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公开(公告)号：US07772182B2
公开(公告)日：2010-08-10
申请号：US11194850
申请日：2005-08-01
Applicant: Kui Liu , Michael A. Desjardin , Beth L. Hill , Zengji Li
Inventor： Kui Liu , Michael A. Desjardin , Beth L. Hill , Zengji Li
IPC: A61K38/18
CPC classification number: A61K9/0004 , A61K9/0024 , A61K9/10 , A61K9/1623 , A61K38/1816 , A61K47/32
Abstract: A suspension formulation for therapeutic use includes a non-aqueous, single-phase vehicle exhibiting viscous fluid characteristics and a particle formulation comprising an erythropoietin receptor agonist dispersed in the vehicle.
Abstract translation: 用于治疗用途的悬浮液制剂包括显示粘性流体特性的非水性单相载体和包含分散在载体中的促红细胞生成素受体激动剂的颗粒制剂。
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公开(公告)号：US07655254B2
公开(公告)日：2010-02-02
申请号：US11347601
申请日：2006-02-03
Applicant: Paula Dennis , Michael A. Desjardin , Stan Lam , Kui Liu , James E. Matsuura , Latha Narayanan , Catherine M. Rohloff , Pauline C. Zamora
Inventor： Paula Dennis , Michael A. Desjardin , Stan Lam , Kui Liu , James E. Matsuura , Latha Narayanan , Catherine M. Rohloff , Pauline C. Zamora
CPC classification number: A61K38/21 , A61F2250/0068 , A61K9/0004 , A61K9/0019 , A61K9/0024 , A61K9/10 , A61K9/1617 , A61K9/1623 , A61K9/1694 , A61K9/19
Abstract: An implantable device includes a reservoir containing a suspension of an interferon in an amount sufficient to provide continuous delivery of the interferon at a therapeutically effective rate of 1 ng/day to 600 μg/day to maintain and achieve therapeutic blood or plasma levels of the interferon throughout a substantial period of the administration period.
Abstract translation: 可植入装置包括含有干扰素悬浮液的储存器，其量足以提供以1ng /天至600ug /天的治疗有效速率连续递送干扰素，以维持和实现干扰素的治疗血浆或血浆水平 在行政期间的相当长的一段时期。
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公开(公告)号：US09511886B2
公开(公告)日：2016-12-06
申请号：US14256035
申请日：2014-04-18
Applicant: Jun-Kui Liu
Inventor： Jun-Kui Liu
CPC classification number: B65B11/045 , B65B61/10
Abstract: A stretch wrapping machine structure contains: a rotary disc including a column on which a guide way is arranged; an abutting plate including a rotating stem and a pushing portion adjacent to the rotating stem; a hot pressing sheet including a cutter seat, a driven bar, and a press segment; a holder including a V-shaped cross section and formed in a plate shape, the holder also including an actuation member, an actuating post, an operating segment, and a third cylinder; a biasing rod including a driving peg and a push segment; a controlling unit secured on a predetermined position of one side of the column; an air blowing unit located at a predetermined position of the holder. Thereby, an object is held on the rotary disc and is packed by a plastic film quickly and easily.
Abstract translation: 一种拉伸包装机结构包括：一个旋转盘，包括一个其上布置有引导方式的柱; 邻接板，包括旋转杆和邻近所述旋转杆的推动部; 包括刀座，从动杆和压榨段的热压片; 包括V形横截面并形成为板状的保持器，所述保持器还包括致动构件，致动柱，操作段和第三气缸; 偏置杆，包括驱动栓和推动段; 控制单元固定在所述列的一侧的预定位置上; 位于所述保持器的预定位置的送风单元。 因此，物体被保持在旋转盘上并且被塑料膜快速且容易地包装。
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公开(公告)号：US09259438B2
公开(公告)日：2016-02-16
申请号：US12812930
申请日：2009-01-19
Applicant: Kui Liu
Inventor： Kui Liu
CPC classification number: C12N5/0682 , A61B17/43 , A61B17/435 , A61K33/24 , C12N5/0609 , C12N15/8776 , C12N2501/73 , C12Q1/42 , G01N33/502
Abstract: The invention relates to methods to be used in the maturation of ovarian follicles and oocytes. More specifically, the invention concerns the use of inhibitors of the phosphatase PTEN, such as oxovanadate and peroxovanadate complexes, in methods for in vitro and in vivo maturation of follicles and oocytes.
