公开(公告)号：US20030216468A1

公开(公告)日：2003-11-20

申请号：US10431462

申请日：2003-05-08

申请人： GUILFORD PHARMACEUTICALS INC.

发明人： Takashi Tsukamoto ,  Pavel Majer ,  Doris Stoermer ,  Barbara S. Slusher

IPC分类号： A61K031/277 ,  A61K031/195 ,  A61K031/192 ,  C07C323/22 ,  C07C323/29

CPC分类号： C07C323/56 ,  C07C323/52 ,  C07C323/58 ,  C07C323/59 ,  C07C323/60 ,  C07C323/62 ,  C07C323/65

摘要： This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-null activity, inhibiting angiogenesis, and treating glutamate abnormalities, diabetic neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.

公开(公告)号：US20030105088A1

公开(公告)日：2003-06-05

申请号：US10046917

申请日：2002-01-17

申请人： GUILFORD PHARMACEUTICALS INC.

发明人： Takashi Tsukamoto ,  Pavel Majer ,  Doris Stoermer ,  Barbara S. Slusher

IPC分类号： A61K031/5415 ,  A61K031/538 ,  A61K031/517 ,  A61K031/47 ,  A61K031/192 ,  C07D265/36

CPC分类号： C07C323/56 ,  C07C323/52 ,  C07C323/58 ,  C07C323/59 ,  C07C323/60 ,  C07C323/62 ,  C07C323/65

摘要： This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-null activity, inhibiting angiogenesis, and treating glutamate abnormalities, diabetic neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.

公开(公告)号：US20040198824A1

公开(公告)日：2004-10-07

申请号：US10819146

申请日：2004-04-07

申请人： Guilford Pharmaceuticals Inc.

发明人： Takashi Tsukamoto ,  Doris Stoermer ,  Dilrukshi Vitharana

IPC分类号： C07D321/02 ,  A61K031/19

CPC分类号： C07C323/62 ,  C07C323/56 ,  C07C323/58

摘要： The present invention relates to new thiolalkyl benzoic acids, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-null activity, inhibiting angiogenesis, and treating glutamate abnormalities, neuropathy, pain, compulsive disorders, prostate diseases, cancers, glaucoma, retinal disorders, and cancer.

摘要翻译： 本发明涉及新的硫醇烷基苯甲酸，包含这些化合物的药物组合物和诊断试剂，以及使用这些化合物抑制NAALADase酶活性的方法，检测其中NAALADase水平被改变，影响神经元活性，影响TGF-β活性，抑制 血管生成和治疗谷氨酸异常，神经病，疼痛，强迫症，前列腺疾病，癌症，青光眼，视网膜疾病和癌症。