apoptosis.
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