Abstract translation: 本发明涉及用于卵泡和卵母细胞成熟的方法。 更具体地，本发明涉及在卵泡和卵母细胞的体外和体内成熟的方法中使用磷酸酶PTEN的抑制剂，例如过氧钒酸盐和过氧钒酸盐络合物。
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5.发明申请公开(公告)号：US20120076800A1
公开(公告)日：2012-03-29
申请号：US13249774
申请日：2011-09-30
Applicant: Weiguo Dai , Beth Hill , Kui Liu , Carl Mieczkowski
Inventor： Weiguo Dai , Beth Hill , Kui Liu , Carl Mieczkowski
IPC: A61K39/395
CPC classification number: A61K9/10 , A61K9/0019 , A61K9/145 , A61K9/19 , A61K38/38 , A61K39/39591 , A61K47/26 , A61K47/44 , C07K16/241
Abstract: The present invention relates to non-aqueous high concentration reduced viscosity suspension formulations of antibodies and methods of making and using them.
Abstract translation: 本发明涉及抗体的非水性高浓度还原粘度悬浮液制剂及其制备和使用方法。
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Patent Agency Ranking
公开(公告)号：US20110015169A1
公开(公告)日：2011-01-20
申请号：US12812930
申请日：2009-01-19
Applicant: Kui Liu
Inventor： Kui Liu
IPC: A61K31/555 , C12N5/10 , C12Q1/42 , A61K31/28 , A61P15/00
CPC classification number: C12N5/0682 , A61B17/43 , A61B17/435 , A61K33/24 , C12N5/0609 , C12N15/8776 , C12N2501/73 , C12Q1/42 , G01N33/502
Abstract: The invention relates to methods to be used in the maturation of ovarian follicles and oocytes. More specifically, the invention concerns the use of inhibitors of the phosphatase PTEN, such as oxovanadate and peroxovanadate complexes, in methods for in vitro and in vivo maturation of follicles and oocytes.
Abstract translation: 本发明涉及用于卵泡和卵母细胞成熟的方法。 更具体地，本发明涉及在卵泡和卵母细胞的体外和体内成熟的方法中使用磷酸酶PTEN的抑制剂，例如过氧钒酸盐和过氧钒酸盐络合物。
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7.发明申请Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium 审中-公开制剂在从疏水载体转移到亲水介质的过程中具有增加的稳定性公开(公告)号：US20080112994A1
公开(公告)日：2008-05-15
申请号：US12008553
申请日：2008-01-11
Applicant: Gunjan Junnarkar , Michael DesJardin , Kui Liu , Zengji Li
Inventor： Gunjan Junnarkar , Michael DesJardin , Kui Liu , Zengji Li
CPC classification number: A61K9/0024 , A61K9/1623 , A61K31/7024 , A61K38/21 , A61K47/183
Abstract: A suspension formulation for therapeutic use includes a non-aqueous, hydrophobic vehicle exhibiting viscous fluid characteristics, a dry particle formulation comprising a biomolecule dispersed in the vehicle, and a surfactant incorporated in at least one of the vehicle and dry particle formulation. A dry particle formulation includes an interferon, a buffer, a surfactant, and one or more stabilizers selected from the group consisting of a carbohydrate, an antioxidant, and an amino acid.
