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    Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium
    2.
    发明申请
    Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium 审中-公开
    制剂在从疏水载体转移到亲水介质的过程中具有增加的稳定性

    公开(公告)号：US20080112994A1

    公开(公告)日：2008-05-15

    申请号：US12008553

    申请日：2008-01-11

    申请人： Gunjan Junnarkar ,  Michael DesJardin ,  Kui Liu ,  Zengji Li

    发明人： Gunjan Junnarkar ,  Michael DesJardin ,  Kui Liu ,  Zengji Li

    IPC分类号： A61K9/14 ,  A61K38/21

    CPC分类号： A61K9/0024 ,  A61K9/1623 ,  A61K31/7024 ,  A61K38/21 ,  A61K47/183

    摘要： A suspension formulation for therapeutic use includes a non-aqueous, hydrophobic vehicle exhibiting viscous fluid characteristics, a dry particle formulation comprising a biomolecule dispersed in the vehicle, and a surfactant incorporated in at least one of the vehicle and dry particle formulation. A dry particle formulation includes an interferon, a buffer, a surfactant, and one or more stabilizers selected from the group consisting of a carbohydrate, an antioxidant, and an amino acid.

    摘要翻译： 用于治疗用途的悬浮液制剂包括显示粘性流体特性的非水性疏水载体，包含分散在载体中的生物分子的干燥颗粒制剂，以及掺入至少一种载体和干燥颗粒制剂中的表面活性剂。 干颗粒制剂包括干扰素，缓冲剂，表面活性剂和一种或多种选自碳水化合物，抗氧化剂和氨基酸的稳定剂。

    Method for making liposomes conjugated with temperature-sensitive ligands
    5.
    发明申请
    Method for making liposomes conjugated with temperature-sensitive ligands 审中-公开
    制备与温度敏感性配体结合的脂质体的方法

    公开(公告)号：US20070264322A1

    公开(公告)日：2007-11-15

    申请号：US11801713

    申请日：2007-05-09

    申请人： Ken Huang ,  Zengji Li ,  Jinkang Wang ,  Guoyang Zhang ,  John Grigsby

    发明人： Ken Huang ,  Zengji Li ,  Jinkang Wang ,  Guoyang Zhang ,  John Grigsby

    IPC分类号： A61K31/704 ,  A61K9/127

    CPC分类号： A61K9/1271 ,  A61K47/6849 ,  A61K47/6913

    摘要： The present invention relates to a method of making a liposome composition. In particular, the invention relates to a method of making liposomes targeted to a specific cell receptor for delivery of a liposome-entrapped drug to the cell. In one embodiment, the process involves the incorporation of lipid-linkers to the surface of pre-formed liposomes, preferably at a higher temperature, followed by the conjugation of one or more temperature-sensitive ligands to the linkers associated with the liposome surface at a lower temperature to avoid deactivation of the temperature sensitive ligands. The present invention also is directed to a product prepared according to the foregoing process, and its use to treat subjects. The present invention is also directed to a kit containing lipid-linker, ligand and pre-formed liposome.

    摘要翻译： 本发明涉及一种制备脂质体组合物的方法。 特别地，本发明涉及制备靶向特定细胞受体的脂质体以将脂质体包埋的药物递送至细胞的方法。 在一个实施方案中，该方法包括将脂质连接体掺入预先形成的脂质体的表面，优选在较高温度下，随后将一种或多种温度敏感性配体与在脂质体表面相关的接头共轭 降低温度以避免温度敏感配体的失活。 本发明还涉及根据前述方法制备的产品及其用于治疗受试者的用途。 本发明还涉及含有脂质连接体，配体和预形成脂质体的试剂盒。