Abstract translation: 用于治疗用途的悬浮液制剂包括显示粘性流体特性的非水性疏水载体，包含分散在载体中的生物分子的干燥颗粒制剂，以及掺入至少一种载体和干燥颗粒制剂中的表面活性剂。 干颗粒制剂包括干扰素，缓冲剂，表面活性剂和一种或多种选自碳水化合物，抗氧化剂和氨基酸的稳定剂。
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公开(公告)号：US20060029551A1
公开(公告)日：2006-02-09
申请号：US11194889
申请日：2005-08-01
Applicant: Kui Liu , Michael Desjardin
Inventor： Kui Liu , Michael Desjardin
IPC: A61K38/18 , A61K31/7012 , A61K9/14 , A61L9/04
CPC classification number: A61K9/1617 , A61K9/1623 , A61K9/19 , A61K31/7012 , A61K38/1816 , A61K47/12 , A61K47/183 , A61K47/26
Abstract: A particle formulation includes an erythropoietin receptor agonist, a buffer, and a sugar, wherein the buffer and sugar stabilize the erythropoietin receptor agonist against aggregation.
Abstract translation: 颗粒制剂包括促红细胞生成素受体激动剂，缓冲剂和糖，其中缓冲液和糖使促红细胞生成素受体激动剂稳定聚集。
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公开(公告)号：US06797341B2
公开(公告)日：2004-09-28
申请号：US10395892
申请日：2003-03-25
Applicant: Xianghui Zeng , Alexej Pogrebnyakov , Xiaoxing Xi , Joan M. Redwing , Zi-Kui Liu , Darrell G. Schlom
Inventor： Xianghui Zeng , Alexej Pogrebnyakov , Xiaoxing Xi , Joan M. Redwing , Zi-Kui Liu , Darrell G. Schlom
IPC: B05D300
CPC classification number: H01L39/2493 , C23C14/0021 , C23C14/0057 , C23C14/067 , C30B23/02 , C30B29/10 , H01L29/7834 , H01L39/2487 , Y10T29/49014
Abstract: Thin films of conducting and superconducting materials are formed by a process which combines physical vapor deposition with chemical vapor deposition. Embodiments include forming boride films, such as magnesium diboride, in high purity with superconducting properties on substrates typically used in the semiconductor industry by physically generating magnesium vapor in a deposition chamber and introducing a boron containing precursor into the chamber which combines with the magnesium vapor to form a thin boride film on the substrate.
Abstract translation: 导电和超导材料的薄膜通过将物理气相沉积与化学气相沉积相结合的方法形成。 实施方案包括在通常用于半导体工业的基底上以高纯度形成具有超导特性的硼化物膜，例如二硼化镁，其通过在沉积室中物理产生镁蒸汽并将含硼前体引入到与镁蒸气结合的室中 在基板上形成薄硼化物膜。
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公开(公告)号：US20060263433A1
公开(公告)日：2006-11-23
申请号：US11347109
申请日：2006-02-03
Applicant: Rupal Ayer , Paula Dennis , Michael Desjardin , Stan Lam , Kui Liu , James Matsuura , Latha Narayanan , Catherine Rohloff , Pauline Zamora
Inventor： Rupal Ayer , Paula Dennis , Michael Desjardin , Stan Lam , Kui Liu , James Matsuura , Latha Narayanan , Catherine Rohloff , Pauline Zamora
CPC classification number: A61K38/21 , A61F2250/0068 , A61K9/0004 , A61K9/0019 , A61K9/0024 , A61K9/10 , A61K9/1617 , A61K9/1623 , A61K9/1694 , A61K9/19
Abstract: A suspension formulation of interferon includes a non-aqueous, single-phase vehicle including at least one polymer and at least one solvent, the vehicle exhibiting viscous fluid characteristics, and an interferon contained in a particle formulation dispersed in the vehicle. The particle formulation includes a stabilizing component comprising one or more stabilizers selected from the group consisting of carbohydrates, antioxidants, and amino acids. The suspension formulation is characterized in that less than 10% of the interferon degrades over 3 months under an accelerated storage condition.
Abstract translation: 干扰素的悬浮液制剂包括非水性单相载体，其包含至少一种聚合物和至少一种溶剂，所述载体表现出粘性流体特性，以及包含在分散在载体中的颗粒制剂中的干扰素。 颗粒制剂包括稳定组分，其包含一种或多种选自碳水化合物，抗氧化剂和氨基酸的稳定剂。 悬浮液制剂的特征在于，在加速储存条件下，少于10％的干扰素在3个月内降解。
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